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- Antibody Data
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- References [287]
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- Product number
- 10956-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10956-1-AP, RRID:AB_2102532
- Product name
- FIS1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated FIS1 antibody (Cat. #10956-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat, pig and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat, Porcine
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references CD62E- and ROS-Responsive ETS Improves Cartilage Repair by Inhibiting Endothelial Cell Activation through OPA1-Mediated Mitochondrial Homeostasis.
Loss of MTX2 causes mitochondrial dysfunction, podocyte injury, nephrotic proteinuria and glomerulopathy in mice and patients.
The Footprints of Mitochondrial Fission and Apoptosis in Fluoride-Induced Renal Dysfunction.
SIRT1 regulates mitochondrial fission to alleviate high altitude hypoxia inducedcardiac dysfunction in rats via the PGC-1α-DRP1/FIS1/MFF pathway.
SIRT1, a target of miR-708-3p, alleviates fluoride-induced neuronal damage via remodeling mitochondrial network dynamics.
Deafness-associated tRNA(Phe) mutation impaired mitochondrial and cellular integrity.
circUSP13 facilitates the fast-to-slow myofiber shift via the MAPK/ERK signaling pathway in goat skeletal muscles.
Puerarin Delays Mammary Gland Aging by Regulating Gut Microbiota and Inhibiting the p38MAPK Signaling Pathway.
Ginkgolide C inhibits ROS-mediated activation of NLRP3 inflammasome in chondrocytes to ameliorate osteoarthritis.
Met-Exo attenuates mitochondrial dysfunction after hepatic ischemia-reperfusion injury in rats by modulating AMPK/SIRT1 signaling pathway.
IGF2BP3-stabilized CAMK1 regulates the mitochondrial dynamics of renal tubule to alleviate diabetic nephropathy.
Doxycycline induces mitochondrial dysfunction in aortic smooth muscle cells.
Inhibition of Drp1- Fis1 interaction alleviates aberrant mitochondrial fragmentation and acute kidney injury.
NME3 is a gatekeeper for DRP1-dependent mitophagy in hypoxia.
Leucine Supplementation Prevents the Development of Skeletal Muscle Dysfunction in a Rat Model of HFpEF.
Mechanistic of AMPK/ACC2 regulating myoblast differentiation by fatty acid oxidation of goat.
Hydrogen alleviates impaired lung epithelial barrier in acute respiratory distress syndrome via inhibiting Drp1-mediated mitochondrial fission through the Trx1 pathway.
Peptide-encoding gene transfer to modulate intracellular protein-protein interactions.
Dulaglutide restores endothelial progenitor cell levels in diabetic mice and mitigates high glucose-induced endothelial injury through SIRT1-mediated mitochondrial fission.
MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels.
NAD(+) supplementation improves mitochondrial functions and normalizes glaucomatous trabecular meshwork features.
NAMPT regulates mitochondria function and lipid metabolism during porcine oocyte maturation.
Sentrin-specific protease 1 maintains mitochondrial homeostasis through targeting the deSUMOylation of sirtuin-3 to alleviate oxidative damage induced by hepatic ischemia/reperfusion.
Nicotinamide mononucleotide alleviates seizures via modulating SIRT1-PGC-1α mediated mitochondrial fusion and fission.
Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4‑mediated ferritinophagy.
Intermittent Theta Burst Stimulation Attenuates Cognitive Deficits and Alzheimer's Disease-Type Pathologies via ISCA1-Mediated Mitochondrial Modulation in APP/PS1 Mice.
Rescue of mitochondrial import failure by intercellular organellar transfer.
Deficient tRNA posttranscription modification dysregulated the mitochondrial quality controls and apoptosis.
Mitochondrial dynamics disruption: Unraveling Dinotefuran's impact on cardiotoxicity.
VDR regulates mitochondrial function as a protective mechanism against renal tubular cell injury in diabetic rats.
DsbA-L ameliorates renal aging and renal fibrosis by maintaining mitochondrial homeostasis.
Cadmium-induced global DNA hypermethylation promoting mitochondrial dynamics dysregulation in hippocampal neurons.
Astragaloside IV combined with ligustrazine ameliorates abnormal mitochondrial dynamics via Drp1 SUMO/deSUMOylation in cerebral ischemia-reperfusion injury.
Resveratrol Inhibits Zinc Deficiency-Induced Mitophagy and Exerts Cardiac Cytoprotective Effects.
Mitochondria-associated membranes contribution to exercise-mediated alleviation of hepatic insulin resistance: Contrasting high-intensity interval training with moderate-intensity continuous training in a high-fat diet mouse model.
Dietary fat supplementation relieves cold temperature-induced energy stress through AMPK-mediated mitochondrial homeostasis in pigs.
TDCPP and TiO(2) NPs aggregates synergistically induce SH-SY5Y cell neurotoxicity by excessive mitochondrial fission and mitophagy inhibition.
Phosphoglycerate mutase 5 exacerbates liver ischemia-reperfusion injury by activating mitochondrial fission.
Nanocurcumin Reduces High Glucose and Particulate Matter-Induced Endothelial Inflammation: Mitochondrial Function and Involvement of miR-221/222.
Selenium-enriched Cardamine violifolia protects against sepsis-induced intestinal injury by regulating mitochondrial fusion in weaned pigs.
Hypoxia-induced GPCPD1 depalmitoylation triggers mitophagy via regulating PRKN-mediated ubiquitination of VDAC1.
Aerobic exercise enhances mitochondrial homeostasis to counteract D-galactose-induced sarcopenia in zebrafish.
Photobiomodulation provides neuroprotection through regulating mitochondrial fission imbalance in the subacute phase of spinal cord injury.
Mitochondrial miR-12294-5p regulated copper-induced mitochondrial oxidative stress and mitochondrial quality control imbalance by targeted inhibition of CISD1 in chicken livers.
High-resolution visualization and assessment of basal and OXPHOS-induced mitophagy in H9c2 cardiomyoblasts.
Histone deacetylase inhibitor pracinostat suppresses colorectal cancer by inducing CDK5-Drp1 signaling-mediated peripheral mitofission.
Polydatin improves vascular endothelial function by maintaining mitochondrial homeostasis under high glucose conditions.
A conserved, noncanonical insert in FIS1 mediates TBC1D15 and DRP1 recruitment for mitochondrial fission.
The mystery of phospho-Drp1 with four adaptors in cell cycle: when mitochondrial fission couples to cell fate decisions.
The poxvirus F17 protein counteracts mitochondrially orchestrated antiviral responses.
CCDC127 regulates lipid droplet homeostasis by enhancing mitochondria-ER contacts.
Sodium Sulfite-Triggered Hepatocyte Ferroptosis via mtROS/Lysosomal Membrane Permeabilization-Mediated Lysosome Iron Efflux.
miR-27a-3p relieves heat stress-induced mitochondrial damage and aberrant milk protein synthesis through MEK/ERK pathway in BMECs.
Heme oxygenase-1 prevents non-alcoholic steatohepatitis through modulating mitochondrial quality control.
HC067047 as a potent TRPV4 inhibitor repairs endotoxemia colonic injury.
Empagliflozin ameliorates cardiac dysfunction in heart failure mice via regulating mitochondrial dynamics.
Macrophage Inactivation by Small Molecule Wedelolactone via Targeting sEH for the Treatment of LPS-Induced Acute Lung Injury.
MFN1 augmentation prevents retinal degeneration in a Charcot-Marie-Tooth type 2A mouse model.
miR-484 mediates oxidative stress-induced ovarian dysfunction and promotes granulosa cell apoptosis via SESN2 downregulation.
Senomorphic effect of diphenyleneiodonium through AMPK/MFF/DRP1 mediated mitochondrial fission.
Paraquat-induced neurogenesis abnormalities via Drp1-mediated mitochondrial fission.
Pseudolaric acid B triggers cell apoptosis by activating AMPK/JNK/DRP1/mitochondrial fission pathway in hepatocellular carcinoma.
Myricetin improves pathological changes in 3×Tg-AD mice by regulating the mitochondria-NLRP3 inflammasome-microglia channel by targeting P38 MAPK signaling pathway.
Hydrogen sulfide alleviates mitochondrial damage and ferroptosis by regulating OPA3-NFS1 axis in doxorubicin-induced cardiotoxicity.
Parkin regulates amino acid homeostasis at mitochondria-lysosome (M/L) contact sites in Parkinson's disease.
Targeting an allosteric site in dynamin-related protein 1 to inhibit Fis1-mediated mitochondrial dysfunction.
High-intensity interval training induces renal injury and fibrosis in type 2 diabetic mice.
Bavachin and Corylifol A Improve Muscle Atrophy by Enhancing Mitochondria Quality Control in Type 2 Diabetic Mice.
N-acetyl-L-cysteine alleviates FUNDC1-mediated mitophagy by regulating mitochondrial dynamics in type 1 diabetic nephropathy canine.
Endoplasmic reticulum stress mediated by ROS participates in cadmium exposure-induced MC3T3-E1 cell apoptosis.
Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis.
PKM2-mediated neuronal hyperglycolysis enhances the risk of Parkinson's disease in diabetic rats.
Osthole: A potential AMPK agonist that inhibits NLRP3 inflammasome activation by regulating mitochondrial homeostasis for combating rheumatoid arthritis.
METTL14-dependent maturation of pri-miR-17 regulates mitochondrial homeostasis and induces chemoresistance in colorectal cancer.
Selenium alleviates cadmium-induced mitophagy through FUNDC1-mediated mitochondrial quality control pathway in the lungs of sheep.
SIRT3-dependent mitochondrial redox homeostasis mitigates CHK1 inhibition combined with gemcitabine treatment induced cardiotoxicity in hiPSC-CMs and mice.
Nogo-B mediates endothelial oxidative stress and inflammation to promote coronary atherosclerosis in pressure-overloaded mouse hearts.
Mitochondrial fission drives neuronal metabolic burden to promote stress susceptibility in male mice.
Zinc Overload Induces Damage to H9c2 Cardiomyocyte Through Mitochondrial Dysfunction and ROS-Mediated Mitophagy.
Zearalenone promotes porcine ESCs apoptosis by enhancing Drp1-mediated mitochondrial fragmentation and activating the JNK pathway.
Ramelteon attenuates renal ischemia and reperfusion injury through reducing mitochondrial fission and fusion and inflammation.
The Binding of HSPA8 and Mitochondrial ALDH2 Mediates Oxygen-Glucose Deprivation-Induced Fibroblast Senescence.
CircRNA SCAR Improves High-Glucose-Induced Mitochondrial Dysfunction and Permeability Damage in Retinal Microvascular Endothelial Cells.
Loganin alleviated cognitive impairment in 3×Tg-AD mice through promoting mitophagy mediated by optineurin.
LDLR heterozygous deletion reduces hamster testicular cholesterol toxicity via AMPK/Sirt1/PGC-1α pathway.
Aristolochic acid I exposure triggers ovarian dysfunction by activating NLRP3 inflammasome and affecting mitochondrial homeostasis.
A single dose of exercise stimulates skeletal muscle mitochondrial plasticity in myotonic dystrophy type 1.
Possible frequent multiple mitochondrial DNA copies in a single nucleoid in HeLa cells.
Molybdenum and Cadmium Co-induce Mitochondrial Quality Control Disorder via FUNDC1-Mediated Mitophagy in Sheep Kidney.
Impact of UCP2 depletion on heat stroke-induced mitochondrial function in human umbilical vein endothelial cells.
Selenium Attenuates TBHP-Induced Apoptosis of Nucleus Pulposus Cells by Suppressing Mitochondrial Fission through Activating Nuclear Factor Erythroid 2-Related Factor 2.
Dynamin-Related Protein 1 Is Involved in Mitochondrial Damage, Defective Mitophagy, and NLRP3 Inflammasome Activation Induced by MSU Crystals.
Change in Oxidative Stress and Mitochondrial Dynamics in Response to Elevated Cold-Inducible RNA-Binding Protein in Cardiac Surgery-Associated Acute Kidney Injury.
Intracellular Ca(2+) Signaling and Calcium Release-Activated Calcium Modulator ORAI1 Are Associated With CD4(+) T Lymphocytes in Dairy Cows.
COA3 overexpression promotes non-small cell lung cancer metastasis by reprogramming glucose metabolism.
Non-invasive photobiomodulation treatment in an Alzheimer Disease-like transgenic rat model.
Mannose inhibits the growth of prostate cancer through a mitochondrial mechanism.
Empagliflozin Preserves Skeletal Muscle Function in a HFpEF Rat Model.
Depletion of serum-derived exosomes aggravates heat stress-induced damage of bovine mammary epithelial cells.
Blocking exosomal secretion aggravates 1,4-benzoquinone-induced mitochondrial fission activated by the AMPK/MFF/Drp1 pathway in HL-60 cells.
Integrated Analysis of Transcriptome and microRNA Profile Reveals the Toxicity of Euphorbia Factors toward Human Colon Adenocarcinoma Cell Line Caco-2.
The Endoplasmic Reticulum ATP13A1 is Essential for MAVS-Mediated Antiviral Innate Immunity.
Cadmium-induced apoptosis of Leydig cells is mediated by excessive mitochondrial fission and inhibition of mitophagy.
Sirt3 deficiency accelerates ovarian senescence without affecting spermatogenesis in aging mice.
Dihydromyricetin contributes to weight loss via pro-browning mediated by mitochondrial fission in white adipose.
AMPK/MFF Activation: Role in Mitochondrial Fission and Mitophagy in Dry Eye.
SIRT4 Expression Ameliorates the Detrimental Effect of Heat Stress via AMPK/mTOR Signaling Pathway in BMECs.
Heat shock protein 60 couples an oxidative stress-responsive p38/MK2 signaling and NF-κB survival machinery in cancer cells.
PACS-2 Ameliorates Tubular Injury by Facilitating Endoplasmic Reticulum-Mitochondria Contact and Mitophagy in Diabetic Nephropathy.
HSP70 attenuates compression-induced apoptosis of nucleus pulposus cells by suppressing mitochondrial fission via upregulating the expression of SIRT3.
PINK1 regulates mitochondrial fission/fusion and neuroinflammation in β-amyloid-induced Alzheimer's disease models.
Chicoric Acid Attenuated Renal Tubular Injury in HFD-Induced Chronic Kidney Disease Mice through the Promotion of Mitophagy via the Nrf2/PINK/Parkin Pathway.
PINK1/TAX1BP1-directed mitophagy attenuates vascular endothelial injury induced by copper oxide nanoparticles.
Carbon tetrachloride induced mitochondrial division, respiratory chain damage, abnormal intracellular [H(+)] and apoptosis are due to the activation of 5-HT degradation system in hepatocytes.
Autophagy and mitochondrial dynamics contribute to the protective effect of diosgenin against 3-MCPD induced kidney injury.
Long-term exercise pre-training attenuates Alzheimer's disease-related pathology in a transgenic rat model of Alzheimer's disease.
Regulatory roles of external cholesterol in human airway epithelial mitochondrial function through STARD3 signalling.
Effects of amyloid-β on protein SUMOylation and levels of mitochondrial proteins in primary cortical neurons.
Novel Thermosensitive Hydrogel Promotes Spinal Cord Repair by Regulating Mitochondrial Function.
Breast Cancer Selective Disruption of Actin Cytoskeleton by Diallyl Trisulfide.
Myosin II proteins are required for organization of calcium-induced actin networks upstream of mitochondrial division.
Aldehyde dehydrogenase 2 deficiency promotes skeletal muscle atrophy in aged mice.
Inhibition of nuclear deacetylase Sirtuin-1 induces mitochondrial acetylation and calcium overload leading to cell death.
Selenium alleviates cadmium-induced aging via mitochondrial quality control in the livers of sheep.
PEX11β and FIS1 cooperate in peroxisome division independently of mitochondrial fission factor.
Herceptin induces ferroptosis and mitochondrial dysfunction in H9c2 cells.
The SUMO protease SENP3 regulates mitochondrial autophagy mediated by Fis1.
Attenuates of NAD(+) impair BMSC osteogenesis and fracture repair through OXPHOS.
Protective Effects of Chaya against Mitochondrial and Synaptic Toxicities in the Type 2 Diabetes Mouse Model TallyHO.
Early Cellular, Molecular, Morphological and Behavioral Changes in the Humanized Amyloid-Beta-Knock-In Mouse Model of Late-Onset Alzheimer's Disease.
Protein C receptor maintains cancer stem cell properties via activating lipid synthesis in nasopharyngeal carcinoma.
Myricetin Restores Aβ-Induced Mitochondrial Impairments in N2a-SW Cells.
CHCHD2 and CHCHD10 regulate mitochondrial dynamics and integrated stress response.
Generation of a homozygous FIS1 knockout human embryonic stem cell line GIBHe015-B by CRISPR/Cas9 system.
Cdk5 Promotes Mitochondrial Fission via Drp1 Phosphorylation at S616 in Chronic Ethanol Exposure-Induced Cognitive Impairment.
SARS-CoV-2 mitochondriopathy in COVID-19 pneumonia exacerbates hypoxemia.
Perinatal exposure to glyphosate-based herbicides impairs progeny health and placental angiogenesis by disturbing mitochondrial function.
