Antibody data
- Antibody Data
- Antigen structure
- References [19]
- Comments [0]
- Validations
- Western blot [2]
- Immunocytochemistry [1]
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Validation data
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- Product number
- 10615-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10615-1-AP, RRID:AB_2213944
- Product name
- UFD1L antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated UFD1L antibody (Cat. #10615-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references New mode of action of curcumin on prostate cancer cells: Modulation of endoplasmic reticulum-associated degradation mechanism and estrogenic signaling.
Triiodothyronine positively regulates endoplasmic reticulum-associated degradation (ERAD) and promotes androgenic signaling in androgen-dependent prostate cancer cells.
The FAM104 proteins VCF1/2 promote the nuclear localization of p97/VCP.
TRIM55 promotes noncanonical NF-κB signaling and B cell-mediated immune responses by coordinating p100 ubiquitination and processing.
1,25(OH)(2) D(3) induced vitamin D receptor signaling negatively regulates endoplasmic reticulum-associated degradation (ERAD) and androgen receptor signaling in human prostate cancer cells.
Dexamethasone-stimulated glucocorticoid receptor signaling positively regulates the endoplasmic reticulum-associated degradation (ERAD) mechanism in hepatocellular carcinoma cells.
Progesterone regulates the endoplasmic reticulum-associated degradation and Unfolded Protein Response axis by mimicking the androgenic stimulation in prostate cancer cells.
The ubiquitin-26S proteasome system and autophagy relay proteome homeostasis regulation during silique development.
Yeast Smy2 and its human homologs GIGYF1 and -2 regulate Cdc48/VCP function during transcription stress.
Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner.
PCBP2 Posttranscriptional Modifications Induce Breast Cancer Progression via Upregulation of UFD1 and NT5E.
The ESCRT machinery counteracts Nesprin-2G-mediated mechanical forces during nuclear envelope repair.
The p97-UBXN1 complex regulates aggresome formation.
Involvement of VCP/UFD1/Nucleolin in the viral entry of Enterovirus A species.
WWP2 ameliorates acute kidney injury by mediating p53 ubiquitylation and degradation.
The VCP-UBXN1 Complex Mediates Triage of Ubiquitylated Cytosolic Proteins Bound to the BAG6 Complex.
Pathogenic Mutations in the Valosin-containing Protein/p97(VCP) N-domain Inhibit the SUMOylation of VCP and Lead to Impaired Stress Response.
ESCRT-III controls nuclear envelope reformation.
Secretome profiling of primary cells reveals that THBS2 is a salivary biomarker of oral cavity squamous cell carcinoma.
Erzurumlu Y, Dogan HK, Catakli D
Journal of biochemical and molecular toxicology 2024 Jan;38(1):e23636
Journal of biochemical and molecular toxicology 2024 Jan;38(1):e23636
Triiodothyronine positively regulates endoplasmic reticulum-associated degradation (ERAD) and promotes androgenic signaling in androgen-dependent prostate cancer cells.
Erzurumlu Y, Muhammed MT
Cellular signalling 2023 Sep;109:110745
Cellular signalling 2023 Sep;109:110745
The FAM104 proteins VCF1/2 promote the nuclear localization of p97/VCP.
Körner M, Meyer SR, Marincola G, Kern MJ, Grimm C, Schuelein-Voelk C, Fischer U, Hofmann K, Buchberger A
eLife 2023 Sep 15;12
eLife 2023 Sep 15;12
TRIM55 promotes noncanonical NF-κB signaling and B cell-mediated immune responses by coordinating p100 ubiquitination and processing.
Lin L, Yu H, Li L, Yang W, Chen X, Gong Y, Lei Q, Li Z, Zhou Z, Dai L, Zhang H, Hu H
Science signaling 2023 Oct 10;16(806):eabn5410
Science signaling 2023 Oct 10;16(806):eabn5410
1,25(OH)(2) D(3) induced vitamin D receptor signaling negatively regulates endoplasmic reticulum-associated degradation (ERAD) and androgen receptor signaling in human prostate cancer cells.
Erzurumlu Y, Aydogdu E, Dogan HK, Catakli D, Muhammed MT, Buyuksandic B
Cellular signalling 2023 Mar;103:110577
Cellular signalling 2023 Mar;103:110577
Dexamethasone-stimulated glucocorticoid receptor signaling positively regulates the endoplasmic reticulum-associated degradation (ERAD) mechanism in hepatocellular carcinoma cells.
Erzurumlu Y, Dogan HK, Cataklı D
Steroids 2023 Jul;195:109238
Steroids 2023 Jul;195:109238
Progesterone regulates the endoplasmic reticulum-associated degradation and Unfolded Protein Response axis by mimicking the androgenic stimulation in prostate cancer cells.
