Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [467]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 10956-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10956-1-AP, RRID:AB_2102532
- Product name
- FIS1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated FIS1 antibody (Cat. #10956-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat, pig and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat, Porcine
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Integrating multi-omics and network toxicology to identify FIS1 as a key target of environmental pollutants in male infertility.
The purinergic receptor P2rx7 mediated ATP sensing is required to prevent bone aging by directing mitochondrial fitness of MSCs.
Trans-Omics Integration Reveals That the Kidney Contributes to Systemic Aging via Sexually Dimorphic Accumulation of Glycosphingolipids.
Targeting NME3 to Restore Mitochondrial Fission-Fusion Balance Defines a Novel Disease-Modifying Strategy for Parkinson's Disease.
Regulation of mitophagy by Fis1 and Fascin1-organized actin.
Metabolic beneficial effects of targeting a long non-coding RNA, lnc-megacluster, in obesity.
A dual-responsive CO-releasing nanogel ameliorates retinal ischemia-reperfusion injury by restoring mitochondrial homeostasis and attenuating cGAS-STING pathway activation.
RIPK3 Inhibition Mitigates Denervated Muscle Atrophy via NOX4-Mediated Mitochondrial Restoration and Inflammation Suppression.
Brusatol derivative ameliorates rheumatoid arthritis and atherosclerosis with associated suppression of mitochondrial fission.
Overexpression of mitofusin 2 ameliorates inflammation and oxidative stress in lipopolysaccharide-induced mastitis model by regulating phosphofurin acidic cluster sorting protein 2.
Volitional exercise elicits physiological and molecular improvements in the severe D2.mdx mouse model of Duchenne muscular dystrophy.
BDH1 Mediates Aerobic Exercise-Induced Improvement in Skeletal Muscle Metabolic Remodeling in Type 2 Diabetes Mellitus.
Macelignan, a lignan from Myristica fragrans Houtt., rescues mitochondrial homeostasis and prevents cognitive decline in vascular dementia by modulating the mTOR-Mitophagy axis.
Systematic evaluation of mitochondrial morphology regulators for amelioration of neuronal α-synucleinopathy.
Dying oligodendrocytes persist without mitochondria.
The Synthetic Cannabinoid ADB-FUBINACA Disrupts Mitochondrial Morphology and Dynamics during Neuronal Differentiation of NG108-15 Cells.
The UBC/SIRT5/DRP1 axis regulates mitochondrial dynamics to alleviate Staphylococcus aureus-induced oxidative stress and senescence in bovine mammary epithelial cells.
Idebenone alleviates rotenone-induced mitochondrial dysfunction through mitophagy and mitochondrial biogenesis in muscle cells.
The synthetic cannabinoid THJ-2201 modulates mitochondrial activity and enhances mitochondrial recruitment to newly-forming neurites during neurodifferentiation of NG108-15 cells.
Curcumin-loaded silk fibroin scaffold promotes cartilage regeneration by inhibiting angiogenesis via Drp1/ROS-mediated mitochondrial regulation.
Redox switch C674 in SERCA2 triggers Ca(2+)-calcineurin-MCU-Drp1 cascade and pulmonary vascular remodeling.
Mitigation of Ischemia/Reperfusion-Induced Acute Kidney Injury by Canagliflozin Is Associated with Altered Mitochondrial Dynamics and Reduced Proliferation in Swine.
Trimethylamine-N-oxide disrupts spermatogenesis by inducing mitochondrial oxidative stress injury through Hippo signaling.
Modified Erxian Decoction ameliorates premature ovarian insufficiency via HIF-1α-mediated regulation of mitochondrial fission and oxidative stress.
Mitochondrial TRPV1 exacerbates cognitive deficits in sepsis-associated encephalopathy by driving microglial metabolic reprogramming.
Schisandrol B protects against lithocholic acid-induced cholestatic liver injury in mice through mitochondrial biogenesis.
Macrophage-derived S100A9 promotes diabetic cardiomyopathy by disturbing mitochondrial quality control via STAT3 activation.
Lipin3 deficiency aggravates cisplatin induced acute kidney injury via activating Sirt1-p21-Caspase 3-GSDME pyroptosis pathway.
Astragaloside IV Alleviates H(2)O(2)-Induced Mitochondrial Dysfunction and Inhibits Mitophagy Via PI3K/AKT/mTOR Pathway.
Social jetlag alters markers of exercise-induced mitochondrial adaptations in the heart.
The Role of Placental MFF-Mediated Mitochondrial Fission in Gestational Diabetes Mellitus.
Metformin Activation of Sirtuin 3 Signaling Regulates Mitochondrial Function Improves Diabetes-Associated Cognitive Impairment.
Bone-targeted mitochondrial delivery via magnetic-temperature responsive artificial cells for repairing age-related fractures.
Calcium dysregulation disrupts mitochondrial homeostasis by interfering AMPK/Drp1 pathway to aggravate plaque progression and instability.
Reniformin A Suppresses Triple-Negative Breast Cancer Progression by Inducing DRP1-Mediated Mitochondrial Dysfunction and Apoptosis.
Isatin ameliorates ovarian inflammation and apoptosis caused by hormonal imbalances in PCOS mice.
Mito-tempo ameliorates tubular injury of diabetic nephropathy via inhibiting mt-dsRNA release and PKR/eIF2α pathway activation.
Hsp60 lactylation promotes mitochondrial dysfunction and trophoblast apoptosis in preeclampsia.
Kaempferol improves mitochondrial homeostasis via mitochondrial dynamics and mitophagy in diabetic kidney disease.
Rab14 promotes Parkin-mediated mitophagy.
Sex-specific impact of selective reduced uterine placental perfusion model of preeclampsia on fetal cardiac maturation and mitochondrial function.
Gestational zearalenone causes fetal intrauterine growth restriction partially through deriving ROS-Drp1 mediated placental PANoptosis.
Mechanistic study of the novel peroxidase mimetic DhHP-6 in metabolic cataracts.
PPP1R3G inhibition impairs OPCs differentiation and myelination in aged mice.
Atrazine-induced hippocampal neurotoxicity: Involvement of Drp1-mediated mitochondrial fission.
One day of environment-induced heat stress causes injury to the murine kidney.
SAP30BP aggravates mitochondrial-related ferroptosis in diabetic cardiomyopathy by regulating MFN2-ACSL4 axis.
S100A9 inhibition ameliorates HFpEF by modulating mitochondrial fission and oxidative stress.
Disruption of cellular redox homeostasis by bigelovin triggers oxidative stress-mediated apoptosis in Fibrosarcoma.
AMPK impairment caused by gelatin disturbs mitochondrial dynamics leading to enhanced phagocytosis of bacteria in PMA-stimulated U937 cells.
Lactoferrin alleviates doxorubicin-induced myocardial injury in mice: Associations with gut microbiota and microbial metabolites.
Oxymatrine Alleviates Cerebral Ischemia/Reperfusion Injury By Targeting HDAC1 to Regulate Mitochondria-Related Autophagy and Oxidative Stress.
Inhibition of SIRT1/PGC-1α Axis Exacerbates Fluorine and Aluminium Induced Neurotoxicity via Drp1-dependent Aggravated Mitochondrial Fission.
MSCs ameliorates hyperglycemia-induced endothelial injury through modulation of mitochondrial dynamics.
B355252 Targets UCP2 to Rescue Intracerebral Hemorrhage-Induced Injury by Promoting Mitochondrial Fusion and Inhibiting Ferroptosis.
GLP-1/GIP dual agonist tirzepatide alleviates mice model of Parkinson's disease by promoting mitochondrial homeostasis.
Activin A protects against lipopolysaccharide/TNF-α induced damage of dopaminergic neurons both in vivo and in vitro by regulating mitochondrial fusion.
Protective effect of astragaloside IV against zinc oxide nanoparticles induced human neuroblastoma SH-SY5Y cell death: a focus on mitochondrial quality control.
Effective compound combination of Bufei Yishen formula ameliorates PM2.5-induced COPD by inhibiting mitochondrial oxidative stress through SIRT3-mediated FOXO3 deacetylation.
Silicon Enhances Functional Mitochondrial Transfer to Improve Neurovascularization in Diabetic Bone Regeneration.
Lycium barbarum glycopeptide attenuates intracerebral hemorrhage-induced inflammation and oxidative stress via activation of the Sirt3 signaling pathway.
A hidden cysteine in Fis1 targeted to prevent excessive mitochondrial fission and dysfunction under oxidative stress.
Lithium with environmentally relevant concentrations interferes with mitochondrial function, antioxidant response, and autophagy processes in Daphnia magna, leading to changes in life-history traits and behavior.
ZLN005, a PGC-1α agonist, delays photoreceptor degeneration by enhancing mitochondrial biogenesis in a murine model of retinitis pigmentosa.
JAK2/STAT3/HMGCS2 signaling aggravates mitochondrial dysfunction and oxidative stress in hyperuricemia-induced cardiac dysfunction.
Coral calcium hydride promotes peripheral mitochondrial division and reduces AT-II cells damage in ARDS via activation of the Trx2/Myo19/Drp1 pathway.
Zn(2+) protects H9C2 cardiomyocytes by alleviating MAMs-associated apoptosis and calcium signaling dysregulation.
Procyanidin B2 alleviates damage to mouse testicular tissue after freezing by inhibiting oxidative stress and apoptosis.
Melatonin refines ovarian mitochondrial dysfunction in PCOS by regulating the circadian rhythm gene Clock.
Impact of POU3F4 mutation on cochlear development and auditory function.
Electroacupuncture promotes neural function recovery by alleviating mitochondria damage in cerebral ischemia mice.
Melatonin ameliorates Pb-induced mitochondrial homeostasis and ovarian damage through regulating the p38 signaling pathway.
Inhibition of autophagy attenuates cognitive decline and mitochondrial dysfunction in an Alzheimer's disease mouse model with chronic cerebral hypoperfusion.
SIRT4 Protects Müller Glial Cells Against Apoptosis by Mediating Mitochondrial Dynamics and Oxidative Stress.
Lycium barbarum polysaccharide alleviate cadmium-induced mitochondrial dysfunction mediated pyroptosis in duck liver.
The crucial function of IDO1 in pulmonary fibrosis: From the perspective of mitochondrial fusion in lung fibroblasts and targeted molecular inhibition.
PFOS causes lysosomes-regulated mitochondrial fission through TRPML1-VDAC1 and oligomerization of MCU/ATP5J2.
Identification and validation of PARK7 as a novel mitochondria-related signature associated with immune microenvironment in asthma.
MiR221/222 in the conditioned medium of adipose-derived stem cells attenuates particulate matter and high-fat diet-induced cardiac apoptosis.
Icariin mitigates depressive-like behavior in rats by regulating mitochondrial function.
Mechanisms of Cisplatin-Induced Acute Kidney Injury: The Role of NRF2 in Mitochondrial Dysfunction and Metabolic Reprogramming.
Ginsenoside Rh2 Exerts a Therapeutic Effect against Myocardial Infarction via Promoting Angiogenesis and Mitochondrial Bioenergetics.
Acetaldehyde dehydrogenase 2 attenuates lipopolysaccharide -induced endothelial barrier damage by inhibiting mitochondrial fission in sepsis-associated encephalopathy.
The Gut Microbial Metabolite Butyrate Alleviates IL-1β-Induced Mitochondrial Dysfunction and Oxidative Stress in Pancreatic Islets.
Drp1-Mediated Mitochondrial Fission Is Essential for Chemical-Induced Neuronal Transdifferentiation from Human Primary Fibroblasts.
AMPK-YAP signaling pathway-mediated mitochondrial dynamics and mitophagy participate in the protective effect of silibinin on HaCaT cells under high glucose conditions.
Norepinephrine Attenuates Benzalkonium Chloride-Induced Dry Eye Disease by Regulating the PINK1/Parkin Mitophagy Pathway.
Pathogenicity analysis of three SCA14-associated missense mutations in PRKCG gene of Chinese patients with ataxia.
The DRP1 receptor FIS1 is critical to the expansion of triple-negative breast cancer tumor-initiating cells.
S-COS-Se mitigates cadmium-induced oxidative stress, inflammation, and immunotoxicity by restoring immune balance and inhibiting mitochondria-pyroptosis crosstalk.
Exosomes derived from ALR-modified adipose mesenchymal stem cells mediate hepatoprotective effects on hepatic ischemia-reperfusion injury by promoting regeneration and protecting mitochondria.
Aerobic Exercise Delays Age-Related Sarcopenia in Mice via Alleviating Imbalance in Mitochondrial Quality Control.
Tang Bi formula alleviates diabetic sciatic neuropathy via AMPK/PGC-1α/MFN2 pathway activation.
Drp1-Dependent Mitochondrial Fission Contributes to Lactic Acid-Induced Chicken Cardiomyocyte Damage.
Calcium-mediated mitochondrial fission and mitophagy drive glycolysis to facilitate arterivirus proliferation.
9-PAHSA ameliorates microvascular damage during cardiac ischaemia/reperfusion injury by promoting LKB1/AMPK/ULK1-mediated autophagy-dependent STING degradation.
Cadmium and polyvinyl chloride microplastics induce mitochondrial damage and apoptosis under oxidative stress in duck kidney.
Fis1 is required for the development of the dendritic mitochondrial network in pyramidal cortical neurons.
Klebsiella pneumoniae causes mammary gland damage via FNIP1-mediated mitochondrial dysfunction.
SIRT4 Protects Retina Against Excitotoxic Injury by Promoting OPA1-Mediated Müller Glial Cell Mitochondrial Fusion and GLAST Expression.
Notoginsenoside R1 Attenuates H/R Injury in H9c2 Cells by Maintaining Mitochondrial Homeostasis.
Depleting chemoresponsive mitochondrial fission mediator DRP1 does not mitigate sarcoma resistance.
Cleaving PINK1 or PGAM5? Involvement of PARL in Methamphetamine-Induced Excessive Mitophagy and Neuronal Necroptosis.
SREBP1c-Mediated Transcriptional Repression of YME1L1 Contributes to Acute Kidney Injury by Inducing Mitochondrial Dysfunction in Tubular Epithelial Cells.
Disrupted Mitochondrial Dynamics Impair Corneal Epithelial Healing in Neurotrophic Keratopathy.
l-Glutamic Acid Alleviates Mastitis in Dairy Cows by Targeting the Sirt5/Nrf2/Prdx1 Signaling Axis and Mitochondrial Function.
Zn(2 +) alleviates ischemia/reperfusion injury in H9c2 cells by modulating mitochondrial biogenesis and dynamics via MCU.
High-Frequency rTMS can Improve Depressive Symptoms by Promoting Mitochondrial Fusion.
Melatonin attenuates high-fat diet- and particulate matter-induced cardiac injury: involvement of mitochondrial quality and miR-221/222 expression.
The binding of PCBP2 to IGF2 mRNA restores mitochondrial function in granulosa cells to ameliorate ovarian function in premature ovarian insufficiency mice.
Defective vascular smooth muscle cell tafazzin impairs mitochondrial function and promotes atherosclerosis in preclinical models.
A role for Fis1 in dendritic development.
Mitofusin 2 is required for preventing deoxynivalenol-induced porcine intestinal epithelial cell damage.
Mitochondrial dysfunction in mesenchymal stem cells impairs osteogenesis in radiation-induced bone injury via Ca(2+)-NFATc1-Fis1 pathway.
Liraglutide alleviates diabetic cardiomyopathy in streptozotocin-induced diabetic rats by enhancing mitophagy mediated by the AMPK-Parkin signaling pathway.
FUNDC1-dependent mitochondrial-ER membranes mediate mitochondrial dysfunction and melanocyte damage under oxidative stress.
Leber's hereditary optic neuropathy-associated ND1 3733G>C mutation ameliorates the mitochondrial quality control and cellular homeostasis.
Targeting Wnt/beta-catenin signaling to attenuate short-chain chlorinated paraffins-triggered hepatocyte mitochondrial fission and subsequent pyroptosis.
NR3C1/GLMN-Mediated FKBP12.6 Ubiquitination Disrupts Calcium Homeostasis and Impairs Mitochondrial Quality Control in Stress-Induced Myocardial Damage.
Ankyrin-B modulates mitochondrial fission in skeletal muscle and is required for optimal endurance exercise capacity.
Opantimirs: A class of antagonizing microRNAs that upregulate Opa1 and improve mitochondrial and disuse myopathies.
Succinate accumulation induces pyroptosis and mitochondrial damage via the inhibition of ATP5F1D in HUVECs.
Radiocleavable rare-earth nanoactivators targeting over-expressed folate receptors induce mitochondrial dysfunction and remodel immune suppressive microenvironment in pancreatic cancer.
Dynamin-Related Protein 1 Orchestrates Inflammatory Responses in Periodontal Macrophages via Interaction With Hexokinase 1.
O-GlcNAcylation of hexokinase 2 modulates mitochondrial dynamics and enhances the progression of lung cancer.
Molybdenum nanodots act as antioxidants for photothermal therapy osteoarthritis.
sLithospermic acid etched ZIF-8 nanoparticles delays osteoarthritis progression by inhibiting inflammatory signaling pathways and rescuing mitochondrial damage.
