14877-1-AP

antibody from Proteintech Group

Targeting: DHODH

Provider product page for 14877-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [129]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [2]

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Product number: 14877-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14877-1-AP, RRID:AB_2091723
Product name: DHODH antibody
Antibody type: Polyclonal
Description: KD/KO validated DHODH antibody (Cat. #14877-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

DHODH protein structure - 14877-1-AP shown in red.

Submitted references Liquiritigenin targets transferrin receptor to potentiate ferroptosis sensitivity in colorectal cancer cells.

Li R, Song C, Jia T, Xia T, Guo M, Wang Q, Yao Y, Xu X, Bao X, Yang P, Li Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158057

RRM2/GCH1 signaling decreased cisplatin sensitivity in cervical cancer by modulating the ferroptosis process.

Zhao J, Wang L, Shao N, Qu Y, Chen W, Sun H
Histology and histopathology 2026 Mar 6;:25056

Biomimetic Nanoplatform for Targeted Glioblastoma Therapy via Concurrently Triggering GPX4/DHODH Mediated Ferroptosis.

Ren G, Wang X, Li P, Wu H, Bi Z, Gao Q, Ma B, Tian Z, Liu J, Feng F, Liu W, Li L, Zhang C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 23;:e21236

FAK/SRC-JNK axis promotes ferroptosis via upregulating ACSL4 expression.

Qin J, Ma S, Wang J, Huang S, Luan J, He J, Hou G, Sun N, Zhang W, Gao M
Cell death & disease 2026 Mar 20;17(1)

Isobavachalcone exerts anti-gastric cancer effects by targeting dihydroorotate dehydrogenase to induce ROS release and activating the STING pathway.

Kuang Y, Shao Y, Chen J, Dai C, Nomura S, Wang F, Chen J, He Y, Xiao X, Zhang C, Feng J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158126

Mitochondrial ACSS1 links acetate metabolism to pyrimidine biosynthesis in nutrient-stressed B-cell lymphomas.

Basappa J, Goldman AR, Lobello C, Wang S, Rushmore D, Melnikov O, Sen NV, Mallikarjuna VS, Jain P, Edalati M, Nelson DS, Cai KQ, Lu P, Nejati R, Borghaei H, Gupta PK, Nath K, Wellen KE, Wasik MA
Cancer letters 2026 Jul 1;649:218488

DHODH links mitochondrial bioenergetics, one-carbon metabolism, and DNA repair to sustain aggressive prostate adenocarcinoma.

Rajaratnam S, Piyarathna DWB, Mehta RK, Mekala V, Park JH, Rasaily U, Venkatappa V, Kami Reddy KR, Putluri V, Goel K, Grimm SL, Thota SM, Morrison T, Coarfa C, Kaipparettu BA, Cheng C, Putluri N, Jones JA, Nyati MK, Ittmann M, Gassman NR, Sreekumar A
Cell communication and signaling : CCS 2026 Jan 29;24(1)

TET1 as a master regulator controlling GPX4-dependent and -independent ferroptosis surveillance in acute myeloid leukemia.

Yang L, Lu J, Yun W, Yang X, Sun J, Ge C, Han F, Li X, Min J, Huang H, Wang F, Jiang X
Nature communications 2026 Jan 20;17(1):1800

Targeting mitochondrial phosphatase PGAM5 alleviates ferroptosis and acute pancreatitis by upregulating NRF2-mediated FSP1 expression.

Ma S, Qin J, Luan J, Hou G, He J, Gao M
Cell death & disease 2026 Feb 21;17(1)

CypD Dependent mPTP Opening Is Crucial for Oxidized Mitochondrial DNA Release in Ferroptosis.

Zhou H, Fu W, Liu S, Zhang Z, Luo H, Zhong Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(20):e02239

Inhibition of Calcium-Dependent Lipid Droplets Relocation of ACSL4-PKCβ-ALOX15 Complex Alleviates Ferroptosis and Acute Pancreatitis.

Hou G, Luan J, Xu X, Qin J, Ma S, He J, Sun N, Zhang W, Gao M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(19):e15768

Oncolytic virus hijacks GOT1 and pyrimidinosomes to fuel pyrimidine synthesis for replication in tumor cells.

Tang N, Gong Y, Zhao C, Niu Y, Tan L, Song C, Qiu X, Liao Y, Yu S, Ding C, Lin S, Sun Y
Tumour virus research 2026 Apr 9;21:200342

Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice.

Savani MR, Li B, Smith BC, Gu W, Xiao Y, Baquer G, Shipman T, Oken SS, Manoj N, Zacharias LG, Puliyappadamba VT, Stopka SA, Regan MS, Levitt MM, Edgar CK, Hicks WH, Anand S, Martin-Sandoval MS, Winston R, S Patrício J, Johnson X, Tippetts TS, Shi DD, Lemoff A, Richardson TE, Zinn PO, Solmonson A, Mathews TP, Agar NYR, DeBerardinis RJ, Abdullah KG, McBrayer SK
Nature metabolism 2026 Apr 29;

Lactate-driven pyrimidine synthesis promotes ferroptosis resistance in hepatocellular carcinoma.

Park MJ, Lee S, Kim DH, Kim MK, Jang BK, Yoon G, Park M, Jeong GH, Byun JK, Choi YK, Park KG
Molecular biomedicine 2026 Apr 17;7(1)

Multi-omics integration reveals that pyrimidine metabolism in lung adenocarcinoma drives an immunosuppressive microenvironment.

Liu M, Li H, Xu S, Zhou Y, Yao M, Shi J, Zhong L
iScience 2026 Apr 17;29(4):115326

Deficiency in beclin1 alleviates doxorubicin-induced liver injury through inhibiting ferroptosis and autophagy.