A Combination Therapy of Urolithin A+EGCG Has Stronger Protective Effects than Single Drug Urolithin A in a Humanized Amyloid Beta Knockin Mice for Late-Onset Alzheimer's Disease.
A pivotal role of selective autophagy in mitochondrial quality control: Implications for zinc oxide nanoparticles induced neurotoxicity.
N(6)-adenomethylation of GsdmC is essential for Lgr5(+) stem cell survival to maintain normal colonic epithelial morphogenesis.
Chrono-Aerobic Exercise Optimizes Metabolic State in DB/DB Mice through CLOCK-Mitophagy-Apoptosis.
Nicotinamide mononucleotide alleviates heat stress-induced oxidative stress and apoptosis in BMECs through reducing mitochondrial damage and endoplasmic reticulum stress.
CLOCK regulates Drp1 mRNA stability and mitochondrial homeostasis by interacting with PUF60.
BNIP3 (BCL2 interacting protein 3) regulates pluripotency by modulating mitochondrial homeostasis via mitophagy.
Phosphorylation of Dynamin-Related Protein 1 (DRP1) Regulates Mitochondrial Dynamics and Skeletal Muscle Wasting in Cancer Cachexia.
KCa3.1 Mediates Dysregulation of Mitochondrial Quality Control in Diabetic Kidney Disease.
PP2 Ameliorates Renal Fibrosis by Regulating the NF-κB/COX-2 and PPARγ/UCP2 Pathway in Diabetic Mice.
RNA-Seq Profiling to Investigate the Mechanism of Qishen Granules on Regulating Mitochondrial Energy Metabolism of Heart Failure in Rats.
Tortoise Plastron and Deer Antler Gelatin Prevents Against Neuronal Mitochondrial Dysfunction In Vitro: Implication for a Potential Therapy of Alzheimer's Disease.
Elevated Lactate by High-Intensity Interval Training Regulates the Hippocampal BDNF Expression and the Mitochondrial Quality Control System.
Antioxidant activity of mesenchymal stem cell-derived extracellular vesicles restores hippocampal neurons following seizure damage.
Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington's disease.
Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity.
Effects of andrographolide on renal tubulointersticial injury and fibrosis. Evidence of its mechanism of action.
Mechanisms of impaired mitochondrial homeostasis and NAD(+) metabolism in a model of mitochondrial heart disease exhibiting redox active iron accumulation.
Inhibition of ER stress attenuates kidney injury and apoptosis induced by 3-MCPD via regulating mitochondrial fission/fusion and Ca(2+) homeostasis.
SIRT3 protects bovine mammary epithelial cells from heat stress damage by activating the AMPK signaling pathway.
Melatonin protects against excessive autophagy-induced mitochondrial and ovarian reserve function deficiency though ERK signaling pathway in Chinese hamster ovary (CHO) cells.
Distinct fission signatures predict mitochondrial degradation or biogenesis.
Protective effects of a mitochondria-targeted small peptide SS31 against hyperglycemia-induced mitochondrial abnormalities in the liver tissues of diabetic mice, Tallyho/JngJ mice.
Dihydromyricetin attenuates heat stress-induced apoptosis in dairy cow mammary epithelial cells through suppressing mitochondrial dysfunction.
Protective effects of antidepressant citalopram against abnormal APP processing and amyloid beta-induced mitochondrial dynamics, biogenesis, mitophagy and synaptic toxicities in Alzheimer's disease.
Effects of photoperiod on morphology and function in testis and epididymis of Cricetulus barabensis.
Haemodynamic-directed cardiopulmonary resuscitation promotes mitochondrial fusion and preservation of mitochondrial mass after successful resuscitation in a pediatric porcine model.
The detrimental effect of iron on OA chondrocytes: Importance of pro-inflammatory cytokines induced iron influx and oxidative stress.
ALS/FTD mutations in UBQLN2 are linked to mitochondrial dysfunction through loss-of-function in mitochondrial protein import.
Effect of the interference with DRP1 expression on the biological characteristics of glioma stem cells.
Resveratrol and exercise combined to treat functional limitations in late life: A pilot randomized controlled trial.
ATPIF1 maintains normal mitochondrial structure which is impaired by CCM3 deficiency in endothelial cells.
Selonsertib, a potential drug for liver failure therapy by rescuing the mitochondrial dysfunction of macrophage via ASK1-JNK-DRP1 pathway.
Mesenchymal stem cells ameliorate lipid metabolism through reducing mitochondrial damage of hepatocytes in the treatment of post-hepatectomy liver failure.
CHIP protects against MPP(+)/MPTP-induced damage by regulating Drp1 in two models of Parkinson's disease.
Restoring metabolism of myeloid cells reverses cognitive decline in ageing.
The XBP1‒MARCH5‒MFN2 Axis Confers Endoplasmic Reticulum Stress Resistance by Coordinating Mitochondrial Fission and Mitophagy in Melanoma.
Carnosol alleviates nonalcoholic fatty liver disease by inhibiting mitochondrial dysfunction and apoptosis through targeting of PRDX3.
Chronic hypoxia alters cardiac mitochondrial complex protein expression and activity in fetal guinea pigs in a sex-selective manner.
Intranasal administration of DHED protects against exhaustive exercise-induced brain injury in rats.
Targeting P2RX1 alleviates renal ischemia/reperfusion injury by preserving mitochondrial dynamics.
LKB1/AMPKα signaling pathway and mitochondrial fission/fusion dynamics regulate apoptosis induced by 3-chlorpropane-1,2-diol in HEK293 cells.
Extract of Cynomorium songaricum ameliorates mitochondrial ultrastructure impairments and dysfunction in two different in vitro models of Alzheimer's disease.
Fis1 ablation in the male germline disrupts mitochondrial morphology and mitophagy, and arrests spermatid maturation.
Change on apoptosis, autophagy and mitochondria of the Harderian gland in Cricetulus barabensis during age.
Mst1 Knockout Alleviates Mitochondrial Fission and Mitigates Left Ventricular Remodeling in the Development of Diabetic Cardiomyopathy.
Deletion of Bmal1 Impairs Pancreatic β-Cell Function via Mitochondrial Signaling Pathway.
Proteomic Profile of Mouse Brain Aging Contributions to Mitochondrial Dysfunction, DNA Oxidative Damage, Loss of Neurotrophic Factor, and Synaptic and Ribosomal Proteins.
Drp1-mediated mitochondrial fission contributes to baicalein-induced apoptosis and autophagy in lung cancer via activation of AMPK signaling pathway.
The effect of autophagy and mitochondrial fission on Harderian gland is greater than apoptosis in male hamsters during different photoperiods.
Bu-Yin-Qian-Zheng Formula Ameliorates MPP(+)-Induced Mitochondrial Dysfunction in Parkinson's Disease via Parkin.
High-Intensity Interval Training Restores Glycolipid Metabolism and Mitochondrial Function in Skeletal Muscle of Mice With Type 2 Diabetes.
Photoperiod Affects Harderian Gland Morphology and Secretion in Female Cricetulus barabensis: Autophagy, Apoptosis, and Mitochondria.
Promotion of mitochondrial fusion protects against developmental PBDE-47 neurotoxicity by restoring mitochondrial homeostasis and suppressing excessive apoptosis.
Exercise enhances mitochondrial fission and mitophagy to improve myopathy following critical limb ischemia in elderly mice via the PGC1a/FNDC5/irisin pathway.
PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth.
HIF-1α ameliorates tubular injury in diabetic nephropathy via HO-1-mediated control of mitochondrial dynamics.
Novel ultrastructural findings on cardiac mitochondria of huddling Brandt's voles in mild cold environment.
Hypoxia induces pulmonary artery smooth muscle dysfunction through mitochondrial fragmentation-mediated endoplasmic reticulum stress.
Formation of colorectal liver metastases induces musculoskeletal and metabolic abnormalities consistent with exacerbated cachexia.
AIM2 promotes the development of non-small cell lung cancer by modulating mitochondrial dynamics.
PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway.
Mitochondrial Dynamics Regulation in Skin Fibroblasts from Mitochondrial Disease Patients.
ChREBP-β regulates thermogenesis in brown adipose tissue.
Drp1/Mff signaling pathway is involved in fluoride-induced abnormal fission of hepatocyte mitochondria in mice.
FKBP8 LIRL-dependent mitochondrial fragmentation facilitates mitophagy under stress conditions.
PKM2 suppresses osteogenesis and facilitates adipogenesis by regulating β-catenin signaling and mitochondrial fusion and fission.
Microcystin-leucine-arginine induced neurotoxicity by initiating mitochondrial fission in hippocampal neurons.
Genome-wide synthetic lethal CRISPR screen identifies FIS1 as a genetic interactor of ALS-linked C9ORF72.
Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease.
Desferoxamine protects against glucocorticoid-induced osteonecrosis of the femoral head via activating HIF-1α expression.
Mitochondrial Safeguard: a stress response that offsets extreme fusion and protects respiratory function via flickering-induced Oma1 activation.
PRCC-TFE3 regulates migration and invasion of translocation renal cell carcinomas via activation of Drp1-dependent mitochondrial fission.
USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation.
Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission.
Heat stress induces apoptosis through disruption of dynamic mitochondrial networks in dairy cow mammary epithelial cells.
An epigenetic increase in mitochondrial fission by MiD49 and MiD51 regulates the cell cycle in cancer: Diagnostic and therapeutic implications.
Exogenous H(2)S Promoted USP8 Sulfhydration to Regulate Mitophagy in the Hearts of db/db Mice.
DsbA-L deficiency exacerbates mitochondrial dysfunction of tubular cells in diabetic kidney disease.
SIRT3-Dependent Mitochondrial Dynamics Remodeling Contributes to Oxidative Stress-Induced Melanocyte Degeneration in Vitiligo.
Spermidine Prevents Heart Injury in Neonatal Rats Exposed to Intrauterine Hypoxia by Inhibiting Oxidative Stress and Mitochondrial Fragmentation.
Impaired Mitochondrial Fusion and Oxidative Phosphorylation Triggered by High Glucose Is Mediated by Tom22 in Endothelial Cells.
Parkin-mediated ubiquitination contributes to the constitutive turnover of mitochondrial fission factor (Mff).
Propofol Ameliorates H9c2 Cells Apoptosis Induced by Oxygen Glucose Deprivation and Reperfusion Injury via Inhibiting High Levels of Mitochondrial Fusion and Fission.
Da-Bu-Yin-Wan and Qian-Zheng-San Ameliorate Mitochondrial Dynamics in the Parkinson's Disease Cell Model Induced by MPP().
Icariin Protects Bone Marrow Mesenchymal Stem Cells Against Iron Overload Induced Dysfunction Through Mitochondrial Fusion and Fission, PI3K/AKT/mTOR and MAPK Pathways.
Mitochondrial dysfunction in endothelial cells induced by airborne fine particulate matter (<2.5 μm).
Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae.
SS-31 reduces inflammation and oxidative stress through the inhibition of Fis1 expression in lipopolysaccharide-stimulated microglia.
Proteomic Analysis and Biochemical Correlates of Mitochondrial Dysfunction after Low-Intensity Primary Blast Exposure.
Low-dose oral copper treatment changes the hippocampal phosphoproteomic profile and perturbs mitochondrial function in a mouse model of Alzheimer's disease.
Roles of mitochondrial fission inhibition in developmental fluoride neurotoxicity: mechanisms of action in vitro and associations with cognition in rats and children.
ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects.
Angiotensin II suppresses autophagy and disrupts ultrastructural morphology and function of mitochondria in mouse skeletal muscle.
Oxidative pathophysiology following volumetric muscle loss injury in a porcine model.
Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations.
Fibroblast growth factor 18 exerts anti-osteoarthritic effects through PI3K-AKT signaling and mitochondrial fusion and fission.
Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy.
Two separate functions of NME3 critical for cell survival underlie a neurodegenerative disorder.
Mitochondrial division inhibitor 1 reduces dynamin-related protein 1 and mitochondrial fission activity.
Hepatic HKDC1 Expression Contributes to Liver Metabolism.
Burn-induced reductions in mitochondrial abundance and efficiency are more pronounced with small volumes of colloids in swine.
Novel findings on ultrastructural protection of skeletal muscle fibers during hibernation of Daurian ground squirrels: Mitochondria, nuclei, cytoskeleton, glycogen.
Pyridostigmine regulates glucose metabolism and mitochondrial homeostasis to reduce myocardial vulnerability to injury in diabetic mice.
Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells.
Polybrene induces neural degeneration by bidirectional Ca(2+) influx-dependent mitochondrial and ER-mitochondrial dynamics.
In Vivo Deletion of β-Cell Drp1 Impairs Insulin Secretion Without Affecting Islet Oxygen Consumption.
A high-fat diet impairs mitochondrial biogenesis, mitochondrial dynamics, and the respiratory chain complex in rat myocardial tissues.
Aerobic Exercise Preconception and During Pregnancy Enhances Oxidative Capacity in the Hindlimb Muscles of Mice Offspring.
AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells.
Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer's disease.
INF2-mediated actin polymerization at the ER stimulates mitochondrial calcium uptake, inner membrane constriction, and division.
GLUT10 maintains the integrity of major arteries through regulation of redox homeostasis and mitochondrial function.
Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer's disease.
Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer's disease.
Neuroprotective Effect and Mechanism of Thiazolidinedione on Dopaminergic Neurons In Vivo and In Vitro in Parkinson's Disease.
Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission.
Salvianolic acid B inhibits mitochondrial dysfunction by up-regulating mortalin.
Mitochondrial dynamics changes with age in an APPsw/PS1dE9 mouse model of Alzheimer's disease.
Phosphorylation of dynamin-related protein 1 at Ser616 regulates mitochondrial fission and is involved in mitochondrial calcium uniporter-mediated neutrophil polarization and chemotaxis.
p62-Mediated mitochondrial clustering attenuates apoptosis induced by mitochondrial depolarization.
Low-level laser therapy for beta amyloid toxicity in rat hippocampus.
Sirtuin 5 protects mitochondria from fragmentation and degradation during starvation.
Hydrogen Sulphide modulating mitochondrial morphology to promote mitophagy in endothelial cells under high-glucose and high-palmitate.
Receptor-mediated Drp1 oligomerization on endoplasmic reticulum.
Ischemia-induced Drp1 and Fis1-mediated mitochondrial fission and right ventricular dysfunction in pulmonary hypertension.
AP39, a Mitochondria-Targeted Hydrogen Sulfide Donor, Supports Cellular Bioenergetics and Protects against Alzheimer's Disease by Preserving Mitochondrial Function in APP/PS1 Mice and Neurons.
Autophagy plays a role in skeletal muscle mitochondrial biogenesis in an endurance exercise-trained condition.
Dysfunctional tubular endoplasmic reticulum constitutes a pathological feature of Alzheimer's disease.
Quantification and Characterization of UVB-Induced Mitochondrial Fragmentation in Normal Primary Human Keratinocytes.
Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease.
Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology.
FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions.
Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria.
Resveratrol Induces Cancer Cell Apoptosis through MiR-326/PKM2-Mediated ER Stress and Mitochondrial Fission.
Protective effects of reduced dynamin-related protein 1 against amyloid beta-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease.
Mitochondrial division inhibitor 1 protects against mutant huntingtin-induced abnormal mitochondrial dynamics and neuronal damage in Huntington's disease.
The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission.
Mutations in Fis1 disrupt orderly disposal of defective mitochondria.
RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway.
PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation.
Loss of Yme1L perturbates mitochondrial dynamics.
Mitochondrial abnormalities in temporal lobe of autistic brain.
A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity.
Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration.
Dynamin-related protein 1 heterozygote knockout mice do not have synaptic and mitochondrial deficiencies.
Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage.
Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease.
Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage.
Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons.
Tu P, Pan Y, Wang L, Li B, Sun X, Liang Z, Liu M, Zhao Z, Wu C, Wang J, Wang Z, Song Y, Zhang Y, Ma Y, Guo Y
Biomaterials research 2024;28:0006
Biomaterials research 2024;28:0006
Loss of MTX2 causes mitochondrial dysfunction, podocyte injury, nephrotic proteinuria and glomerulopathy in mice and patients.
Li T, Bao Y, Xia Y, Meng H, Zhou C, Huang L, Wang X, Lai EY, Jiang P, Mao J
International journal of biological sciences 2024;20(3):937-952
International journal of biological sciences 2024;20(3):937-952
The Footprints of Mitochondrial Fission and Apoptosis in Fluoride-Induced Renal Dysfunction.
Zuo Q, Lin L, Zhang Y, Ommati MM, Wang H, Zhao J
Biological trace element research 2024 Sep;202(9):4125-4135
Biological trace element research 2024 Sep;202(9):4125-4135
SIRT1 regulates mitochondrial fission to alleviate high altitude hypoxia inducedcardiac dysfunction in rats via the PGC-1α-DRP1/FIS1/MFF pathway.
Xu H, Song X, Zhang X, Wang G, Cheng X, Zhang L, Wang Z, Li R, Ai C, Wang X, Pu L, Chen Z, Liu W
Apoptosis : an international journal on programmed cell death 2024 Oct;29(9-10):1663-1678
Apoptosis : an international journal on programmed cell death 2024 Oct;29(9-10):1663-1678
SIRT1, a target of miR-708-3p, alleviates fluoride-induced neuronal damage via remodeling mitochondrial network dynamics.