Butyrate Regulates Intestinal DNA Virome and Lipopolysaccharide Levels to Prevent High-Fat Diet-Related Liver Damage in Rats.
Inhibition of Drp1-mediated mitochondrial fission by P110 ameliorates renal injury in diabetic nephropathy.
Loss of lipid droplet-mitochondria contacts confers protection against ethanol-induced cardiotoxicity.
ARMC1 partitions between distinct complexes and assembles MIRO with MTFR to control mitochondrial distribution.
Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis.
CD62E- and ROS-Responsive ETS Improves Cartilage Repair by Inhibiting Endothelial Cell Activation through OPA1-Mediated Mitochondrial Homeostasis.
Loss of MTX2 causes mitochondrial dysfunction, podocyte injury, nephrotic proteinuria and glomerulopathy in mice and patients.
Interaction Between the PERK/ATF4 Branch of the Endoplasmic Reticulum Stress and Mitochondrial One-Carbon Metabolism Regulates Neuronal Survival After Intracerebral Hemorrhage.
JiangyaTongluo decoction ameliorates tubulointerstitial fibrosis via regulating the SIRT1/PGC-1α/mitophagy axis in hypertensive nephropathy.
The toxic effects of polystyrene microplastic/nanoplastic particles on retinal pigment epithelial cells and retinal tissue.
The Footprints of Mitochondrial Fission and Apoptosis in Fluoride-Induced Renal Dysfunction.
Elevated serum neurologic biomarker profiles after cardiac arrest in a porcine model.
Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation.
Prophylactic Effects of Betaine on Depression and Anxiety Behaviors in Mice with Dextran Sulfate Sodium-Induced Colitis.
Acutely blocking excessive mitochondrial fission prevents chronic neurodegeneration after traumatic brain injury.
Helicobacter pylori CagA mediated mitophagy to attenuate the NLRP3 inflammasome activation and enhance the survival of infected cells.
Dysregulation of mitochondrial dynamics and mitophagy are involved in high-fat diet-induced steroidogenesis inhibition.
Resveratrol protects against a high-fat diet-induced neuroinflammation by suppressing mitochondrial fission via targeting SIRT1/PGC-1α.
Melatonin Protects Against Mitochondrial Dyshomeostasis and Ovarian Damage Caused by Chronic Unpredictable Mild Stress Through the eIF2α-AFT4 Signaling Pathway in Mice.
SIRT1 regulates mitochondrial fission to alleviate high altitude hypoxia inducedcardiac dysfunction in rats via the PGC-1α-DRP1/FIS1/MFF pathway.
piR112710 attenuates diabetic cardiomyopathy through inhibiting Txnip/NLRP3-mediated pyroptosis in db/db mice.
Slc25a3-dependent copper transport controls flickering-induced Opa1 processing for mitochondrial safeguard.
Homoplantaginin alleviates high glucose-induced vascular endothelial senescence by inhibiting mtDNA-cGAS-STING pathway via blunting DRP1-mitochondrial fission-VDAC1 axis.
SETDB1 targeting SESN2 regulates mitochondrial damage and oxidative stress in renal ischemia-reperfusion injury.
Yiqihuoxue decoction (GSC) inhibits mitochondrial fission through the AMPK pathway to ameliorate EPCs senescence and optimize vascular aging transplantation regimens.
One day of environment-induced heat stress damages the murine myocardium.
Readdressing the Localization of Apolipoprotein E (APOE) in Mitochondria-Associated Endoplasmic Reticulum (ER) Membranes (MAMs): An Investigation of the Hepatic Protein-Protein Interactions of APOE with the Mitochondrial Proteins Lon Protease (LONP1), Mitochondrial Import Receptor Subunit TOM40 (TOMM40) and Voltage-Dependent Anion-Selective Channel 1 (VDAC1).
Contribution of impaired autophagy, mitochondrial dysfunction and abnormal lipolysis to epididymal aging in mice.
Renal denervation ameliorates atrial remodeling in type 2 diabetic rats by regulating mitochondrial dynamics.
Isoliquiritigenin alleviates cerebral ischemia-reperfusion injury by reducing oxidative stress and ameliorating mitochondrial dysfunction via activating the Nrf2 pathway.
SIRT1, a target of miR-708-3p, alleviates fluoride-induced neuronal damage via remodeling mitochondrial network dynamics.
Mitochondrial elongation confers protection against doxorubicin-induced cardiotoxicity.
Ligustilide alleviates oxidative stress during renal ischemia-reperfusion injury through maintaining Sirt3-dependent mitochondrial homeostasis.
Diacylglycerol O-acyltransferase isoforms play a role in peridroplet mitochondrial fatty acid metabolism in bovine liver.
Resistance Exercise Improves Glycolipid Metabolism and Mitochondrial Biogenesis in Skeletal Muscle of T2DM Mice via miR-30d-5p/SIRT1/PGC-1α Axis.
Acrolein exposure affects ovarian function by interfering with glycolysis and mitochondrial energy metabolism in mouse.
TRPA1 protects against contrast-induced renal tubular injury by preserving mitochondrial dynamics via the AMPK/DRP1 pathway.
HIF-2α/TFR1 mediated iron homeostasis disruption aggravates cartilage endplate degeneration through ferroptotic damage and mtDNA release: A new mechanism of intervertebral disc degeneration.
Deafness-associated tRNA(Phe) mutation impaired mitochondrial and cellular integrity.
circUSP13 facilitates the fast-to-slow myofiber shift via the MAPK/ERK signaling pathway in goat skeletal muscles.
PRR34-AS1 promotes mitochondrial division and glycolytic reprogramming in hepatocellular carcinoma cells through upregulation of MIEF2.
Puerarin Delays Mammary Gland Aging by Regulating Gut Microbiota and Inhibiting the p38MAPK Signaling Pathway.
Ginkgolide C inhibits ROS-mediated activation of NLRP3 inflammasome in chondrocytes to ameliorate osteoarthritis.
Met-Exo attenuates mitochondrial dysfunction after hepatic ischemia-reperfusion injury in rats by modulating AMPK/SIRT1 signaling pathway.
IGF2BP3-stabilized CAMK1 regulates the mitochondrial dynamics of renal tubule to alleviate diabetic nephropathy.
Doxycycline induces mitochondrial dysfunction in aortic smooth muscle cells.
Inhibition of Drp1- Fis1 interaction alleviates aberrant mitochondrial fragmentation and acute kidney injury.
NME3 is a gatekeeper for DRP1-dependent mitophagy in hypoxia.
Leucine Supplementation Prevents the Development of Skeletal Muscle Dysfunction in a Rat Model of HFpEF.
Sex-Specific Effect of CARM1 in Skeletal Muscle Adaptations to Exercise.
Mechanistic of AMPK/ACC2 regulating myoblast differentiation by fatty acid oxidation of goat.
Hydrogen alleviates impaired lung epithelial barrier in acute respiratory distress syndrome via inhibiting Drp1-mediated mitochondrial fission through the Trx1 pathway.
HTR1B regulates mitochondrial homeostasis and mitophagy by activating the ERK/ MAPK signalling pathway during human embryonic arrest.
Inhibiting Pink1/Parkin-mediated mitophagy enhances the anticancer effects of quercetin in hepatocellular carcinomaf.
PEG300 Protects Mitochondrial Function By Upregulating PGC-1α to Delay Central Nervous System Oxygen Toxicity in Mice.
Peptide-encoding gene transfer to modulate intracellular protein-protein interactions.
Chemerin regulates glucose and lipid metabolism by changing mitochondrial structure and function associated with androgen/androgen receptor.
Acid Neutralization by Composite Lysine Nanoparticles for Spinal Cord Injury Recovery through Mitigating Mitochondrial Dysfunction.
Dulaglutide restores endothelial progenitor cell levels in diabetic mice and mitigates high glucose-induced endothelial injury through SIRT1-mediated mitochondrial fission.
MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels.
NAD(+) supplementation improves mitochondrial functions and normalizes glaucomatous trabecular meshwork features.
NAMPT regulates mitochondria function and lipid metabolism during porcine oocyte maturation.
Sentrin-specific protease 1 maintains mitochondrial homeostasis through targeting the deSUMOylation of sirtuin-3 to alleviate oxidative damage induced by hepatic ischemia/reperfusion.
Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4‑mediated ferritinophagy.
Intermittent Theta Burst Stimulation Attenuates Cognitive Deficits and Alzheimer's Disease-Type Pathologies via ISCA1-Mediated Mitochondrial Modulation in APP/PS1 Mice.
Rescue of mitochondrial import failure by intercellular organellar transfer.
Deficient tRNA posttranscription modification dysregulated the mitochondrial quality controls and apoptosis.
Mitochondrial dynamics disruption: Unraveling Dinotefuran's impact on cardiotoxicity.
Nicotinamide mononucleotide alleviates seizures via modulating SIRT1-PGC-1α mediated mitochondrial fusion and fission.
Alizarin attenuates oxidative stress-induced mitochondrial damage in vascular dementia rats by promoting TRPM2 ubiquitination and proteasomal degradation via Smurf2.
SENP3-FIS1 axis promotes mitophagy and cell survival under hypoxia.
IDH1/MDH1 deacetylation promotes NETosis by regulating OPA1 and autophagy.
Myricetin Alleviates Silica-Mediated Lung Fibrosis via PPARγ-PGC-1α Loop and Suppressing Mitochondrial Senescence in Epithelial Cells.
Aldehyde Dehydrogenase 2 Deficiency Aggravates Lung Fibrosis through Mitochondrial Dysfunction and Aging in Fibroblasts.
Pathological characteristics of axons and alterations of proteomic and lipidomic profiles in midbrain dopaminergic neurodegeneration induced by WDR45-deficiency.
ML335 inhibits TWIK2 channel-mediated potassium efflux and attenuates mitochondrial damage in MSU crystal-induced inflammation.
Matrix stiffness aggravates osteoarthritis progression through H3K27me3 demethylation induced by mitochondrial damage.
VDR regulates mitochondrial function as a protective mechanism against renal tubular cell injury in diabetic rats.
DsbA-L ameliorates renal aging and renal fibrosis by maintaining mitochondrial homeostasis.
Cadmium-induced global DNA hypermethylation promoting mitochondrial dynamics dysregulation in hippocampal neurons.
Astragaloside IV combined with ligustrazine ameliorates abnormal mitochondrial dynamics via Drp1 SUMO/deSUMOylation in cerebral ischemia-reperfusion injury.
Resveratrol Inhibits Zinc Deficiency-Induced Mitophagy and Exerts Cardiac Cytoprotective Effects.
Mitochondria-associated membranes contribution to exercise-mediated alleviation of hepatic insulin resistance: Contrasting high-intensity interval training with moderate-intensity continuous training in a high-fat diet mouse model.
Dietary fat supplementation relieves cold temperature-induced energy stress through AMPK-mediated mitochondrial homeostasis in pigs.
Dietary cysteine and methionine promote peroxisome elevation and fat loss by induction of CG33474 expression in Drosophila adipose tissue.
TDCPP and TiO(2) NPs aggregates synergistically induce SH-SY5Y cell neurotoxicity by excessive mitochondrial fission and mitophagy inhibition.
Phosphoglycerate mutase 5 exacerbates liver ischemia-reperfusion injury by activating mitochondrial fission.
Early Mitochondrial Defects in the 5xFAD Mouse Model of Alzheimer's Disease.
Nanocurcumin Reduces High Glucose and Particulate Matter-Induced Endothelial Inflammation: Mitochondrial Function and Involvement of miR-221/222.
Selenium-enriched Cardamine violifolia protects against sepsis-induced intestinal injury by regulating mitochondrial fusion in weaned pigs.
Hypoxia-induced GPCPD1 depalmitoylation triggers mitophagy via regulating PRKN-mediated ubiquitination of VDAC1.
Aerobic exercise enhances mitochondrial homeostasis to counteract D-galactose-induced sarcopenia in zebrafish.
Photobiomodulation provides neuroprotection through regulating mitochondrial fission imbalance in the subacute phase of spinal cord injury.
Mitochondrial miR-12294-5p regulated copper-induced mitochondrial oxidative stress and mitochondrial quality control imbalance by targeted inhibition of CISD1 in chicken livers.
High-resolution visualization and assessment of basal and OXPHOS-induced mitophagy in H9c2 cardiomyoblasts.
Histone deacetylase inhibitor pracinostat suppresses colorectal cancer by inducing CDK5-Drp1 signaling-mediated peripheral mitofission.
Polydatin improves vascular endothelial function by maintaining mitochondrial homeostasis under high glucose conditions.
A conserved, noncanonical insert in FIS1 mediates TBC1D15 and DRP1 recruitment for mitochondrial fission.
The mystery of phospho-Drp1 with four adaptors in cell cycle: when mitochondrial fission couples to cell fate decisions.
The poxvirus F17 protein counteracts mitochondrially orchestrated antiviral responses.
CCDC127 regulates lipid droplet homeostasis by enhancing mitochondria-ER contacts.
Sodium Sulfite-Triggered Hepatocyte Ferroptosis via mtROS/Lysosomal Membrane Permeabilization-Mediated Lysosome Iron Efflux.
miR-27a-3p relieves heat stress-induced mitochondrial damage and aberrant milk protein synthesis through MEK/ERK pathway in BMECs.
Heme oxygenase-1 prevents non-alcoholic steatohepatitis through modulating mitochondrial quality control.
HC067047 as a potent TRPV4 inhibitor repairs endotoxemia colonic injury.
Empagliflozin ameliorates cardiac dysfunction in heart failure mice via regulating mitochondrial dynamics.
Macrophage Inactivation by Small Molecule Wedelolactone via Targeting sEH for the Treatment of LPS-Induced Acute Lung Injury.
MFN1 augmentation prevents retinal degeneration in a Charcot-Marie-Tooth type 2A mouse model.
miR-484 mediates oxidative stress-induced ovarian dysfunction and promotes granulosa cell apoptosis via SESN2 downregulation.
Senomorphic effect of diphenyleneiodonium through AMPK/MFF/DRP1 mediated mitochondrial fission.
Paraquat-induced neurogenesis abnormalities via Drp1-mediated mitochondrial fission.
Pseudolaric acid B triggers cell apoptosis by activating AMPK/JNK/DRP1/mitochondrial fission pathway in hepatocellular carcinoma.
Myricetin improves pathological changes in 3×Tg-AD mice by regulating the mitochondria-NLRP3 inflammasome-microglia channel by targeting P38 MAPK signaling pathway.
Hydrogen sulfide alleviates mitochondrial damage and ferroptosis by regulating OPA3-NFS1 axis in doxorubicin-induced cardiotoxicity.
Parkin regulates amino acid homeostasis at mitochondria-lysosome (M/L) contact sites in Parkinson's disease.
Targeting an allosteric site in dynamin-related protein 1 to inhibit Fis1-mediated mitochondrial dysfunction.
High-intensity interval training induces renal injury and fibrosis in type 2 diabetic mice.
Bavachin and Corylifol A Improve Muscle Atrophy by Enhancing Mitochondria Quality Control in Type 2 Diabetic Mice.
N-acetyl-L-cysteine alleviates FUNDC1-mediated mitophagy by regulating mitochondrial dynamics in type 1 diabetic nephropathy canine.
Endoplasmic reticulum stress mediated by ROS participates in cadmium exposure-induced MC3T3-E1 cell apoptosis.
Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis.
PKM2-mediated neuronal hyperglycolysis enhances the risk of Parkinson's disease in diabetic rats.
Osthole: A potential AMPK agonist that inhibits NLRP3 inflammasome activation by regulating mitochondrial homeostasis for combating rheumatoid arthritis.
METTL14-dependent maturation of pri-miR-17 regulates mitochondrial homeostasis and induces chemoresistance in colorectal cancer.
Selenium alleviates cadmium-induced mitophagy through FUNDC1-mediated mitochondrial quality control pathway in the lungs of sheep.
SIRT3-dependent mitochondrial redox homeostasis mitigates CHK1 inhibition combined with gemcitabine treatment induced cardiotoxicity in hiPSC-CMs and mice.
Nogo-B mediates endothelial oxidative stress and inflammation to promote coronary atherosclerosis in pressure-overloaded mouse hearts.
Mitochondrial fission drives neuronal metabolic burden to promote stress susceptibility in male mice.
Zinc Overload Induces Damage to H9c2 Cardiomyocyte Through Mitochondrial Dysfunction and ROS-Mediated Mitophagy.
Zearalenone promotes porcine ESCs apoptosis by enhancing Drp1-mediated mitochondrial fragmentation and activating the JNK pathway.
Ramelteon attenuates renal ischemia and reperfusion injury through reducing mitochondrial fission and fusion and inflammation.
The Binding of HSPA8 and Mitochondrial ALDH2 Mediates Oxygen-Glucose Deprivation-Induced Fibroblast Senescence.
CircRNA SCAR Improves High-Glucose-Induced Mitochondrial Dysfunction and Permeability Damage in Retinal Microvascular Endothelial Cells.
Loganin alleviated cognitive impairment in 3×Tg-AD mice through promoting mitophagy mediated by optineurin.
LDLR heterozygous deletion reduces hamster testicular cholesterol toxicity via AMPK/Sirt1/PGC-1α pathway.