Zhang L, He Y, Zhao A, Han H, Li Y, Li L, Zhang Y, Gao Q, Ye H
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2026 Apr 15;1274:124971

Cold atmospheric plasma potentiates ferroptosis via EGFR(Y1068)-mediated dual axes on GPX4 among triple negative breast cancer cells.

Dai X, Xu Z, Lv X, Li C, Jiang R, Wang D, Xi M, Li T
International journal of biological sciences 2025;21(2):874-892

MFN2-a multifaceted guardian against Parkinson's pathophysiology: mitochondria, ferroptosis, inflammation and oxidative stress.

Cheng Y, Zhai H, Liu Y, Yang Y, Fang B, Song M, Wang X, Zhong P
Frontiers in aging neuroscience 2025;17:1611958

SLC16A3 drives lung adenocarcinoma progression and gefitinib resistance through coordinated regulation of ferroptosis and lactate metabolism.

Cai W, Liu Y, Zhao K, Zhu Z, Jin J, Wen J, Xue Z
Frontiers in immunology 2025;16:1699540

Cepharanthine hydrochloride: a novel ferroptosis-inducing agent for prostate cancer treatment.

Guan JS, Jia J, Huang ZX, Zhou YQ, Zheng JJ, Lin QM, Wang YF, Fan JL, Wang Y
Frontiers in pharmacology 2025;16:1536375

De novo pyrimidine synthesis is a collateral metabolic vulnerability in NF2-deficient mesothelioma.

Xu D, Gao Y, Liu S, Yin S, Hu T, Deng H, Zhang T, Hegedüs B, Marti TM, Dorn P, Liang SQ, Schmid RA, Peng RW, Shu Y
EMBO molecular medicine 2025 Sep;17(9):2258-2298

β-elemene promotes ferroptosis to improve the sensitivity of imatinib in gastrointestinal stromal tumours by targeting N6AMT1.

Lan J, Zhang W, Zeng K, Li C, He J, Li X, Yang R, Chi J, Hong Z, Wang W, Zhou C, Xiao B, Fan W, Lin J, Ou Q, Fang Y, Pan Z, Peng J, Li W, Wu X
Clinical and translational medicine 2025 Sep;15(9):e70438

USP10 Inhibits Ferroptosis via Deubiquinating POLR2A in Head and Neck Squamous Cell Carcinoma.

Zhang D, Wang X, Lu S, Gao Y, Zhu G, Li G, Yu Z, Hou J, Yan H, Yuan W, Zhang X, Hung MC, Liu Z, Liu Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(36):e12271

SLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer.

Zhou X, Wang G, Wu Y, Wu M, Zhai X, Tian C, Prochownik EV, Jiang C, Li Y
Cell reports 2025 Sep 23;44(9):116139

PPARα activation attenuated heat-induced myocardial injury in mice.

Hu Z, Zhao L, Ma X, Li R, Qin L, Zhang L, Hou T, Zhang G, Liu C
Ecotoxicology and environmental safety 2025 Sep 1;302:118520

Regenerating liver uses ammonia to support de novo pyrimidine synthesis and cell proliferation.

Endaya BB, Kučera L, Le DT, Spinelli JB, Brožková A, Luptáková D, Klíma K, Oliveira GL, Brisudová P, Boháčová K, Boukalová Š, Zobalová R, Kolář F, Chalupsky K, Dohnalová K, Yarmohammadi-Barzegar A, Dvořáková Š, Biryukova E, Kaliaeva M, Havlíček V, Sedláček R, Procházka J, Vítek L, Park S, Martásek P, Krška Z, Oliveira PJ, Berridge MV, Neužil J
Nature communications 2025 Nov 4;16(1):9664

An immunometabolic prodrug strategy overcomes DHODH inhibitor resistance in refractory melanoma.

Hai Y, Wang W, Fan R, Chen Y, Zhuang J, Fu S, Ding G, Liang L, Song J, Wei G
Journal of experimental & clinical cancer research : CR 2025 Nov 14;44(1):306

GPX4-dependent ferroptosis sensitivity is a fitness trade-off for cell enlargement.

Chan KY, Yu Y, Kong Y, Cheng L, Yao R, Yin Chair PS, Wang P, Wang R, Sun WY, He RR, Min J, Wang F, Björklund M
iScience 2025 May 16;28(5):112363

Targeting YBX1-m5C mediates RNF115 mRNA circularisation and translation to enhance vulnerability of ferroptosis in hepatocellular carcinoma.

Li O, An K, Wang H, Li X, Wang Y, Huang L, Du Y, Qin N, Dong J, Wei J, Sun R, Shi Y, Guo Y, Sun X, Yang Y, Yang YG, Kan Q, Tian X
Clinical and translational medicine 2025 Mar;15(3):e70270

Novel pH-responsive lipid nanoparticles deliver UA-mediated mitophagy and ferroptosis for osteoarthritis treatment.

Yi G, Li M, Zhou J, Li J, Song X, Li S, Liu J, Zhang H, Chen Z
Materials today. Bio 2025 Jun;32:101697

Dipyridamole Acts as Clinical Ferroptosis Inhibitor to Prevent from Tissue Injury.

Zhuang X, Shi S, Liu S, Jiao Y, Huang B, Yang Y, Yang L, Yang X, Wang H, Liang C, Song D, Yu H, Zou D, Sun Q, Yang S, Yin C, Li J, Liu Y, Min J, Wang F, Nian Y, Du L, Chu B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(23):e2500566

The deubiquitinase USP24 suppresses ferroptosis in triple-negative breast cancer by stabilizing DHODH protein.

Yang L, An X, Yang S, Lin X, Chen Z, Xue Q, Chen X, Wang Y, Yan D, Chen S, Fan Y, Tang D, Yu W, Liu J, Chen X
Cell death & disease 2025 Jul 26;16(1):564

Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice.