Erzurumlu Y, Dogan HK, Catakli D
Molecular biology reports 2023 Feb;50(2):1253-1265
Molecular biology reports 2023 Feb;50(2):1253-1265
The ubiquitin-26S proteasome system and autophagy relay proteome homeostasis regulation during silique development.
Yu P, Hua Z
The Plant journal : for cell and molecular biology 2022 Sep;111(5):1324-1339
The Plant journal : for cell and molecular biology 2022 Sep;111(5):1324-1339
Yeast Smy2 and its human homologs GIGYF1 and -2 regulate Cdc48/VCP function during transcription stress.
Lehner MH, Walker J, Temcinaite K, Herlihy A, Taschner M, Berger AC, Corbett AH, Dirac Svejstrup AB, Svejstrup JQ
Cell reports 2022 Oct 25;41(4):111536
Cell reports 2022 Oct 25;41(4):111536
Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner.
Gwon Y, Maxwell BA, Kolaitis RM, Zhang P, Kim HJ, Taylor JP
Science (New York, N.Y.) 2021 Jun 25;372(6549):eabf6548
Science (New York, N.Y.) 2021 Jun 25;372(6549):eabf6548
PCBP2 Posttranscriptional Modifications Induce Breast Cancer Progression via Upregulation of UFD1 and NT5E.
Wang X, Guo Q, Wang H, Yuan X, Wang B, Lobie PE, Zhu T, Tan S, Wu Z
Molecular cancer research : MCR 2021 Jan;19(1):86-98
Molecular cancer research : MCR 2021 Jan;19(1):86-98
The ESCRT machinery counteracts Nesprin-2G-mediated mechanical forces during nuclear envelope repair.
Wallis SS, Ventimiglia LN, Otigbah E, Infante E, Cuesta-Geijo MA, Kidiyoor GR, Carbajal MA, Fleck RA, Foiani M, Garcia-Manyes S, Martin-Serrano J, Agromayor M
Developmental cell 2021 Dec 6;56(23):3192-3202.e8
Developmental cell 2021 Dec 6;56(23):3192-3202.e8
The p97-UBXN1 complex regulates aggresome formation.
Mukkavalli S, Klickstein JA, Ortiz B, Juo P, Raman M
Journal of cell science 2021 Apr 1;134(7)
Journal of cell science 2021 Apr 1;134(7)
Involvement of VCP/UFD1/Nucleolin in the viral entry of Enterovirus A species.
Yan J, Wang M, Wang M, Dun Y, Zhu L, Yi Z, Zhang S
Virus research 2020 Jul 2;283:197974
Virus research 2020 Jul 2;283:197974
WWP2 ameliorates acute kidney injury by mediating p53 ubiquitylation and degradation.
Che H, He W, Feng J, Dong W, Liu S, Chen T, Ge S, Zhou J, Liang C
Cell biochemistry and function 2020 Aug;38(6):695-701
Cell biochemistry and function 2020 Aug;38(6):695-701
The VCP-UBXN1 Complex Mediates Triage of Ubiquitylated Cytosolic Proteins Bound to the BAG6 Complex.
Ganji R, Mukkavalli S, Somanji F, Raman M
Molecular and cellular biology 2018 Jul 1;38(13)
Molecular and cellular biology 2018 Jul 1;38(13)
Pathogenic Mutations in the Valosin-containing Protein/p97(VCP) N-domain Inhibit the SUMOylation of VCP and Lead to Impaired Stress Response.
Wang T, Xu W, Qin M, Yang Y, Bao P, Shen F, Zhang Z, Xu J
The Journal of biological chemistry 2016 Jul 1;291(27):14373-14384
The Journal of biological chemistry 2016 Jul 1;291(27):14373-14384
ESCRT-III controls nuclear envelope reformation.
Olmos Y, Hodgson L, Mantell J, Verkade P, Carlton JG
Nature 2015 Jun 11;522(7555):236-9
Nature 2015 Jun 11;522(7555):236-9
Secretome profiling of primary cells reveals that THBS2 is a salivary biomarker of oral cavity squamous cell carcinoma.
Hsu CW, Yu JS, Peng PH, Liu SC, Chang YS, Chang KP, Wu CC
Journal of proteome research 2014 Nov 7;13(11):4796-807
Journal of proteome research 2014 Nov 7;13(11):4796-807
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Raji cells were subjected to SDS PAGE followed by western blot with 10615-1-AP( UFD1L Antibody) at dilution of 1:1000
- Sample type
- cell line
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse thymus tissue were subjected to SDS PAGE followed by western blot with 10615-1-AP( UFD1L Antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The UFD1L antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human UFD1L. This antibody recognizes human,mouse,rat antigen. The UFD1L antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.