Aristolochic acid I exposure triggers ovarian dysfunction by activating NLRP3 inflammasome and affecting mitochondrial homeostasis.
A single dose of exercise stimulates skeletal muscle mitochondrial plasticity in myotonic dystrophy type 1.
Possible frequent multiple mitochondrial DNA copies in a single nucleoid in HeLa cells.
Molybdenum and Cadmium Co-induce Mitochondrial Quality Control Disorder via FUNDC1-Mediated Mitophagy in Sheep Kidney.
Impact of UCP2 depletion on heat stroke-induced mitochondrial function in human umbilical vein endothelial cells.
Selenium Attenuates TBHP-Induced Apoptosis of Nucleus Pulposus Cells by Suppressing Mitochondrial Fission through Activating Nuclear Factor Erythroid 2-Related Factor 2.
Dynamin-Related Protein 1 Is Involved in Mitochondrial Damage, Defective Mitophagy, and NLRP3 Inflammasome Activation Induced by MSU Crystals.
Change in Oxidative Stress and Mitochondrial Dynamics in Response to Elevated Cold-Inducible RNA-Binding Protein in Cardiac Surgery-Associated Acute Kidney Injury.
Intracellular Ca(2+) Signaling and Calcium Release-Activated Calcium Modulator ORAI1 Are Associated With CD4(+) T Lymphocytes in Dairy Cows.
COA3 overexpression promotes non-small cell lung cancer metastasis by reprogramming glucose metabolism.
Non-invasive photobiomodulation treatment in an Alzheimer Disease-like transgenic rat model.
Mannose inhibits the growth of prostate cancer through a mitochondrial mechanism.
Empagliflozin Preserves Skeletal Muscle Function in a HFpEF Rat Model.
Depletion of serum-derived exosomes aggravates heat stress-induced damage of bovine mammary epithelial cells.
Blocking exosomal secretion aggravates 1,4-benzoquinone-induced mitochondrial fission activated by the AMPK/MFF/Drp1 pathway in HL-60 cells.
Integrated Analysis of Transcriptome and microRNA Profile Reveals the Toxicity of Euphorbia Factors toward Human Colon Adenocarcinoma Cell Line Caco-2.
The Endoplasmic Reticulum ATP13A1 is Essential for MAVS-Mediated Antiviral Innate Immunity.
Cadmium-induced apoptosis of Leydig cells is mediated by excessive mitochondrial fission and inhibition of mitophagy.
Sirt3 deficiency accelerates ovarian senescence without affecting spermatogenesis in aging mice.
Dihydromyricetin contributes to weight loss via pro-browning mediated by mitochondrial fission in white adipose.
AMPK/MFF Activation: Role in Mitochondrial Fission and Mitophagy in Dry Eye.
SIRT4 Expression Ameliorates the Detrimental Effect of Heat Stress via AMPK/mTOR Signaling Pathway in BMECs.
Heat shock protein 60 couples an oxidative stress-responsive p38/MK2 signaling and NF-κB survival machinery in cancer cells.
PACS-2 Ameliorates Tubular Injury by Facilitating Endoplasmic Reticulum-Mitochondria Contact and Mitophagy in Diabetic Nephropathy.
HSP70 attenuates compression-induced apoptosis of nucleus pulposus cells by suppressing mitochondrial fission via upregulating the expression of SIRT3.
PINK1 regulates mitochondrial fission/fusion and neuroinflammation in β-amyloid-induced Alzheimer's disease models.
Chicoric Acid Attenuated Renal Tubular Injury in HFD-Induced Chronic Kidney Disease Mice through the Promotion of Mitophagy via the Nrf2/PINK/Parkin Pathway.
PINK1/TAX1BP1-directed mitophagy attenuates vascular endothelial injury induced by copper oxide nanoparticles.
Carbon tetrachloride induced mitochondrial division, respiratory chain damage, abnormal intracellular [H(+)] and apoptosis are due to the activation of 5-HT degradation system in hepatocytes.
Autophagy and mitochondrial dynamics contribute to the protective effect of diosgenin against 3-MCPD induced kidney injury.
Long-term exercise pre-training attenuates Alzheimer's disease-related pathology in a transgenic rat model of Alzheimer's disease.
Regulatory roles of external cholesterol in human airway epithelial mitochondrial function through STARD3 signalling.
Effects of amyloid-β on protein SUMOylation and levels of mitochondrial proteins in primary cortical neurons.
Novel Thermosensitive Hydrogel Promotes Spinal Cord Repair by Regulating Mitochondrial Function.
Breast Cancer Selective Disruption of Actin Cytoskeleton by Diallyl Trisulfide.
Myosin II proteins are required for organization of calcium-induced actin networks upstream of mitochondrial division.
Aldehyde dehydrogenase 2 deficiency promotes skeletal muscle atrophy in aged mice.
Inhibition of nuclear deacetylase Sirtuin-1 induces mitochondrial acetylation and calcium overload leading to cell death.
Selenium alleviates cadmium-induced aging via mitochondrial quality control in the livers of sheep.
PEX11β and FIS1 cooperate in peroxisome division independently of mitochondrial fission factor.
Herceptin induces ferroptosis and mitochondrial dysfunction in H9c2 cells.
The SUMO protease SENP3 regulates mitochondrial autophagy mediated by Fis1.
Attenuates of NAD(+) impair BMSC osteogenesis and fracture repair through OXPHOS.
Protective Effects of Chaya against Mitochondrial and Synaptic Toxicities in the Type 2 Diabetes Mouse Model TallyHO.
Early Cellular, Molecular, Morphological and Behavioral Changes in the Humanized Amyloid-Beta-Knock-In Mouse Model of Late-Onset Alzheimer's Disease.
Protein C receptor maintains cancer stem cell properties via activating lipid synthesis in nasopharyngeal carcinoma.
Myricetin Restores Aβ-Induced Mitochondrial Impairments in N2a-SW Cells.
CHCHD2 and CHCHD10 regulate mitochondrial dynamics and integrated stress response.
Generation of a homozygous FIS1 knockout human embryonic stem cell line GIBHe015-B by CRISPR/Cas9 system.
Cdk5 Promotes Mitochondrial Fission via Drp1 Phosphorylation at S616 in Chronic Ethanol Exposure-Induced Cognitive Impairment.
SARS-CoV-2 mitochondriopathy in COVID-19 pneumonia exacerbates hypoxemia.
Perinatal exposure to glyphosate-based herbicides impairs progeny health and placental angiogenesis by disturbing mitochondrial function.
Protective Effect and Mechanism of Melatonin on Cisplatin-Induced Ovarian Damage in Mice.
A Combination Therapy of Urolithin A+EGCG Has Stronger Protective Effects than Single Drug Urolithin A in a Humanized Amyloid Beta Knockin Mice for Late-Onset Alzheimer's Disease.
A pivotal role of selective autophagy in mitochondrial quality control: Implications for zinc oxide nanoparticles induced neurotoxicity.
N(6)-adenomethylation of GsdmC is essential for Lgr5(+) stem cell survival to maintain normal colonic epithelial morphogenesis.
Chrono-Aerobic Exercise Optimizes Metabolic State in DB/DB Mice through CLOCK-Mitophagy-Apoptosis.
Nicotinamide mononucleotide alleviates heat stress-induced oxidative stress and apoptosis in BMECs through reducing mitochondrial damage and endoplasmic reticulum stress.
CLOCK regulates Drp1 mRNA stability and mitochondrial homeostasis by interacting with PUF60.
BNIP3 (BCL2 interacting protein 3) regulates pluripotency by modulating mitochondrial homeostasis via mitophagy.
Phosphorylation of Dynamin-Related Protein 1 (DRP1) Regulates Mitochondrial Dynamics and Skeletal Muscle Wasting in Cancer Cachexia.
KCa3.1 Mediates Dysregulation of Mitochondrial Quality Control in Diabetic Kidney Disease.
PP2 Ameliorates Renal Fibrosis by Regulating the NF-κB/COX-2 and PPARγ/UCP2 Pathway in Diabetic Mice.
RNA-Seq Profiling to Investigate the Mechanism of Qishen Granules on Regulating Mitochondrial Energy Metabolism of Heart Failure in Rats.
Tortoise Plastron and Deer Antler Gelatin Prevents Against Neuronal Mitochondrial Dysfunction In Vitro: Implication for a Potential Therapy of Alzheimer's Disease.
Elevated Lactate by High-Intensity Interval Training Regulates the Hippocampal BDNF Expression and the Mitochondrial Quality Control System.
Antioxidant activity of mesenchymal stem cell-derived extracellular vesicles restores hippocampal neurons following seizure damage.
Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington's disease.
Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity.
Effects of andrographolide on renal tubulointersticial injury and fibrosis. Evidence of its mechanism of action.
Calcium chelator BAPTA‑AM protects against iron overload‑induced chondrocyte mitochondrial dysfunction and cartilage degeneration.
Mechanisms of impaired mitochondrial homeostasis and NAD(+) metabolism in a model of mitochondrial heart disease exhibiting redox active iron accumulation.
Inhibition of ER stress attenuates kidney injury and apoptosis induced by 3-MCPD via regulating mitochondrial fission/fusion and Ca(2+) homeostasis.
SIRT3 protects bovine mammary epithelial cells from heat stress damage by activating the AMPK signaling pathway.
Melatonin protects against excessive autophagy-induced mitochondrial and ovarian reserve function deficiency though ERK signaling pathway in Chinese hamster ovary (CHO) cells.
Distinct fission signatures predict mitochondrial degradation or biogenesis.
Protective effects of a mitochondria-targeted small peptide SS31 against hyperglycemia-induced mitochondrial abnormalities in the liver tissues of diabetic mice, Tallyho/JngJ mice.
Dihydromyricetin attenuates heat stress-induced apoptosis in dairy cow mammary epithelial cells through suppressing mitochondrial dysfunction.
Protective effects of antidepressant citalopram against abnormal APP processing and amyloid beta-induced mitochondrial dynamics, biogenesis, mitophagy and synaptic toxicities in Alzheimer's disease.
Effects of photoperiod on morphology and function in testis and epididymis of Cricetulus barabensis.
Haemodynamic-directed cardiopulmonary resuscitation promotes mitochondrial fusion and preservation of mitochondrial mass after successful resuscitation in a pediatric porcine model.
The detrimental effect of iron on OA chondrocytes: Importance of pro-inflammatory cytokines induced iron influx and oxidative stress.
ALS/FTD mutations in UBQLN2 are linked to mitochondrial dysfunction through loss-of-function in mitochondrial protein import.
Effect of the interference with DRP1 expression on the biological characteristics of glioma stem cells.
Resveratrol and exercise combined to treat functional limitations in late life: A pilot randomized controlled trial.
ATPIF1 maintains normal mitochondrial structure which is impaired by CCM3 deficiency in endothelial cells.
Selonsertib, a potential drug for liver failure therapy by rescuing the mitochondrial dysfunction of macrophage via ASK1-JNK-DRP1 pathway.
Mesenchymal stem cells ameliorate lipid metabolism through reducing mitochondrial damage of hepatocytes in the treatment of post-hepatectomy liver failure.
CHIP protects against MPP(+)/MPTP-induced damage by regulating Drp1 in two models of Parkinson's disease.
Restoring metabolism of myeloid cells reverses cognitive decline in ageing.
The XBP1‒MARCH5‒MFN2 Axis Confers Endoplasmic Reticulum Stress Resistance by Coordinating Mitochondrial Fission and Mitophagy in Melanoma.
Carnosol alleviates nonalcoholic fatty liver disease by inhibiting mitochondrial dysfunction and apoptosis through targeting of PRDX3.
Chronic hypoxia alters cardiac mitochondrial complex protein expression and activity in fetal guinea pigs in a sex-selective manner.
Intranasal administration of DHED protects against exhaustive exercise-induced brain injury in rats.
Targeting P2RX1 alleviates renal ischemia/reperfusion injury by preserving mitochondrial dynamics.
LKB1/AMPKα signaling pathway and mitochondrial fission/fusion dynamics regulate apoptosis induced by 3-chlorpropane-1,2-diol in HEK293 cells.
Extract of Cynomorium songaricum ameliorates mitochondrial ultrastructure impairments and dysfunction in two different in vitro models of Alzheimer's disease.
Fis1 ablation in the male germline disrupts mitochondrial morphology and mitophagy, and arrests spermatid maturation.
Change on apoptosis, autophagy and mitochondria of the Harderian gland in Cricetulus barabensis during age.
Mst1 Knockout Alleviates Mitochondrial Fission and Mitigates Left Ventricular Remodeling in the Development of Diabetic Cardiomyopathy.
Deletion of Bmal1 Impairs Pancreatic β-Cell Function via Mitochondrial Signaling Pathway.
Proteomic Profile of Mouse Brain Aging Contributions to Mitochondrial Dysfunction, DNA Oxidative Damage, Loss of Neurotrophic Factor, and Synaptic and Ribosomal Proteins.
Drp1-mediated mitochondrial fission contributes to baicalein-induced apoptosis and autophagy in lung cancer via activation of AMPK signaling pathway.
The effect of autophagy and mitochondrial fission on Harderian gland is greater than apoptosis in male hamsters during different photoperiods.
Bu-Yin-Qian-Zheng Formula Ameliorates MPP(+)-Induced Mitochondrial Dysfunction in Parkinson's Disease via Parkin.
High-Intensity Interval Training Restores Glycolipid Metabolism and Mitochondrial Function in Skeletal Muscle of Mice With Type 2 Diabetes.
Photoperiod Affects Harderian Gland Morphology and Secretion in Female Cricetulus barabensis: Autophagy, Apoptosis, and Mitochondria.
Promotion of mitochondrial fusion protects against developmental PBDE-47 neurotoxicity by restoring mitochondrial homeostasis and suppressing excessive apoptosis.
Exercise enhances mitochondrial fission and mitophagy to improve myopathy following critical limb ischemia in elderly mice via the PGC1a/FNDC5/irisin pathway.
PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth.
HIF-1α ameliorates tubular injury in diabetic nephropathy via HO-1-mediated control of mitochondrial dynamics.
Novel ultrastructural findings on cardiac mitochondria of huddling Brandt's voles in mild cold environment.
Hypoxia induces pulmonary artery smooth muscle dysfunction through mitochondrial fragmentation-mediated endoplasmic reticulum stress.
Formation of colorectal liver metastases induces musculoskeletal and metabolic abnormalities consistent with exacerbated cachexia.
AIM2 promotes the development of non-small cell lung cancer by modulating mitochondrial dynamics.
PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway.
Mitochondrial Dynamics Regulation in Skin Fibroblasts from Mitochondrial Disease Patients.
ChREBP-β regulates thermogenesis in brown adipose tissue.
Drp1/Mff signaling pathway is involved in fluoride-induced abnormal fission of hepatocyte mitochondria in mice.
FKBP8 LIRL-dependent mitochondrial fragmentation facilitates mitophagy under stress conditions.
PKM2 suppresses osteogenesis and facilitates adipogenesis by regulating β-catenin signaling and mitochondrial fusion and fission.
Microcystin-leucine-arginine induced neurotoxicity by initiating mitochondrial fission in hippocampal neurons.
Genome-wide synthetic lethal CRISPR screen identifies FIS1 as a genetic interactor of ALS-linked C9ORF72.
Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease.
Desferoxamine protects against glucocorticoid-induced osteonecrosis of the femoral head via activating HIF-1α expression.
Mitochondrial Safeguard: a stress response that offsets extreme fusion and protects respiratory function via flickering-induced Oma1 activation.
PRCC-TFE3 regulates migration and invasion of translocation renal cell carcinomas via activation of Drp1-dependent mitochondrial fission.
USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation.
Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission.
Heat stress induces apoptosis through disruption of dynamic mitochondrial networks in dairy cow mammary epithelial cells.
An epigenetic increase in mitochondrial fission by MiD49 and MiD51 regulates the cell cycle in cancer: Diagnostic and therapeutic implications.
Exogenous H(2)S Promoted USP8 Sulfhydration to Regulate Mitophagy in the Hearts of db/db Mice.
DsbA-L deficiency exacerbates mitochondrial dysfunction of tubular cells in diabetic kidney disease.
SIRT3-Dependent Mitochondrial Dynamics Remodeling Contributes to Oxidative Stress-Induced Melanocyte Degeneration in Vitiligo.
Spermidine Prevents Heart Injury in Neonatal Rats Exposed to Intrauterine Hypoxia by Inhibiting Oxidative Stress and Mitochondrial Fragmentation.
Impaired Mitochondrial Fusion and Oxidative Phosphorylation Triggered by High Glucose Is Mediated by Tom22 in Endothelial Cells.
Parkin-mediated ubiquitination contributes to the constitutive turnover of mitochondrial fission factor (Mff).
Propofol Ameliorates H9c2 Cells Apoptosis Induced by Oxygen Glucose Deprivation and Reperfusion Injury via Inhibiting High Levels of Mitochondrial Fusion and Fission.
Da-Bu-Yin-Wan and Qian-Zheng-San Ameliorate Mitochondrial Dynamics in the Parkinson's Disease Cell Model Induced by MPP().