Savani MR, Smith BC, Gu W, Xiao Y, Baquer G, Li B, Oken SS, Manoj N, Zacharias LG, Puliyappadamba VT, Stopka SA, Regan MS, Levitt MM, Edgar CK, Hicks WH, Anand S, Shipman T, Martin-Sandoval MS, Winston R, Patrício JS, Johnson X, Tippetts TS, Shi DD, Lemoff A, Richardson TE, Zinn PO, Solmonson A, Mathews TP, Agar NYR, DeBerardinis RJ, Abdullah KG, McBrayer SK
bioRxiv : the preprint server for biology 2025 Jul 24;

Astragalin promotes HSCs ferroptosis through NCOA4 mediated ferritinophagy to alleviate liver fibrosis in zebrafish and mice.

Wang Y, Kuang S, Li K, Chen S, Yang M, Deng K, Li M, Xie S, Chen Q, Wen J, Zhou C, Cheng W, Huang S, Lv Z
Communications biology 2025 Jul 21;8(1):1081

Lipocalin-2 silencing alleviates sepsis-induced liver injury through inhibition of ferroptosis.

Li Y, Li L, Zhang Y, Yun Q, Du R, Ye H, Li Z, Gao Q
Annals of hepatology 2025 Jan-Jun;30(1):101756

S100P is a ferroptosis suppressor to facilitate hepatocellular carcinoma development by rewiring lipid metabolism.

Yang M, Cui W, Lv X, Xiong G, Sun C, Xuan H, Ma W, Cui X, Cheng Y, Han L, Chu B
Nature communications 2025 Jan 8;16(1):509

Anticancer effect of the antirheumatic drug leflunomide on oral squamous cell carcinoma by the inhibition of tumor angiogenesis.

Niwata C, Nakagawa T, Naruse T, Sakuma M, Yamakado N, Akagi M, Ono S, Tobiume K, Gao J, Jimi E, Ohta K, Aikawa T
Discover oncology 2025 Jan 16;16(1):53

Ferroptosis and PANoptosis under hypoxia pivoting on the crosstalk between DHODH and GPX4 in corneal epithelium.

Wu MF, Peng X, Zhang MC, Guo H, Xie HT
Free radical biology & medicine 2025 Feb 16;228:173-182

S100A4 regulates ferroptosis to suppress cell proliferation via the SLC7A11-GSH axis but facilitates Brucella infection in RAW264.7 macrophages.

Zhang G, Yin Y, Hu H, Tian M, Ding C, Yu S
International journal of biological macromolecules 2025 Dec;333(Pt 1):148831

Inhibition of EgRad50 leads to impaired DNA repair in Echinococcus granulosus sensu stricto.

Zhao J, Xu S, Du Y, Tuniyazi X, Li J, Liao X, Jia Y, Lü G, Zhao J
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2025 Dec;136:105855

UMP functions as an endogenous regulator of NR4A1 to control gastric cancer progression.

Cai G, Zhang Z, Zhong L, Wang H, Miao M, Su J, An Y, Zhang C, Luo X, Ju HQ, Zhang J, Huang W, Li Z, Liu P, Wu D, Chan FL, Zhou H, Han F, Chen HW, Su T, Wang J
Molecular cell 2025 Dec 4;85(23):4347-4364.e12

The Nrf2/GPX4 antioxidant pathway suppresses ferroptosis to protect against hearing impairment in cochlear ischemia-reperfusion injury.

Zou T, Huang S, Xie R, Liu J
International immunopharmacology 2025 Dec 10;167:115655

N-acetylaspartate from fat cells regulates postprandial body temperature.

Felix JB, Saha PK, de Groot EL, Tan L, Sharp R, Anaya ES, Li Y, Quang H, Saidi N, Abushamat L, Ballantyne CM, Amos CI, Lorenzi PL, Klein S, Gao X, Hartig SM
Nature metabolism 2025 Aug;7(8):1524-1535

Overexpression of GPX4 in diabetic rat kidney alleviates renal injury induced by ferroptosis.

Wu K, Zhu E, Chen J, Kuang Q, Lin J, Zhao S, Xu X, Li S, Sui Y, Huang M, Zhang Y
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2025 Aug;38(4):1281-1297

Resveratrol mitigated acute sleep deprivation-induced cognitive impairment by suppressing hippocampal neuronal ferroptosis.

Zhong Y, Qin J, Chen H, Zheng H, Wang JT
3 Biotech 2025 Aug;15(8):236

Pharmacological targeting of the mitochondrial phosphatase PTPMT1 sensitizes hepatocellular carcinoma to ferroptosis.

Li M, Wang Y, Li X, Xu J, Yan L, Tang S, Liu C, Shi M, Liu R, Zhao Y, Zhang Y, Yang L, Zhang Y, Wang G, Li Z, Guo Y, Feng Y, Liu P
Cell death & disease 2025 Apr 6;16(1):257

Inhibition of mitochondrial complex I induces mitochondrial ferroptosis by regulating CoQH2 levels in cancer.

Deng R, Fu L, Liang H, Ai X, Liu F, Li N, Wu L, Li S, Yang X, Lin Y, Huang Y, Yun J
Cell death & disease 2025 Apr 5;16(1):254

DHODH modulates immune evasion of cancer cells via CDP-Choline dependent regulation of phospholipid metabolism and ferroptosis.

Teng D, Swanson KD, Wang R, Zhuang A, Wu H, Niu Z, Cai L, Avritt FR, Gu L, Asara JM, Zhang Y, Zheng B
Nature communications 2025 Apr 24;16(1):3867

Blocking SLC7A11 attenuates the proliferation of esophageal squamous cell carcinoma cells.

