CASC5

gene product
AF15Q14, CT29, D40, hKNL-1, hSpc105, KNL1, PPP1R55, Spc7
The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11;15)(q23;q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jan 2013]
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104 antibodies from 17 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
4 antibodies
antibodies-online
30 antibodies
LifeSpan BioSciences, Inc.
21 antibodies
Bethyl Laboratories
3 antibodies
Invitrogen Antibodies
3 antibodies
Atlas Antibodies
2 antibodies
Abnova Corporation
1 antibody
Biorbyt
8 antibodies
Cell Signaling Technology, Inc
1 antibody
NovoPro Bioscience Inc.
1 antibody
Abgent
1 antibody
Abiocode, Inc.
1 antibody
GeneTex
1 antibody
St John's Laboratory
1 antibody
Sigma-Aldrich
1 antibody
United States Biological
13 antibodies