Icariin Protects Bone Marrow Mesenchymal Stem Cells Against Iron Overload Induced Dysfunction Through Mitochondrial Fusion and Fission, PI3K/AKT/mTOR and MAPK Pathways.
Mitochondrial dysfunction in endothelial cells induced by airborne fine particulate matter (<2.5 μm).
Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae.
SS-31 reduces inflammation and oxidative stress through the inhibition of Fis1 expression in lipopolysaccharide-stimulated microglia.
Proteomic Analysis and Biochemical Correlates of Mitochondrial Dysfunction after Low-Intensity Primary Blast Exposure.
A maternal high-fat, high-sucrose diet induces transgenerational cardiac mitochondrial dysfunction independently of maternal mitochondrial inheritance.
Low-dose oral copper treatment changes the hippocampal phosphoproteomic profile and perturbs mitochondrial function in a mouse model of Alzheimer's disease.
Roles of mitochondrial fission inhibition in developmental fluoride neurotoxicity: mechanisms of action in vitro and associations with cognition in rats and children.
ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects.
Angiotensin II suppresses autophagy and disrupts ultrastructural morphology and function of mitochondria in mouse skeletal muscle.
Oxidative pathophysiology following volumetric muscle loss injury in a porcine model.
Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations.
Fibroblast growth factor 18 exerts anti-osteoarthritic effects through PI3K-AKT signaling and mitochondrial fusion and fission.
Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy.
Two separate functions of NME3 critical for cell survival underlie a neurodegenerative disorder.
Mitochondrial division inhibitor 1 reduces dynamin-related protein 1 and mitochondrial fission activity.
Hepatic HKDC1 Expression Contributes to Liver Metabolism.
Burn-induced reductions in mitochondrial abundance and efficiency are more pronounced with small volumes of colloids in swine.
Novel findings on ultrastructural protection of skeletal muscle fibers during hibernation of Daurian ground squirrels: Mitochondria, nuclei, cytoskeleton, glycogen.
Pyridostigmine regulates glucose metabolism and mitochondrial homeostasis to reduce myocardial vulnerability to injury in diabetic mice.
Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells.
Polybrene induces neural degeneration by bidirectional Ca(2+) influx-dependent mitochondrial and ER-mitochondrial dynamics.
In Vivo Deletion of β-Cell Drp1 Impairs Insulin Secretion Without Affecting Islet Oxygen Consumption.
A high-fat diet impairs mitochondrial biogenesis, mitochondrial dynamics, and the respiratory chain complex in rat myocardial tissues.
Aerobic Exercise Preconception and During Pregnancy Enhances Oxidative Capacity in the Hindlimb Muscles of Mice Offspring.
AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells.
Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer's disease.
INF2-mediated actin polymerization at the ER stimulates mitochondrial calcium uptake, inner membrane constriction, and division.
GLUT10 maintains the integrity of major arteries through regulation of redox homeostasis and mitochondrial function.
Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer's disease.
Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer's disease.
Neuroprotective Effect and Mechanism of Thiazolidinedione on Dopaminergic Neurons In Vivo and In Vitro in Parkinson's Disease.
Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission.
Salvianolic acid B inhibits mitochondrial dysfunction by up-regulating mortalin.
Mitochondrial dynamics changes with age in an APPsw/PS1dE9 mouse model of Alzheimer's disease.
Phosphorylation of dynamin-related protein 1 at Ser616 regulates mitochondrial fission and is involved in mitochondrial calcium uniporter-mediated neutrophil polarization and chemotaxis.
p62-Mediated mitochondrial clustering attenuates apoptosis induced by mitochondrial depolarization.
Low-level laser therapy for beta amyloid toxicity in rat hippocampus.
Sirtuin 5 protects mitochondria from fragmentation and degradation during starvation.
Hydrogen Sulphide modulating mitochondrial morphology to promote mitophagy in endothelial cells under high-glucose and high-palmitate.
Receptor-mediated Drp1 oligomerization on endoplasmic reticulum.
Ischemia-induced Drp1 and Fis1-mediated mitochondrial fission and right ventricular dysfunction in pulmonary hypertension.
AP39, a Mitochondria-Targeted Hydrogen Sulfide Donor, Supports Cellular Bioenergetics and Protects against Alzheimer's Disease by Preserving Mitochondrial Function in APP/PS1 Mice and Neurons.
Autophagy plays a role in skeletal muscle mitochondrial biogenesis in an endurance exercise-trained condition.
Dysfunctional tubular endoplasmic reticulum constitutes a pathological feature of Alzheimer's disease.
Quantification and Characterization of UVB-Induced Mitochondrial Fragmentation in Normal Primary Human Keratinocytes.
Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease.
Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology.
FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions.
Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria.
Resveratrol Induces Cancer Cell Apoptosis through MiR-326/PKM2-Mediated ER Stress and Mitochondrial Fission.
Protective effects of reduced dynamin-related protein 1 against amyloid beta-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease.
Mitochondrial division inhibitor 1 protects against mutant huntingtin-induced abnormal mitochondrial dynamics and neuronal damage in Huntington's disease.
The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission.
Mutations in Fis1 disrupt orderly disposal of defective mitochondria.
RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway.
PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation.
Loss of Yme1L perturbates mitochondrial dynamics.
Mitochondrial abnormalities in temporal lobe of autistic brain.
A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity.
Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration.
Dynamin-related protein 1 heterozygote knockout mice do not have synaptic and mitochondrial deficiencies.
Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage.
Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease.
Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage.
Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons.
Yu Q, Wei X, Shi J, Li W, Zhao Y, Yang Q, Qiao J, Sun F, Li T
Frontiers in cell and developmental biology 2026;14:1788805
Frontiers in cell and developmental biology 2026;14:1788805
The purinergic receptor P2rx7 mediated ATP sensing is required to prevent bone aging by directing mitochondrial fitness of MSCs.
Zhuang Z, Han C, Cai M, Li M, Lin S, Chen L, Zhu Z, Zhang H, Xing C, Han B, Yang R
Journal of advanced research 2026 Mar;81:349-364
Journal of advanced research 2026 Mar;81:349-364
Trans-Omics Integration Reveals That the Kidney Contributes to Systemic Aging via Sexually Dimorphic Accumulation of Glycosphingolipids.
Ni Z, Cao C, Tian Y, Mu J, Tian H, Wang Z, Zhang S, Cao M, Yang Y, Lim WLF, Cui J, Sun H, Miao H, Wang Y, Du J, Kwok T, Chen H, Lam SM, Shui G
MedComm 2026 Mar;7(3):e70669
MedComm 2026 Mar;7(3):e70669
Targeting NME3 to Restore Mitochondrial Fission-Fusion Balance Defines a Novel Disease-Modifying Strategy for Parkinson's Disease.
Qiao C, Hu XQ, Xu SH, Yao MF, Liu JP, Cao L
CNS neuroscience & therapeutics 2026 Mar;32(3):e70822
CNS neuroscience & therapeutics 2026 Mar;32(3):e70822
Regulation of mitophagy by Fis1 and Fascin1-organized actin.
Nakajima S, Wang TY, Chou TF, Chakrabarty Y, Chan DC
Current biology : CB 2026 Mar 9;36(5):1205-1219.e8
Current biology : CB 2026 Mar 9;36(5):1205-1219.e8
Metabolic beneficial effects of targeting a long non-coding RNA, lnc-megacluster, in obesity.
Abdollahi M, Malek V, Tanwar VS, Kato M, Lanting L, Rezaei A, Zhang L, Yang L, Pillai RK, Kebrom L, Nandi J, Huang W, Ma K, Natarajan R
Molecular therapy. Nucleic acids 2026 Mar 12;37(1):102792
Molecular therapy. Nucleic acids 2026 Mar 12;37(1):102792
A dual-responsive CO-releasing nanogel ameliorates retinal ischemia-reperfusion injury by restoring mitochondrial homeostasis and attenuating cGAS-STING pathway activation.
Xiao D, Qin J, Zhang F, Tao T, Tang W, Cai X, Tao L, Wang X, Jiang Z
Materials today. Bio 2026 Jun;38:102974
Materials today. Bio 2026 Jun;38:102974
RIPK3 Inhibition Mitigates Denervated Muscle Atrophy via NOX4-Mediated Mitochondrial Restoration and Inflammation Suppression.
Shen Y, Zhang C, Zhao Z, Yi J, Yao X, Chen B, Sun H
Journal of cachexia, sarcopenia and muscle 2026 Jun;17(3):e70311
Journal of cachexia, sarcopenia and muscle 2026 Jun;17(3):e70311
Brusatol derivative ameliorates rheumatoid arthritis and atherosclerosis with associated suppression of mitochondrial fission.
Ma R, Liu J, Yang S, Chen G, Ren J, Zhang C, Chen X, Zhao Y, Zhang J, Yin C, Li X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158171
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158171
Overexpression of mitofusin 2 ameliorates inflammation and oxidative stress in lipopolysaccharide-induced mastitis model by regulating phosphofurin acidic cluster sorting protein 2.
Zhou X, Zhang Y, Ma H, Fu S, Liu J, Guo W, Tian X, Huang B
Animal models and experimental medicine 2026 Jan;9(1):154-167
Animal models and experimental medicine 2026 Jan;9(1):154-167
Volitional exercise elicits physiological and molecular improvements in the severe D2.mdx mouse model of Duchenne muscular dystrophy.
Mattina SR, Ng SY, Mikhail AI, Stouth DW, Jornacion CE, Rebalka IA, Hawke TJ, Ljubicic V
The Journal of physiology 2026 Jan;604(2):849-867
The Journal of physiology 2026 Jan;604(2):849-867
BDH1 Mediates Aerobic Exercise-Induced Improvement in Skeletal Muscle Metabolic Remodeling in Type 2 Diabetes Mellitus.
Wu M, Ma X, Dai W, Li K, Gao H, Guo Y, Xiao W
Biomolecules 2026 Jan 8;16(1)
Biomolecules 2026 Jan 8;16(1)
Macelignan, a lignan from Myristica fragrans Houtt., rescues mitochondrial homeostasis and prevents cognitive decline in vascular dementia by modulating the mTOR-Mitophagy axis.
Qi Z, Chu X, Li S, Bai Q, Ding N, Yan G, Yu H, Cui C
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120603
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120603
Systematic evaluation of mitochondrial morphology regulators for amelioration of neuronal α-synucleinopathy.
Kim SY, Choi J, Jang DC, Lee PR, Hong GS, Kim J, Jeong WK, Han K, Kwon SK
NPJ Parkinson's disease 2026 Jan 27;12(1)
NPJ Parkinson's disease 2026 Jan 27;12(1)
Dying oligodendrocytes persist without mitochondria.
Bame X, Gilani SZ, Kamen Y, Hill RA
bioRxiv : the preprint server for biology 2026 Jan 22;
bioRxiv : the preprint server for biology 2026 Jan 22;
The Synthetic Cannabinoid ADB-FUBINACA Disrupts Mitochondrial Morphology and Dynamics during Neuronal Differentiation of NG108-15 Cells.
Malheiro RF, Costa AC, Pereira-Teixeira C, Carmo H, Carvalho F, Silva JP
Molecular neurobiology 2026 Jan 21;63(1):382
Molecular neurobiology 2026 Jan 21;63(1):382
The UBC/SIRT5/DRP1 axis regulates mitochondrial dynamics to alleviate Staphylococcus aureus-induced oxidative stress and senescence in bovine mammary epithelial cells.
Hu H, Jiang N, Liu J, Bi J, Liu X, Xu B, Cao Y, Guo W, Fu S
PLoS pathogens 2026 Feb;22(2):e1013975
PLoS pathogens 2026 Feb;22(2):e1013975
Idebenone alleviates rotenone-induced mitochondrial dysfunction through mitophagy and mitochondrial biogenesis in muscle cells.
Zhang C, Li M, Meng L, Xia W, Wu G
Cellular signalling 2026 Feb;138:112221
Cellular signalling 2026 Feb;138:112221
The synthetic cannabinoid THJ-2201 modulates mitochondrial activity and enhances mitochondrial recruitment to newly-forming neurites during neurodifferentiation of NG108-15 cells.
Malheiro RF, Costa AC, Carmo H, Carvalho F, Silva JP
Archives of toxicology 2026 Feb;100(2):657-676
Archives of toxicology 2026 Feb;100(2):657-676
Curcumin-loaded silk fibroin scaffold promotes cartilage regeneration by inhibiting angiogenesis via Drp1/ROS-mediated mitochondrial regulation.
Zhao Z, Fu J, Han J, Pan Y, Xue B, Sun X, Ma Y, Li B, Chen K, Li Z, Liang Z, Zhou X, Guo Y, Tu P
Journal of biological engineering 2026 Feb 2;20(1)
Journal of biological engineering 2026 Feb 2;20(1)
Redox switch C674 in SERCA2 triggers Ca(2+)-calcineurin-MCU-Drp1 cascade and pulmonary vascular remodeling.
Chen H, Qiu YX, Xie YF, Chen X, Xiang YY, Zhang HL, Yu WM, Hu PP, Wang LT, Wu FH, Tong XY
Free radical biology & medicine 2026 Feb 16;244:380-394
Free radical biology & medicine 2026 Feb 16;244:380-394
Mitigation of Ischemia/Reperfusion-Induced Acute Kidney Injury by Canagliflozin Is Associated with Altered Mitochondrial Dynamics and Reduced Proliferation in Swine.
Killingsworth ZK, Chaudhary M, Mares JA, Ellery H, Rowe CJ, Stewart IJ, Walker PF, Burmeister DM
Biomolecules 2026 Feb 10;16(2)
Biomolecules 2026 Feb 10;16(2)
Trimethylamine-N-oxide disrupts spermatogenesis by inducing mitochondrial oxidative stress injury through Hippo signaling.
Wang S, Ma G, Qi C, Cheng S, Lai H, Zhou L, Wu G, Chen Z, Mao X, Jing T, He Y, Zhou H
Free radical biology & medicine 2026 Feb 1;243:452-465
Free radical biology & medicine 2026 Feb 1;243:452-465
Modified Erxian Decoction ameliorates premature ovarian insufficiency via HIF-1α-mediated regulation of mitochondrial fission and oxidative stress.
Deng D, Zeng Z, Feng J, Guo J
Journal of ethnopharmacology 2026 Aug 10;367:121768
Journal of ethnopharmacology 2026 Aug 10;367:121768
Mitochondrial TRPV1 exacerbates cognitive deficits in sepsis-associated encephalopathy by driving microglial metabolic reprogramming.
Fan Z, Du L, Yin L, Liu H, Li M, Li J, Liu F, Yang L, Li J, Wang Q, Wu Y, Ma H, Zhang X
Free radical biology & medicine 2026 Apr;247:448-468
Free radical biology & medicine 2026 Apr;247:448-468
Schisandrol B protects against lithocholic acid-induced cholestatic liver injury in mice through mitochondrial biogenesis.
Yang X, Liang H, Li X, Tian J, Fan S, Huang M, Wan J, Zuo Z, Guo H, Bi H
Chinese medicine 2026 Apr 14;21(1)
Chinese medicine 2026 Apr 14;21(1)
Macrophage-derived S100A9 promotes diabetic cardiomyopathy by disturbing mitochondrial quality control via STAT3 activation.
Huo S, Wang M, Du M, Ren B, Yang T, Peng L, Jiang Y, Peng D, Men L, Shi W, Guo J, Zhang C, Lv J, Li S, Lin L
International journal of biological sciences 2025;21(7):3061-3080
International journal of biological sciences 2025;21(7):3061-3080
Lipin3 deficiency aggravates cisplatin induced acute kidney injury via activating Sirt1-p21-Caspase 3-GSDME pyroptosis pathway.
Liu YX, Huang H, Wang F, Zhao MF, Jin JY, Dong Y, Wang Q, Fan LL, Xiang R
International journal of biological sciences 2025;21(12):5185-5205
International journal of biological sciences 2025;21(12):5185-5205
Astragaloside IV Alleviates H(2)O(2)-Induced Mitochondrial Dysfunction and Inhibits Mitophagy Via PI3K/AKT/mTOR Pathway.
Qi M, Wang Q, Sun R, Cheng Z, Li M, Fan X, Bai F, Yu J
Cardiovascular therapeutics 2025;2025:9549175
Cardiovascular therapeutics 2025;2025:9549175
Social jetlag alters markers of exercise-induced mitochondrial adaptations in the heart.
Dial MB, Malek EM, Cooper AR, Neblina GA, Vasileva NI, McGinnis GR
Npj biological timing and sleep 2025;2(1)
Npj biological timing and sleep 2025;2(1)
The Role of Placental MFF-Mediated Mitochondrial Fission in Gestational Diabetes Mellitus.
Wei L, Fang C, Jiang Y, Zhang H, Gao P, Zhou X, Zhu S, Du Y, Su R, Guo L, He M, Wang S, Feng L, Yu J
Diabetes, metabolic syndrome and obesity : targets and therapy 2025;18:541-554
Diabetes, metabolic syndrome and obesity : targets and therapy 2025;18:541-554
Metformin Activation of Sirtuin 3 Signaling Regulates Mitochondrial Function Improves Diabetes-Associated Cognitive Impairment.