Li WT, Jin X, Song SJ, Wang C, Fu C, Jiang W, Bai J, Shi ZZ
Animal cells and systems 2024;28(1):237-250

Discovery of piperine derivatives as inhibitors of human dihydroorotate dehydrogenase to induce ferroptosis in cancer cells.

Zhang JF, Hong LH, Fan SY, Zhu L, Yu ZP, Chen C, Kong LY, Luo JG
Bioorganic chemistry 2024 Sep;150:107594

Identification of genes supporting cold resistance of mammalian cells: lessons from a hibernator.

Sone M, Mitsuhashi N, Sugiura Y, Matsuoka Y, Maeda R, Yamauchi A, Okahashi R, Yamashita J, Sone K, Enju S, Anegawa D, Yamaguchi Y
Cell death & disease 2024 Sep 19;15(9):685

Proteomic analysis of ferroptosis pathways reveals a role of CEPT1 in suppressing ferroptosis.

Liu X, Chen Z, Yan Y, Zandkarimi F, Nie L, Li Q, Horbath A, Olszewski K, Kondiparthi L, Mao C, Lee H, Zhuang L, Poyurovsky M, Stockwell BR, Chen J, Gan B
Protein & cell 2024 Sep 1;15(9):686-703

Spliceosomal GTPase Eftud2 deficiency-triggered ferroptosis leads to Purkinje cell degeneration.

Yang G, Yang Y, Song Z, Chen L, Liu F, Li Y, Jiang S, Xue S, Pei J, Wu Y, He Y, Chu B, Wu H
Neuron 2024 Oct 23;112(20):3452-3469.e9

Upregulation of PRRX2 by silencing Marveld3 as a protective mechanism against radiation-induced ferroptosis in skin cells.

Cao J, Wu M, Mo W, Zhao M, Gu L, Wang X, Zhang B, Cao J
Molecular medicine (Cambridge, Mass.) 2024 Oct 21;30(1):182

Sensing steroid hormone 17α-hydroxypregnenolone by GPR56 enables protection from ferroptosis-induced liver injury.

Lin H, Ma C, Zhuang X, Liu S, Liu D, Zhang M, Lu Y, Zhou G, Zhang C, Wang T, Zhang Z, Lv L, Zhang D, Ruan XZ, Xu Y, Chai R, Yu X, Sun JP, Chu B
Cell metabolism 2024 Nov 5;36(11):2402-2418.e10

Knockdown of SLC16A3 decreases extracellular lactate concentration in hepatocellular carcinoma, alleviates hypoxia and induces ferroptosis.

Shen J, Wu Z, Zhou Y, Yang D, Wang X, Yu B, Zhao K, Ding Y
Biochemical and biophysical research communications 2024 Nov 12;733:150709

LncRNA MALAT1 promotes Erastin-induced ferroptosis in the HBV-infected diffuse large B-cell lymphoma.

Bai X, Li J, Guo X, Huang Y, Xu X, Tan A, Jia Y, Sun Q, Guo X, Chen J, Kang J
Cell death & disease 2024 Nov 12;15(11):819

p53 activation enhances the sensitivity of non-small cell lung cancer to the combination of SH003 and docetaxel by inhibiting de novo pyrimidine synthesis.

Choi YJ, Lee K, Lee SY, Kwon Y, Woo J, Jeon CY, Ko SG
Cancer cell international 2024 May 4;24(1):156

Quercetin Inhibits Neuronal Pyroptosis and Ferroptosis by Modulating Microglial M1/M2 Polarization in Atherosclerosis.

Li H, Cao Z, Liu C, Wang Y, Wang L, Tang Y, Yao P
Journal of agricultural and food chemistry 2024 May 29;72(21):12156-12170

Bioinformatics analysis and experimental verification of the cancer-promoting effect of DHODH in clear cell renal cell carcinoma.

Wang S, Li Y, Lin Y, Li J, Guo L, Wang H, Lin X, Liu Z, Zhang B, Liao Z, Zhang Z
Scientific reports 2024 May 25;14(1):11985

Unraveling ETC complex I function in ferroptosis reveals a potential ferroptosis-inducing therapeutic strategy for LKB1-deficient cancers.

Mao C, Lei G, Horbath A, Wang M, Lu Z, Yan Y, Liu X, Kondiparthi L, Chen X, Cheng J, Li Q, Xu Z, Zhuang L, Fang B, Marszalek JR, Poyurovsky MV, Olszewski K, Gan B
Molecular cell 2024 May 16;84(10):1964-1979.e6

Involvement of ferroptosis in eribulin-induced cytotoxicity in ovarian clear cell carcinoma.

Azumi M, Kusama K, Yoshie M, Nakano S, Tsuru A, Kato T, Tamura K
European journal of pharmacology 2024 May 15;971:176544

Reprogramming of pyrimidine nucleotide metabolism supports vigorous cell proliferation of normal and malignant T cells.

Watanabe T, Yamamoto Y, Kurahashi Y, Kawasoe K, Kidoguchi K, Ureshino H, Kamachi K, Yoshida-Sakai N, Fukuda-Kurahashi Y, Nakamura H, Okada S, Sueoka E, Kimura S
Blood advances 2024 Mar 26;8(6):1345-1358

GAS41 modulates ferroptosis by anchoring NRF2 on chromatin.

Wang Z, Yang X, Chen D, Liu Y, Li Z, Duan S, Zhang Z, Jiang X, Stockwell BR, Gu W
Nature communications 2024 Mar 21;15(1):2531

PM(2.5)-induced iron homeostasis imbalance triggers cardiac hypertrophy through ferroptosis in a selective autophagy crosstalk manner.

