Antibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations [0]
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- Product number
- ABIN360194 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1) (N-Term) antibody
- Antibody type
- Polyclonal
- Description
- Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
- Reactivity
- Human
- Host
- Rabbit
- Epitope
- N-Term
- Vial size
- 0.4 mL
- Storage
- Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
- Handling
- Avoid repeated freezing and thawing.
Submitted references The phosphatase PHLPP controls the cellular levels of protein kinase C.
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms.
PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth.
Gao T, Brognard J, Newton AC
The Journal of biological chemistry 2008 Mar 7;283(10):6300-11
The Journal of biological chemistry 2008 Mar 7;283(10):6300-11
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms.
Brognard J, Sierecki E, Gao T, Newton AC
Molecular cell 2007 Mar 23;25(6):917-31
Molecular cell 2007 Mar 23;25(6):917-31
PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth.
Gao T, Furnari F, Newton AC
Molecular cell 2005 Apr 1;18(1):13-24
Molecular cell 2005 Apr 1;18(1):13-24
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