337302

antibody from BioLegend
Targeting: SIRPB1 CD172b, SIRP-BETA-1
Provider product page for 337302
Western blot
Immunoprecipitation
Flow cytometry

Antibody data

Product number
337302 - Provider product page
Provider
BioLegend
Product name
Purified anti-human CD172a/b (SIRP‡/‰)
Antibody type
Monoclonal
Antigen
CD172a/b (SIRPa/b)
Description
SIRPs (signal-regulatory proteins) are a family of transmembrane glycoproteins that belong to Ig superfamily. SIRPa (CD172a, SIRPb),(SIRPb1,CD172b), and SIRPg (SIRPb2,CD172g) have been described. CD172a/b molecules are expressed on myeloid cells and neurons. CD172a serves as a substrate of activated receptor tyrosine kinases (RTKs). The interaction of CD172a intracellular domain with SHP-1 and SHP-2 displays negative signaling in the regulation of leukocyte adhesion and transmigration. CD47 (IAP) is an extracellular ligand for CD172a. CD172b is a disulfide-linked homodimer. CD172b has been shown to regulate neutrophil transepithelial migration through the interaction with DAP12 and Syk kinase (through TYROBP).
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Isotype
IgG
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
The antibody solution should be stored undiluted at 4° C.
SIRPB1 protein structure - 337302 shown in red.