10-4120-25

antibody from ABEOMICS Inc.
Targeting: CLEC4E CLECSF9, mincle
Provider product page for 10-4120-25

Antibody data

Product number
10-4120-25 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-CLEC4E Antibody
Antibody type
Monoclonal
Description
CLEC4E (C-type lectin domain family 4, member E), also called as Mincle, is a type II transmembrane C-type lectin receptor that specifically binds to the cord factor TDM (trehalose-6,6-dimycolate), a unique glycolipid of mycobacterial cell-surface components, and activates immune cells to confer adjuvant activity. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. CLEC4E is mainly expressed in myeloid cells, such as macrophages and neutrophils and possesses a single carbohydrate-recognition domain (CRD) in the extracellular region. It is associated with FcRgamma chain, an immunoreceptor tyrosine-based activation motif (ITAM)-containing adaptor, and acts as an activating receptor that senses damaged cells. CLEC4E is also a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPbeta) and may play a role in inflammation.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
A full length human CLEC4E protein
was used as the immunogen for this
antibody.
Isotype
IgG
Antibody clone number
ABM42C6
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
CLEC4E protein structure - 10-4120-25 shown in red.