Li T, Sun M, Sun Q, Ren X, Xu Q, Sun Z, Duan J
Redox biology 2024 Jun;72:103158

A platinum(IV)-artesunate complex triggers ferroptosis by boosting cytoplasmic and mitochondrial lipid peroxidation to enhance tumor immunotherapy.

Fan R, Deng A, Lin R, Zhang S, Cheng C, Zhuang J, Hai Y, Zhao M, Yang L, Wei G
MedComm 2024 Jun;5(6):e570

CGI1746 targets σ(1)R to modulate ferroptosis through mitochondria-associated membranes.

Zhang Z, Zhou H, Gu W, Wei Y, Mou S, Wang Y, Zhang J, Zhong Q
Nature chemical biology 2024 Jun;20(6):699-709

Ciprofloxacin is a novel anti-ferroptotic antibiotic.

Chen F, Tang H, Lin J, Kang R, Tang D, Liu J
Heliyon 2024 Jun 15;10(11):e32571

Classical swine fever virus non-structural protein 4A recruits dihydroorotate dehydrogenase to facilitate viral replication.

Zhao B-q, Chen J, Chen J-X, Cheng Y, Zhou J-f, Bai J-s, Mao D-y, Zhou B
Journal of virology 2024 Jun 13;98(6):e0049424

Redistribution of defective mitochondria-mediated dihydroorotate dehydrogenase imparts 5-fluorouracil resistance in colorectal cancer.

Dong S, Zhang M, Cheng Z, Zhang X, Liang W, Li S, Li L, Xu Q, Song S, Liu Z, Yang G, Zhao X, Tao Z, Liang S, Wang K, Zhang G, Hu S
Redox biology 2024 Jul;73:103207

Mitochondrial miR-12294-5p-Regulated Copper Exposure-Caused Mitochondrial-Dependent Ferroptosis by Targeted Inhibition of CISD1 in Chicken Hepatocytes.

Zhong G, Wang M, Sun B, Ma F, Yu W, Hu L, Liao J, Tang Z
Journal of agricultural and food chemistry 2024 Jul 17;72(28):15948-15958

Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition.

Cui W, Guo M, Liu D, Xiao P, Yang C, Huang H, Liang C, Yang Y, Fu X, Zhang Y, Liu J, Shi S, Cong J, Han Z, Xu Y, Du L, Yin C, Zhang Y, Sun J, Gu W, Chai R, Zhu S, Chu B
Nature cell biology 2024 Jan;26(1):124-137

N-acetylaspartate from fat cells regulates postprandial body temperature.

Felix JB, Saha PK, de Groot E, Tan L, Sharp R, Anaya ES, Li Y, Quang H, Saidi N, Abushamat L, Ballantyne CM, Amos CI, Lorenzi PL, Klein S, Gao X, Hartig SM
Research square 2024 Jan 9;

Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance.

Lee H, Horbath A, Kondiparthi L, Meena JK, Lei G, Dasgupta S, Liu X, Zhuang L, Koppula P, Li M, Mahmud I, Wei B, Lorenzi PL, Keyomarsi K, Poyurovsky MV, Olszewski K, Gan B
Nature communications 2024 Jan 2;15(1):79

Alkaliptosis induction counteracts paclitaxel-resistant ovarian cancer cells via ATP6V0D1-mediated ABCB1 inhibition.

Chen F, Lin J, Kang R, Tang D, Liu J
Molecular carcinogenesis 2024 Aug;63(8):1515-1527

OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response.

Liang FG, Zandkarimi F, Lee J, Axelrod JL, Pekson R, Yoon Y, Stockwell BR, Kitsis RN
Molecular cell 2024 Aug 22;84(16):3098-3114.e6

BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in BRCA1-Deficient Cancers.

Lei G, Mao C, Horbath AD, Yan Y, Cai S, Yao J, Jiang Y, Sun M, Liu X, Cheng J, Xu Z, Lee H, Li Q, Lu Z, Zhuang L, Chen MK, Alapati A, Yap TA, Hung MC, You MJ, Piwnica-Worms H, Gan B
Cancer discovery 2024 Aug 2;14(8):1476-1495

β-Caryophyllene Confers Cardioprotection by Scavenging Radicals and Blocking Ferroptosis.

Li Y, Wu W, Song Y, Zhang J, Han D, Shu C, Lian F, Fang X
Journal of agricultural and food chemistry 2024 Aug 14;72(32):18003-18012

SGLT2 inhibition leads to a restoration of hepatic and circulating metabolites involved in the folate cycle and pyrimidine biosynthesis.

Mendez Espinoza I, Choos END, Ecelbarger CM, Shepard BD
American journal of physiology. Gastrointestinal and liver physiology 2024 Aug 1;327(2):G235-G253

Mitochondrial regulation of GPX4 inhibition-mediated ferroptosis in acute myeloid leukemia.

Akiyama H, Zhao R, Ostermann LB, Li Z, Tcheng M, Yazdani SJ, Moayed A, Pryor ML 2nd, Slngh S, Baran N, Ayoub E, Nishida Y, Mak PY, Ruvolo VR, Carter BZ, Schimmer AD, Andreeff M, Ishizawa J
Leukemia 2024 Apr;38(4):729-740

A novel mitochondria-targeting DHODH inhibitor induces robust ferroptosis and alleviates immune suppression.

Hai Y, Fan R, Zhao T, Lin R, Zhuang J, Deng A, Meng S, Hou Z, Wei G
Pharmacological research 2024 Apr;202:107115

POLQ inhibition attenuates the stemness and ferroptosis resistance in gastric cancer cells via downregulation of dihydroorotate dehydrogenase.

Peng Y, Zheng W, Chen Y, Lei X, Yang Z, Yang Y, Liang W, Sun K, Li G, Yu J
Cell death & disease 2024 Apr 4;15(4):248

SIRT6 drives sensitivity to ferroptosis in anaplastic thyroid cancer through NCOA4-dependent autophagy.

