Antibody data
- Antibody Data
- Antigen structure
- References [4]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- ABIN1449987 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1) (N-Term) antibody
- Antibody type
- Polyclonal
- Antigen
- Other
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 mg
Submitted references Increased levels of the Akt-specific phosphatase PH domain leucine-rich repeat protein phosphatase (PHLPP)-1 in obese participants are associated with insulin resistance.
PHLiPPing the switch on Akt and protein kinase C signaling.
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms.
PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth.
Andreozzi F, Procopio C, Greco A, Mannino GC, Miele C, Raciti GA, Iadicicco C, Beguinot F, Pontiroli AE, Hribal ML, Folli F, Sesti G
Diabetologia 2011 Jul;54(7):1879-87
Diabetologia 2011 Jul;54(7):1879-87
PHLiPPing the switch on Akt and protein kinase C signaling.
Brognard J, Newton AC
Trends in endocrinology and metabolism: TEM 2008 Aug;19(6):223-30
Trends in endocrinology and metabolism: TEM 2008 Aug;19(6):223-30
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms.
Brognard J, Sierecki E, Gao T, Newton AC
Molecular cell 2007 Mar 23;25(6):917-31
Molecular cell 2007 Mar 23;25(6):917-31
PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth.
Gao T, Furnari F, Newton AC
Molecular cell 2005 Apr 1;18(1):13-24
Molecular cell 2005 Apr 1;18(1):13-24
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Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Western blot analysis of PHLPP1 in SW480 cell lysate with PHLPP1 antibody Cat.-No AP55483PU-N at (A) 1 and (B) 2 ?g/ml.