BS6608
antibody from Bioworld Technology, Inc
Targeting: FKBP1A
FKBP-12, FKBP1, FKBP12, FKBP12C, PKC12, PPIASE
Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS6608 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- FKBP1A polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human FKBP1A.
- Description
- Immunophilins are a highly conserved family of cis-trans peptidyl-prolyl isomerases which bind to and mediate the effects of immunosuppressive drugs such as Cyclosporin, FK506 and Rapamycin. The prototypic member of the family, FKBP12, was originally identified as a target of FK506 and Rapamycin activity. FKBP12 is an abundant, evolutionarily conserved cytoplasmic protein. Although the molecular role of FKBP12 activity is not well understood, the protein has been implicated as a regulator of diverse array of cellular processes including T cell activation, entry into the cell cycle and intracellular calcium release. Interestingly, FKBP12 has been shown to associate with the intracellular cytoplasmic domain of the type I TGFÉÇ receptor. This association is constitutive and not dependent on the activation of the receptor.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
- Submitted by
- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot analysis of extracts of mouse cerebellum tissue, using FKBP1A antibody.