Yang Z, Huang R, Wang Y, Guan Q, Li D, Wu Y, Liao T, Wang Y, Xiang J
American journal of cancer research 2023;13(2):464-474

Dihydroorotate dehydrogenase promotes cell proliferation and suppresses cell death in esophageal squamous cell carcinoma and colorectal carcinoma.

Shi ZZ, Jin X, Li WT, Tao H, Song SJ, Fan ZW, Jiang W, Liang JW, Bai J
Translational cancer research 2023 Sep 30;12(9):2294-2307

Targeting DHODH reveals therapeutic opportunities in ATRA-resistant acute promyelocytic leukemia.

Yang T, Shi X, Li S, Zhao Z, Wang J, Yu P, Li H, Wang R, Chen Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115314

Blockade of de novo pyrimidine biosynthesis triggers autophagic degradation of oncoprotein FLT3-ITD in acute myeloid leukemia.

Ma H, Cui J, Liu Z, Fang W, Lu S, Cao S, Zhang Y, Chen JA, Lu L, Xie Q, Wang Y, Huang Y, Li K, Tong H, Huang J, Lu W
Oncogene 2023 Nov;42(45):3331-3343

The deubiquitinase ZRANB1 is an E3 ubiquitin ligase for SLC7A11 and regulates ferroptotic resistance.

Huang S, Zhang Q, Zhao M, Wang X, Zhang Y, Gan B, Zhang P
The Journal of cell biology 2023 Nov 6;222(11)

Ferroptosis sensitization in glioma: exploring the regulatory mechanism of SOAT1 and its therapeutic implications.

Sun S, Qi G, Chen H, He D, Ma D, Bie Y, Xu L, Feng B, Pang Q, Guo H, Zhang R
Cell death & disease 2023 Nov 18;14(11):754

Cholesterol mediated ferroptosis suppression reveals essential roles of Coenzyme Q and squalene.

Sun Q, Liu D, Cui W, Cheng H, Huang L, Zhang R, Gu J, Liu S, Zhuang X, Lu Y, Chu B, Li J
Communications biology 2023 Nov 1;6(1):1108

De novo pyrimidine biosynthetic complexes support cancer cell proliferation and ferroptosis defence.

Yang C, Zhao Y, Wang L, Guo Z, Ma L, Yang R, Wu Y, Li X, Niu J, Chu Q, Fu Y, Li B
Nature cell biology 2023 Jun;25(6):836-847

Reply to: DHODH inhibitors sensitize to ferroptosis by FSP1 inhibition.

Mao C, Liu X, Yan Y, Olszewski K, Gan B
Nature 2023 Jul;619(7968):E19-E23

SLC25A22 as a Key Mitochondrial Transporter Against Ferroptosis by Producing Glutathione and Monounsaturated Fatty Acids.

Liu Y, Wang Y, Lin Z, Kang R, Tang D, Liu J
Antioxidants & redox signaling 2023 Jul;39(1-3):166-185

Dihydroorotate dehydrogenase regulates ferroptosis in neurons after spinal cord injury via the P53-ALOX15 signaling pathway.

Li D, Lu X, Xu G, Liu S, Gong Z, Lu F, Xia X, Jiang J, Wang H, Zou F, Ma X
CNS neuroscience & therapeutics 2023 Jul;29(7):1923-1939

ML390 inhibits enterovirus 71 replication by targeting de novo pyrimidine biosynthesis pathway.

Yang Q, Wu C, Zhu G, Ren F, Lin B, Huang R, Hu X, Zhao D, Peng K, Wu Y, Wang Q, Huang C, Zhang D
Antiviral research 2023 Jan;209:105498

SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4.

Cheng L, He Q, Liu B, Chen L, Lv F, Li X, Li Y, Liu C, Song Y, Xing Y
Cell death & disease 2023 Jan 31;14(1):74

Tryptophan Metabolism Acts as a New Anti-Ferroptotic Pathway to Mediate Tumor Growth.

Liu D, Liang CH, Huang B, Zhuang X, Cui W, Yang L, Yang Y, Zhang Y, Fu X, Zhang X, Du L, Gu W, Wang X, Yin C, Chai R, Chu B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Feb;10(6):e2204006

Depletion of SOD2 enhances nasopharyngeal carcinoma cell radiosensitivity via ferroptosis induction modulated by DHODH inhibition.

Amos A, Jiang N, Zong D, Gu J, Zhou J, Yin L, He X, Xu Y, Wu L
BMC cancer 2023 Feb 3;23(1):117

Neurotoxic A1 astrocytes promote neuronal ferroptosis via CXCL10/CXCR3 axis in epilepsy.

Liang P, Zhang X, Zhang Y, Wu Y, Song Y, Wang X, Chen T, Liu W, Peng B, Yin J, He F, Fan Y, Han S, He X
Free radical biology & medicine 2023 Feb 1;195:329-342

SMURF2 predisposes cancer cell toward ferroptosis in GPX4-independent manners by promoting GSTP1 degradation.

Zhang W, Dai J, Hou G, Liu H, Zheng S, Wang X, Lin Q, Zhang Y, Lu M, Gong Y, Xiang Z, Yu Y, Hu Y
Molecular cell 2023 Dec 7;83(23):4352-4369.e8

Cloning and Characterization of Yak DHODH Gene and Its Functional Studies in a Bisphenol S-Induced Ferroptosis Model of Fetal Fibroblasts.

Xu H, Li Y, Li Q, Ma Z, Yin S, He H, Xiong Y, Xiong X, Lan D, Li J, Fu W
Animals : an open access journal from MDPI 2023 Dec 13;13(24)

Oxoglutarate dehydrogenase-like inhibits the progression of hepatocellular carcinoma by inducing DNA damage through non-canonical function.

