TNNT3

gene product
AMCD2B, DA2B, DKFZp779M2348, FSSV
The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). [provided by RefSeq, Oct 2009]
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265 antibodies from 28 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
22 antibodies
GeneTex
5 antibodies
Atlas Antibodies
2 antibodies
antibodies-online
79 antibodies
NovoPro Bioscience Inc.
4 antibodies
LifeSpan BioSciences, Inc.
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Antibodies.com
2 antibodies
NSJ Bioreagents
2 antibodies
Acris Antibodies GmbH
1 antibody
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1 antibody
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15 antibodies
Abgent
4 antibodies
OriGene
4 antibodies
Invitrogen Antibodies
4 antibodies
ProSci
5 antibodies
St John's Laboratory
3 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Everest Biotech
1 antibody
Abnova Corporation
6 antibodies
Aviva Systems Biology
3 antibodies
Creative Biolabs
5 antibodies
Creative Diagnostics
6 antibodies
MyBioSource
2 antibodies
RayBiotech, Inc.
2 antibodies
Abbexa
1 antibody
United States Biological
29 antibodies
Sigma-Aldrich
3 antibodies