Antibody data
- Antibody Data
- Antigen structure
- References [4]
- Comments [0]
- Validations [0]
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- Product number
- MAB1072 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Mouse Monoclonal Siglec-5/CD170 Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human Siglec-5/CD170 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human Siglec-2, -3, -7, -9, or -14 is observed.
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 500 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references Siglec expression on the surface of human, bull and ram sperm.
Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus.
Human Siglec-5 inhibitory receptor and immunoglobulin A (IgA) have separate binding sites in streptococcal beta protein.
Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates.
Alkhodair K, Almhanna H, McGetrick J, Gedair S, Gallagher ME, Fernandez-Fuertes B, Tharmalingam T, Larsen PB, Fitzpatrick E, Lonergan P, Evans ACO, Carrington SD, Reid CJ
Reproduction (Cambridge, England) 2018 Apr;155(4):361-371
Reproduction (Cambridge, England) 2018 Apr;155(4):361-371
Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus.
Ali SR, Fong JJ, Carlin AF, Busch TD, Linden R, Angata T, Areschoug T, Parast M, Varki N, Murray J, Nizet V, Varki A
The Journal of experimental medicine 2014 Jun 2;211(6):1231-42
The Journal of experimental medicine 2014 Jun 2;211(6):1231-42
Human Siglec-5 inhibitory receptor and immunoglobulin A (IgA) have separate binding sites in streptococcal beta protein.
Nordström T, Movert E, Olin AI, Ali SR, Nizet V, Varki A, Areschoug T
The Journal of biological chemistry 2011 Sep 30;286(39):33981-91
The Journal of biological chemistry 2011 Sep 30;286(39):33981-91
Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates.
Angata T, Hayakawa T, Yamanaka M, Varki A, Nakamura M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 Oct;20(12):1964-73
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 Oct;20(12):1964-73
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