Jiang X, Peng J, Xie Y, Xu Y, Liu Q, Cheng C, Yan P, Xu S, Wang Y, Zhang L, Li H, Li Y, Li B, Han J, Yu D
Cell death and differentiation 2023 Aug;30(8):1931-1942

Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression.

Qiu S, Zhong X, Meng X, Li S, Qian X, Lu H, Cai J, Zhang Y, Wang M, Ye Z, Zhang H, Gao P
Cell research 2023 Apr;33(4):299-311

Glucose Starvation Inhibits Ferroptosis by Activating the LKB1/AMPK Signaling Pathway and Promotes the High Speed Linear Motility of Dairy Goat Sperm.

Li Y, Zhang G, Wen F, Xian M, Guo S, Zhang X, Feng X, Hu Z, Hu J
Animals : an open access journal from MDPI 2023 Apr 23;13(9)

Hepatic TGFβr1 Deficiency Attenuates Lipopolysaccharide/D-Galactosamine-Induced Acute Liver Failure Through Inhibiting GSK3β-Nrf2-Mediated Hepatocyte Apoptosis and Ferroptosis.

Huang S, Wang Y, Xie S, Lai Y, Mo C, Zeng T, Kuang S, Deng G, Zhou C, Chen Y, Huang S, Gao L, Lv Z
Cellular and molecular gastroenterology and hepatology 2022;13(6):1649-1672

Designer Exosomes for Targeted Delivery of a Novel Therapeutic Cargo to Enhance Sorafenib-Mediated Ferroptosis in Hepatocellular Carcinoma.

Li X, Yu Q, Zhao R, Guo X, Liu C, Zhang K, Zhang W, Liu J, Yu J, Wang S, Hao Q, Li W, Zhang W, Li M, Zhang Y, Zhang C, Gao Y
Frontiers in oncology 2022;12:898156

A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma.

Pal S, Kaplan JP, Nguyen H, Stopka SA, Savani MR, Regan MS, Nguyen QD, Jones KL, Moreau LA, Peng J, Dipiazza MG, Perciaccante AJ, Zhu X, Hunsel BR, Liu KX, Alexandrescu S, Drissi R, Filbin MG, McBrayer SK, Agar NYR, Chowdhury D, Haas-Kogan DA
Cancer cell 2022 Sep 12;40(9):957-972.e10

De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma.

Shi DD, Savani MR, Levitt MM, Wang AC, Endress JE, Bird CE, Buehler J, Stopka SA, Regan MS, Lin YF, Puliyappadamba VT, Gao W, Khanal J, Evans L, Lee JH, Guo L, Xiao Y, Xu M, Huang B, Jennings RB, Bonal DM, Martin-Sandoval MS, Dang T, Gattie LC, Cameron AB, Lee S, Asara JM, Kornblum HI, Mak TW, Looper RE, Nguyen QD, Signoretti S, Gradl S, Sutter A, Jeffers M, Janzer A, Lehrman MA, Zacharias LG, Mathews TP, Losman JA, Richardson TE, Cahill DP, DeBerardinis RJ, Ligon KL, Xu L, Ly P, Agar NYR, Abdullah KG, Harris IS, Kaelin WG Jr, McBrayer SK
Cancer cell 2022 Sep 12;40(9):939-956.e16

De novo pyrimidine synthesis fuels glycolysis and confers chemoresistance in gastric cancer.

He D, Chen M, Chang L, Gu J, Liu F, Gao X, Ruan Y
Cancer letters 2022 Nov 28;549:215837

Identification of purine biosynthesis as an NADH-sensing pathway to mediate energy stress.

Yang R, Yang C, Ma L, Zhao Y, Guo Z, Niu J, Chu Q, Ma Y, Li B
Nature communications 2022 Nov 17;13(1):7031

Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway.

Soflaee MH, Kesavan R, Sahu U, Tasdogan A, Villa E, Djabari Z, Cai F, Tran DH, Vu HS, Ali ES, Rion H, O'Hara BP, Kelekar S, Hallett JH, Martin M, Mathews TP, Gao P, Asara JM, Manning BD, Ben-Sahra I, Hoxhaj G
Nature communications 2022 May 16;13(1):2698

Synchronous Disintegration of Ferroptosis Defense Axis via Engineered Exosome-Conjugated Magnetic Nanoparticles for Glioblastoma Therapy.

Li B, Chen X, Qiu W, Zhao R, Duan J, Zhang S, Pan Z, Zhao S, Guo Q, Qi Y, Wang W, Deng L, Ni S, Sang Y, Xue H, Liu H, Li G
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Jun;9(17):e2105451

A ferroptosis defense mechanism mediated by glycerol-3-phosphate dehydrogenase 2 in mitochondria.

Wu S, Mao C, Kondiparthi L, Poyurovsky MV, Olszewski K, Gan B
Proceedings of the National Academy of Sciences of the United States of America 2022 Jun 28;119(26):e2121987119

Isoliquiritigenin alleviates liver fibrosis through caveolin-1-mediated hepatic stellate cells ferroptosis in zebrafish and mice.

Huang S, Wang Y, Xie S, Lai Y, Mo C, Zeng T, Kuang S, Zhou C, Zeng Z, Chen Y, Huang S, Gao L, Lv Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jul;101:154117

RNA binding protein NKAP protects glioblastoma cells from ferroptosis by promoting SLC7A11 mRNA splicing in an m(6)A-dependent manner.

Sun S, Gao T, Pang B, Su X, Guo C, Zhang R, Pang Q
Cell death & disease 2022 Jan 21;13(1):73

Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma.

