ABIN251529
antibody from antibodies-online
Targeting: DOT1L
DOT1, KIAA1814, KMT4
Antibody data
- Antibody Data
- Antigen structure
- References [5]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- ABIN251529 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Vial size
- 0.1 mL
- Storage
- Store at 4°C. Do not freeze.
- Handling
- Do not freeze.
Submitted references Functional interdependence of BRD4 and DOT1L in MLL leukemia.
Histone methyltransferase DOT1L drives recovery of gene expression after a genotoxic attack.
A novel disrupter of telomere silencing 1-like (DOT1L) interaction is required for signal transducer and activator of transcription 1 (STAT1)-activated gene expression.
Impaired recruitment of the histone methyltransferase DOT1L contributes to the incomplete reactivation of tumor suppressor genes upon DNA demethylation.
DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells.
Gilan O, Lam EY, Becher I, Lugo D, Cannizzaro E, Joberty G, Ward A, Wiese M, Fong CY, Ftouni S, Tyler D, Stanley K, MacPherson L, Weng CF, Chan YC, Ghisi M, Smil D, Carpenter C, Brown P, Garton N, Blewitt ME, Bannister AJ, Kouzarides T, Huntly BJ, Johnstone RW, Drewes G, Dawson SJ, Arrowsmith CH, Grandi P, Prinjha RK, Dawson MA
Nature structural & molecular biology 2016 Jul;23(7):673-81
Nature structural & molecular biology 2016 Jul;23(7):673-81
Histone methyltransferase DOT1L drives recovery of gene expression after a genotoxic attack.
Oksenych V, Zhovmer A, Ziani S, Mari PO, Eberova J, Nardo T, Stefanini M, Giglia-Mari G, Egly JM, Coin F
PLoS genetics 2013;9(7):e1003611
PLoS genetics 2013;9(7):e1003611
A novel disrupter of telomere silencing 1-like (DOT1L) interaction is required for signal transducer and activator of transcription 1 (STAT1)-activated gene expression.
Shah S, Henriksen MA
The Journal of biological chemistry 2011 Dec 2;286(48):41195-204
The Journal of biological chemistry 2011 Dec 2;286(48):41195-204
Impaired recruitment of the histone methyltransferase DOT1L contributes to the incomplete reactivation of tumor suppressor genes upon DNA demethylation.
Jacinto FV, Ballestar E, Esteller M
Oncogene 2009 Nov 26;28(47):4212-24
Oncogene 2009 Nov 26;28(47):4212-24
DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells.
Steger DJ, Lefterova MI, Ying L, Stonestrom AJ, Schupp M, Zhuo D, Vakoc AL, Kim JE, Chen J, Lazar MA, Blobel GA, Vakoc CR
Molecular and cellular biology 2008 Apr;28(8):2825-39
Molecular and cellular biology 2008 Apr;28(8):2825-39
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Supportive validation
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- antibodies-online (provider)
- Main image
- Experimental details
- WB
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- IHC
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- IHC