Zhao Q, Zhou GY, Niu Q, Chen JW, Li P, Tian ZY, Li DJ, Xia T, Zhang S, Wang AG
Journal of advanced research 2024 Nov;65:197-210
Journal of advanced research 2024 Nov;65:197-210
Deafness-associated tRNA(Phe) mutation impaired mitochondrial and cellular integrity.
Chen X, Meng F, Chen C, Li S, Chou Z, Xu B, Mo JQ, Guo Y, Guan MX
The Journal of biological chemistry 2024 May;300(5):107235
The Journal of biological chemistry 2024 May;300(5):107235
circUSP13 facilitates the fast-to-slow myofiber shift via the MAPK/ERK signaling pathway in goat skeletal muscles.
Zhang Z, Kang Z, Deng K, Li J, Liu Z, Huang X, Wang F, Fan Y
Journal of cellular physiology 2024 May;239(5):e31226
Journal of cellular physiology 2024 May;239(5):e31226
Puerarin Delays Mammary Gland Aging by Regulating Gut Microbiota and Inhibiting the p38MAPK Signaling Pathway.
Liu S, Hu H, Zhang M, Zhang Y, Geng R, Jin Y, Cao Y, Guo W, Liu J, Fu S
Journal of agricultural and food chemistry 2024 May 15;72(19):10879-10896
Journal of agricultural and food chemistry 2024 May 15;72(19):10879-10896
Ginkgolide C inhibits ROS-mediated activation of NLRP3 inflammasome in chondrocytes to ameliorate osteoarthritis.
Jia L, Gong Y, Jiang X, Fan X, Ji Z, Ma T, Li R, Liu F
Journal of ethnopharmacology 2024 May 10;325:117887
Journal of ethnopharmacology 2024 May 10;325:117887
Met-Exo attenuates mitochondrial dysfunction after hepatic ischemia-reperfusion injury in rats by modulating AMPK/SIRT1 signaling pathway.
Piao C, Wang Y, Lu X, Liu T, Ma Y, Li Y, Zhang J, Wang H
Free radical biology & medicine 2024 Mar;213:430-442
Free radical biology & medicine 2024 Mar;213:430-442
IGF2BP3-stabilized CAMK1 regulates the mitochondrial dynamics of renal tubule to alleviate diabetic nephropathy.
Yuan D, Li H, Dai W, Zhou X, Zhou W, He L
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167022
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167022
Doxycycline induces mitochondrial dysfunction in aortic smooth muscle cells.
Yap C, Wanga S, Wüst RCI, van Os BW, Pijls MME, Keijzer S, van Zanten E, Koolbergen DR, Driessen AHG, Balm R, Yeung KK, de Vries CJM, Houtkooper RH, Lindeman JHN, de Waard V
Vascular pharmacology 2024 Mar;154:107279
Vascular pharmacology 2024 Mar;154:107279
Inhibition of Drp1- Fis1 interaction alleviates aberrant mitochondrial fragmentation and acute kidney injury.
Song Z, Xia Y, Shi L, Zha H, Huang J, Xiang X, Li H, Huang H, Yue R, Wang H, Zhu J
Cellular & molecular biology letters 2024 Mar 4;29(1):31
Cellular & molecular biology letters 2024 Mar 4;29(1):31
NME3 is a gatekeeper for DRP1-dependent mitophagy in hypoxia.
Chen CW, Su C, Huang CY, Huang XR, Cuili X, Chao T, Fan CH, Ting CW, Tsai YW, Yang KC, Yeh TY, Hsieh ST, Chen YJ, Feng Y, Hunter T, Chang ZF
Nature communications 2024 Mar 13;15(1):2264
Nature communications 2024 Mar 13;15(1):2264
Leucine Supplementation Prevents the Development of Skeletal Muscle Dysfunction in a Rat Model of HFpEF.
Alves PKN, Schauer A, Augstein A, Prieto Jarabo ME, Männel A, Barthel P, Vahle B, Moriscot AS, Linke A, Adams V
Cells 2024 Mar 13;13(6)
Cells 2024 Mar 13;13(6)
Mechanistic of AMPK/ACC2 regulating myoblast differentiation by fatty acid oxidation of goat.
Kang Z, Zhang Z, Li J, Deng K, Wang F, Fan Y
International journal of biological macromolecules 2024 Jun;270(Pt 2):132243
International journal of biological macromolecules 2024 Jun;270(Pt 2):132243
Hydrogen alleviates impaired lung epithelial barrier in acute respiratory distress syndrome via inhibiting Drp1-mediated mitochondrial fission through the Trx1 pathway.
Long Y, Ang Y, Chen W, Wang Y, Shi M, Hu F, Zhou Q, Shi Y, Ge B, Peng Y, Yu W, Bao H, Li Q, Duan M, Gao J
Free radical biology & medicine 2024 Jun;218:132-148
Free radical biology & medicine 2024 Jun;218:132-148
Peptide-encoding gene transfer to modulate intracellular protein-protein interactions.
Taya T, Kami D, Teruyama F, Matoba S, Gojo S
Molecular therapy. Methods & clinical development 2024 Jun 13;32(2):101226
Molecular therapy. Methods & clinical development 2024 Jun 13;32(2):101226
Dulaglutide restores endothelial progenitor cell levels in diabetic mice and mitigates high glucose-induced endothelial injury through SIRT1-mediated mitochondrial fission.
Mei X, Li Y, Wu J, Liao L, Lu D, Qiu P, Yang HL, Tang MW, Liang XY, Liu D
Biochemical and biophysical research communications 2024 Jul 5;716:150002
Biochemical and biophysical research communications 2024 Jul 5;716:150002
MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels.
Tábara LC, Burr SP, Frison M, Chowdhury SR, Paupe V, Nie Y, Johnson M, Villar-Azpillaga J, Viegas F, Segawa M, Anand H, Petkevicius K, Chinnery PF, Prudent J
Cell 2024 Jul 11;187(14):3619-3637.e27
Cell 2024 Jul 11;187(14):3619-3637.e27
NAD(+) supplementation improves mitochondrial functions and normalizes glaucomatous trabecular meshwork features.
Liu Y, Bu Q, Hu D, Chen C, Zhu J, Zhou Q, Li Z, Pan X
Experimental cell research 2024 Jul 1;440(1):114137
Experimental cell research 2024 Jul 1;440(1):114137
NAMPT regulates mitochondria function and lipid metabolism during porcine oocyte maturation.
Guo X, Jiao L, Yi Y, Zhang HL, Liu YX, Wang ZY, Sun SC
Journal of cellular physiology 2024 Jan;239(1):180-192
Journal of cellular physiology 2024 Jan;239(1):180-192
Sentrin-specific protease 1 maintains mitochondrial homeostasis through targeting the deSUMOylation of sirtuin-3 to alleviate oxidative damage induced by hepatic ischemia/reperfusion.
Xia K, Guo J, Yu B, Wang T, Qiu Q, Chen Q, Qiu T, Zhou J, Zheng S
Free radical biology & medicine 2024 Jan;210:378-389
Free radical biology & medicine 2024 Jan;210:378-389
Nicotinamide mononucleotide alleviates seizures via modulating SIRT1-PGC-1α mediated mitochondrial fusion and fission.
Cheng Y, Huang P, Zou Q, Tian H, Cheng Q, Ding H
Journal of neurochemistry 2024 Jan 9;
Journal of neurochemistry 2024 Jan 9;
Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4‑mediated ferritinophagy.
Ma Z, Lu H, Feng X, Du T, Li J, Zhang Q, Gu X, Shao Y, Jing X, Su C
International journal of molecular medicine 2024 Feb;53(2)
International journal of molecular medicine 2024 Feb;53(2)
Intermittent Theta Burst Stimulation Attenuates Cognitive Deficits and Alzheimer's Disease-Type Pathologies via ISCA1-Mediated Mitochondrial Modulation in APP/PS1 Mice.
Zhu Y, Huang H, Chen Z, Tao Y, Liao LY, Gao SH, Wang YJ, Gao CY
Neuroscience bulletin 2024 Feb;40(2):182-200
Neuroscience bulletin 2024 Feb;40(2):182-200
Rescue of mitochondrial import failure by intercellular organellar transfer.
Needs HI, Glover E, Pereira GC, Witt A, Hübner W, Dodding MP, Henley JM, Collinson I
Nature communications 2024 Feb 2;15(1):988
Nature communications 2024 Feb 2;15(1):988
Deficient tRNA posttranscription modification dysregulated the mitochondrial quality controls and apoptosis.
He Y, Zhu G, Li X, Zhou M, Guan MX
iScience 2024 Feb 16;27(2):108883
iScience 2024 Feb 16;27(2):108883
Mitochondrial dynamics disruption: Unraveling Dinotefuran's impact on cardiotoxicity.
Zhu J, Tao Q, Du G, Huang L, Li M, Wang M, Wang Q
Environmental pollution (Barking, Essex : 1987) 2024 Feb 15;343:123238
Environmental pollution (Barking, Essex : 1987) 2024 Feb 15;343:123238
VDR regulates mitochondrial function as a protective mechanism against renal tubular cell injury in diabetic rats.
Chen H, Zhang H, Li AM, Liu YT, Liu Y, Zhang W, Yang C, Song N, Zhan M, Yang S
Redox biology 2024 Apr;70:103062
Redox biology 2024 Apr;70:103062
DsbA-L ameliorates renal aging and renal fibrosis by maintaining mitochondrial homeostasis.
Yang M, Liu Y, Luo SL, Liu CB, Jiang N, Li CR, Zhao H, Han YC, Chen W, Li L, Sun L
Acta pharmacologica Sinica 2024 Apr;45(4):777-789
Acta pharmacologica Sinica 2024 Apr;45(4):777-789
Cadmium-induced global DNA hypermethylation promoting mitochondrial dynamics dysregulation in hippocampal neurons.
Geng H, An Q, Song J, He D, Han H, Wang L
Environmental toxicology 2024 Apr;39(4):2043-2051
Environmental toxicology 2024 Apr;39(4):2043-2051
Astragaloside IV combined with ligustrazine ameliorates abnormal mitochondrial dynamics via Drp1 SUMO/deSUMOylation in cerebral ischemia-reperfusion injury.
Chen X, Yang T, Zhou Y, Mei Z, Zhang W
CNS neuroscience & therapeutics 2024 Apr;30(4):e14725
CNS neuroscience & therapeutics 2024 Apr;30(4):e14725
Resveratrol Inhibits Zinc Deficiency-Induced Mitophagy and Exerts Cardiac Cytoprotective Effects.
Wang P, Yang Y, Guo J, Ma T, Hu Y, Huang L, He Y, Xi J
Biological trace element research 2024 Apr;202(4):1669-1682
Biological trace element research 2024 Apr;202(4):1669-1682
Mitochondria-associated membranes contribution to exercise-mediated alleviation of hepatic insulin resistance: Contrasting high-intensity interval training with moderate-intensity continuous training in a high-fat diet mouse model.
Li X, Yang JY, Hu WZ, Ruan Y, Chen HY, Zhang Q, Zhang Z, Ding ZS
Journal of diabetes 2024 Apr;16(4):e13540
Journal of diabetes 2024 Apr;16(4):e13540
Dietary fat supplementation relieves cold temperature-induced energy stress through AMPK-mediated mitochondrial homeostasis in pigs.
He W, Liu X, Feng Y, Ding H, Sun H, Li Z, Shi B
Journal of animal science and biotechnology 2024 Apr 8;15(1):56
Journal of animal science and biotechnology 2024 Apr 8;15(1):56
TDCPP and TiO(2) NPs aggregates synergistically induce SH-SY5Y cell neurotoxicity by excessive mitochondrial fission and mitophagy inhibition.
Wang L, Wang B, Zhang X, Yang Z, Zhang X, Gong H, Song Y, Zhang K, Sun M
Environmental pollution (Barking, Essex : 1987) 2024 Apr 15;347:123740
Environmental pollution (Barking, Essex : 1987) 2024 Apr 15;347:123740
Phosphoglycerate mutase 5 exacerbates liver ischemia-reperfusion injury by activating mitochondrial fission.
Tang H, Yu Q, Chen X, Zhang J, Guo D, Guo W, Zhang S, Shi X
Scientific reports 2024 Apr 12;14(1):8535
Scientific reports 2024 Apr 12;14(1):8535
Nanocurcumin Reduces High Glucose and Particulate Matter-Induced Endothelial Inflammation: Mitochondrial Function and Involvement of miR-221/222.
Lai TC, Lee CW, Hsu MH, Chen YC, Lin SR, Lin SW, Lee TL, Lin SY, Hsu SH, Tsai JS, Chen YL
International journal of nanomedicine 2023;18:7379-7402
International journal of nanomedicine 2023;18:7379-7402
Selenium-enriched Cardamine violifolia protects against sepsis-induced intestinal injury by regulating mitochondrial fusion in weaned pigs.
Wang D, Kuang Y, Lv Q, Xie W, Xu X, Zhu H, Zhang Y, Cong X, Cheng S, Liu Y
Science China. Life sciences 2023 Sep;66(9):2099-2111
Science China. Life sciences 2023 Sep;66(9):2099-2111
Hypoxia-induced GPCPD1 depalmitoylation triggers mitophagy via regulating PRKN-mediated ubiquitination of VDAC1.
Liu Y, Zhang H, Liu Y, Zhang S, Su P, Wang L, Li Y, Liang Y, Wang X, Zhao W, Chen B, Luo D, Zhang N, Yang Q
Autophagy 2023 Sep;19(9):2443-2463
Autophagy 2023 Sep;19(9):2443-2463
Aerobic exercise enhances mitochondrial homeostasis to counteract D-galactose-induced sarcopenia in zebrafish.
Chen ZL, Guo C, Zou YY, Feng C, Yang DX, Sun CC, Wen W, Jian ZJ, Zhao Z, Xiao Q, Zheng L, Peng XY, Zhou ZQ, Tang CF
Experimental gerontology 2023 Sep;180:112265
Experimental gerontology 2023 Sep;180:112265
Photobiomodulation provides neuroprotection through regulating mitochondrial fission imbalance in the subacute phase of spinal cord injury.
Li X, Wang XK, Zhu ZJ, Liang ZW, Li PH, Ma YG, Ding T, Li K, Zuo XS, Ju C, Zhang ZH, Song ZW, Quan HL, Zhang JW, Luo L, Wang Z, Hu XY
Neural regeneration research 2023 Sep;18(9):2005-2010
Neural regeneration research 2023 Sep;18(9):2005-2010
Mitochondrial miR-12294-5p regulated copper-induced mitochondrial oxidative stress and mitochondrial quality control imbalance by targeted inhibition of CISD1 in chicken livers.
Zhong G, Li Y, Li L, Huo Y, Zhang W, Li T, Ma F, Liao J, Li Y, Zhang H, Guo J, Pan J, Yu W, Hu L, Tang Z
Journal of hazardous materials 2023 Sep 15;458:131908
Journal of hazardous materials 2023 Sep 15;458:131908
High-resolution visualization and assessment of basal and OXPHOS-induced mitophagy in H9c2 cardiomyoblasts.
Godtliebsen G, Larsen KB, Bhujabal Z, Opstad IS, Nager M, Punnakkal AR, Kalstad TB, Olsen R, Lund T, Prasad DK, Agarwal K, Myrmel T, Birgisdottir AB
Autophagy 2023 Oct;19(10):2769-2788
Autophagy 2023 Oct;19(10):2769-2788
Histone deacetylase inhibitor pracinostat suppresses colorectal cancer by inducing CDK5-Drp1 signaling-mediated peripheral mitofission.
Liang XL, Ouyang L, Yu NN, Sun ZH, Gui ZK, Niu YL, He QY, Zhang J, Wang Y
Journal of pharmaceutical analysis 2023 Oct;13(10):1168-1182
Journal of pharmaceutical analysis 2023 Oct;13(10):1168-1182
Polydatin improves vascular endothelial function by maintaining mitochondrial homeostasis under high glucose conditions.
Shah W, Zhao Q, Wang S, Zhang M, Ma H, Guan Y, Zhang Y, Liu Y, Zhu C, Wang S, Zhang X, Dong J, Ma H
Scientific reports 2023 Oct 2;13(1):16550
Scientific reports 2023 Oct 2;13(1):16550
A conserved, noncanonical insert in FIS1 mediates TBC1D15 and DRP1 recruitment for mitochondrial fission.
Ihenacho UK, Toro R, Mansour RH, Hill RB
The Journal of biological chemistry 2023 Nov;299(11):105303
The Journal of biological chemistry 2023 Nov;299(11):105303
The mystery of phospho-Drp1 with four adaptors in cell cycle: when mitochondrial fission couples to cell fate decisions.
Wu NS, Ma IC, Lin YF, Ko HJ, Loh JK, Hong YR
Cell cycle (Georgetown, Tex.) 2023 Nov;22(21-22):2485-2503
Cell cycle (Georgetown, Tex.) 2023 Nov;22(21-22):2485-2503
The poxvirus F17 protein counteracts mitochondrially orchestrated antiviral responses.
Meade N, Toreev HK, Chakrabarty RP, Hesser CR, Park C, Chandel NS, Walsh D
Nature communications 2023 Nov 30;14(1):7889
Nature communications 2023 Nov 30;14(1):7889
CCDC127 regulates lipid droplet homeostasis by enhancing mitochondria-ER contacts.
