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- Antigen structure
- References [21]
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- Product number
- 21699-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#21699-1-AP, RRID:AB_10859251
- Product name
- DCLK1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated DCLK1 antibody (Cat. #21699-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Tuft-cell-derived IL-25 regulates intestinal ILC2 in response to Brucella infection.
Desaminotyrosine promotes tuft cell expansion and integrates intestinal type 2 immunity.
Acetylcholine from tuft cells promotes M2 macrophages polarization in Hirschsprung-associated enterocolitis.
The histone acetylation-related gene signature predicts prognosis and immunotherapy response in stomach adenocarcinoma.
Doublecortin-like kinase 1, regulated by STIP1 homology and U-box containing protein 1 or Sp1 transcription factor, affects the malignant behaviors and drug sensitivity in adriamycin-resistant breast cancer cells.
ALKBH8-mediated codon-specific translation promotes colorectal tumorigenesis.
The critical role of Id2 gene in mesenchymal stem cell therapy for colitis through regulating immune response and microbiota.
Chronic sleep deprivation induces plasma exosome-derived miR-150-5p downregulation as a novel mechanism involved in Parkinson's disease progression by targeting DCLK1.
Deficiency of Aging-Related Gene Chitinase-Like 4 Impairs Olfactory Epithelium Homeostasis.
Hippocampal proteomic changes in high-fat diet-induced obese mice associated with memory decline.
Hsc70 phosphorylation patterns and calmodulin regulate AP2 Clathrin-Coated-Vesicle life span for cell adhesion protein transport.
Folate supports IL-25-induced tuft cell expansion following enteroviral infections.
Albumin binding domain fusion improved the therapeutic efficacy of Inhibitor of Differentiation-2 protein in colitis mice.
Paneth cell-derived iNOS is required to maintain homeostasis in the intestinal stem cell niche.
FUT2-dependent fucosylation of HYOU1 protects intestinal stem cells against inflammatory injury by regulating unfolded protein response.
CXCL12/CXCR7/β-arrestin1 biased signal promotes epithelial-to-mesenchymal transition of colorectal cancer by repressing miRNAs through YAP1 nuclear translocation.
Targeting DCLK1 overcomes 5-fluorouracil resistance in colorectal cancer through inhibiting CCAR1/β-catenin pathway-mediated cancer stemness.
Intestinal Tuft-2 cells exert antimicrobial immunity via sensing bacterial metabolite N-undecanoylglycine.
XMD-17-51 Inhibits DCLK1 Kinase and Prevents Lung Cancer Progression.
High-throughput screening identified miR-7-2-3p and miR-29c-3p as metastasis suppressors in gallbladder carcinoma.
MicroRNA-195 Suppresses the Progression of Pancreatic Cancer by Targeting DCLK1.
Shang K, Chen N, Tian T, Shi H, Shi J, Qi X, Zhu Y, Zhang F
Frontiers in immunology 2026;17:1732274
Frontiers in immunology 2026;17:1732274
Desaminotyrosine promotes tuft cell expansion and integrates intestinal type 2 immunity.
Zang W, Zhou Z, Shen Y, Zhang B, Chen X, Yue W, Li X, Cai Y, Chen J, Bian J, Huang L, Li H, Dai Y, Yang H
mBio 2026 Feb 11;17(2):e0328925
mBio 2026 Feb 11;17(2):e0328925
Acetylcholine from tuft cells promotes M2 macrophages polarization in Hirschsprung-associated enterocolitis.
Zheng Z, Lin L, Lin H, Zhou J, Wang Z, Wang Y, Chen J, Lai C, Li R, Shen Z, Zhong M, Xie C, Chen Y, Zhang X, Guo Z, Dong R, He S, Chen F
Frontiers in immunology 2025;16:1559966
Frontiers in immunology 2025;16:1559966
The histone acetylation-related gene signature predicts prognosis and immunotherapy response in stomach adenocarcinoma.
Dai C, Su R, Zhao Z, Guo Y, Hou W, He Y, Liu G, Yin S, Zhang C
Frontiers in oncology 2025;15:1527253
Frontiers in oncology 2025;15:1527253
Doublecortin-like kinase 1, regulated by STIP1 homology and U-box containing protein 1 or Sp1 transcription factor, affects the malignant behaviors and drug sensitivity in adriamycin-resistant breast cancer cells.
Cheng L, Qi P, Guo W, Gao S
Naunyn-Schmiedeberg's archives of pharmacology 2025 Oct;398(10):13995-14008
Naunyn-Schmiedeberg's archives of pharmacology 2025 Oct;398(10):13995-14008
ALKBH8-mediated codon-specific translation promotes colorectal tumorigenesis.
Qian Y, Wu C, Wei S, Yan S, Peng J, Yu L, Gao Y, Hou J, Yu W, Chen Z, Zhang J, Gao X
Nature communications 2025 Oct 13;16(1):9075
Nature communications 2025 Oct 13;16(1):9075
The critical role of Id2 gene in mesenchymal stem cell therapy for colitis through regulating immune response and microbiota.