An JF, Su H, Zhang CQ, Wang XT, Zhang GQ, Fu LY, Xu YN, Tao L, Shen XC
Diabetes, metabolic syndrome and obesity : targets and therapy 2025;18:2317-2330
Diabetes, metabolic syndrome and obesity : targets and therapy 2025;18:2317-2330
Bone-targeted mitochondrial delivery via magnetic-temperature responsive artificial cells for repairing age-related fractures.
Nie S, Yu Y, Yan R, Liu T, Du Y, Luo Z, Li S, Huang J
Frontiers in pharmacology 2025;16:1725973
Frontiers in pharmacology 2025;16:1725973
Calcium dysregulation disrupts mitochondrial homeostasis by interfering AMPK/Drp1 pathway to aggravate plaque progression and instability.
Hu P, Liu M, Wu T, Zhang Y, Liu C, Wang L, Zhang W, Que Y, You J, Yu W, Tong X
Theranostics 2025;15(15):7567-7583
Theranostics 2025;15(15):7567-7583
Reniformin A Suppresses Triple-Negative Breast Cancer Progression by Inducing DRP1-Mediated Mitochondrial Dysfunction and Apoptosis.
Guan Y, Liu L, Wang W, Zheng R, Lin P, Liu Y, Chen S, Zhu H, Liu X, Huang H
Phytotherapy research : PTR 2025 Sep;39(9):4011-4027
Phytotherapy research : PTR 2025 Sep;39(9):4011-4027
Isatin ameliorates ovarian inflammation and apoptosis caused by hormonal imbalances in PCOS mice.
Li X, Ye T, Zhu W, Gu J, Zheng Z, Wang C, Zhang X, Geng H, Zhou W, Tan X, Ma Y, Zhang H, Wang X
Biochemical pharmacology 2025 Sep;239:117083
Biochemical pharmacology 2025 Sep;239:117083
Mito-tempo ameliorates tubular injury of diabetic nephropathy via inhibiting mt-dsRNA release and PKR/eIF2α pathway activation.
Duan T, Sun L, Xi Y, Li C, Zhao Q, Xu L, Yang M, Liu C, Xiao L, Deng T, Sun L
Free radical biology & medicine 2025 Sep;237:147-159
Free radical biology & medicine 2025 Sep;237:147-159
Hsp60 lactylation promotes mitochondrial dysfunction and trophoblast apoptosis in preeclampsia.
Xu J, Wang X, Qin Z, Liu J, Chen J, Li Q, Wang X, Zhuang L
Biochemical and biophysical research communications 2025 Sep 8;778:152379
Biochemical and biophysical research communications 2025 Sep 8;778:152379
Kaempferol improves mitochondrial homeostasis via mitochondrial dynamics and mitophagy in diabetic kidney disease.
Xia C, Zhang J, Chen H, Jiang W, Zhou S, Zheng H, Sun W
International immunopharmacology 2025 Sep 23;162:115121
International immunopharmacology 2025 Sep 23;162:115121
Rab14 promotes Parkin-mediated mitophagy.
Momtaz S, Padilla-Rodriguez M, Flores PC, Rulli N, Lee NY, Wilson JM
Molecular biology of the cell 2025 Sep 1;36(9):ar117
Molecular biology of the cell 2025 Sep 1;36(9):ar117
Sex-specific impact of selective reduced uterine placental perfusion model of preeclampsia on fetal cardiac maturation and mitochondrial function.
Chatterjee P, Molberg R, Kirschenman R, Holody CD, Quon A, Spaans F, Bourque SL, Lemieux H, Davidge ST
American journal of physiology. Regulatory, integrative and comparative physiology 2025 Sep 1;329(3):R474-R486
American journal of physiology. Regulatory, integrative and comparative physiology 2025 Sep 1;329(3):R474-R486
Gestational zearalenone causes fetal intrauterine growth restriction partially through deriving ROS-Drp1 mediated placental PANoptosis.
Liu JR, Wu FN, Lin S, Chen C, Liu Y, Fan JW, Hong Q, Chen YH
Ecotoxicology and environmental safety 2025 Sep 1;302:118636
Ecotoxicology and environmental safety 2025 Sep 1;302:118636
Mechanistic study of the novel peroxidase mimetic DhHP-6 in metabolic cataracts.
Li Z, Gong P, Tian Y, Wang X, Zhang H
Free radical biology & medicine 2025 Oct;238:450-462
Free radical biology & medicine 2025 Oct;238:450-462
PPP1R3G inhibition impairs OPCs differentiation and myelination in aged mice.
Feng ZW, Miao X, Shi H, Zhang C, Wang G, Ding YN, Shi KX, Tang ZM, Yao RQ, Liu HY
International immunopharmacology 2025 Oct 30;164:115365
International immunopharmacology 2025 Oct 30;164:115365
Atrazine-induced hippocampal neurotoxicity: Involvement of Drp1-mediated mitochondrial fission.
Yang J, Qi L, Zhang C, Ding R, Bi H, Li P, Qi Z, Niu Q, Song W, Li J
Chemico-biological interactions 2025 Oct 22;420:111676
Chemico-biological interactions 2025 Oct 22;420:111676
One day of environment-induced heat stress causes injury to the murine kidney.
Roths M, Michael A, Schlader ZJ, Selsby JT
Experimental physiology 2025 Oct 2;
Experimental physiology 2025 Oct 2;
SAP30BP aggravates mitochondrial-related ferroptosis in diabetic cardiomyopathy by regulating MFN2-ACSL4 axis.
Zhao T, Chen C, Zhao W, Han J, Omar Jan M, Lou H, Chen Z, Liu X, Jing S
European journal of pharmacology 2025 Oct 15;1005:178046
European journal of pharmacology 2025 Oct 15;1005:178046
S100A9 inhibition ameliorates HFpEF by modulating mitochondrial fission and oxidative stress.
Wang M, Ren B, Wu X, Guo J, Cao Y, Men L, Shi W, Zhang C, Lin L, Lv J, Li S, Huo S
International immunopharmacology 2025 Oct 10;163:115280
International immunopharmacology 2025 Oct 10;163:115280
Disruption of cellular redox homeostasis by bigelovin triggers oxidative stress-mediated apoptosis in Fibrosarcoma.
Xi J, Wu Q, Wang Y, Liu Y, Yang G, Wang Y, Yao X, Zhang Z, Fang J
Bioorganic chemistry 2025 Nov;166:109147
Bioorganic chemistry 2025 Nov;166:109147
AMPK impairment caused by gelatin disturbs mitochondrial dynamics leading to enhanced phagocytosis of bacteria in PMA-stimulated U937 cells.
Chen K, Sun X, Feng Y, Jiang S, Hayashi T, Itoh K, Mizuno K, Hattori S, Fujisaki H, Liu W, Ikejima T
Cellular signalling 2025 Nov;135:111985
Cellular signalling 2025 Nov;135:111985
Lactoferrin alleviates doxorubicin-induced myocardial injury in mice: Associations with gut microbiota and microbial metabolites.
Wu X, Yang J, Suo H, Song J
Journal of dairy science 2025 Nov;108(11):11853-11870
Journal of dairy science 2025 Nov;108(11):11853-11870
Oxymatrine Alleviates Cerebral Ischemia/Reperfusion Injury By Targeting HDAC1 to Regulate Mitochondria-Related Autophagy and Oxidative Stress.
Ma CS, Han B, Liu YX, Shi CK, Li DL, Guo JF, Bai M, Meng SC, Zhang LY, Duan MY, He MT
Molecular neurobiology 2025 Nov 29;63(1):219
Molecular neurobiology 2025 Nov 29;63(1):219
Inhibition of SIRT1/PGC-1α Axis Exacerbates Fluorine and Aluminium Induced Neurotoxicity via Drp1-dependent Aggravated Mitochondrial Fission.
Yang L, Qian X, Jiang H, Xie C
Molecular neurobiology 2025 Nov 26;63(1):177
Molecular neurobiology 2025 Nov 26;63(1):177
MSCs ameliorates hyperglycemia-induced endothelial injury through modulation of mitochondrial dynamics.
Wei J, Mao R, Chen Y, Si K, Li Y, Li J, Zhu W
Cell death & disease 2025 Nov 17;16(1):832
Cell death & disease 2025 Nov 17;16(1):832
B355252 Targets UCP2 to Rescue Intracerebral Hemorrhage-Induced Injury by Promoting Mitochondrial Fusion and Inhibiting Ferroptosis.
Han B, Ma C, Liu Y, Shi C, Guo J, Bai M, Duan M, Meng S, Liu J, He M
Molecular neurobiology 2025 Nov 15;63(1):43
Molecular neurobiology 2025 Nov 15;63(1):43
GLP-1/GIP dual agonist tirzepatide alleviates mice model of Parkinson's disease by promoting mitochondrial homeostasis.
Tian R, Liu K, Lai H, Liao C, Li J, Tu H
International immunopharmacology 2025 Nov 14;165:115443
International immunopharmacology 2025 Nov 14;165:115443
Activin A protects against lipopolysaccharide/TNF-α induced damage of dopaminergic neurons both in vivo and in vitro by regulating mitochondrial fusion.
Zhang Y, Tian S, Niu M, Yang H, Liu L, Kang Y, Yin Y
Neuroscience 2025 Nov 10;587:108-122
Neuroscience 2025 Nov 10;587:108-122
Protective effect of astragaloside IV against zinc oxide nanoparticles induced human neuroblastoma SH-SY5Y cell death: a focus on mitochondrial quality control.
Wang L, Zhang L, Yun Y, Liang T, Yan C, Mao Z, Zhang J, Liu B, Zhang J, Liang T
Molecular and cellular biochemistry 2025 May;480(5):3079-3095
Molecular and cellular biochemistry 2025 May;480(5):3079-3095
Effective compound combination of Bufei Yishen formula ameliorates PM2.5-induced COPD by inhibiting mitochondrial oxidative stress through SIRT3-mediated FOXO3 deacetylation.
Wang J, Yue H, Dong Y, Liu T, Li J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156568
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156568
Silicon Enhances Functional Mitochondrial Transfer to Improve Neurovascularization in Diabetic Bone Regeneration.
Ma YX, Lei C, Ye T, Wan QQ, Wang KY, Zhu YN, Li L, Liu XF, Niu LZ, Tay FR, Mu Z, Jiao K, Niu LN
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(19):e2415459
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(19):e2415459
Lycium barbarum glycopeptide attenuates intracerebral hemorrhage-induced inflammation and oxidative stress via activation of the Sirt3 signaling pathway.
Ma CS, Han B, Meng SC, Bai M, Yi WJ, Zhang LY, Duan MY, Wang YJ, He MT
International immunopharmacology 2025 May 8;154:114518
International immunopharmacology 2025 May 8;154:114518
A hidden cysteine in Fis1 targeted to prevent excessive mitochondrial fission and dysfunction under oxidative stress.
Pokhrel S, Heo G, Mathews I, Yokoi S, Matsui T, Mitsutake A, Wakatsuki S, Mochly-Rosen D
Nature communications 2025 May 6;16(1):4187
Nature communications 2025 May 6;16(1):4187
Lithium with environmentally relevant concentrations interferes with mitochondrial function, antioxidant response, and autophagy processes in Daphnia magna, leading to changes in life-history traits and behavior.
Duan C, Zhao Y, Xiao Y, Hou Y, Gong W, Zhang H, Wang Y, Nie X
Journal of hazardous materials 2025 May 5;488:137420
Journal of hazardous materials 2025 May 5;488:137420
ZLN005, a PGC-1α agonist, delays photoreceptor degeneration by enhancing mitochondrial biogenesis in a murine model of retinitis pigmentosa.
Hu C, Ren C, Wu Y, Lin R, Shen T, Li T, Yu D, Jiang L, Wan Z, Luo Y, Su T, Yu J, Qiu Y
Neuropharmacology 2025 May 15;269:110361
Neuropharmacology 2025 May 15;269:110361
JAK2/STAT3/HMGCS2 signaling aggravates mitochondrial dysfunction and oxidative stress in hyperuricemia-induced cardiac dysfunction.
Peng D, He X, Ren B, Wang Q, Peng L, Jiang Y, Huo S, Men L, Shi W, Luo P, Zhu M, Zhang C, Lv J, Lin L, Li S
Molecular medicine (Cambridge, Mass.) 2025 May 13;31(1):184
Molecular medicine (Cambridge, Mass.) 2025 May 13;31(1):184
Coral calcium hydride promotes peripheral mitochondrial division and reduces AT-II cells damage in ARDS via activation of the Trx2/Myo19/Drp1 pathway.
Li Q, Ang Y, Zhou QQ, Shi M, Chen W, Wang Y, Yu P, Wan B, Yu W, Jiang L, Shi Y, Lin Z, Song S, Duan M, Long Y, Wang Q, Liu W, Bao H
Journal of pharmaceutical analysis 2025 Mar;15(3):101039
Journal of pharmaceutical analysis 2025 Mar;15(3):101039
Zn(2+) protects H9C2 cardiomyocytes by alleviating MAMs-associated apoptosis and calcium signaling dysregulation.
Guo J, Ma T, Wang B, Xing B, Huang L, Li X, Zheng H, He Y, Xi J
Cellular signalling 2025 Mar;127:111629
Cellular signalling 2025 Mar;127:111629
Procyanidin B2 alleviates damage to mouse testicular tissue after freezing by inhibiting oxidative stress and apoptosis.
Cao G, Li C, Zhang J, Deng L, Li R, Xu C
Cryobiology 2025 Mar;118:105196
Cryobiology 2025 Mar;118:105196
Melatonin refines ovarian mitochondrial dysfunction in PCOS by regulating the circadian rhythm gene Clock.
Chen W, Zhang H, Guo B, Tao Y, Zhang J, Wang J, Chen G, Cheng M, Hong Q, Cao Y, Xie F
Cellular and molecular life sciences : CMLS 2025 Mar 6;82(1):104
Cellular and molecular life sciences : CMLS 2025 Mar 6;82(1):104
Impact of POU3F4 mutation on cochlear development and auditory function.
Dang J, Bian P, Chen C, Chen C, Shan W, Cai L, Li Y, Tan H, Xu B, Guan M, Guo Y
Cell communication and signaling : CCS 2025 Mar 5;23(1):121
Cell communication and signaling : CCS 2025 Mar 5;23(1):121
Electroacupuncture promotes neural function recovery by alleviating mitochondria damage in cerebral ischemia mice.
Yashuo F, Chong G, Zhe Y, Lu C, Hongyu X, Yi W, Nianhong W
Brain research 2025 Mar 15;1851:149479
Brain research 2025 Mar 15;1851:149479
Melatonin ameliorates Pb-induced mitochondrial homeostasis and ovarian damage through regulating the p38 signaling pathway.
Yang ZN, Du X, Wang A, Zhao YH, Xia YH, Shi LG, Ding SM, Yue XY, Xing F, Ji DM, Liang D, Zha ZB, Liang CM, Cao YX, Liu YJ
Ecotoxicology and environmental safety 2025 Mar 1;292:117937
Ecotoxicology and environmental safety 2025 Mar 1;292:117937
Inhibition of autophagy attenuates cognitive decline and mitochondrial dysfunction in an Alzheimer's disease mouse model with chronic cerebral hypoperfusion.
Yang Q, Chen T, Li S, Yang C, Zheng X, Mao S, Liu N, Mo S, Li D, Yang M, Lu Z, Tang L, Huang X, Liu X, Jian C, Yin Y, Shang J
Brain research 2025 Mar 1;1850:149416
Brain research 2025 Mar 1;1850:149416
SIRT4 Protects Müller Glial Cells Against Apoptosis by Mediating Mitochondrial Dynamics and Oxidative Stress.
Luo H, Jin M, Hu H, Ying Q, Hu P, Sheng W, Huang Y, Xu K, Lu C, Zhang X
Molecular neurobiology 2025 Jun;62(6):6683-6702
Molecular neurobiology 2025 Jun;62(6):6683-6702
Lycium barbarum polysaccharide alleviate cadmium-induced mitochondrial dysfunction mediated pyroptosis in duck liver.
Song J, Luo X, Xiong L, Li S, Chen Y, Liu W, Yuan Y, Ma Y, Bian J, Liu Z, Zou H
International journal of biological macromolecules 2025 Jun;311(Pt 4):143989
International journal of biological macromolecules 2025 Jun;311(Pt 4):143989
The crucial function of IDO1 in pulmonary fibrosis: From the perspective of mitochondrial fusion in lung fibroblasts and targeted molecular inhibition.
Wang L, Ge S, Zhang Y, Feng D, Zhu T, Zhang L, Zhang C
Acta pharmaceutica Sinica. B 2025 Jun;15(6):3125-3148
Acta pharmaceutica Sinica. B 2025 Jun;15(6):3125-3148
PFOS causes lysosomes-regulated mitochondrial fission through TRPML1-VDAC1 and oligomerization of MCU/ATP5J2.
Yang W, Li Y, Feng R, Liang P, Tian K, Hu L, Wang K, Qiu T, Zhang J, Sun X, Yao X
Journal of hazardous materials 2025 Jun 5;489:137685
Journal of hazardous materials 2025 Jun 5;489:137685
Identification and validation of PARK7 as a novel mitochondria-related signature associated with immune microenvironment in asthma.