Xia Y, Zhang Y, Sun Y, He L
Biochemical and biophysical research communications 2023 Nov 26;683:149116
Biochemical and biophysical research communications 2023 Nov 26;683:149116
Sodium Sulfite-Triggered Hepatocyte Ferroptosis via mtROS/Lysosomal Membrane Permeabilization-Mediated Lysosome Iron Efflux.
Liu M, Lu J, Chen Y, Zhang S, Guo J, Guan S
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16310-16322
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16310-16322
miR-27a-3p relieves heat stress-induced mitochondrial damage and aberrant milk protein synthesis through MEK/ERK pathway in BMECs.
Wang Y, Wu J, Xia SW, Zhao F, Ding Q, Ye XM, Zhong JF, Chen KL, Wang HL
Cell stress & chaperones 2023 May;28(3):265-274
Cell stress & chaperones 2023 May;28(3):265-274
Heme oxygenase-1 prevents non-alcoholic steatohepatitis through modulating mitochondrial quality control.
Li D, Yuan X, Dong S, Al-Dhamin Z, Du J, Fu N, Nan Y
Acta physiologica (Oxford, England) 2023 Mar;237(3):e13918
Acta physiologica (Oxford, England) 2023 Mar;237(3):e13918
HC067047 as a potent TRPV4 inhibitor repairs endotoxemia colonic injury.
Chen L, Mao M, Liu D, Liu W, Wang Y, Xie L, Deng Y, Lin Y, Xu Y, Zhong X, Cao W
International immunopharmacology 2023 Mar;116:109648
International immunopharmacology 2023 Mar;116:109648
Empagliflozin ameliorates cardiac dysfunction in heart failure mice via regulating mitochondrial dynamics.
Lyu Y, Huo J, Jiang W, Yang W, Wang S, Zhang S, Cheng Y, Jiang Z, Shan Q
European journal of pharmacology 2023 Mar 5;942:175531
European journal of pharmacology 2023 Mar 5;942:175531
Macrophage Inactivation by Small Molecule Wedelolactone via Targeting sEH for the Treatment of LPS-Induced Acute Lung Injury.
Zhang J, Zhang M, Huo XK, Ning J, Yu ZL, Morisseau C, Sun CP, Hammock BD, Ma XC
ACS central science 2023 Mar 22;9(3):440-456
ACS central science 2023 Mar 22;9(3):440-456
MFN1 augmentation prevents retinal degeneration in a Charcot-Marie-Tooth type 2A mouse model.
Shahin S, Lu B, Zhou Y, Xu H, Chetsawang J, Baloh RH, Wang S
iScience 2023 Mar 17;26(3):106270
iScience 2023 Mar 17;26(3):106270
miR-484 mediates oxidative stress-induced ovarian dysfunction and promotes granulosa cell apoptosis via SESN2 downregulation.
Wang X, Yang J, Li H, Mu H, Zeng L, Cai S, Su P, Li H, Zhang L, Xiang W
Redox biology 2023 Jun;62:102684
Redox biology 2023 Jun;62:102684
Senomorphic effect of diphenyleneiodonium through AMPK/MFF/DRP1 mediated mitochondrial fission.
Liao KM, Chen CJ, Luo WJ, Hsu CW, Yu SL, Yang PC, Su KY
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jun;162:114616
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jun;162:114616
Paraquat-induced neurogenesis abnormalities via Drp1-mediated mitochondrial fission.
Zhang B, Zhang Y, Zuo Z, Xiong G, Luo H, Song B, Zhao L, Zhou Z, Chang X
Ecotoxicology and environmental safety 2023 Jun 1;257:114939
Ecotoxicology and environmental safety 2023 Jun 1;257:114939
Pseudolaric acid B triggers cell apoptosis by activating AMPK/JNK/DRP1/mitochondrial fission pathway in hepatocellular carcinoma.
Liu Z, Wang N, Meng Z, Lu S, Peng G
Toxicology 2023 Jul;493:153556
Toxicology 2023 Jul;493:153556
Myricetin improves pathological changes in 3×Tg-AD mice by regulating the mitochondria-NLRP3 inflammasome-microglia channel by targeting P38 MAPK signaling pathway.
Liu P, Zhou Y, Shi J, Wang F, Yang X, Zheng X, Wang Y, He Y, Xie X, Pang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul;115:154801
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul;115:154801
Hydrogen sulfide alleviates mitochondrial damage and ferroptosis by regulating OPA3-NFS1 axis in doxorubicin-induced cardiotoxicity.
Wang Y, Ying X, Wang Y, Zou Z, Yuan A, Xiao Z, Geng N, Qiao Z, Li W, Lu X, Pu J
Cellular signalling 2023 Jul;107:110655
Cellular signalling 2023 Jul;107:110655
Parkin regulates amino acid homeostasis at mitochondria-lysosome (M/L) contact sites in Parkinson's disease.
Peng W, Schröder LF, Song P, Wong YC, Krainc D
Science advances 2023 Jul 21;9(29):eadh3347
Science advances 2023 Jul 21;9(29):eadh3347
Targeting an allosteric site in dynamin-related protein 1 to inhibit Fis1-mediated mitochondrial dysfunction.
Rios L, Pokhrel S, Li SJ, Heo G, Haileselassie B, Mochly-Rosen D
Nature communications 2023 Jul 19;14(1):4356
Nature communications 2023 Jul 19;14(1):4356
High-intensity interval training induces renal injury and fibrosis in type 2 diabetic mice.
Zheng L, Qin R, Rao Z, Xiao W
Life sciences 2023 Jul 1;324:121740
Life sciences 2023 Jul 1;324:121740
Bavachin and Corylifol A Improve Muscle Atrophy by Enhancing Mitochondria Quality Control in Type 2 Diabetic Mice.
Yeon MH, Seo E, Lee JH, Jun HS
Antioxidants (Basel, Switzerland) 2023 Jan 6;12(1)
Antioxidants (Basel, Switzerland) 2023 Jan 6;12(1)
N-acetyl-L-cysteine alleviates FUNDC1-mediated mitophagy by regulating mitochondrial dynamics in type 1 diabetic nephropathy canine.
Ma F, Li H, Huo H, Han Q, Liao J, Zhang H, Li Y, Pan J, Hu L, Guo J, Tang Z
Life sciences 2023 Jan 15;313:121278
Life sciences 2023 Jan 15;313:121278
Endoplasmic reticulum stress mediated by ROS participates in cadmium exposure-induced MC3T3-E1 cell apoptosis.
Jia L, Ma T, Lv L, Yu Y, Zhao M, Chen H, Gao L
Ecotoxicology and environmental safety 2023 Feb;251:114517
Ecotoxicology and environmental safety 2023 Feb;251:114517
Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis.
Zhou Y, Tang J, Lan J, Zhang Y, Wang H, Chen Q, Kang Y, Sun Y, Feng X, Wu L, Jin H, Chen S, Peng Y
Acta pharmaceutica Sinica. B 2023 Feb;13(2):577-597
Acta pharmaceutica Sinica. B 2023 Feb;13(2):577-597
PKM2-mediated neuronal hyperglycolysis enhances the risk of Parkinson's disease in diabetic rats.
Zhao Y, Wang Y, Wu Y, Tao C, Xu R, Chen Y, Qian L, Xu T, Lian X
Journal of pharmaceutical analysis 2023 Feb;13(2):187-200
Journal of pharmaceutical analysis 2023 Feb;13(2):187-200
Osthole: A potential AMPK agonist that inhibits NLRP3 inflammasome activation by regulating mitochondrial homeostasis for combating rheumatoid arthritis.
Jiang X, Lu Z, Zhang Q, Yu J, Han D, Liu J, Li P, Li F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154640
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154640
METTL14-dependent maturation of pri-miR-17 regulates mitochondrial homeostasis and induces chemoresistance in colorectal cancer.
Sun K, Chen L, Li Y, Huang B, Yan Q, Wu C, Lai Q, Fang Y, Cai J, Liu Y, Chen J, Wang X, Zhu Y, Dong S, Tan J, Li A, Liu S, Zhang Y
Cell death & disease 2023 Feb 21;14(2):148
Cell death & disease 2023 Feb 21;14(2):148
Selenium alleviates cadmium-induced mitophagy through FUNDC1-mediated mitochondrial quality control pathway in the lungs of sheep.
Lin S, Yang F, Hu M, Chen J, Chen G, Hu A, Li X, Fu D, Xing C, Xiong Z, Wu Y, Cao H
Environmental pollution (Barking, Essex : 1987) 2023 Feb 15;319:120954
Environmental pollution (Barking, Essex : 1987) 2023 Feb 15;319:120954
SIRT3-dependent mitochondrial redox homeostasis mitigates CHK1 inhibition combined with gemcitabine treatment induced cardiotoxicity in hiPSC-CMs and mice.
Chen JW, Shan TK, Wei TW, Jiang QQ, Du C, Gu LF, Yang TT, Zhou LH, Wang SB, Bao YL, Wang H, Ji Y, Xie LP, Gu AH, Sun CQ, Wang QM, Wang LS
Archives of toxicology 2023 Dec;97(12):3209-3226
Archives of toxicology 2023 Dec;97(12):3209-3226
Nogo-B mediates endothelial oxidative stress and inflammation to promote coronary atherosclerosis in pressure-overloaded mouse hearts.
Zhang Y, Li JJ, Xu R, Wang XP, Zhao XY, Fang Y, Chen YP, Ma S, Di XH, Wu W, She G, Pang ZD, Wang YD, Zhang X, Xie W, Deng XL, Du XJ, Zhang Y
Redox biology 2023 Dec;68:102944
Redox biology 2023 Dec;68:102944
Mitochondrial fission drives neuronal metabolic burden to promote stress susceptibility in male mice.
Dong WT, Long LH, Deng Q, Liu D, Wang JL, Wang F, Chen JG
Nature metabolism 2023 Dec;5(12):2220-2236
Nature metabolism 2023 Dec;5(12):2220-2236
Zinc Overload Induces Damage to H9c2 Cardiomyocyte Through Mitochondrial Dysfunction and ROS-Mediated Mitophagy.
Yang Y, Wang P, Guo J, Ma T, Hu Y, Huang L, Xing B, He Y, Xi J
Cardiovascular toxicology 2023 Dec;23(11-12):388-405
Cardiovascular toxicology 2023 Dec;23(11-12):388-405
Zearalenone promotes porcine ESCs apoptosis by enhancing Drp1-mediated mitochondrial fragmentation and activating the JNK pathway.
Hai S, Zhao J, Chen C, Wang C, Ma L, Rahman SU, Zhao C, Feng S, Wu J, Wang X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Dec;182:114110
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Dec;182:114110
Ramelteon attenuates renal ischemia and reperfusion injury through reducing mitochondrial fission and fusion and inflammation.
Chen P, Liu W, Wei Y
Translational andrology and urology 2023 Dec 31;12(12):1859-1870
Translational andrology and urology 2023 Dec 31;12(12):1859-1870
The Binding of HSPA8 and Mitochondrial ALDH2 Mediates Oxygen-Glucose Deprivation-Induced Fibroblast Senescence.
Hui W, Song T, Yu L, Chen X
Antioxidants (Basel, Switzerland) 2023 Dec 25;13(1)
Antioxidants (Basel, Switzerland) 2023 Dec 25;13(1)
CircRNA SCAR Improves High-Glucose-Induced Mitochondrial Dysfunction and Permeability Damage in Retinal Microvascular Endothelial Cells.
Wu R, Huang S, Xie JF, Wen NL, Wen M, Zhong SE
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2023 Aug;55(8):555-562
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2023 Aug;55(8):555-562
Loganin alleviated cognitive impairment in 3×Tg-AD mice through promoting mitophagy mediated by optineurin.
Zhou Y, Luo D, Shi J, Yang X, Xu W, Gao W, Guo Y, Zhao Q, Xie X, He Y, Du G, Pang X
Journal of ethnopharmacology 2023 Aug 10;312:116455
Journal of ethnopharmacology 2023 Aug 10;312:116455
LDLR heterozygous deletion reduces hamster testicular cholesterol toxicity via AMPK/Sirt1/PGC-1α pathway.
Bai Y, Hei N, Gao M, Dong X, Li M, Jiang S, Zhang L
Toxicology letters 2023 Aug 1;384:30-43
Toxicology letters 2023 Aug 1;384:30-43
Aristolochic acid I exposure triggers ovarian dysfunction by activating NLRP3 inflammasome and affecting mitochondrial homeostasis.
Sun MX, Qiao FX, Xu ZR, Liu YC, Xu CL, Wang HL, Qi ZQ, Liu Y
Free radical biology & medicine 2023 Aug 1;204:313-324
Free radical biology & medicine 2023 Aug 1;204:313-324
A single dose of exercise stimulates skeletal muscle mitochondrial plasticity in myotonic dystrophy type 1.
Mikhail AI, Manta A, Ng SY, Osborne AK, Mattina SR, Mackie MR, Ljubicic V
Acta physiologica (Oxford, England) 2023 Apr;237(4):e13943
Acta physiologica (Oxford, England) 2023 Apr;237(4):e13943
Possible frequent multiple mitochondrial DNA copies in a single nucleoid in HeLa cells.
Pavluch V, Špaček T, Engstová H, Dlasková A, Ježek P
Scientific reports 2023 Apr 8;13(1):5788
Scientific reports 2023 Apr 8;13(1):5788
Molybdenum and Cadmium Co-induce Mitochondrial Quality Control Disorder via FUNDC1-Mediated Mitophagy in Sheep Kidney.
Wu Y, Yang F, Zhou G, Wang Q, Xing C, Bai H, Yi X, Xiong Z, Yang S, Cao H
Frontiers in veterinary science 2022;9:842259
Frontiers in veterinary science 2022;9:842259
Impact of UCP2 depletion on heat stroke-induced mitochondrial function in human umbilical vein endothelial cells.
Huang W, Mao L, Xie W, Cai S, Huang Q, Liu Y, Chen Z
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2022;39(1):287-296
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2022;39(1):287-296
Selenium Attenuates TBHP-Induced Apoptosis of Nucleus Pulposus Cells by Suppressing Mitochondrial Fission through Activating Nuclear Factor Erythroid 2-Related Factor 2.
Wang P, Zhang S, Liu W, Chen S, Lv X, Hu B, Shao Z
Oxidative medicine and cellular longevity 2022;2022:7531788
Oxidative medicine and cellular longevity 2022;2022:7531788
Dynamin-Related Protein 1 Is Involved in Mitochondrial Damage, Defective Mitophagy, and NLRP3 Inflammasome Activation Induced by MSU Crystals.
Jiang H, Chen F, Song D, Zhou X, Ren L, Zeng M
Oxidative medicine and cellular longevity 2022;2022:5064494
Oxidative medicine and cellular longevity 2022;2022:5064494
Change in Oxidative Stress and Mitochondrial Dynamics in Response to Elevated Cold-Inducible RNA-Binding Protein in Cardiac Surgery-Associated Acute Kidney Injury.
Zheng X, Fan Y, Li J, Ma T, Li Y, Wang Q, Yan Y, Liu W
Oxidative medicine and cellular longevity 2022;2022:3576892
Oxidative medicine and cellular longevity 2022;2022:3576892
Intracellular Ca(2+) Signaling and Calcium Release-Activated Calcium Modulator ORAI1 Are Associated With CD4(+) T Lymphocytes in Dairy Cows.
Li M, Zhang B, Yin Y, Wen J, Wang J, He Y, Jiang Q, Loor JJ, Wang S, Yang W, Xu C
Frontiers in immunology 2022;13:835936
Frontiers in immunology 2022;13:835936
COA3 overexpression promotes non-small cell lung cancer metastasis by reprogramming glucose metabolism.
Lin H, Gao Y, Sun K, Zhang Q, Li Y, Chen M, Jin F
American journal of cancer research 2022;12(8):3662-3678
American journal of cancer research 2022;12(8):3662-3678
Non-invasive photobiomodulation treatment in an Alzheimer Disease-like transgenic rat model.
Yang L, Wu C, Parker E, Li Y, Dong Y, Tucker L, Brann DW, Lin HW, Zhang Q
Theranostics 2022;12(5):2205-2231
Theranostics 2022;12(5):2205-2231
Mannose inhibits the growth of prostate cancer through a mitochondrial mechanism.
Deng YL, Liu R, Cai ZD, Han ZD, Feng YF, Cai SH, Chen QB, Zhu JG, Zhong WD
Asian journal of andrology 2022 Sep-Oct;24(5):540-548
Asian journal of andrology 2022 Sep-Oct;24(5):540-548
Empagliflozin Preserves Skeletal Muscle Function in a HFpEF Rat Model.
Winzer EB, Schauer A, Langner E, Augstein A, Goto K, Männel A, Barthel P, Jannasch A, Labeit S, Mangner N, Linke A, Adams V
International journal of molecular sciences 2022 Sep 20;23(19)
International journal of molecular sciences 2022 Sep 20;23(19)
Depletion of serum-derived exosomes aggravates heat stress-induced damage of bovine mammary epithelial cells.