Wu M, Wang Y, Wei X, Han X, Xu L, Yan D, Li M, Zhong G, Liu Y, Lin J
International immunopharmacology 2025 Jul 28;160:114974
International immunopharmacology 2025 Jul 28;160:114974
Chronic sleep deprivation induces plasma exosome-derived miR-150-5p downregulation as a novel mechanism involved in Parkinson's disease progression by targeting DCLK1.
Liu L, Liu X, Zhang R, Sun X, Zhang K, Zheng B, Yang R, Yang K, Song G, Zhang Z
Journal of translational medicine 2025 Jul 11;23(1):781
Journal of translational medicine 2025 Jul 11;23(1):781
Deficiency of Aging-Related Gene Chitinase-Like 4 Impairs Olfactory Epithelium Homeostasis.
Wu T, Li W, Zhuang L, Liu J, Wang P, Gu Y, Liu Y, Yu Y
Cell proliferation 2025 Aug;58(8):e70055
Cell proliferation 2025 Aug;58(8):e70055
Hippocampal proteomic changes in high-fat diet-induced obese mice associated with memory decline.
Lu P, Gao CX, Luo FJ, Huang YT, Gao MM, Long YS
The Journal of nutritional biochemistry 2024 Mar;125:109554
The Journal of nutritional biochemistry 2024 Mar;125:109554
Hsc70 phosphorylation patterns and calmodulin regulate AP2 Clathrin-Coated-Vesicle life span for cell adhesion protein transport.
Sengül GF, Mishra R, Candiello E, Schu P
Biochimica et biophysica acta. Molecular cell research 2024 Jan;1871(1):119611
Biochimica et biophysica acta. Molecular cell research 2024 Jan;1871(1):119611
Folate supports IL-25-induced tuft cell expansion following enteroviral infections.
Lyu R, Wu J, He Y, You Q, Qian Y, Jiang N, Cai Y, Chen D, Wu Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan 31;38(2):e23430
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan 31;38(2):e23430
Albumin binding domain fusion improved the therapeutic efficacy of Inhibitor of Differentiation-2 protein in colitis mice.
Xu L, Wang Y, Yan D, Li M, Qiao L, Chen Z, Wu M, Zhong G
Life sciences 2024 Dec 15;359:123237
Life sciences 2024 Dec 15;359:123237
Paneth cell-derived iNOS is required to maintain homeostasis in the intestinal stem cell niche.
Huang L, Xu Z, Lei X, Huang Y, Tu S, Xu L, Xia J, Liu D
Journal of translational medicine 2023 Nov 25;21(1):852
Journal of translational medicine 2023 Nov 25;21(1):852
FUT2-dependent fucosylation of HYOU1 protects intestinal stem cells against inflammatory injury by regulating unfolded protein response.
Wang Z, Tan C, Duan C, Wu J, Zhou D, Hou L, Qian W, Han C, Hou X
Redox biology 2023 Apr;60:102618
Redox biology 2023 Apr;60:102618
CXCL12/CXCR7/β-arrestin1 biased signal promotes epithelial-to-mesenchymal transition of colorectal cancer by repressing miRNAs through YAP1 nuclear translocation.
Si M, Song Y, Wang X, Wang D, Liu X, Qu X, Song Z, Yu X
Cell & bioscience 2022 Oct 9;12(1):171
Cell & bioscience 2022 Oct 9;12(1):171
Targeting DCLK1 overcomes 5-fluorouracil resistance in colorectal cancer through inhibiting CCAR1/β-catenin pathway-mediated cancer stemness.
Wang L, Zhao L, Lin Z, Yu D, Jin M, Zhou P, Ren J, Cheng J, Yang K, Wu G, Zhang T, Zhang D
Clinical and translational medicine 2022 May;12(5):e743
Clinical and translational medicine 2022 May;12(5):e743
Intestinal Tuft-2 cells exert antimicrobial immunity via sensing bacterial metabolite N-undecanoylglycine.
Xiong Z, Zhu X, Geng J, Xu Y, Wu R, Li C, Fan D, Qin X, Du Y, Tian Y, Fan Z
Immunity 2022 Apr 12;55(4):686-700.e7
Immunity 2022 Apr 12;55(4):686-700.e7
XMD-17-51 Inhibits DCLK1 Kinase and Prevents Lung Cancer Progression.
Yang WQ, Zhao WJ, Zhu LL, Xu SJ, Zhang XL, Liang Y, Ding XF, Kiselyov A, Chen G
Frontiers in pharmacology 2021;12:603453
Frontiers in pharmacology 2021;12:603453
High-throughput screening identified miR-7-2-3p and miR-29c-3p as metastasis suppressors in gallbladder carcinoma.
Lu K, Feng F, Yang Y, Liu K, Duan J, Liu H, Yang J, Wu M, Liu C, Chang Y
Journal of gastroenterology 2020 Jan;55(1):51-66
Journal of gastroenterology 2020 Jan;55(1):51-66
MicroRNA-195 Suppresses the Progression of Pancreatic Cancer by Targeting DCLK1.
Zhou B, Sun C, Hu X, Zhan H, Zou H, Feng Y, Qiu F, Zhang S, Wu L, Zhang B
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;44(5):1867-1881
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;44(5):1867-1881
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The DCLK1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human DCLK1. This antibody recognizes human,mouse,rat antigen. The DCLK1 antibody has been validated for the following applications: ELISA, WB analysis.