Li X, Qi S, Jiang Y, Nie X, Wang W
International immunopharmacology 2025 Jun 5;157:114750
International immunopharmacology 2025 Jun 5;157:114750
MiR221/222 in the conditioned medium of adipose-derived stem cells attenuates particulate matter and high-fat diet-induced cardiac apoptosis.
Chen YC, Pu CM, Lin SR, Lin SW, Yu IS, Shih HJ, Lee CW, Lee MH, Kuo YT, Chen YL
Stem cell research & therapy 2025 Jun 3;16(1):285
Stem cell research & therapy 2025 Jun 3;16(1):285
Icariin mitigates depressive-like behavior in rats by regulating mitochondrial function.
Zhao H, Zhang S, Gong Z, Chen T, Guo H, Yang M, Wang L, Zhou X, Xie J, Li H, Lu Y, Zhu Z
Journal of ethnopharmacology 2025 Jun 26;350:120036
Journal of ethnopharmacology 2025 Jun 26;350:120036
Mechanisms of Cisplatin-Induced Acute Kidney Injury: The Role of NRF2 in Mitochondrial Dysfunction and Metabolic Reprogramming.
Liu J, Wang Y, Qiao P, Ying Y, Lin S, Lu F, Gao C, Li M, Yang B, Zhou H
Antioxidants (Basel, Switzerland) 2025 Jun 24;14(7)
Antioxidants (Basel, Switzerland) 2025 Jun 24;14(7)
Ginsenoside Rh2 Exerts a Therapeutic Effect against Myocardial Infarction via Promoting Angiogenesis and Mitochondrial Bioenergetics.
Duan Z, Yuan B, Li H, Yang J, Xiao X, Wei K
Journal of agricultural and food chemistry 2025 Jun 18;73(24):15056-15066
Journal of agricultural and food chemistry 2025 Jun 18;73(24):15056-15066
Acetaldehyde dehydrogenase 2 attenuates lipopolysaccharide -induced endothelial barrier damage by inhibiting mitochondrial fission in sepsis-associated encephalopathy.
Wang S, Liu Z, Li R, Wang L, Wu Y, Zhang W, Yu Y
European journal of pharmacology 2025 Jun 15;997:177468
European journal of pharmacology 2025 Jun 15;997:177468
The Gut Microbial Metabolite Butyrate Alleviates IL-1β-Induced Mitochondrial Dysfunction and Oxidative Stress in Pancreatic Islets.
Pedersen SS, De Mets RDM, de Melo JML, Irazoki A, MacDonald PE, Prause M, Billestrup N
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 15;39(11):e70623
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 15;39(11):e70623
Drp1-Mediated Mitochondrial Fission Is Essential for Chemical-Induced Neuronal Transdifferentiation from Human Primary Fibroblasts.
Yang J, Li C, Wang C, Wang X, Liu J, Yu N, Du W, Chi S
Journal of molecular neuroscience : MN 2025 Jun 13;75(2):75
Journal of molecular neuroscience : MN 2025 Jun 13;75(2):75
AMPK-YAP signaling pathway-mediated mitochondrial dynamics and mitophagy participate in the protective effect of silibinin on HaCaT cells under high glucose conditions.
Wang X, Sun X, Zhang X, Shen N, Xia J, Wang L, Ye S
Archives of biochemistry and biophysics 2025 Jul;769:110433
Archives of biochemistry and biophysics 2025 Jul;769:110433
Norepinephrine Attenuates Benzalkonium Chloride-Induced Dry Eye Disease by Regulating the PINK1/Parkin Mitophagy Pathway.
Zhao H, Wang W, Yang Y, Feng C, Lin T, Gong L
Ocular immunology and inflammation 2025 Jul;33(5):766-780
Ocular immunology and inflammation 2025 Jul;33(5):766-780
Pathogenicity analysis of three SCA14-associated missense mutations in PRKCG gene of Chinese patients with ataxia.
Yuan H, Chen Z, Wan L, Peng L, Long Z, He L, Wang C, Qiu R, Tang B, Jiang H
Gene 2025 Jul 20;958:149483
Gene 2025 Jul 20;958:149483
The DRP1 receptor FIS1 is critical to the expansion of triple-negative breast cancer tumor-initiating cells.
Katrii T, Freywald T, Estrada MG, El Zawily A, Toosi B, Vizeacoumar FS, Vizeacoumar FJ, Freywald A, Leary SC
Cancer cell international 2025 Jul 19;25(1):272
Cancer cell international 2025 Jul 19;25(1):272
S-COS-Se mitigates cadmium-induced oxidative stress, inflammation, and immunotoxicity by restoring immune balance and inhibiting mitochondria-pyroptosis crosstalk.
Zheng H, Dong W, Qiu H, Gao S, Hou L, Dong J, Zhao P, Chen F
Ecotoxicology and environmental safety 2025 Jul 15;300:118462
Ecotoxicology and environmental safety 2025 Jul 15;300:118462
Exosomes derived from ALR-modified adipose mesenchymal stem cells mediate hepatoprotective effects on hepatic ischemia-reperfusion injury by promoting regeneration and protecting mitochondria.
Ma Y, Liu T, Li P, Cao L, Lu X, Wang H
Stem cell research & therapy 2025 Jul 15;16(1):361
Stem cell research & therapy 2025 Jul 15;16(1):361
Aerobic Exercise Delays Age-Related Sarcopenia in Mice via Alleviating Imbalance in Mitochondrial Quality Control.
Zhu D, Wang L, Gao H, Wang Z, Li K, Ma X, Zhao L, Xiao W
Metabolites 2025 Jul 11;15(7)
Metabolites 2025 Jul 11;15(7)
Tang Bi formula alleviates diabetic sciatic neuropathy via AMPK/PGC-1α/MFN2 pathway activation.
Yang C, Yu H, Zhou L, Su H, Li X, Qi W, Lian F
Scientific reports 2025 Jul 11;15(1):25069
Scientific reports 2025 Jul 11;15(1):25069
Drp1-Dependent Mitochondrial Fission Contributes to Lactic Acid-Induced Chicken Cardiomyocyte Damage.
Hu D, Cui Y, Hou X, Wang X, Shen Z, Pang H, Ge Y, Ning H
Journal of biochemical and molecular toxicology 2025 Jan;39(1):e70128
Journal of biochemical and molecular toxicology 2025 Jan;39(1):e70128
Calcium-mediated mitochondrial fission and mitophagy drive glycolysis to facilitate arterivirus proliferation.
Sun Z, Ma Z, Cao W, Jiang C, Guo L, Liu K, Gao Y, Bai J, Pi J, Jiang P, Liu X
PLoS pathogens 2025 Jan;21(1):e1012872
PLoS pathogens 2025 Jan;21(1):e1012872
9-PAHSA ameliorates microvascular damage during cardiac ischaemia/reperfusion injury by promoting LKB1/AMPK/ULK1-mediated autophagy-dependent STING degradation.
Liu W, Hu J, Wang Y, Gan T, Ding Y, Wang X, Xu Q, Xiong J, Xiong N, Lu S, Wang Y, Wang Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156241
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156241
Cadmium and polyvinyl chloride microplastics induce mitochondrial damage and apoptosis under oxidative stress in duck kidney.
Zou H, Song J, Luo X, Ali W, Li S, Xiong L, Chen Y, Yuan Y, Ma Y, Tong X, Liu Z
Poultry science 2025 Jan;104(1):104490
Poultry science 2025 Jan;104(1):104490
Fis1 is required for the development of the dendritic mitochondrial network in pyramidal cortical neurons.
Strucinska K, Kneis P, Pennington T, Cizio K, Szybowska P, Morgan A, Weertman J, Lewis TL Jr
bioRxiv : the preprint server for biology 2025 Jan 7;
bioRxiv : the preprint server for biology 2025 Jan 7;
Klebsiella pneumoniae causes mammary gland damage via FNIP1-mediated mitochondrial dysfunction.
Dong P, Yuan C, Wang Z, Mao P, Liu K, Li J, Dong J, Cui L, Guo L, Meng X, Zhu G, Liu H, Wang R, Zhang L, Wang H
Journal of animal science 2025 Jan 4;103
Journal of animal science 2025 Jan 4;103
SIRT4 Protects Retina Against Excitotoxic Injury by Promoting OPA1-Mediated Müller Glial Cell Mitochondrial Fusion and GLAST Expression.
Ying Q, Luo H, Xie Z, Huang Y, Hu H, Jin M, Xu K, Pang Y, Song Y, Zhang X
Investigative ophthalmology & visual science 2025 Jan 2;66(1):62
Investigative ophthalmology & visual science 2025 Jan 2;66(1):62
Notoginsenoside R1 Attenuates H/R Injury in H9c2 Cells by Maintaining Mitochondrial Homeostasis.
Xu Y, Wang P, Hu T, Ning K, Bao Y
Current issues in molecular biology 2025 Jan 10;47(1)
Current issues in molecular biology 2025 Jan 10;47(1)
Depleting chemoresponsive mitochondrial fission mediator DRP1 does not mitigate sarcoma resistance.
Borankova K, Solny M, Krchniakova M, Skoda J
Life science alliance 2025 Feb;8(2)
Life science alliance 2025 Feb;8(2)
Cleaving PINK1 or PGAM5? Involvement of PARL in Methamphetamine-Induced Excessive Mitophagy and Neuronal Necroptosis.
An D, Zhang C, Zhou P, Wang Y, Meng S, Chen Y, Xu W, Xuan J, Xiong J, Cheng J, Gao R, Wang J, Chen X
CNS neuroscience & therapeutics 2025 Feb;31(2):e70293
CNS neuroscience & therapeutics 2025 Feb;31(2):e70293
SREBP1c-Mediated Transcriptional Repression of YME1L1 Contributes to Acute Kidney Injury by Inducing Mitochondrial Dysfunction in Tubular Epithelial Cells.
Xin W, Zhou J, Peng Y, Gong S, Liao W, Wang Y, Huang X, Mao Y, Yao M, Qin S, Xiong J, Li Y, Lan Q, Huang Y, Zhao J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(6):e2412233
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(6):e2412233
Disrupted Mitochondrial Dynamics Impair Corneal Epithelial Healing in Neurotrophic Keratopathy.
Jin M, Liu Z, Shi R, Deng Y, Lin J, Zhang Y, Lin L, Wang Y, Shi Y, Li C, Liu Z
International journal of molecular sciences 2025 Feb 3;26(3)
International journal of molecular sciences 2025 Feb 3;26(3)
l-Glutamic Acid Alleviates Mastitis in Dairy Cows by Targeting the Sirt5/Nrf2/Prdx1 Signaling Axis and Mitochondrial Function.
Liu S, Jin Y, Zhou W, Liu J, Tu L, Zhang Y, Zhang M, Liu X, Cao Y, Guo W, Fu S
Journal of agricultural and food chemistry 2025 Feb 12;73(6):3483-3493
Journal of agricultural and food chemistry 2025 Feb 12;73(6):3483-3493
Zn(2 +) alleviates ischemia/reperfusion injury in H9c2 cells by modulating mitochondrial biogenesis and dynamics via MCU.
Wang B, Xing B, Huang L, Li X, Bian X, Xi J
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2025 Dec;92:127769
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2025 Dec;92:127769
High-Frequency rTMS can Improve Depressive Symptoms by Promoting Mitochondrial Fusion.
Song J, Wang Y, Li S, Yuan J, Zhang Z, Pan Y, Lu J, Zhang Y
Actas espanolas de psiquiatria 2025 Dec;53(6):1252-1264
Actas espanolas de psiquiatria 2025 Dec;53(6):1252-1264
Melatonin attenuates high-fat diet- and particulate matter-induced cardiac injury: involvement of mitochondrial quality and miR-221/222 expression.
Chen YC, Lee MH, Fu SJ, Lee CW, Shen WC, Lai TC, Lin SR, Lin SW, Yu IS, Chuang TY, Tsai JS, Chen YL
Biochemical pharmacology 2025 Dec;242(Pt 3):117346
Biochemical pharmacology 2025 Dec;242(Pt 3):117346
The binding of PCBP2 to IGF2 mRNA restores mitochondrial function in granulosa cells to ameliorate ovarian function in premature ovarian insufficiency mice.
Chen Y, Pan X, Tang J, Liu Z, Luo M, Wen Y
Cellular signalling 2025 Dec;136:112103
Cellular signalling 2025 Dec;136:112103
Defective vascular smooth muscle cell tafazzin impairs mitochondrial function and promotes atherosclerosis in preclinical models.
Dong C, Finigan A, Figg N, Jenkins B, Koulman A, Chowdhury SR, Tricolici AM, Lambert J, Oc S, Jørgensen HF, Prudent J, Murphy MP, Bennett M, Yu E
Nature communications 2025 Dec 4;16(1):10909
Nature communications 2025 Dec 4;16(1):10909
A role for Fis1 in dendritic development.
Strucinska K, Kneis P, Pennington T, Cizio K, Szybowska P, Morgan A, Weertman J, Lewis TL Jr
Scientific reports 2025 Dec 23;16(1):3594
Scientific reports 2025 Dec 23;16(1):3594
Mitofusin 2 is required for preventing deoxynivalenol-induced porcine intestinal epithelial cell damage.
Xiao K, Zhang M, Lv Q, Huang F, Xu Q, Guo J, Zhao J, Zhu H, Chen S, Liu Y
Journal of animal science and biotechnology 2025 Dec 23;16(1):178
Journal of animal science and biotechnology 2025 Dec 23;16(1):178
Mitochondrial dysfunction in mesenchymal stem cells impairs osteogenesis in radiation-induced bone injury via Ca(2+)-NFATc1-Fis1 pathway.
Ren L, Chen X, Zheng Y, Li J, Yu J, Ou L, Liu G, Cheng B, Toh WS, Xia J
Cell death & disease 2025 Dec 2;17(1):69
Cell death & disease 2025 Dec 2;17(1):69
Liraglutide alleviates diabetic cardiomyopathy in streptozotocin-induced diabetic rats by enhancing mitophagy mediated by the AMPK-Parkin signaling pathway.
Zhu YX, Zhang W, Qu HL, Zhang Y, Zhou RQ, Li P, Wang F, Zhang Y, Liu HH, Li S, Dong Q, Dou KF, Guo YL, Li JJ, Xu RX
World journal of diabetes 2025 Dec 15;16(12):112423
World journal of diabetes 2025 Dec 15;16(12):112423
FUNDC1-dependent mitochondrial-ER membranes mediate mitochondrial dysfunction and melanocyte damage under oxidative stress.
Ma J, Yuan M, Guo S, Gao T, Li C, Liu L
Free radical biology & medicine 2025 Dec 1;240:108-123
Free radical biology & medicine 2025 Dec 1;240:108-123
Leber's hereditary optic neuropathy-associated ND1 3733G>C mutation ameliorates the mitochondrial quality control and cellular homeostasis.
Yasheng M, Ji Y, He Y, Yi Q, Zhang H, Shan W, Wang K, Zhang J, Li Y, Meng F, Zhang M, Mo JQ, Wei S, Guan MX
The Journal of biological chemistry 2025 Aug;301(8):110464
The Journal of biological chemistry 2025 Aug;301(8):110464
Targeting Wnt/beta-catenin signaling to attenuate short-chain chlorinated paraffins-triggered hepatocyte mitochondrial fission and subsequent pyroptosis.
Xiao J, Huang D, Wang F, Gan L, Zhang W, Zhang F, Tang J, Shen Z, Jiang M, Egbobe JO, Shao J, Wang X, Zhang Y, Ju L, Zhao X
International immunopharmacology 2025 Aug 28;161:115102
International immunopharmacology 2025 Aug 28;161:115102
NR3C1/GLMN-Mediated FKBP12.6 Ubiquitination Disrupts Calcium Homeostasis and Impairs Mitochondrial Quality Control in Stress-Induced Myocardial Damage.
Cong J, Liu L, Shi R, He M, An Y, Feng X, Yin X, Li Y, Cong B, Shi W
International journal of molecular sciences 2025 Aug 25;26(17)
International journal of molecular sciences 2025 Aug 25;26(17)
Ankyrin-B modulates mitochondrial fission in skeletal muscle and is required for optimal endurance exercise capacity.
Voos KM, Tzeng J, Patel P, Rubinsky S, Choi HE, Pharr T, Sookram S, Baur JA, Soderblom EJ, Lorenzo DN
Nature communications 2025 Aug 25;16(1):7671
Nature communications 2025 Aug 25;16(1):7671
Opantimirs: A class of antagonizing microRNAs that upregulate Opa1 and improve mitochondrial and disuse myopathies.
Djalalvandi A, Takeda K, Grespi F, Fan H, Fonseca TB, Nogara L, Sharifi S, Barison C, Semenzato M, Omori A, Cerutti R, Steffan D, Tsansizi L, Balmaceda V, Alan L, Bean C, Blaauw B, Viscomi C, Scorrano L
Cell reports. Medicine 2025 Aug 19;6(8):102248
Cell reports. Medicine 2025 Aug 19;6(8):102248
Succinate accumulation induces pyroptosis and mitochondrial damage via the inhibition of ATP5F1D in HUVECs.
