323902

antibody from BioLegend

Targeting: SIRPB1 CD172b, SIRP-BETA-1

Antibody data

Submit

Validation data

Product number: 323902 - Provider product page
Provider: BioLegend
Proper citation: BioLegend Cat#323902, RRID:AB_2301799
Product name: Purified anti-human CD172b (SIRP)
Antibody type: Monoclonal
Antigen: NIH-3T3 cells transfected with SIRPbeta
Description: The B4B6 antibody recognizes human CD172b also known as signal-regulatory protein beta, and SIRP-beta. CD172b is a member of the signal regulatory protein family and immunoglobulin superfamily. CD172b contains a single pass transmembrane region with immunoglobulin-like domains and unlike CD172a, this receptor lacks a cytoplasmic SHP-2 binding domain. CD172b is a disulfide-linked homodimer with a predicted molecular weight of approximately 43 kD. Two isoforms of CD172b are produced by alternative splicing. CD172b is expressed on myeloid cells including monocytes and dendritic cells where it functions in the negative regulation of tyrosine-kinase coupled signaling processes. CD172b has been shown to regulate neutrophil transepithelial migration. CD172b interacts with DAP12 and Syk kinase (through TYROBP). The B4B6 antibody has been shown to be useful for flow cytometry.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Vial size: 100 µg
Concentration: 0.5 mg/ml
Storage: The antibody solution should be stored undiluted at 4°C.

SIRPB1 protein structure - 323902 shown in red.