Wang Y, Wang HL, Lin ZP, Zhong JF, Chen KL, Duan X
Molecular biology reports 2022 Oct;49(10):9297-9305
Molecular biology reports 2022 Oct;49(10):9297-9305
Blocking exosomal secretion aggravates 1,4-benzoquinone-induced mitochondrial fission activated by the AMPK/MFF/Drp1 pathway in HL-60 cells.
Lu F, Zhang Q, Zhang M, Sun S, Yang X, Yan H
Journal of applied toxicology : JAT 2022 Oct;42(10):1618-1627
Journal of applied toxicology : JAT 2022 Oct;42(10):1618-1627
Integrated Analysis of Transcriptome and microRNA Profile Reveals the Toxicity of Euphorbia Factors toward Human Colon Adenocarcinoma Cell Line Caco-2.
Zou L, Bao W, Gao Y, Chen M, Wu Y, Wang S, Li C, Zhang J, Zhang D, Wang Q, Zhu A
Molecules (Basel, Switzerland) 2022 Oct 16;27(20)
Molecules (Basel, Switzerland) 2022 Oct 16;27(20)
The Endoplasmic Reticulum ATP13A1 is Essential for MAVS-Mediated Antiviral Innate Immunity.
Zhang R, Hou X, Wang C, Li J, Zhu J, Jiang Y, Hou F
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Nov;9(33):e2203831
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Nov;9(33):e2203831
Cadmium-induced apoptosis of Leydig cells is mediated by excessive mitochondrial fission and inhibition of mitophagy.
Yi L, Shang XJ, Lv L, Wang Y, Zhang J, Quan C, Shi Y, Liu Y, Zhang L
Cell death & disease 2022 Nov 5;13(11):928
Cell death & disease 2022 Nov 5;13(11):928
Sirt3 deficiency accelerates ovarian senescence without affecting spermatogenesis in aging mice.
Zhu J, Yang Q, Li H, Wang Y, Jiang Y, Wang H, Cong L, Xu J, Shen Z, Chen W, Zeng X, Wang M, Lei M, Sun Y
Free radical biology & medicine 2022 Nov 20;193(Pt 2):511-525
Free radical biology & medicine 2022 Nov 20;193(Pt 2):511-525
Dihydromyricetin contributes to weight loss via pro-browning mediated by mitochondrial fission in white adipose.
Xiong X, Xia M, Niu A, Zhang Y, Yin T, Huang Q
European journal of pharmacology 2022 Nov 15;935:175345
European journal of pharmacology 2022 Nov 15;935:175345
AMPK/MFF Activation: Role in Mitochondrial Fission and Mitophagy in Dry Eye.
Peng F, Jiang D, Xu W, Sun Y, Zha Z, Tan X, Yu J, Pan C, Zheng Q, Chen W
Investigative ophthalmology & visual science 2022 Nov 1;63(12):18
Investigative ophthalmology & visual science 2022 Nov 1;63(12):18
SIRT4 Expression Ameliorates the Detrimental Effect of Heat Stress via AMPK/mTOR Signaling Pathway in BMECs.
Ding Q, Wang Y, Xia SW, Zhao F, Zhong JF, Wang HL, Chen KL
International journal of molecular sciences 2022 Nov 1;23(21)
International journal of molecular sciences 2022 Nov 1;23(21)
Heat shock protein 60 couples an oxidative stress-responsive p38/MK2 signaling and NF-κB survival machinery in cancer cells.
Min S, Kim JY, Cho HM, Park S, Hwang JM, You H, Chan Chae Y, Lee WJ, Sun W, Kang D, Lee S, Kang SW
Redox biology 2022 May;51:102293
Redox biology 2022 May;51:102293
PACS-2 Ameliorates Tubular Injury by Facilitating Endoplasmic Reticulum-Mitochondria Contact and Mitophagy in Diabetic Nephropathy.
Li C, Li L, Yang M, Yang J, Zhao C, Han Y, Zhao H, Jiang N, Wei L, Xiao Y, Liu Y, Xiong X, Xi Y, Luo S, Deng F, Chen W, Yuan S, Zhu X, Xiao L, Sun L
Diabetes 2022 May 1;71(5):1034-1050
Diabetes 2022 May 1;71(5):1034-1050
HSP70 attenuates compression-induced apoptosis of nucleus pulposus cells by suppressing mitochondrial fission via upregulating the expression of SIRT3.
Hu B, Wang P, Zhang S, Liu W, Lv X, Shi D, Zhao L, Liu H, Wang B, Chen S, Shao Z
Experimental & molecular medicine 2022 Mar;54(3):309-323
Experimental & molecular medicine 2022 Mar;54(3):309-323
PINK1 regulates mitochondrial fission/fusion and neuroinflammation in β-amyloid-induced Alzheimer's disease models.
Wang X, Xue Y, Yao Y, Li Y, Ji X, Chi T, Liu P, Zou L
Neurochemistry international 2022 Mar;154:105298
Neurochemistry international 2022 Mar;154:105298
Chicoric Acid Attenuated Renal Tubular Injury in HFD-Induced Chronic Kidney Disease Mice through the Promotion of Mitophagy via the Nrf2/PINK/Parkin Pathway.
Ding XQ, Jian TY, Gai YN, Niu GT, Liu Y, Meng XH, Li J, Lyu H, Ren BR, Chen J
Journal of agricultural and food chemistry 2022 Mar 9;70(9):2923-2935
Journal of agricultural and food chemistry 2022 Mar 9;70(9):2923-2935
PINK1/TAX1BP1-directed mitophagy attenuates vascular endothelial injury induced by copper oxide nanoparticles.
Fan Y, Cheng Z, Mao L, Xu G, Li N, Zhang M, Weng P, Zheng L, Dong X, Hu S, Wang B, Qin X, Jiang X, Chen C, Zhang J, Zou Z
Journal of nanobiotechnology 2022 Mar 19;20(1):149
Journal of nanobiotechnology 2022 Mar 19;20(1):149
Carbon tetrachloride induced mitochondrial division, respiratory chain damage, abnormal intracellular [H(+)] and apoptosis are due to the activation of 5-HT degradation system in hepatocytes.
Zhang Y, Liang X, Guan J, Jin J, Zhang Y, Xu F, Fu J
Toxicology and applied pharmacology 2022 Mar 15;439:115929
Toxicology and applied pharmacology 2022 Mar 15;439:115929
Autophagy and mitochondrial dynamics contribute to the protective effect of diosgenin against 3-MCPD induced kidney injury.
Zhong Y, Sun D, Yao Y, Liu Q, Guo T, Wang X, Peng X
Chemico-biological interactions 2022 Mar 1;355:109850
Chemico-biological interactions 2022 Mar 1;355:109850
Long-term exercise pre-training attenuates Alzheimer's disease-related pathology in a transgenic rat model of Alzheimer's disease.
Yang L, Wu C, Li Y, Dong Y, Wu CY, Lee RH, Brann DW, Lin HW, Zhang Q
GeroScience 2022 Jun;44(3):1457-1477
GeroScience 2022 Jun;44(3):1457-1477
Regulatory roles of external cholesterol in human airway epithelial mitochondrial function through STARD3 signalling.
Li L, Liu Y, Liu X, Zheng N, Gu Y, Song Y, Wang X
Clinical and translational medicine 2022 Jun;12(6):e902
Clinical and translational medicine 2022 Jun;12(6):e902
Effects of amyloid-β on protein SUMOylation and levels of mitochondrial proteins in primary cortical neurons.
Soares ES, de Souza ACG, Zanella CA, Carmichael RE, Henley JM, Wilkinson KA, Cimarosti HI
IBRO neuroscience reports 2022 Jun;12:142-148
IBRO neuroscience reports 2022 Jun;12:142-148
Novel Thermosensitive Hydrogel Promotes Spinal Cord Repair by Regulating Mitochondrial Function.
Li Y, Yang L, Hu F, Xu J, Ye J, Liu S, Wang L, Zhuo M, Ran B, Zhang H, Ye J, Xiao J
ACS applied materials & interfaces 2022 Jun 8;14(22):25155-25172
ACS applied materials & interfaces 2022 Jun 8;14(22):25155-25172
Breast Cancer Selective Disruption of Actin Cytoskeleton by Diallyl Trisulfide.
Hahm ER, Mathan SV, Singh RP, Singh SV
Journal of cancer prevention 2022 Jun 30;27(2):101-111
Journal of cancer prevention 2022 Jun 30;27(2):101-111
Myosin II proteins are required for organization of calcium-induced actin networks upstream of mitochondrial division.
Kage F, Vicente-Manzanares M, McEwan BC, Kettenbach AN, Higgs HN
Molecular biology of the cell 2022 Jun 1;33(7):ar63
Molecular biology of the cell 2022 Jun 1;33(7):ar63
Aldehyde dehydrogenase 2 deficiency promotes skeletal muscle atrophy in aged mice.
Kasai A, Jee E, Tamura Y, Kouzaki K, Kotani T, Nakazato K
American journal of physiology. Regulatory, integrative and comparative physiology 2022 Jun 1;322(6):R511-R525
American journal of physiology. Regulatory, integrative and comparative physiology 2022 Jun 1;322(6):R511-R525
Inhibition of nuclear deacetylase Sirtuin-1 induces mitochondrial acetylation and calcium overload leading to cell death.
Sun Y, Yang YM, Hu YY, Ouyang L, Sun ZH, Yin XF, Li N, He QY, Wang Y
Redox biology 2022 Jul;53:102334
Redox biology 2022 Jul;53:102334
Selenium alleviates cadmium-induced aging via mitochondrial quality control in the livers of sheep.
Xiong Z, Yang F, Xu T, Yang Y, Wang F, Zhou G, Wang Q, Guo X, Xing C, Bai H, Chen J, Wu Y, Yang S, Cao H
Journal of inorganic biochemistry 2022 Jul;232:111818
Journal of inorganic biochemistry 2022 Jul;232:111818
PEX11β and FIS1 cooperate in peroxisome division independently of mitochondrial fission factor.
Schrader TA, Carmichael RE, Islinger M, Costello JL, Hacker C, Bonekamp NA, Weishaupt JH, Andersen PM, Schrader M
Journal of cell science 2022 Jul 1;135(13)
Journal of cell science 2022 Jul 1;135(13)
Herceptin induces ferroptosis and mitochondrial dysfunction in H9c2 cells.
Sun L, Wang H, Yu S, Zhang L, Jiang J, Zhou Q
International journal of molecular medicine 2022 Feb;49(2)
International journal of molecular medicine 2022 Feb;49(2)
The SUMO protease SENP3 regulates mitochondrial autophagy mediated by Fis1.
Waters E, Wilkinson KA, Harding AL, Carmichael RE, Robinson D, Colley HE, Guo C
EMBO reports 2022 Feb 3;23(2):e48754
EMBO reports 2022 Feb 3;23(2):e48754
Attenuates of NAD(+) impair BMSC osteogenesis and fracture repair through OXPHOS.
Li B, Shi Y, Liu M, Wu F, Hu X, Yu F, Wang C, Ye L
Stem cell research & therapy 2022 Feb 22;13(1):77
Stem cell research & therapy 2022 Feb 22;13(1):77
Protective Effects of Chaya against Mitochondrial and Synaptic Toxicities in the Type 2 Diabetes Mouse Model TallyHO.
Ramasubramanian B, Griffith C, Hanson M, Bunquin LE, Reddy AP, Hegde V, Reddy PH
Cells 2022 Feb 21;11(4)
Cells 2022 Feb 21;11(4)
Early Cellular, Molecular, Morphological and Behavioral Changes in the Humanized Amyloid-Beta-Knock-In Mouse Model of Late-Onset Alzheimer's Disease.
Kshirsagar S, Alvir RV, Hindle A, Kumar S, Vijayan M, Pradeepkiran JA, Reddy AP, Ramasubramanian B, Reddy PH
Cells 2022 Feb 19;11(4)
Cells 2022 Feb 19;11(4)
Protein C receptor maintains cancer stem cell properties via activating lipid synthesis in nasopharyngeal carcinoma.
Zhang P, He Q, Wang Y, Zhou G, Chen Y, Tang L, Zhang Y, Hong X, Mao Y, He Q, Yang X, Liu N, Ma J
Signal transduction and targeted therapy 2022 Feb 16;7(1):46
Signal transduction and targeted therapy 2022 Feb 16;7(1):46
Myricetin Restores Aβ-Induced Mitochondrial Impairments in N2a-SW Cells.
Yao X, Zhang J, Lu Y, Deng Y, Zhao R, Xiao S
ACS chemical neuroscience 2022 Feb 16;13(4):454-463
ACS chemical neuroscience 2022 Feb 16;13(4):454-463
CHCHD2 and CHCHD10 regulate mitochondrial dynamics and integrated stress response.
Ruan Y, Hu J, Che Y, Liu Y, Luo Z, Cheng J, Han Q, He H, Zhou Q
Cell death & disease 2022 Feb 16;13(2):156
Cell death & disease 2022 Feb 16;13(2):156
Generation of a homozygous FIS1 knockout human embryonic stem cell line GIBHe015-B by CRISPR/Cas9 system.
Wang M, Tang J, Zhou T, Mai Y, Zhu Y
Stem cell research 2022 Dec;65:102980
Stem cell research 2022 Dec;65:102980
Cdk5 Promotes Mitochondrial Fission via Drp1 Phosphorylation at S616 in Chronic Ethanol Exposure-Induced Cognitive Impairment.
Liu D, Li J, Rong X, Li J, Peng Y, Shen Q
Molecular neurobiology 2022 Dec;59(12):7075-7094
Molecular neurobiology 2022 Dec;59(12):7075-7094
SARS-CoV-2 mitochondriopathy in COVID-19 pneumonia exacerbates hypoxemia.
Archer SL, Dasgupta A, Chen KH, Wu D, Baid K, Mamatis JE, Gonzalez V, Read A, Bentley RE, Martin AY, Mewburn JD, Dunham-Snary KJ, Evans GA, Levy G, Jones O, Al-Qazazi R, Ring B, Alizadeh E, Hindmarch CC, Rossi J, Lima PD, Falzarano D, Banerjee A, Colpitts CC
Redox biology 2022 Dec;58:102508
Redox biology 2022 Dec;58:102508
Perinatal exposure to glyphosate-based herbicides impairs progeny health and placental angiogenesis by disturbing mitochondrial function.
Bai G, Jiang X, Qin J, Zou Y, Zhang W, Teng T, Shi B, Sun H
Environment international 2022 Dec;170:107579
Environment international 2022 Dec;170:107579
A Combination Therapy of Urolithin A+EGCG Has Stronger Protective Effects than Single Drug Urolithin A in a Humanized Amyloid Beta Knockin Mice for Late-Onset Alzheimer's Disease.
Kshirsagar S, Alvir RV, Pradeepkiran JA, Hindle A, Vijayan M, Ramasubramaniam B, Kumar S, Reddy AP, Reddy PH
Cells 2022 Aug 27;11(17)
Cells 2022 Aug 27;11(17)
A pivotal role of selective autophagy in mitochondrial quality control: Implications for zinc oxide nanoparticles induced neurotoxicity.
Wang L, Duan Z, Liang M, Wang C, Liang T, Sun L, Yan C, Li Q, Liang T
Chemico-biological interactions 2022 Aug 25;363:110003
Chemico-biological interactions 2022 Aug 25;363:110003
N(6)-adenomethylation of GsdmC is essential for Lgr5(+) stem cell survival to maintain normal colonic epithelial morphogenesis.
Du J, Sarkar R, Li Y, He L, Kang W, Liao W, Liu W, Nguyen T, Zhang L, Deng Z, Dougherty U, Kupfer SS, Chen M, Pekow J, Bissonnette M, He C, Li YC
Developmental cell 2022 Aug 22;57(16):1976-1994.e8
Developmental cell 2022 Aug 22;57(16):1976-1994.e8
Chrono-Aerobic Exercise Optimizes Metabolic State in DB/DB Mice through CLOCK-Mitophagy-Apoptosis.
Zhang Z, Li X, Zhang J, Du J, Zhang Q, Ge Z, Ding S
International journal of molecular sciences 2022 Aug 18;23(16)
International journal of molecular sciences 2022 Aug 18;23(16)
Nicotinamide mononucleotide alleviates heat stress-induced oxidative stress and apoptosis in BMECs through reducing mitochondrial damage and endoplasmic reticulum stress.
Zeng HF, Xu J, Wang XL, Li SJ, Han ZY
Ecotoxicology and environmental safety 2022 Apr 15;235:113441
Ecotoxicology and environmental safety 2022 Apr 15;235:113441
CLOCK regulates Drp1 mRNA stability and mitochondrial homeostasis by interacting with PUF60.
Xu L, Lin J, Liu Y, Hua B, Cheng Q, Lin C, Yan Z, Wang Y, Sun N, Qian R, Lu C
Cell reports 2022 Apr 12;39(2):110635
Cell reports 2022 Apr 12;39(2):110635
BNIP3 (BCL2 interacting protein 3) regulates pluripotency by modulating mitochondrial homeostasis via mitophagy.
Liu K, Zhao Q, Sun H, Liu L, Wang C, Li Z, Xu Y, Wang L, Zhang L, Zhang H, Chen Q, Zhao T
Cell death & disease 2022 Apr 11;13(4):334
Cell death & disease 2022 Apr 11;13(4):334
Phosphorylation of Dynamin-Related Protein 1 (DRP1) Regulates Mitochondrial Dynamics and Skeletal Muscle Wasting in Cancer Cachexia.