Huang H, Cui J, Tang D, Xiang X, Mao J, He Z, Hu H, He Z, He L, Tang H
Acta biochimica et biophysica Sinica 2025 Aug 15;57(12):2011-21
Acta biochimica et biophysica Sinica 2025 Aug 15;57(12):2011-21
Radiocleavable rare-earth nanoactivators targeting over-expressed folate receptors induce mitochondrial dysfunction and remodel immune suppressive microenvironment in pancreatic cancer.
Gupta T, Wu SR, Chang LC, Lin FC, Shan YS, Yeh CS, Su WP
Journal of nanobiotechnology 2025 Aug 12;23(1):562
Journal of nanobiotechnology 2025 Aug 12;23(1):562
Dynamin-Related Protein 1 Orchestrates Inflammatory Responses in Periodontal Macrophages via Interaction With Hexokinase 1.
Jiang Y, Wang Z, Zhang K, Hu Y, Shang D, Jiang L, Huang M, Wang B, He X, Wu Z, Yan X, Zhang X
Journal of clinical periodontology 2025 Apr;52(4):622-636
Journal of clinical periodontology 2025 Apr;52(4):622-636
O-GlcNAcylation of hexokinase 2 modulates mitochondrial dynamics and enhances the progression of lung cancer.
Panpan SI, Wei GE, Kaiming WU, Zhang R
Molecular and cellular biochemistry 2025 Apr;480(4):2633-2643
Molecular and cellular biochemistry 2025 Apr;480(4):2633-2643
Molybdenum nanodots act as antioxidants for photothermal therapy osteoarthritis.
Shi G, Lan S, Zhang Q, Wang J, Shu F, Hao Z, Chen T, Zhu M, Chen R, Chen J, Wu Z, Wu B, Zou Z, Li J
Biomaterials 2025 Apr;315:122909
Biomaterials 2025 Apr;315:122909
sLithospermic acid etched ZIF-8 nanoparticles delays osteoarthritis progression by inhibiting inflammatory signaling pathways and rescuing mitochondrial damage.
Zhang Y, Lou Q, Lian H, Yang R, Cui R, Wang L, Ma B, Hou L, Jin L, Teng W
Materials today. Bio 2025 Apr;31:101589
Materials today. Bio 2025 Apr;31:101589
Butyrate Regulates Intestinal DNA Virome and Lipopolysaccharide Levels to Prevent High-Fat Diet-Related Liver Damage in Rats.
Zhang Z, Zhu T, Li Y, Yu B, Tao H, Zhao H, Cui B
Journal of agricultural and food chemistry 2025 Apr 9;73(14):8277-8289
Journal of agricultural and food chemistry 2025 Apr 9;73(14):8277-8289
Inhibition of Drp1-mediated mitochondrial fission by P110 ameliorates renal injury in diabetic nephropathy.
Yue R, Yan Z, Zha H, Xia Y, Huang H, Li H, Ding M, Abdullah MMH, Hu B, Shi L, Zhu J, Song Z
International immunopharmacology 2025 Apr 16;152:114342
International immunopharmacology 2025 Apr 16;152:114342
Loss of lipid droplet-mitochondria contacts confers protection against ethanol-induced cardiotoxicity.
He W, He W, Zeng L, Zhao R, Qiu K, He P, Sun Z, Tan N
Experimental cell research 2025 Apr 15;447(2):114517
Experimental cell research 2025 Apr 15;447(2):114517
ARMC1 partitions between distinct complexes and assembles MIRO with MTFR to control mitochondrial distribution.
McKenna MJ, Kraus F, Coelho JPL, Vasandani M, Zhang J, Adams BM, Paulo JA, Harper JW, Shao S
Science advances 2025 Apr 11;11(15):eadu5091
Science advances 2025 Apr 11;11(15):eadu5091
Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis.
Tang X, Zheng N, Lin Q, You Y, Gong Z, Zhuang Y, Wu J, Wang Y, Huang H, Ke J, Chen F
Neural regeneration research 2025 Apr 1;20(4):1103-1123
Neural regeneration research 2025 Apr 1;20(4):1103-1123
CD62E- and ROS-Responsive ETS Improves Cartilage Repair by Inhibiting Endothelial Cell Activation through OPA1-Mediated Mitochondrial Homeostasis.
Tu P, Pan Y, Wang L, Li B, Sun X, Liang Z, Liu M, Zhao Z, Wu C, Wang J, Wang Z, Song Y, Zhang Y, Ma Y, Guo Y
Biomaterials research 2024;28:0006
Biomaterials research 2024;28:0006
Loss of MTX2 causes mitochondrial dysfunction, podocyte injury, nephrotic proteinuria and glomerulopathy in mice and patients.
Li T, Bao Y, Xia Y, Meng H, Zhou C, Huang L, Wang X, Lai EY, Jiang P, Mao J
International journal of biological sciences 2024;20(3):937-952
International journal of biological sciences 2024;20(3):937-952
Interaction Between the PERK/ATF4 Branch of the Endoplasmic Reticulum Stress and Mitochondrial One-Carbon Metabolism Regulates Neuronal Survival After Intracerebral Hemorrhage.
Liu Y, Cui F, Xu A, Wang B, Ma Y, Zhang Q, Sun Q, Zheng Y, Xue Y, Sun Y, Bian L
International journal of biological sciences 2024;20(11):4277-4296
International journal of biological sciences 2024;20(11):4277-4296
JiangyaTongluo decoction ameliorates tubulointerstitial fibrosis via regulating the SIRT1/PGC-1α/mitophagy axis in hypertensive nephropathy.
Zhao Y, Jia Q, Hao G, Han L, Gao Y, Zhang X, Yan Z, Li B, Wu Y, Zhang B, Li Y, Qin J
Frontiers in pharmacology 2024;15:1491315
Frontiers in pharmacology 2024;15:1491315
The toxic effects of polystyrene microplastic/nanoplastic particles on retinal pigment epithelial cells and retinal tissue.
Li X, Piao J, Kang B, Eom Y, Kim DH, Song JS
Environmental science and pollution research international 2024 Sep;31(42):54950-54961
Environmental science and pollution research international 2024 Sep;31(42):54950-54961
The Footprints of Mitochondrial Fission and Apoptosis in Fluoride-Induced Renal Dysfunction.
Zuo Q, Lin L, Zhang Y, Ommati MM, Wang H, Zhao J
Biological trace element research 2024 Sep;202(9):4125-4135
Biological trace element research 2024 Sep;202(9):4125-4135
Elevated serum neurologic biomarker profiles after cardiac arrest in a porcine model.
Senthil K, Ranganathan A, Piel S, Hefti MM, Reeder RW, Kirschen MP, Starr J, Morton S, Gaudio HA, Slovis JC, Herrmann JR, Berg RA, Kilbaugh TJ, Morgan RW
Resuscitation plus 2024 Sep;19:100726
Resuscitation plus 2024 Sep;19:100726
Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation.
Zhou J, Zhang L, Peng J, Zhang X, Zhang F, Wu Y, Huang A, Du F, Liao Y, He Y, Xie Y, Gu L, Kuang C, Ou W, Xie M, Tu T, Pang J, Zhang D, Guo K, Feng Y, Yin S, Cao Y, Li T, Jiang Y
Cell metabolism 2024 Sep 3;36(9):2054-2068.e14
Cell metabolism 2024 Sep 3;36(9):2054-2068.e14
Prophylactic Effects of Betaine on Depression and Anxiety Behaviors in Mice with Dextran Sulfate Sodium-Induced Colitis.
Liu W, Zhong X, Yi Y, Xie L, Zhou W, Cao W, Chen L
Journal of agricultural and food chemistry 2024 Sep 25;72(38):21041-21051
Journal of agricultural and food chemistry 2024 Sep 25;72(38):21041-21051
Acutely blocking excessive mitochondrial fission prevents chronic neurodegeneration after traumatic brain injury.
Sridharan PS, Koh Y, Miller E, Hu D, Chakraborty S, Tripathi SJ, Kee TR, Chaubey K, Vázquez-Rosa E, Barker S, Liu H, León-Alvarado RA, Franke K, Cintrón-Pérez CJ, Dhar M, Shin MK, Flanagan ME, Castellani RJ, Gefen T, Bykova M, Dou L, Cheng F, Wilson BM, Fujioka H, Kang DE, Woo JA, Paul BD, Qi X, Pieper AA
Cell reports. Medicine 2024 Sep 17;5(9):101715
Cell reports. Medicine 2024 Sep 17;5(9):101715
Helicobacter pylori CagA mediated mitophagy to attenuate the NLRP3 inflammasome activation and enhance the survival of infected cells.
Chen D, Wu L, Liu X, Wang Q, Gui S, Bao L, Wang Z, He X, Zhao Y, Zhou J, Xie Y
Scientific reports 2024 Sep 17;14(1):21648
Scientific reports 2024 Sep 17;14(1):21648
Dysregulation of mitochondrial dynamics and mitophagy are involved in high-fat diet-induced steroidogenesis inhibition.
Lv ZM, Liu C, Wang P, Chen YH
Journal of lipid research 2024 Oct;65(10):100639
Journal of lipid research 2024 Oct;65(10):100639
Resveratrol protects against a high-fat diet-induced neuroinflammation by suppressing mitochondrial fission via targeting SIRT1/PGC-1α.
Su X, Li Q, Yang M, Zhang W, Liu X, Ba Y, Deng Q, Zhang Y, Han L, Huang H
Experimental neurology 2024 Oct;380:114899
Experimental neurology 2024 Oct;380:114899
Melatonin Protects Against Mitochondrial Dyshomeostasis and Ovarian Damage Caused by Chronic Unpredictable Mild Stress Through the eIF2α-AFT4 Signaling Pathway in Mice.
Ding SM, Shi LG, Xing F, Cui SS, Cheng HR, Liu Y, Ji DM, Liang D, Cao YX, Liu YJ
Reproductive sciences (Thousand Oaks, Calif.) 2024 Oct;31(10):3191-3201
Reproductive sciences (Thousand Oaks, Calif.) 2024 Oct;31(10):3191-3201
SIRT1 regulates mitochondrial fission to alleviate high altitude hypoxia inducedcardiac dysfunction in rats via the PGC-1α-DRP1/FIS1/MFF pathway.
Xu H, Song X, Zhang X, Wang G, Cheng X, Zhang L, Wang Z, Li R, Ai C, Wang X, Pu L, Chen Z, Liu W
Apoptosis : an international journal on programmed cell death 2024 Oct;29(9-10):1663-1678
Apoptosis : an international journal on programmed cell death 2024 Oct;29(9-10):1663-1678
piR112710 attenuates diabetic cardiomyopathy through inhibiting Txnip/NLRP3-mediated pyroptosis in db/db mice.
Jiao A, Liu H, Wang H, Yu J, Gong L, Zhang H, Fu L
Cellular signalling 2024 Oct;122:111333
Cellular signalling 2024 Oct;122:111333
Slc25a3-dependent copper transport controls flickering-induced Opa1 processing for mitochondrial safeguard.
Murata D, Roy S, Lutsenko S, Iijima M, Sesaki H
Developmental cell 2024 Oct 7;59(19):2578-2592.e7
Developmental cell 2024 Oct 7;59(19):2578-2592.e7
Homoplantaginin alleviates high glucose-induced vascular endothelial senescence by inhibiting mtDNA-cGAS-STING pathway via blunting DRP1-mitochondrial fission-VDAC1 axis.
Wang L, Zhang X, Huang X, Sha X, Li X, Zheng J, Li S, Wei Z, Wu F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Oct 31;38(20):e70127
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Oct 31;38(20):e70127
SETDB1 targeting SESN2 regulates mitochondrial damage and oxidative stress in renal ischemia-reperfusion injury.
Xia K, Hui Y, Zhang L, Qiu Q, Zhong J, Chen H, Liu X, Wang L, Chen Z
BMC biology 2024 Oct 23;22(1):246
BMC biology 2024 Oct 23;22(1):246
Yiqihuoxue decoction (GSC) inhibits mitochondrial fission through the AMPK pathway to ameliorate EPCs senescence and optimize vascular aging transplantation regimens.
Liu Y, Niu Z, Wang X, Xiu C, Hu Y, Wang J, Lei Y, Yang J
Chinese medicine 2024 Oct 14;19(1):143
Chinese medicine 2024 Oct 14;19(1):143
One day of environment-induced heat stress damages the murine myocardium.
Roths M, Rudolph TE, Krishna S, Michael A, Selsby JT
American journal of physiology. Heart and circulatory physiology 2024 Oct 1;327(4):H978-H988
American journal of physiology. Heart and circulatory physiology 2024 Oct 1;327(4):H978-H988
Readdressing the Localization of Apolipoprotein E (APOE) in Mitochondria-Associated Endoplasmic Reticulum (ER) Membranes (MAMs): An Investigation of the Hepatic Protein-Protein Interactions of APOE with the Mitochondrial Proteins Lon Protease (LONP1), Mitochondrial Import Receptor Subunit TOM40 (TOMM40) and Voltage-Dependent Anion-Selective Channel 1 (VDAC1).
Rueter J, Rimbach G, Bilke S, Tholey A, Huebbe P
International journal of molecular sciences 2024 Oct 1;25(19)
International journal of molecular sciences 2024 Oct 1;25(19)
Contribution of impaired autophagy, mitochondrial dysfunction and abnormal lipolysis to epididymal aging in mice.
Liu C, Wu C, Zhang S, Lv Z
Experimental gerontology 2024 Oct 1;195:112528
Experimental gerontology 2024 Oct 1;195:112528
Renal denervation ameliorates atrial remodeling in type 2 diabetic rats by regulating mitochondrial dynamics.
Huo JY, Hou C, Li XL, Yang L, Jiang WY
Journal of physiology and biochemistry 2024 Nov;80(4):935-948
Journal of physiology and biochemistry 2024 Nov;80(4):935-948
Isoliquiritigenin alleviates cerebral ischemia-reperfusion injury by reducing oxidative stress and ameliorating mitochondrial dysfunction via activating the Nrf2 pathway.
Lan X, Wang Q, Liu Y, You Q, Wei W, Zhu C, Hai D, Cai Z, Yu J, Zhang J, Liu N
Redox biology 2024 Nov;77:103406
Redox biology 2024 Nov;77:103406
SIRT1, a target of miR-708-3p, alleviates fluoride-induced neuronal damage via remodeling mitochondrial network dynamics.
Zhao Q, Zhou GY, Niu Q, Chen JW, Li P, Tian ZY, Li DJ, Xia T, Zhang S, Wang AG
Journal of advanced research 2024 Nov;65:197-210
Journal of advanced research 2024 Nov;65:197-210
Mitochondrial elongation confers protection against doxorubicin-induced cardiotoxicity.
He W, He W, Chen X, Zeng L, Zeng L, Liu Y, He P, Sun Z
Biochemical pharmacology 2024 Nov;229:116495
Biochemical pharmacology 2024 Nov;229:116495
Ligustilide alleviates oxidative stress during renal ischemia-reperfusion injury through maintaining Sirt3-dependent mitochondrial homeostasis.
Xia K, Jin Z, Qiu Q, Zhou Y, Lu Y, Qiu T, Zhou J, Chen Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Nov;134:155975
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Nov;134:155975
Diacylglycerol O-acyltransferase isoforms play a role in peridroplet mitochondrial fatty acid metabolism in bovine liver.
Wang S, Zhang B, Mauck J, Loor JJ, Fan W, Tian Y, Yang T, Chang Y, Xie M, Aernouts B, Yang W, Xu C
Journal of dairy science 2024 Nov;107(11):9897-9914
Journal of dairy science 2024 Nov;107(11):9897-9914
Resistance Exercise Improves Glycolipid Metabolism and Mitochondrial Biogenesis in Skeletal Muscle of T2DM Mice via miR-30d-5p/SIRT1/PGC-1α Axis.
Zheng L, Rao Z, Wu J, Ma X, Jiang Z, Xiao W
International journal of molecular sciences 2024 Nov 19;25(22)
International journal of molecular sciences 2024 Nov 19;25(22)
Acrolein exposure affects ovarian function by interfering with glycolysis and mitochondrial energy metabolism in mouse.
Chen YZ, Wang WK, Yang YF, Cheng SY, Li LF, Shen H, Qi ZM, Liu Y
Environmental pollution (Barking, Essex : 1987) 2024 Nov 15;361:124776
Environmental pollution (Barking, Essex : 1987) 2024 Nov 15;361:124776
TRPA1 protects against contrast-induced renal tubular injury by preserving mitochondrial dynamics via the AMPK/DRP1 pathway.
Wang X, Luo T, Yang Y, Yang L, Liu M, Zou Q, Wang D, Yang C, Xue Q, Liu S, Wan J, He G, Zeng A, Hou J, Ma S, Wang P
Free radical biology & medicine 2024 Nov 1;224:521-539
Free radical biology & medicine 2024 Nov 1;224:521-539
HIF-2α/TFR1 mediated iron homeostasis disruption aggravates cartilage endplate degeneration through ferroptotic damage and mtDNA release: A new mechanism of intervertebral disc degeneration.
Jing X, Wang W, He X, Liu X, Yang X, Su C, Shao Y, Ge Z, Wang H, Cui X
Journal of orthopaedic translation 2024 May;46:65-78
Journal of orthopaedic translation 2024 May;46:65-78
Deafness-associated tRNA(Phe) mutation impaired mitochondrial and cellular integrity.
