BS60080

antibody from Bioworld Technology, Inc
Targeting: GADD45B DKFZP566B133, GADD45BETA, MYD118
Provider product page for BS60080

Antibody data

Product number
BS60080 - Provider product page
Provider
Bioworld Technology, Inc
Product name
GADD45B polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human GADD45B.
Description
Cellcycle progression issubject to arrest at G1 and G2 checkpointsin response to DNA damage, presumablyto allow time for DNA repair prior to entryinto S andMphase, respectively. The p53 tumorsuppressor isrequired for one such G1 checkpoint and functionsto upregulate expression of GADD 45 and p21. GADD 45 binds both Cdks and PCNA, a protein involved in DNA replication and repair. GADD 45 stimulates DNA excision repair in vitro and inhibits entry ofcellsinto S phase. Thus, it has been suggested that GADD 45 mayserve as a link between the p53-dependentcellcycle checkpoint and DNA repair. GADD 45-like proteins, GADD 45ÉÇ and GADD 45ÎÛ, have been shown to be induced by environmentalstresses. GADD 45ÉÇ and GADD 45ÎÛ are thought to induce p38/JNK activation via MEKK4 activation.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
GADD45B protein structure - BS60080 shown in red.