Mao X, Gu Y, Sui X, Shen L, Han J, Wang H, Xi Q, Zhuang Q, Meng Q, Wu G
Frontiers in cell and developmental biology 2021;9:673618
Frontiers in cell and developmental biology 2021;9:673618
KCa3.1 Mediates Dysregulation of Mitochondrial Quality Control in Diabetic Kidney Disease.
Huang C, Yi H, Shi Y, Cao Q, Shi Y, Cheng D, Braet F, Chen XM, Pollock CA
Frontiers in cell and developmental biology 2021;9:573814
Frontiers in cell and developmental biology 2021;9:573814
PP2 Ameliorates Renal Fibrosis by Regulating the NF-κB/COX-2 and PPARγ/UCP2 Pathway in Diabetic Mice.
Wei J, Deng X, Li Y, Li R, Yang Z, Li X, Song S, Shi Y, Duan H, Wu H
Oxidative medicine and cellular longevity 2021;2021:7394344
Oxidative medicine and cellular longevity 2021;2021:7394344
RNA-Seq Profiling to Investigate the Mechanism of Qishen Granules on Regulating Mitochondrial Energy Metabolism of Heart Failure in Rats.
He H, Li C, Lu X, Li Y, Li X, Sun X, Tang B, Wu Y, Li C
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5779307
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5779307
Tortoise Plastron and Deer Antler Gelatin Prevents Against Neuronal Mitochondrial Dysfunction In Vitro: Implication for a Potential Therapy of Alzheimer's Disease.
Cheng D, Yang XJ, Zhang L, Qin ZS, Li WQ, Xu HC, Zhang ZJ
Frontiers in pharmacology 2021;12:690256
Frontiers in pharmacology 2021;12:690256
Elevated Lactate by High-Intensity Interval Training Regulates the Hippocampal BDNF Expression and the Mitochondrial Quality Control System.
Hu J, Cai M, Shang Q, Li Z, Feng Y, Liu B, Xue X, Lou S
Frontiers in physiology 2021;12:629914
Frontiers in physiology 2021;12:629914
Antioxidant activity of mesenchymal stem cell-derived extracellular vesicles restores hippocampal neurons following seizure damage.
Luo Q, Xian P, Wang T, Wu S, Sun T, Wang W, Wang B, Yang H, Yang Y, Wang H, Liu W, Long Q
Theranostics 2021;11(12):5986-6005
Theranostics 2021;11(12):5986-6005
Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington's disease.
Hu D, Sun X, Magpusao A, Fedorov Y, Thompson M, Wang B, Lundberg K, Adams DJ, Qi X
Nature communications 2021 Sep 6;12(1):5305
Nature communications 2021 Sep 6;12(1):5305
Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity.
Xiao X, Yeghiazaryan G, Hess S, Klemm P, Sieben A, Kleinridders A, Morgan DA, Wunderlich FT, Rahmouni K, Kong D, Scammell TE, Lowell BB, Kloppenburg P, Brüning JC, Hausen AC
Nature communications 2021 Sep 2;12(1):5249
Nature communications 2021 Sep 2;12(1):5249
Effects of andrographolide on renal tubulointersticial injury and fibrosis. Evidence of its mechanism of action.
Liu W, Liang L, Zhang Q, Li Y, Yan S, Tang T, Ren Y, Mo J, Liu F, Chen X, Lan T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct;91:153650
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct;91:153650
Mechanisms of impaired mitochondrial homeostasis and NAD(+) metabolism in a model of mitochondrial heart disease exhibiting redox active iron accumulation.
Chiang S, Braidy N, Maleki S, Lal S, Richardson DR, Huang ML
Redox biology 2021 Oct;46:102038
Redox biology 2021 Oct;46:102038
Inhibition of ER stress attenuates kidney injury and apoptosis induced by 3-MCPD via regulating mitochondrial fission/fusion and Ca(2+) homeostasis.
Zhong Y, Jin C, Han J, Zhu J, Liu Q, Sun D, Xia X, Peng X
Cell biology and toxicology 2021 Oct;37(5):795-809
Cell biology and toxicology 2021 Oct;37(5):795-809
SIRT3 protects bovine mammary epithelial cells from heat stress damage by activating the AMPK signaling pathway.
Sun XC, Wang Y, Zeng HF, Xi YM, Lin H, Han ZY, Chen KL
Cell death discovery 2021 Oct 21;7(1):304
Cell death discovery 2021 Oct 21;7(1):304
Melatonin protects against excessive autophagy-induced mitochondrial and ovarian reserve function deficiency though ERK signaling pathway in Chinese hamster ovary (CHO) cells.
Xie QE, Wang MY, Cao ZP, Du X, Ji DM, Liang D, Cao YX, Liu YJ
Mitochondrion 2021 Nov;61:44-53
Mitochondrion 2021 Nov;61:44-53
Distinct fission signatures predict mitochondrial degradation or biogenesis.
Kleele T, Rey T, Winter J, Zaganelli S, Mahecic D, Perreten Lambert H, Ruberto FP, Nemir M, Wai T, Pedrazzini T, Manley S
Nature 2021 May;593(7859):435-439
Nature 2021 May;593(7859):435-439
Protective effects of a mitochondria-targeted small peptide SS31 against hyperglycemia-induced mitochondrial abnormalities in the liver tissues of diabetic mice, Tallyho/JngJ mice.
Bhatti JS, Tamarai K, Kandimalla R, Manczak M, Yin X, Ramasubramanian B, Sawant N, Pradeepkiran JA, Vijayan M, Kumar S, Reddy PH
Mitochondrion 2021 May;58:49-58
Mitochondrion 2021 May;58:49-58
Dihydromyricetin attenuates heat stress-induced apoptosis in dairy cow mammary epithelial cells through suppressing mitochondrial dysfunction.
Wang HL, Xing GD, Qian Y, Sun XF, Zhong JF, Chen KL
Ecotoxicology and environmental safety 2021 May;214:112078
Ecotoxicology and environmental safety 2021 May;214:112078
Protective effects of antidepressant citalopram against abnormal APP processing and amyloid beta-induced mitochondrial dynamics, biogenesis, mitophagy and synaptic toxicities in Alzheimer's disease.
Reddy AP, Yin X, Sawant N, Reddy PH
Human molecular genetics 2021 May 29;30(10):847-864
Human molecular genetics 2021 May 29;30(10):847-864
Effects of photoperiod on morphology and function in testis and epididymis of Cricetulus barabensis.
Mou J, Xu J, Wang Z, Wang C, Yang X, Wang X, Xue H, Wu M, Xu L
Journal of cellular physiology 2021 Mar;236(3):2109-2125
Journal of cellular physiology 2021 Mar;236(3):2109-2125
Haemodynamic-directed cardiopulmonary resuscitation promotes mitochondrial fusion and preservation of mitochondrial mass after successful resuscitation in a pediatric porcine model.
Senthil K, Morgan RW, Hefti MM, Karlsson M, Lautz AJ, Mavroudis CD, Ko T, Nadkarni VM, Ehinger J, Berg RA, Sutton RM, McGowan FX, Kilbaugh TJ
Resuscitation plus 2021 Jun;6:100124
Resuscitation plus 2021 Jun;6:100124
The detrimental effect of iron on OA chondrocytes: Importance of pro-inflammatory cytokines induced iron influx and oxidative stress.
Jing X, Du T, Li T, Yang X, Wang G, Liu X, Jiang Z, Cui X
Journal of cellular and molecular medicine 2021 Jun;25(12):5671-5680
Journal of cellular and molecular medicine 2021 Jun;25(12):5671-5680
ALS/FTD mutations in UBQLN2 are linked to mitochondrial dysfunction through loss-of-function in mitochondrial protein import.
Lin BC, Phung TH, Higgins NR, Greenslade JE, Prado MA, Finley D, Karbowski M, Polster BM, Monteiro MJ
Human molecular genetics 2021 Jun 17;30(13):1230-1246
Human molecular genetics 2021 Jun 17;30(13):1230-1246
Effect of the interference with DRP1 expression on the biological characteristics of glioma stem cells.
Zhang L, Cao H, Tao H, Yang J, Gong W, Hu Q
Experimental and therapeutic medicine 2021 Jul;22(1):696
Experimental and therapeutic medicine 2021 Jul;22(1):696
Resveratrol and exercise combined to treat functional limitations in late life: A pilot randomized controlled trial.
Harper SA, Bassler JR, Peramsetty S, Yang Y, Roberts LM, Drummer D, Mankowski RT, Leeuwenburgh C, Ricart K, Patel RP, Bamman MM, Anton SD, Jaeger BC, Buford TW
Experimental gerontology 2021 Jan;143:111111
Experimental gerontology 2021 Jan;143:111111
ATPIF1 maintains normal mitochondrial structure which is impaired by CCM3 deficiency in endothelial cells.
Wang K, Chen H, Zhou Z, Zhang H, Zhou HJ, Min W
Cell & bioscience 2021 Jan 9;11(1):11
Cell & bioscience 2021 Jan 9;11(1):11
Selonsertib, a potential drug for liver failure therapy by rescuing the mitochondrial dysfunction of macrophage via ASK1-JNK-DRP1 pathway.
Lou G, Li A, Cen Y, Yang Q, Zhang T, Qi J, Chen Z, Liu Y
Cell & bioscience 2021 Jan 7;11(1):9
Cell & bioscience 2021 Jan 7;11(1):9
Mesenchymal stem cells ameliorate lipid metabolism through reducing mitochondrial damage of hepatocytes in the treatment of post-hepatectomy liver failure.
Wang JL, Ding HR, Pan CY, Shi XL, Ren HZ
Cell death & disease 2021 Jan 21;12(1):111
Cell death & disease 2021 Jan 21;12(1):111
CHIP protects against MPP(+)/MPTP-induced damage by regulating Drp1 in two models of Parkinson's disease.
Hu Z, Mao C, Wang H, Zhang Z, Zhang S, Luo H, Tang M, Yang J, Yuan Y, Wang Y, Liu Y, Fan L, Zhang Q, Yao D, Liu F, Schisler JC, Shi C, Xu Y
Aging 2021 Jan 2;13(1):1458-1472
Aging 2021 Jan 2;13(1):1458-1472
Restoring metabolism of myeloid cells reverses cognitive decline in ageing.
Minhas PS, Latif-Hernandez A, McReynolds MR, Durairaj AS, Wang Q, Rubin A, Joshi AU, He JQ, Gauba E, Liu L, Wang C, Linde M, Sugiura Y, Moon PK, Majeti R, Suematsu M, Mochly-Rosen D, Weissman IL, Longo FM, Rabinowitz JD, Andreasson KI
Nature 2021 Feb;590(7844):122-128
Nature 2021 Feb;590(7844):122-128
The XBP1‒MARCH5‒MFN2 Axis Confers Endoplasmic Reticulum Stress Resistance by Coordinating Mitochondrial Fission and Mitophagy in Melanoma.
Wang H, Yi X, Guo S, Wang S, Ma J, Zhao T, Shi Q, Tian Y, Wang H, Jia L, Gao T, Li C, Guo W
The Journal of investigative dermatology 2021 Dec;141(12):2932-2943.e12
The Journal of investigative dermatology 2021 Dec;141(12):2932-2943.e12
Carnosol alleviates nonalcoholic fatty liver disease by inhibiting mitochondrial dysfunction and apoptosis through targeting of PRDX3.
Geng Y, Wang Y, Sun R, Kang X, Zhao H, Zhu M, Sun Y, Hu Y, Wang Z, Tian X, Zhao Y, Yao J
Toxicology and applied pharmacology 2021 Dec 1;432:115758
Toxicology and applied pharmacology 2021 Dec 1;432:115758
Chronic hypoxia alters cardiac mitochondrial complex protein expression and activity in fetal guinea pigs in a sex-selective manner.
Song H, Polster BM, Thompson LP
American journal of physiology. Regulatory, integrative and comparative physiology 2021 Dec 1;321(6):R912-R924
American journal of physiology. Regulatory, integrative and comparative physiology 2021 Dec 1;321(6):R912-R924
Intranasal administration of DHED protects against exhaustive exercise-induced brain injury in rats.
Peng G, Zheng H, Wu C, Wu C, Ma X, Xiong J, Hou J, Zhang L, Yang L, Pan H
Brain research 2021 Dec 1;1772:147665
Brain research 2021 Dec 1;1772:147665
Targeting P2RX1 alleviates renal ischemia/reperfusion injury by preserving mitochondrial dynamics.
Zhuang S, Xia S, Huang P, Wu J, Qu J, Chen R, Sun N, Li D, Wu H, Zhang M, Zhang J, Yuan X, Wang X
Pharmacological research 2021 Aug;170:105712
Pharmacological research 2021 Aug;170:105712
LKB1/AMPKα signaling pathway and mitochondrial fission/fusion dynamics regulate apoptosis induced by 3-chlorpropane-1,2-diol in HEK293 cells.
Jin C, Xue W, Liu Q, Han J, Luo R, Feng J, Liu J, Guo T, Peng X, Hu T
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Aug;154:112350
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Aug;154:112350
Extract of Cynomorium songaricum ameliorates mitochondrial ultrastructure impairments and dysfunction in two different in vitro models of Alzheimer's disease.
Cheng D, Su L, Wang X, Li X, Li L, Hu M, Lu Y
BMC complementary medicine and therapies 2021 Aug 9;21(1):206
BMC complementary medicine and therapies 2021 Aug 9;21(1):206
Fis1 ablation in the male germline disrupts mitochondrial morphology and mitophagy, and arrests spermatid maturation.
Varuzhanyan G, Ladinsky MS, Yamashita SI, Abe M, Sakimura K, Kanki T, Chan DC
Development (Cambridge, England) 2021 Aug 15;148(16)
Development (Cambridge, England) 2021 Aug 15;148(16)
Change on apoptosis, autophagy and mitochondria of the Harderian gland in Cricetulus barabensis during age.
Kong XT, Wang Z, Mou JJ, Li CS, Xue HL, Wu M, Chen L, Xu JH, Xu LX
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2021 Apr-May;253:110547
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2021 Apr-May;253:110547
Mst1 Knockout Alleviates Mitochondrial Fission and Mitigates Left Ventricular Remodeling in the Development of Diabetic Cardiomyopathy.
Feng X, Wang S, Yang X, Lin J, Man W, Dong Y, Zhang Y, Zhao Z, Wang H, Sun D
Frontiers in cell and developmental biology 2020;8:628842
Frontiers in cell and developmental biology 2020;8:628842
Deletion of Bmal1 Impairs Pancreatic β-Cell Function via Mitochondrial Signaling Pathway.
Ye L, Wu H, Xu W
BioMed research international 2020;2020:9803024
BioMed research international 2020;2020:9803024
Proteomic Profile of Mouse Brain Aging Contributions to Mitochondrial Dysfunction, DNA Oxidative Damage, Loss of Neurotrophic Factor, and Synaptic and Ribosomal Proteins.
Li Y, Yu H, Chen C, Li S, Zhang Z, Xu H, Zhu F, Liu J, Spencer PS, Dai Z, Yang X
Oxidative medicine and cellular longevity 2020;2020:5408452
Oxidative medicine and cellular longevity 2020;2020:5408452
Drp1-mediated mitochondrial fission contributes to baicalein-induced apoptosis and autophagy in lung cancer via activation of AMPK signaling pathway.
Deng X, Liu J, Liu L, Sun X, Huang J, Dong J
International journal of biological sciences 2020;16(8):1403-1416
International journal of biological sciences 2020;16(8):1403-1416
The effect of autophagy and mitochondrial fission on Harderian gland is greater than apoptosis in male hamsters during different photoperiods.
Xu JH, Wang Z, Mou JJ, Zhao XY, Geng XC, Wu M, Xue HL, Chen L, Xu LX
PloS one 2020;15(11):e0241561
PloS one 2020;15(11):e0241561
Bu-Yin-Qian-Zheng Formula Ameliorates MPP(+)-Induced Mitochondrial Dysfunction in Parkinson's Disease via Parkin.
Ma HJ, Gai C, Chai Y, Feng WD, Cheng CC, Zhang JK, Zhang YX, Yang LP, Guo ZY, Gao YS, Sun HM
Frontiers in pharmacology 2020;11:577017
Frontiers in pharmacology 2020;11:577017
High-Intensity Interval Training Restores Glycolipid Metabolism and Mitochondrial Function in Skeletal Muscle of Mice With Type 2 Diabetes.
Zheng L, Rao Z, Guo Y, Chen P, Xiao W
Frontiers in endocrinology 2020;11:561
Frontiers in endocrinology 2020;11:561
Photoperiod Affects Harderian Gland Morphology and Secretion in Female Cricetulus barabensis: Autophagy, Apoptosis, and Mitochondria.
Wang Z, Xu JH, Mou JJ, Kong XT, Wu M, Xue HL, Xu LX
Frontiers in physiology 2020;11:408
Frontiers in physiology 2020;11:408
Promotion of mitochondrial fusion protects against developmental PBDE-47 neurotoxicity by restoring mitochondrial homeostasis and suppressing excessive apoptosis.