Gwynne WD, Suk Y, Custers S, Mikolajewicz N, Chan JK, Zador Z, Chafe SC, Zhai K, Escudero L, Zhang C, Zaslaver O, Chokshi C, Shaikh MV, Bakhshinyan D, Burns I, Chaudhry I, Nachmani O, Mobilio D, Maich WT, Mero P, Brown KR, Quaile AT, Venugopal C, Moffat J, Montenegro-Burke JR, Singh SK
Cancer cell 2022 Dec 12;40(12):1488-1502.e7

3,3'-Diindolylmethane Enhances Fluorouracil Sensitivity via Inhibition of Pyrimidine Metabolism in Colorectal Cancer.

Zhang J, Zou S, Zhang Y, Yang Z, Wang W, Meng M, Feng J, Zhang P, Xiao L, Lee MH, Fang L
Metabolites 2022 Apr 30;12(5)

A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers.

Koppula P, Lei G, Zhang Y, Yan Y, Mao C, Kondiparthi L, Shi J, Liu X, Horbath A, Das M, Li W, Poyurovsky MV, Olszewski K, Gan B
Nature communications 2022 Apr 22;13(1):2206

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer.

Mao C, Liu X, Zhang Y, Lei G, Yan Y, Lee H, Koppula P, Wu S, Zhuang L, Fang B, Poyurovsky MV, Olszewski K, Gan B
Nature 2021 May;593(7860):586-590

Genome-wide CRISPR screening reveals nucleotide synthesis negatively regulates autophagy.

Mimura K, Sakamaki JI, Morishita H, Kawazu M, Mano H, Mizushima N
The Journal of biological chemistry 2021 Jan-Jun;296:100780

Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer.

Halbrook CJ, Pontious C, Kovalenko I, Lapienyte L, Dreyer S, Lee HJ, Thurston G, Zhang Y, Lazarus J, Sajjakulnukit P, Hong HS, Kremer DM, Nelson BS, Kemp S, Zhang L, Chang D, Biankin A, Shi J, Frankel TL, Crawford HC, Morton JP, Pasca di Magliano M, Lyssiotis CA
Cell metabolism 2019 Jun 4;29(6):1390-1399.e6

Mitochondrial fusion exploits a therapeutic vulnerability of pancreatic cancer.

Yu M, Nguyen ND, Huang Y, Lin D, Fujimoto TN, Molkentine JM, Deorukhkar A, Kang Y, San Lucas FA, Fernandes CJ, Koay EJ, Gupta S, Ying H, Koong AC, Herman JM, Fleming JB, Maitra A, Taniguchi CM
JCI insight 2019 Jul 23;5(16)

Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties.

Cao L, Weetall M, Trotta C, Cintron K, Ma J, Kim MJ, Furia B, Romfo C, Graci JD, Li W, Du J, Sheedy J, Hedrick J, Risher N, Yeh S, Qi H, Arasu T, Hwang S, Lennox W, Kong R, Petruska J, Moon YC, Babiak J, Davis TW, Jacobson A, Almstead NG, Branstrom A, Colacino JM, Peltz SW
Molecular cancer therapeutics 2019 Jan;18(1):3-16

Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia.

Wang Y, Bai C, Ruan Y, Liu M, Chu Q, Qiu L, Yang C, Li B
Nature communications 2019 Jan 14;10(1):201

Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells.

Bajzikova M, Kovarova J, Coelho AR, Boukalova S, Oh S, Rohlenova K, Svec D, Hubackova S, Endaya B, Judasova K, Bezawork-Geleta A, Kluckova K, Chatre L, Zobalova R, Novakova A, Vanova K, Ezrova Z, Maghzal GJ, Magalhaes Novais S, Olsinova M, Krobova L, An YJ, Davidova E, Nahacka Z, Sobol M, Cunha-Oliveira T, Sandoval-Acuña C, Strnad H, Zhang T, Huynh T, Serafim TL, Hozak P, Sardao VA, Koopman WJH, Ricchetti M, Oliveira PJ, Kolar F, Kubista M, Truksa J, Dvorakova-Hortova K, Pacak K, Gurlich R, Stocker R, Zhou Y, Berridge MV, Park S, Dong L, Rohlena J, Neuzil J
Cell metabolism 2019 Feb 5;29(2):399-416.e10

Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells.

Wu D, Wang W, Chen W, Lian F, Lang L, Huang Y, Xu Y, Zhang N, Chen Y, Liu M, Nussinov R, Cheng F, Lu W, Huang J
Haematologica 2018 Sep;103(9):1472-1483

Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis.

Santana-Codina N, Roeth AA, Zhang Y, Yang A, Mashadova O, Asara JM, Wang X, Bronson RT, Lyssiotis CA, Ying H, Kimmelman AC
Nature communications 2018 Nov 23;9(1):4945

The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels.

Hoxhaj G, Hughes-Hallett J, Timson RC, Ilagan E, Yuan M, Asara JM, Ben-Sahra I, Manning BD
Cell reports 2017 Oct 31;21(5):1331-1346

PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition.

Mathur D, Stratikopoulos E, Ozturk S, Steinbach N, Pegno S, Schoenfeld S, Yong R, Murty VV, Asara JM, Cantley LC, Parsons R
Cancer discovery 2017 Apr;7(4):380-390

Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.

Ben-Sahra I, Howell JJ, Asara JM, Manning BD
Science (New York, N.Y.) 2013 Mar 15;339(6125):1323-8

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: MCF7 cells were subjected to SDS PAGE followed by western blot with 14877-1-AP(DHODH antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of MCF-7 cells, using DHODH antibody 14877-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human breast cancer using 14877-1-AP(DHODH antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human breast cancer using 14877-1-AP(DHODH antibody) at dilution of 1:100 (under 40x lens)
Sample type: tissue