Dong L, Li P, Yang K, Liu L, Gao H, Zhou G, Zhao Q, Xia T, Wang A, Zhang S
Theranostics 2020;10(3):1245-1261
Theranostics 2020;10(3):1245-1261
Exercise enhances mitochondrial fission and mitophagy to improve myopathy following critical limb ischemia in elderly mice via the PGC1a/FNDC5/irisin pathway.
He W, Wang P, Chen Q, Li C
Skeletal muscle 2020 Sep 15;10(1):25
Skeletal muscle 2020 Sep 15;10(1):25
PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth.
Guo L, Cui C, Wang J, Yuan J, Yang Q, Zhang P, Su W, Bao R, Ran J, Wu C
Nature communications 2020 Oct 1;11(1):4913
Nature communications 2020 Oct 1;11(1):4913
HIF-1α ameliorates tubular injury in diabetic nephropathy via HO-1-mediated control of mitochondrial dynamics.
Jiang N, Zhao H, Han Y, Li L, Xiong S, Zeng L, Xiao Y, Wei L, Xiong X, Gao P, Yang M, Liu Y, Sun L
Cell proliferation 2020 Nov;53(11):e12909
Cell proliferation 2020 Nov;53(11):e12909
Novel ultrastructural findings on cardiac mitochondria of huddling Brandt's voles in mild cold environment.
Wang Z, Xu JH, Mou JJ, Kong XT, Zou JW, Xue HL, Wu M, Xu LX
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2020 Nov;249:110766
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2020 Nov;249:110766
Hypoxia induces pulmonary artery smooth muscle dysfunction through mitochondrial fragmentation-mediated endoplasmic reticulum stress.
Zhuan B, Wang X, Wang MD, Li ZC, Yuan Q, Xie J, Yang Z
Aging 2020 Nov 18;12(23):23684-23697
Aging 2020 Nov 18;12(23):23684-23697
Formation of colorectal liver metastases induces musculoskeletal and metabolic abnormalities consistent with exacerbated cachexia.
Huot JR, Novinger LJ, Pin F, Narasimhan A, Zimmers TA, O'Connell TM, Bonetto A
JCI insight 2020 May 7;5(9)
JCI insight 2020 May 7;5(9)
AIM2 promotes the development of non-small cell lung cancer by modulating mitochondrial dynamics.
Qi M, Dai D, Liu J, Li Z, Liang P, Wang Y, Cheng L, Zhan Y, An Z, Song Y, Yang Y, Yan X, Xiao H, Shao H
Oncogene 2020 Mar;39(13):2707-2723
Oncogene 2020 Mar;39(13):2707-2723
PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway.
Yao X, Yu S, Jing X, Guo J, Sun K, Guo F, Ye Y
Stem cell research & therapy 2020 Mar 30;11(1):140
Stem cell research & therapy 2020 Mar 30;11(1):140
Mitochondrial Dynamics Regulation in Skin Fibroblasts from Mitochondrial Disease Patients.
Tokuyama T, Hirai A, Shiiba I, Ito N, Matsuno K, Takeda K, Saito K, Mii K, Matsushita N, Fukuda T, Inatome R, Yanagi S
Biomolecules 2020 Mar 13;10(3)
Biomolecules 2020 Mar 13;10(3)
ChREBP-β regulates thermogenesis in brown adipose tissue.
Wei C, Ma X, Su K, Qi S, Zhu Y, Lin J, Wang C, Yang R, Chen X, Wang W, Zhang WJ
The Journal of endocrinology 2020 Jun;245(3):343-356
The Journal of endocrinology 2020 Jun;245(3):343-356
Drp1/Mff signaling pathway is involved in fluoride-induced abnormal fission of hepatocyte mitochondria in mice.
Zhou BH, Wei SS, Jia LS, Zhang Y, Miao CY, Wang HW
The Science of the total environment 2020 Jul 10;725:138192
The Science of the total environment 2020 Jul 10;725:138192
FKBP8 LIRL-dependent mitochondrial fragmentation facilitates mitophagy under stress conditions.
Yoo SM, Yamashita SI, Kim H, Na D, Lee H, Kim SJ, Cho DH, Kanki T, Jung YK
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Feb;34(2):2944-2957
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Feb;34(2):2944-2957
PKM2 suppresses osteogenesis and facilitates adipogenesis by regulating β-catenin signaling and mitochondrial fusion and fission.
Guo J, Ren R, Yao X, Ye Y, Sun K, Lin J, Wang G, Guo F, Xiao J, Xu T
Aging 2020 Feb 25;12(4):3976-3992
Aging 2020 Feb 25;12(4):3976-3992
Microcystin-leucine-arginine induced neurotoxicity by initiating mitochondrial fission in hippocampal neurons.
Zhang C, Wang J, Zhu J, Chen Y, Han X
The Science of the total environment 2020 Feb 10;703:134702
The Science of the total environment 2020 Feb 10;703:134702
Genome-wide synthetic lethal CRISPR screen identifies FIS1 as a genetic interactor of ALS-linked C9ORF72.
Chai N, Haney MS, Couthouis J, Morgens DW, Benjamin A, Wu K, Ousey J, Fang S, Finer S, Bassik MC, Gitler AD
Brain research 2020 Feb 1;1728:146601
Brain research 2020 Feb 1;1728:146601
Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease.
Zhang X, Wang R, Hu D, Sun X, Fujioka H, Lundberg K, Chan ER, Wang Q, Xu R, Flanagan ME, Pieper AA, Qi X
Science advances 2020 Dec;6(49)
Science advances 2020 Dec;6(49)
Desferoxamine protects against glucocorticoid-induced osteonecrosis of the femoral head via activating HIF-1α expression.
Jing X, Du T, Yang X, Zhang W, Wang G, Liu X, Li T, Jiang Z
Journal of cellular physiology 2020 Dec;235(12):9864-9875
Journal of cellular physiology 2020 Dec;235(12):9864-9875
Mitochondrial Safeguard: a stress response that offsets extreme fusion and protects respiratory function via flickering-induced Oma1 activation.
Murata D, Yamada T, Tokuyama T, Arai K, Quirós PM, López-Otín C, Iijima M, Sesaki H
The EMBO journal 2020 Dec 15;39(24):e105074
The EMBO journal 2020 Dec 15;39(24):e105074
PRCC-TFE3 regulates migration and invasion of translocation renal cell carcinomas via activation of Drp1-dependent mitochondrial fission.
Wang B, Gan W, Han X, Li D
Cell biology international 2020 Aug;44(8):1727-1733
Cell biology international 2020 Aug;44(8):1727-1733
USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation.
Rusilowicz-Jones EV, Jardine J, Kallinos A, Pinto-Fernandez A, Guenther F, Giurrandino M, Barone FG, McCarron K, Burke CJ, Murad A, Martinez A, Marcassa E, Gersch M, Buckmelter AJ, Kayser-Bricker KJ, Lamoliatte F, Gajbhiye A, Davis S, Scott HC, Murphy E, England K, Mortiboys H, Komander D, Trost M, Kessler BM, Ioannidis S, Ahlijanian MK, Urbé S, Clague MJ
Life science alliance 2020 Aug;3(8)
Life science alliance 2020 Aug;3(8)
Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission.
Ma D, Zheng B, Liu HL, Zhao YB, Liu X, Zhang XH, Li Q, Shi WB, Suzuki T, Wen JK
PLoS biology 2020 Aug;18(8):e3000808
PLoS biology 2020 Aug;18(8):e3000808
Heat stress induces apoptosis through disruption of dynamic mitochondrial networks in dairy cow mammary epithelial cells.
Chen KL, Wang HL, Jiang LZ, Qian Y, Yang CX, Chang WW, Zhong JF, Xing GD
In vitro cellular & developmental biology. Animal 2020 Apr;56(4):322-331
In vitro cellular & developmental biology. Animal 2020 Apr;56(4):322-331
An epigenetic increase in mitochondrial fission by MiD49 and MiD51 regulates the cell cycle in cancer: Diagnostic and therapeutic implications.
Dasgupta A, Chen KH, Wu D, Hoskin V, Mewburn J, Lima PDA, Parlow LRG, Hindmarch CCT, Martin A, Sykes EA, Tayade C, Lightbody ED, Madarnas Y, SenGupta SK, Elliott BE, Nicol CJB, Archer SL
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):5106-5127
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):5106-5127
Exogenous H(2)S Promoted USP8 Sulfhydration to Regulate Mitophagy in the Hearts of db/db Mice.
Sun Y, Lu F, Yu X, Wang B, Chen J, Lu F, Peng S, Sun X, Yu M, Chen H, Wang Y, Zhang L, Liu N, Du H, Zhao D, Zhang W
Aging and disease 2020 Apr;11(2):269-285
Aging and disease 2020 Apr;11(2):269-285
DsbA-L deficiency exacerbates mitochondrial dysfunction of tubular cells in diabetic kidney disease.
Gao P, Yang M, Chen X, Xiong S, Liu J, Sun L
Clinical science (London, England : 1979) 2020 Apr 17;134(7):677-694
Clinical science (London, England : 1979) 2020 Apr 17;134(7):677-694
SIRT3-Dependent Mitochondrial Dynamics Remodeling Contributes to Oxidative Stress-Induced Melanocyte Degeneration in Vitiligo.
Yi X, Guo W, Shi Q, Yang Y, Zhang W, Chen X, Kang P, Chen J, Cui T, Ma J, Wang H, Guo S, Chang Y, Liu L, Jian Z, Wang L, Xiao Q, Li S, Gao T, Li C
Theranostics 2019;9(6):1614-1633
Theranostics 2019;9(6):1614-1633
Spermidine Prevents Heart Injury in Neonatal Rats Exposed to Intrauterine Hypoxia by Inhibiting Oxidative Stress and Mitochondrial Fragmentation.
Chai N, Zhang H, Li L, Yu X, Liu Y, Lin Y, Wang L, Yan J, Nikolaevna SE, Zhao Y
Oxidative medicine and cellular longevity 2019;2019:5406468
Oxidative medicine and cellular longevity 2019;2019:5406468
Impaired Mitochondrial Fusion and Oxidative Phosphorylation Triggered by High Glucose Is Mediated by Tom22 in Endothelial Cells.
Zeng Y, Pan Q, Wang X, Li D, Lin Y, Man F, Xiao F, Guo L
Oxidative medicine and cellular longevity 2019;2019:4508762
Oxidative medicine and cellular longevity 2019;2019:4508762
Parkin-mediated ubiquitination contributes to the constitutive turnover of mitochondrial fission factor (Mff).
Lee L, Seager R, Nakamura Y, Wilkinson KA, Henley JM
PloS one 2019;14(5):e0213116
PloS one 2019;14(5):e0213116
Propofol Ameliorates H9c2 Cells Apoptosis Induced by Oxygen Glucose Deprivation and Reperfusion Injury via Inhibiting High Levels of Mitochondrial Fusion and Fission.
Zhao L, Zhuang J, Wang Y, Zhou D, Zhao D, Zhu S, Pu J, Zhang H, Yin M, Zhao W, Wang Z, Hong J
Frontiers in pharmacology 2019;10:61
Frontiers in pharmacology 2019;10:61
Da-Bu-Yin-Wan and Qian-Zheng-San Ameliorate Mitochondrial Dynamics in the Parkinson's Disease Cell Model Induced by MPP().
Gai C, Feng WD, Qiang TY, Ma HJ, Chai Y, Zhang SJ, Guo ZY, Hu JH, Sun HM
Frontiers in pharmacology 2019;10:372
Frontiers in pharmacology 2019;10:372
Icariin Protects Bone Marrow Mesenchymal Stem Cells Against Iron Overload Induced Dysfunction Through Mitochondrial Fusion and Fission, PI3K/AKT/mTOR and MAPK Pathways.
Yao X, Jing X, Guo J, Sun K, Deng Y, Zhang Y, Guo F, Ye Y
Frontiers in pharmacology 2019;10:163
Frontiers in pharmacology 2019;10:163
Mitochondrial dysfunction in endothelial cells induced by airborne fine particulate matter (<2.5 μm).
Miao X, Li W, Niu B, Li J, Sun J, Qin M, Zhou Z
Journal of applied toxicology : JAT 2019 Oct;39(10):1424-1432
Journal of applied toxicology : JAT 2019 Oct;39(10):1424-1432
Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae.
Yuan J, Chen C, Cui J, Lu J, Yan C, Wei X, Zhao X, Li N, Li S, Xue G, Cheng W, Li B, Li H, Lin W, Tian C, Zhao J, Han J, An D, Zhang Q, Wei H, Zheng M, Ma X, Li W, Chen X, Zhang Z, Zeng H, Ying S, Wu J, Yang R, Liu D
Cell metabolism 2019 Oct 1;30(4):675-688.e7
Cell metabolism 2019 Oct 1;30(4):675-688.e7
SS-31 reduces inflammation and oxidative stress through the inhibition of Fis1 expression in lipopolysaccharide-stimulated microglia.
Mo Y, Deng S, Zhang L, Huang Y, Li W, Peng Q, Liu Z, Ai Y
Biochemical and biophysical research communications 2019 Nov 26;520(1):171-178
Biochemical and biophysical research communications 2019 Nov 26;520(1):171-178
Proteomic Analysis and Biochemical Correlates of Mitochondrial Dysfunction after Low-Intensity Primary Blast Exposure.
Song H, Chen M, Chen C, Cui J, Johnson CE, Cheng J, Wang X, Swerdlow RH, DePalma RG, Xia W, Gu Z
Journal of neurotrauma 2019 May 15;36(10):1591-1605
Journal of neurotrauma 2019 May 15;36(10):1591-1605
Low-dose oral copper treatment changes the hippocampal phosphoproteomic profile and perturbs mitochondrial function in a mouse model of Alzheimer's disease.
Chen C, Jiang X, Li Y, Yu H, Li S, Zhang Z, Xu H, Yang Y, Liu G, Zhu F, Ren X, Zou L, Xu B, Liu J, Spencer PS, Yang X
Free radical biology & medicine 2019 May 1;135:144-156
Free radical biology & medicine 2019 May 1;135:144-156
Roles of mitochondrial fission inhibition in developmental fluoride neurotoxicity: mechanisms of action in vitro and associations with cognition in rats and children.
Zhao Q, Niu Q, Chen J, Xia T, Zhou G, Li P, Dong L, Xu C, Tian Z, Luo C, Liu L, Zhang S, Wang A
Archives of toxicology 2019 Mar;93(3):709-726
Archives of toxicology 2019 Mar;93(3):709-726
ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects.
Zhao Y, Sun X, Hu D, Prosdocimo DA, Hoppel C, Jain MK, Ramachandran R, Qi X
Nature communications 2019 Mar 26;10(1):1371
Nature communications 2019 Mar 26;10(1):1371
Angiotensin II suppresses autophagy and disrupts ultrastructural morphology and function of mitochondria in mouse skeletal muscle.
Silva KAS, Ghiarone T, Schreiber K, Grant D, White T, Frisard MI, Sukhanov S, Chandrasekar B, Delafontaine P, Yoshida T
Journal of applied physiology (Bethesda, Md. : 1985) 2019 Jun 1;126(6):1550-1562
Journal of applied physiology (Bethesda, Md. : 1985) 2019 Jun 1;126(6):1550-1562
Oxidative pathophysiology following volumetric muscle loss injury in a porcine model.
Chao T, Burmeister DM, Corona BT, Greising SM
Journal of applied physiology (Bethesda, Md. : 1985) 2019 Jun 1;126(6):1541-1549
Journal of applied physiology (Bethesda, Md. : 1985) 2019 Jun 1;126(6):1541-1549
Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations.
Li H, Ham A, Ma TC, Kuo SH, Kanter E, Kim D, Ko HS, Quan Y, Sardi SP, Li A, Arancio O, Kang UJ, Sulzer D, Tang G
Autophagy 2019 Jan;15(1):113-130
Autophagy 2019 Jan;15(1):113-130
Fibroblast growth factor 18 exerts anti-osteoarthritic effects through PI3K-AKT signaling and mitochondrial fusion and fission.
Yao X, Zhang J, Jing X, Ye Y, Guo J, Sun K, Guo F
Pharmacological research 2019 Jan;139:314-324
Pharmacological research 2019 Jan;139:314-324
Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy.
Sprenger HG, Wani G, Hesseling A, König T, Patron M, MacVicar T, Ahola S, Wai T, Barth E, Rugarli EI, Bergami M, Langer T
EMBO molecular medicine 2019 Jan;11(1)
EMBO molecular medicine 2019 Jan;11(1)
Two separate functions of NME3 critical for cell survival underlie a neurodegenerative disorder.
Chen CW, Wang HL, Huang CW, Huang CY, Lim WK, Tu IC, Koorapati A, Hsieh ST, Kan HW, Tzeng SR, Liao JC, Chong WM, Naroditzky I, Kidron D, Eran A, Nijim Y, Sela E, Feldman HB, Kalfon L, Raveh-Barak H, Falik-Zaccai TC, Elpeleg O, Mandel H, Chang ZF
Proceedings of the National Academy of Sciences of the United States of America 2019 Jan 8;116(2):566-574
Proceedings of the National Academy of Sciences of the United States of America 2019 Jan 8;116(2):566-574
Mitochondrial division inhibitor 1 reduces dynamin-related protein 1 and mitochondrial fission activity.
Manczak M, Kandimalla R, Yin X, Reddy PH
Human molecular genetics 2019 Jan 15;28(2):177-199
Human molecular genetics 2019 Jan 15;28(2):177-199
Hepatic HKDC1 Expression Contributes to Liver Metabolism.
Pusec CM, De Jesus A, Khan MW, Terry AR, Ludvik AE, Xu K, Giancola N, Pervaiz H, Daviau Smith E, Ding X, Harrison S, Chandel NS, Becker TC, Hay N, Ardehali H, Cordoba-Chacon J, Layden BT
Endocrinology 2019 Feb 1;160(2):313-330
Endocrinology 2019 Feb 1;160(2):313-330
Burn-induced reductions in mitochondrial abundance and efficiency are more pronounced with small volumes of colloids in swine.
Chao T, Gómez BI, Heard TC, Smith BW, Dubick MA, Burmeister DM
American journal of physiology. Cell physiology 2019 Dec 1;317(6):C1229-C1238
American journal of physiology. Cell physiology 2019 Dec 1;317(6):C1229-C1238
Novel findings on ultrastructural protection of skeletal muscle fibers during hibernation of Daurian ground squirrels: Mitochondria, nuclei, cytoskeleton, glycogen.
Wang Z, Jiang SF, Cao J, Liu K, Xu SH, Arfat Y, Guo QL, Chang H, Goswami N, Hinghofer-Szalkay H, Gao YF
Journal of cellular physiology 2019 Aug;234(8):13318-13331
Journal of cellular physiology 2019 Aug;234(8):13318-13331
Pyridostigmine regulates glucose metabolism and mitochondrial homeostasis to reduce myocardial vulnerability to injury in diabetic mice.
Yang Y, Zhao M, Yu XJ, Liu LZ, He X, Deng J, Zang WJ
American journal of physiology. Endocrinology and metabolism 2019 Aug 1;317(2):E312-E326
American journal of physiology. Endocrinology and metabolism 2019 Aug 1;317(2):E312-E326
Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells.
Zhong X, Cui P, Cai Y, Wang L, He X, Long P, Lu K, Yan R, Zhang Y, Pan X, Zhao X, Li W, Zhang H, Zhou Q, Gao P
Cell metabolism 2019 Apr 2;29(4):979-992.e4
Cell metabolism 2019 Apr 2;29(4):979-992.e4
Polybrene induces neural degeneration by bidirectional Ca(2+) influx-dependent mitochondrial and ER-mitochondrial dynamics.
Bao F, Shi H, Gao M, Yang L, Zhou L, Zhao Q, Wu Y, Chen K, Xiang G, Long Q, Guo J, Zhang J, Liu X
Cell death & disease 2018 Sep 20;9(10):966
Cell death & disease 2018 Sep 20;9(10):966
In Vivo Deletion of β-Cell Drp1 Impairs Insulin Secretion Without Affecting Islet Oxygen Consumption.
Hennings TG, Chopra DG, DeLeon ER, VanDeusen HR, Sesaki H, Merrins MJ, Ku GM
Endocrinology 2018 Sep 1;159(9):3245-3256
Endocrinology 2018 Sep 1;159(9):3245-3256
A high-fat diet impairs mitochondrial biogenesis, mitochondrial dynamics, and the respiratory chain complex in rat myocardial tissues.
Chen D, Li X, Zhang L, Zhu M, Gao L
Journal of cellular biochemistry 2018 Nov;119(11):9602
Journal of cellular biochemistry 2018 Nov;119(11):9602
Aerobic Exercise Preconception and During Pregnancy Enhances Oxidative Capacity in the Hindlimb Muscles of Mice Offspring.
Liu J, Lee I, Feng HZ, Galen SS, Hüttemann PP, Perkins GA, Jin JP, Hüttemann M, Malek MH
Journal of strength and conditioning research 2018 May;32(5):1391-1403
Journal of strength and conditioning research 2018 May;32(5):1391-1403
AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells.
Pei S, Minhajuddin M, Adane B, Khan N, Stevens BM, Mack SC, Lai S, Rich JN, Inguva A, Shannon KM, Kim H, Tan AC, Myers JR, Ashton JM, Neff T, Pollyea DA, Smith CA, Jordan CT
Cell stem cell 2018 Jul 5;23(1):86-100.e6
Cell stem cell 2018 Jul 5;23(1):86-100.e6
Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer's disease.
Reddy PH, Yin X, Manczak M, Kumar S, Pradeepkiran JA, Vijayan M, Reddy AP
Human molecular genetics 2018 Jul 15;27(14):2502-2516
Human molecular genetics 2018 Jul 15;27(14):2502-2516
INF2-mediated actin polymerization at the ER stimulates mitochondrial calcium uptake, inner membrane constriction, and division.
Chakrabarti R, Ji WK, Stan RV, de Juan Sanz J, Ryan TA, Higgs HN
The Journal of cell biology 2018 Jan 2;217(1):251-268
The Journal of cell biology 2018 Jan 2;217(1):251-268
GLUT10 maintains the integrity of major arteries through regulation of redox homeostasis and mitochondrial function.
Syu YW, Lai HW, Jiang CL, Tsai HY, Lin CC, Lee YC
Human molecular genetics 2018 Jan 15;27(2):307-321
Human molecular genetics 2018 Jan 15;27(2):307-321
Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer's disease.
Kandimalla R, Manczak M, Yin X, Wang R, Reddy PH
Human molecular genetics 2018 Jan 1;27(1):30-40
Human molecular genetics 2018 Jan 1;27(1):30-40
Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer's disease.
Manczak M, Kandimalla R, Yin X, Reddy PH
Human molecular genetics 2018 Apr 15;27(8):1332-1342
Human molecular genetics 2018 Apr 15;27(8):1332-1342
Neuroprotective Effect and Mechanism of Thiazolidinedione on Dopaminergic Neurons In Vivo and In Vitro in Parkinson's Disease.
Wang Y, Zhao W, Li G, Chen J, Guan X, Chen X, Guan Z
PPAR research 2017;2017:4089214
PPAR research 2017;2017:4089214
Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission.
Wang L, Zhang T, Wang L, Cai Y, Zhong X, He X, Hu L, Tian S, Wu M, Hui L, Zhang H, Gao P
The EMBO journal 2017 May 15;36(10):1330-1347
The EMBO journal 2017 May 15;36(10):1330-1347
Salvianolic acid B inhibits mitochondrial dysfunction by up-regulating mortalin.
Liu Y, Hu Y, E Q, Zuo J, Yang L, Liu W
Scientific reports 2017 Mar 2;7:43097
Scientific reports 2017 Mar 2;7:43097
Mitochondrial dynamics changes with age in an APPsw/PS1dE9 mouse model of Alzheimer's disease.
Xu LL, Shen Y, Wang X, Wei LF, Wang P, Yang H, Wang CF, Xie ZH, Bi JZ
Neuroreport 2017 Mar 1;28(4):222-228
Neuroreport 2017 Mar 1;28(4):222-228
Phosphorylation of dynamin-related protein 1 at Ser616 regulates mitochondrial fission and is involved in mitochondrial calcium uniporter-mediated neutrophil polarization and chemotaxis.
Zheng X, Chen M, Meng X, Chu X, Cai C, Zou F
Molecular immunology 2017 Jul;87:23-32
Molecular immunology 2017 Jul;87:23-32
p62-Mediated mitochondrial clustering attenuates apoptosis induced by mitochondrial depolarization.
Xiao B, Deng X, Lim GGY, Zhou W, Saw WT, Zhou ZD, Lim KL, Tan EK
Biochimica et biophysica acta. Molecular cell research 2017 Jul;1864(7):1308-1317
Biochimica et biophysica acta. Molecular cell research 2017 Jul;1864(7):1308-1317
Low-level laser therapy for beta amyloid toxicity in rat hippocampus.
Lu Y, Wang R, Dong Y, Tucker D, Zhao N, Ahmed ME, Zhu L, Liu TC, Cohen RM, Zhang Q
Neurobiology of aging 2017 Jan;49:165-182
Neurobiology of aging 2017 Jan;49:165-182
Sirtuin 5 protects mitochondria from fragmentation and degradation during starvation.
Guedouari H, Daigle T, Scorrano L, Hebert-Chatelain E
Biochimica et biophysica acta. Molecular cell research 2017 Jan;1864(1):169-176
Biochimica et biophysica acta. Molecular cell research 2017 Jan;1864(1):169-176
Hydrogen Sulphide modulating mitochondrial morphology to promote mitophagy in endothelial cells under high-glucose and high-palmitate.
Liu N, Wu J, Zhang L, Gao Z, Sun Y, Yu M, Zhao Y, Dong S, Lu F, Zhang W
Journal of cellular and molecular medicine 2017 Dec;21(12):3190-3203
Journal of cellular and molecular medicine 2017 Dec;21(12):3190-3203
Receptor-mediated Drp1 oligomerization on endoplasmic reticulum.
Ji WK, Chakrabarti R, Fan X, Schoenfeld L, Strack S, Higgs HN
The Journal of cell biology 2017 Dec 4;216(12):4123-4139
The Journal of cell biology 2017 Dec 4;216(12):4123-4139
Ischemia-induced Drp1 and Fis1-mediated mitochondrial fission and right ventricular dysfunction in pulmonary hypertension.
Tian L, Neuber-Hess M, Mewburn J, Dasgupta A, Dunham-Snary K, Wu D, Chen KH, Hong Z, Sharp WW, Kutty S, Archer SL
Journal of molecular medicine (Berlin, Germany) 2017 Apr;95(4):381-393
Journal of molecular medicine (Berlin, Germany) 2017 Apr;95(4):381-393
AP39, a Mitochondria-Targeted Hydrogen Sulfide Donor, Supports Cellular Bioenergetics and Protects against Alzheimer's Disease by Preserving Mitochondrial Function in APP/PS1 Mice and Neurons.
Zhao FL, Fang F, Qiao PF, Yan N, Gao D, Yan Y
Oxidative medicine and cellular longevity 2016;2016:8360738
Oxidative medicine and cellular longevity 2016;2016:8360738
Autophagy plays a role in skeletal muscle mitochondrial biogenesis in an endurance exercise-trained condition.
Ju JS, Jeon SI, Park JY, Lee JY, Lee SC, Cho KJ, Jeong JM
The journal of physiological sciences : JPS 2016 Sep;66(5):417-30
The journal of physiological sciences : JPS 2016 Sep;66(5):417-30
Dysfunctional tubular endoplasmic reticulum constitutes a pathological feature of Alzheimer's disease.
Sharoar MG, Shi Q, Ge Y, He W, Hu X, Perry G, Zhu X, Yan R
Molecular psychiatry 2016 Sep;21(9):1263-71
Molecular psychiatry 2016 Sep;21(9):1263-71
Quantification and Characterization of UVB-Induced Mitochondrial Fragmentation in Normal Primary Human Keratinocytes.
Jugé R, Breugnot J, Da Silva C, Bordes S, Closs B, Aouacheria A
Scientific reports 2016 Oct 12;6:35065
Scientific reports 2016 Oct 12;6:35065
Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease.
Yin X, Manczak M, Reddy PH
Human molecular genetics 2016 May 1;25(9):1739-53
Human molecular genetics 2016 May 1;25(9):1739-53
Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology.
Zhang C, Shi Z, Zhang L, Zhou Z, Zheng X, Liu G, Bu G, Fraser PE, Xu H, Zhang YW
Journal of cell science 2016 Mar 1;129(5):994-1002
Journal of cell science 2016 Mar 1;129(5):994-1002
FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions.
Wu W, Lin C, Wu K, Jiang L, Wang X, Li W, Zhuang H, Zhang X, Chen H, Li S, Yang Y, Lu Y, Wang J, Zhu R, Zhang L, Sui S, Tan N, Zhao B, Zhang J, Li L, Feng D
The EMBO journal 2016 Jul 1;35(13):1368-84
The EMBO journal 2016 Jul 1;35(13):1368-84
Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria.
Korwitz A, Merkwirth C, Richter-Dennerlein R, Tröder SE, Sprenger HG, Quirós PM, López-Otín C, Rugarli EI, Langer T
The Journal of cell biology 2016 Jan 18;212(2):157-66
The Journal of cell biology 2016 Jan 18;212(2):157-66
Resveratrol Induces Cancer Cell Apoptosis through MiR-326/PKM2-Mediated ER Stress and Mitochondrial Fission.
Wu H, Wang Y, Wu C, Yang P, Li H, Li Z
Journal of agricultural and food chemistry 2016 Dec 14;64(49):9356-9367
Journal of agricultural and food chemistry 2016 Dec 14;64(49):9356-9367
Protective effects of reduced dynamin-related protein 1 against amyloid beta-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease.
Manczak M, Kandimalla R, Fry D, Sesaki H, Reddy PH
Human molecular genetics 2016 Dec 1;25(23):5148-5166
Human molecular genetics 2016 Dec 1;25(23):5148-5166
Mitochondrial division inhibitor 1 protects against mutant huntingtin-induced abnormal mitochondrial dynamics and neuronal damage in Huntington's disease.
Manczak M, Reddy PH
Human molecular genetics 2015 Dec 20;24(25):7308-25
Human molecular genetics 2015 Dec 20;24(25):7308-25
The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission.
Anand R, Wai T, Baker MJ, Kladt N, Schauss AC, Rugarli E, Langer T
The Journal of cell biology 2014 Mar 17;204(6):919-29
The Journal of cell biology 2014 Mar 17;204(6):919-29
Mutations in Fis1 disrupt orderly disposal of defective mitochondria.
Shen Q, Yamano K, Head BP, Kawajiri S, Cheung JT, Wang C, Cho JH, Hattori N, Youle RJ, van der Bliek AM
Molecular biology of the cell 2014 Jan;25(1):145-59
Molecular biology of the cell 2014 Jan;25(1):145-59
RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway.
Wang X, Jiang W, Yan Y, Gong T, Han J, Tian Z, Zhou R
Nature immunology 2014 Dec;15(12):1126-33
Nature immunology 2014 Dec;15(12):1126-33
PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation.
Furuya N, Ikeda S, Sato S, Soma S, Ezaki J, Oliva Trejo JA, Takeda-Ezaki M, Fujimura T, Arikawa-Hirasawa E, Tada N, Komatsu M, Tanaka K, Kominami E, Hattori N, Ueno T
Autophagy 2014 Apr;10(4):631-41
Autophagy 2014 Apr;10(4):631-41
Loss of Yme1L perturbates mitochondrial dynamics.
Ruan Y, Li H, Zhang K, Jian F, Tang J, Song Z
Cell death & disease 2013 Oct 31;4(10):e896
Cell death & disease 2013 Oct 31;4(10):e896
Mitochondrial abnormalities in temporal lobe of autistic brain.
Tang G, Gutierrez Rios P, Kuo SH, Akman HO, Rosoklija G, Tanji K, Dwork A, Schon EA, Dimauro S, Goldman J, Sulzer D
Neurobiology of disease 2013 Jun;54:349-61
Neurobiology of disease 2013 Jun;54:349-61
A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity.
Qi X, Qvit N, Su YC, Mochly-Rosen D
Journal of cell science 2013 Feb 1;126(Pt 3):789-802
Journal of cell science 2013 Feb 1;126(Pt 3):789-802
Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration.
Guo X, Disatnik MH, Monbureau M, Shamloo M, Mochly-Rosen D, Qi X
The Journal of clinical investigation 2013 Dec;123(12):5371-88
The Journal of clinical investigation 2013 Dec;123(12):5371-88
Dynamin-related protein 1 heterozygote knockout mice do not have synaptic and mitochondrial deficiencies.
Manczak M, Sesaki H, Kageyama Y, Reddy PH
Biochimica et biophysica acta 2012 Jun;1822(6):862-74
Biochimica et biophysica acta 2012 Jun;1822(6):862-74
Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage.
Manczak M, Calkins MJ, Reddy PH
Human molecular genetics 2011 Jul 1;20(13):2495-509
Human molecular genetics 2011 Jul 1;20(13):2495-509
Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease.
Calkins MJ, Manczak M, Mao P, Shirendeb U, Reddy PH
Human molecular genetics 2011 Dec 1;20(23):4515-29
Human molecular genetics 2011 Dec 1;20(23):4515-29
Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage.
Shirendeb U, Reddy AP, Manczak M, Calkins MJ, Mao P, Tagle DA, Reddy PH
Human molecular genetics 2011 Apr 1;20(7):1438-55
Human molecular genetics 2011 Apr 1;20(7):1438-55
Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons.
Manczak M, Mao P, Calkins MJ, Cornea A, Reddy AP, Murphy MP, Szeto HH, Park B, Reddy PH
Journal of Alzheimer's disease : JAD 2010;20 Suppl 2(Suppl 2):S609-31
Journal of Alzheimer's disease : JAD 2010;20 Suppl 2(Suppl 2):S609-31
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 10956-1-AP( FIS1 Antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-FIS1 (IP:10956-1-AP, 3ug; Detection:10956-1-AP 1:500) with HeLa cells lysate 3000ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 10956-1-AP(FIS1 antibody) at dilution of 1:25 (under 40x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 10956-1-AP(FIS1 antibody) at dilution of 1:25 (under 10x lens)
- Sample type
- tissue