Chen X, Meng F, Chen C, Li S, Chou Z, Xu B, Mo JQ, Guo Y, Guan MX
The Journal of biological chemistry 2024 May;300(5):107235
The Journal of biological chemistry 2024 May;300(5):107235
circUSP13 facilitates the fast-to-slow myofiber shift via the MAPK/ERK signaling pathway in goat skeletal muscles.
Zhang Z, Kang Z, Deng K, Li J, Liu Z, Huang X, Wang F, Fan Y
Journal of cellular physiology 2024 May;239(5):e31226
Journal of cellular physiology 2024 May;239(5):e31226
PRR34-AS1 promotes mitochondrial division and glycolytic reprogramming in hepatocellular carcinoma cells through upregulation of MIEF2.
Yang X, Feng H, Kim J, Ti G, Wang L, Wang K, Song D
Acta biochimica et biophysica Sinica 2024 May 22;56(11):1604-1617
Acta biochimica et biophysica Sinica 2024 May 22;56(11):1604-1617
Puerarin Delays Mammary Gland Aging by Regulating Gut Microbiota and Inhibiting the p38MAPK Signaling Pathway.
Liu S, Hu H, Zhang M, Zhang Y, Geng R, Jin Y, Cao Y, Guo W, Liu J, Fu S
Journal of agricultural and food chemistry 2024 May 15;72(19):10879-10896
Journal of agricultural and food chemistry 2024 May 15;72(19):10879-10896
Ginkgolide C inhibits ROS-mediated activation of NLRP3 inflammasome in chondrocytes to ameliorate osteoarthritis.
Jia L, Gong Y, Jiang X, Fan X, Ji Z, Ma T, Li R, Liu F
Journal of ethnopharmacology 2024 May 10;325:117887
Journal of ethnopharmacology 2024 May 10;325:117887
Met-Exo attenuates mitochondrial dysfunction after hepatic ischemia-reperfusion injury in rats by modulating AMPK/SIRT1 signaling pathway.
Piao C, Wang Y, Lu X, Liu T, Ma Y, Li Y, Zhang J, Wang H
Free radical biology & medicine 2024 Mar;213:430-442
Free radical biology & medicine 2024 Mar;213:430-442
IGF2BP3-stabilized CAMK1 regulates the mitochondrial dynamics of renal tubule to alleviate diabetic nephropathy.
Yuan D, Li H, Dai W, Zhou X, Zhou W, He L
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167022
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167022
Doxycycline induces mitochondrial dysfunction in aortic smooth muscle cells.
Yap C, Wanga S, Wüst RCI, van Os BW, Pijls MME, Keijzer S, van Zanten E, Koolbergen DR, Driessen AHG, Balm R, Yeung KK, de Vries CJM, Houtkooper RH, Lindeman JHN, de Waard V
Vascular pharmacology 2024 Mar;154:107279
Vascular pharmacology 2024 Mar;154:107279
Inhibition of Drp1- Fis1 interaction alleviates aberrant mitochondrial fragmentation and acute kidney injury.
Song Z, Xia Y, Shi L, Zha H, Huang J, Xiang X, Li H, Huang H, Yue R, Wang H, Zhu J
Cellular & molecular biology letters 2024 Mar 4;29(1):31
Cellular & molecular biology letters 2024 Mar 4;29(1):31
NME3 is a gatekeeper for DRP1-dependent mitophagy in hypoxia.
Chen CW, Su C, Huang CY, Huang XR, Cuili X, Chao T, Fan CH, Ting CW, Tsai YW, Yang KC, Yeh TY, Hsieh ST, Chen YJ, Feng Y, Hunter T, Chang ZF
Nature communications 2024 Mar 13;15(1):2264
Nature communications 2024 Mar 13;15(1):2264
Leucine Supplementation Prevents the Development of Skeletal Muscle Dysfunction in a Rat Model of HFpEF.
Alves PKN, Schauer A, Augstein A, Prieto Jarabo ME, Männel A, Barthel P, Vahle B, Moriscot AS, Linke A, Adams V
Cells 2024 Mar 13;13(6)
Cells 2024 Mar 13;13(6)
Sex-Specific Effect of CARM1 in Skeletal Muscle Adaptations to Exercise.
Vanlieshout TL, Stouth DW, Raziee R, Sraka AJ, Masood HA, Ng SY, Mattina SR, Mikhail AI, Manta A, Ljubicic V
Medicine and science in sports and exercise 2024 Mar 1;56(3):486-498
Medicine and science in sports and exercise 2024 Mar 1;56(3):486-498
Mechanistic of AMPK/ACC2 regulating myoblast differentiation by fatty acid oxidation of goat.
Kang Z, Zhang Z, Li J, Deng K, Wang F, Fan Y
International journal of biological macromolecules 2024 Jun;270(Pt 2):132243
International journal of biological macromolecules 2024 Jun;270(Pt 2):132243
Hydrogen alleviates impaired lung epithelial barrier in acute respiratory distress syndrome via inhibiting Drp1-mediated mitochondrial fission through the Trx1 pathway.
Long Y, Ang Y, Chen W, Wang Y, Shi M, Hu F, Zhou Q, Shi Y, Ge B, Peng Y, Yu W, Bao H, Li Q, Duan M, Gao J
Free radical biology & medicine 2024 Jun;218:132-148
Free radical biology & medicine 2024 Jun;218:132-148
HTR1B regulates mitochondrial homeostasis and mitophagy by activating the ERK/ MAPK signalling pathway during human embryonic arrest.
Ding SM, Shi LG, Cao ZP, Zhu NN, Liu YY, Wang MY, Cui SS, Cheng HR, Liang D, Cao YX, Liu YJ
Heliyon 2024 Jun 30;10(12):e33132
Heliyon 2024 Jun 30;10(12):e33132
Inhibiting Pink1/Parkin-mediated mitophagy enhances the anticancer effects of quercetin in hepatocellular carcinomaf.
Chen F
Biochemical and biophysical research communications 2024 Jun 18;712-713:149899
Biochemical and biophysical research communications 2024 Jun 18;712-713:149899
PEG300 Protects Mitochondrial Function By Upregulating PGC-1α to Delay Central Nervous System Oxygen Toxicity in Mice.
Li X, Shen Y, Li D, Zhang K, Liu J, Yao L, Yang J, Qian J
Neurotoxicity research 2024 Jun 17;42(4):30
Neurotoxicity research 2024 Jun 17;42(4):30
Peptide-encoding gene transfer to modulate intracellular protein-protein interactions.
Taya T, Kami D, Teruyama F, Matoba S, Gojo S
Molecular therapy. Methods & clinical development 2024 Jun 13;32(2):101226
Molecular therapy. Methods & clinical development 2024 Jun 13;32(2):101226
Chemerin regulates glucose and lipid metabolism by changing mitochondrial structure and function associated with androgen/androgen receptor.
Yin L, Tang H, Qu J, Jia Y, Zhang Q, Wang X
American journal of physiology. Endocrinology and metabolism 2024 Jun 1;326(6):E869-E887
American journal of physiology. Endocrinology and metabolism 2024 Jun 1;326(6):E869-E887
Acid Neutralization by Composite Lysine Nanoparticles for Spinal Cord Injury Recovery through Mitigating Mitochondrial Dysfunction.
Wang Q, Ge L, Guo J, Zhang H, Chen T, Lian F, Li L, Xu Y, Xu J, Chen N, Zhang Y, Ruan Z, Xiao J, Zhang H, Yang L
ACS biomaterials science & engineering 2024 Jul 8;10(7):4480-4495
ACS biomaterials science & engineering 2024 Jul 8;10(7):4480-4495
Dulaglutide restores endothelial progenitor cell levels in diabetic mice and mitigates high glucose-induced endothelial injury through SIRT1-mediated mitochondrial fission.
Mei X, Li Y, Wu J, Liao L, Lu D, Qiu P, Yang HL, Tang MW, Liang XY, Liu D
Biochemical and biophysical research communications 2024 Jul 5;716:150002
Biochemical and biophysical research communications 2024 Jul 5;716:150002
MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels.
Tábara LC, Burr SP, Frison M, Chowdhury SR, Paupe V, Nie Y, Johnson M, Villar-Azpillaga J, Viegas F, Segawa M, Anand H, Petkevicius K, Chinnery PF, Prudent J
Cell 2024 Jul 11;187(14):3619-3637.e27
Cell 2024 Jul 11;187(14):3619-3637.e27
NAD(+) supplementation improves mitochondrial functions and normalizes glaucomatous trabecular meshwork features.
Liu Y, Bu Q, Hu D, Chen C, Zhu J, Zhou Q, Li Z, Pan X
Experimental cell research 2024 Jul 1;440(1):114137
Experimental cell research 2024 Jul 1;440(1):114137
NAMPT regulates mitochondria function and lipid metabolism during porcine oocyte maturation.
Guo X, Jiao L, Yi Y, Zhang HL, Liu YX, Wang ZY, Sun SC
Journal of cellular physiology 2024 Jan;239(1):180-192
Journal of cellular physiology 2024 Jan;239(1):180-192
Sentrin-specific protease 1 maintains mitochondrial homeostasis through targeting the deSUMOylation of sirtuin-3 to alleviate oxidative damage induced by hepatic ischemia/reperfusion.
Xia K, Guo J, Yu B, Wang T, Qiu Q, Chen Q, Qiu T, Zhou J, Zheng S
Free radical biology & medicine 2024 Jan;210:378-389
Free radical biology & medicine 2024 Jan;210:378-389
Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4‑mediated ferritinophagy.
Ma Z, Lu H, Feng X, Du T, Li J, Zhang Q, Gu X, Shao Y, Jing X, Su C
International journal of molecular medicine 2024 Feb;53(2)
International journal of molecular medicine 2024 Feb;53(2)
Intermittent Theta Burst Stimulation Attenuates Cognitive Deficits and Alzheimer's Disease-Type Pathologies via ISCA1-Mediated Mitochondrial Modulation in APP/PS1 Mice.
Zhu Y, Huang H, Chen Z, Tao Y, Liao LY, Gao SH, Wang YJ, Gao CY
Neuroscience bulletin 2024 Feb;40(2):182-200
Neuroscience bulletin 2024 Feb;40(2):182-200
Rescue of mitochondrial import failure by intercellular organellar transfer.
Needs HI, Glover E, Pereira GC, Witt A, Hübner W, Dodding MP, Henley JM, Collinson I
Nature communications 2024 Feb 2;15(1):988
Nature communications 2024 Feb 2;15(1):988
Deficient tRNA posttranscription modification dysregulated the mitochondrial quality controls and apoptosis.
He Y, Zhu G, Li X, Zhou M, Guan MX
iScience 2024 Feb 16;27(2):108883
iScience 2024 Feb 16;27(2):108883
Mitochondrial dynamics disruption: Unraveling Dinotefuran's impact on cardiotoxicity.
Zhu J, Tao Q, Du G, Huang L, Li M, Wang M, Wang Q
Environmental pollution (Barking, Essex : 1987) 2024 Feb 15;343:123238
Environmental pollution (Barking, Essex : 1987) 2024 Feb 15;343:123238
Nicotinamide mononucleotide alleviates seizures via modulating SIRT1-PGC-1α mediated mitochondrial fusion and fission.
Cheng Y, Huang P, Zou Q, Tian H, Cheng Q, Ding H
Journal of neurochemistry 2024 Dec;168(12):3962-3981
Journal of neurochemistry 2024 Dec;168(12):3962-3981
Alizarin attenuates oxidative stress-induced mitochondrial damage in vascular dementia rats by promoting TRPM2 ubiquitination and proteasomal degradation via Smurf2.
Pan GP, Liu YH, Qi MX, Guo YQ, Shao ZL, Liu HT, Qian YW, Guo S, Yin YL, Li P
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156119
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156119
SENP3-FIS1 axis promotes mitophagy and cell survival under hypoxia.
Zhao A, Maple L, Jiang J, Myers KN, Jones CG, Gagg H, McGarrity-Cottrell C, Rominiyi O, Collis SJ, Wells G, Rahman M, Danson SJ, Robinson D, Smythe C, Guo C
Cell death & disease 2024 Dec 5;15(12):881
Cell death & disease 2024 Dec 5;15(12):881
IDH1/MDH1 deacetylation promotes NETosis by regulating OPA1 and autophagy.
Wang Y, Guo J, Zhang D, Shi C, Zhang X, Gong Z
International immunopharmacology 2024 Dec 25;143(Pt 1):113270
International immunopharmacology 2024 Dec 25;143(Pt 1):113270
Myricetin Alleviates Silica-Mediated Lung Fibrosis via PPARγ-PGC-1α Loop and Suppressing Mitochondrial Senescence in Epithelial Cells.
Xie W, Deng L, Zhang X, Huang X, Ding J, Liu W, Tang SY
Journal of agricultural and food chemistry 2024 Dec 18;72(50):27737-27749
Journal of agricultural and food chemistry 2024 Dec 18;72(50):27737-27749
Aldehyde Dehydrogenase 2 Deficiency Aggravates Lung Fibrosis through Mitochondrial Dysfunction and Aging in Fibroblasts.
Wei Y, Gao S, Li C, Huang X, Xie B, Geng J, Dai H, Wang C
The American journal of pathology 2024 Aug;194(8):1458-1477
The American journal of pathology 2024 Aug;194(8):1458-1477
Pathological characteristics of axons and alterations of proteomic and lipidomic profiles in midbrain dopaminergic neurodegeneration induced by WDR45-deficiency.
Wang P, Shao Y, Al-Nusaif M, Zhang J, Yang H, Yang Y, Kim K, Li S, Liu C, Cai H, Le W
Molecular neurodegeneration 2024 Aug 26;19(1):62
Molecular neurodegeneration 2024 Aug 26;19(1):62
ML335 inhibits TWIK2 channel-mediated potassium efflux and attenuates mitochondrial damage in MSU crystal-induced inflammation.
Song D, Zhou X, Yu Q, Li R, Dai Q, Zeng M
Journal of translational medicine 2024 Aug 22;22(1):785
Journal of translational medicine 2024 Aug 22;22(1):785
Matrix stiffness aggravates osteoarthritis progression through H3K27me3 demethylation induced by mitochondrial damage.
Kan T, Li H, Hou L, Cui J, Wang Y, Sun L, Wang L, Yan M, Yu Z
iScience 2024 Aug 16;27(8):110507
iScience 2024 Aug 16;27(8):110507
VDR regulates mitochondrial function as a protective mechanism against renal tubular cell injury in diabetic rats.
Chen H, Zhang H, Li AM, Liu YT, Liu Y, Zhang W, Yang C, Song N, Zhan M, Yang S
Redox biology 2024 Apr;70:103062
Redox biology 2024 Apr;70:103062
DsbA-L ameliorates renal aging and renal fibrosis by maintaining mitochondrial homeostasis.
Yang M, Liu Y, Luo SL, Liu CB, Jiang N, Li CR, Zhao H, Han YC, Chen W, Li L, Sun L
Acta pharmacologica Sinica 2024 Apr;45(4):777-789
Acta pharmacologica Sinica 2024 Apr;45(4):777-789
Cadmium-induced global DNA hypermethylation promoting mitochondrial dynamics dysregulation in hippocampal neurons.
Geng H, An Q, Song J, He D, Han H, Wang L
Environmental toxicology 2024 Apr;39(4):2043-2051
Environmental toxicology 2024 Apr;39(4):2043-2051
Astragaloside IV combined with ligustrazine ameliorates abnormal mitochondrial dynamics via Drp1 SUMO/deSUMOylation in cerebral ischemia-reperfusion injury.
Chen X, Yang T, Zhou Y, Mei Z, Zhang W
CNS neuroscience & therapeutics 2024 Apr;30(4):e14725
CNS neuroscience & therapeutics 2024 Apr;30(4):e14725
Resveratrol Inhibits Zinc Deficiency-Induced Mitophagy and Exerts Cardiac Cytoprotective Effects.
Wang P, Yang Y, Guo J, Ma T, Hu Y, Huang L, He Y, Xi J
Biological trace element research 2024 Apr;202(4):1669-1682
Biological trace element research 2024 Apr;202(4):1669-1682
Mitochondria-associated membranes contribution to exercise-mediated alleviation of hepatic insulin resistance: Contrasting high-intensity interval training with moderate-intensity continuous training in a high-fat diet mouse model.
Li X, Yang JY, Hu WZ, Ruan Y, Chen HY, Zhang Q, Zhang Z, Ding ZS
Journal of diabetes 2024 Apr;16(4):e13540
Journal of diabetes 2024 Apr;16(4):e13540
Dietary fat supplementation relieves cold temperature-induced energy stress through AMPK-mediated mitochondrial homeostasis in pigs.
He W, Liu X, Feng Y, Ding H, Sun H, Li Z, Shi B
Journal of animal science and biotechnology 2024 Apr 8;15(1):56
Journal of animal science and biotechnology 2024 Apr 8;15(1):56
Dietary cysteine and methionine promote peroxisome elevation and fat loss by induction of CG33474 expression in Drosophila adipose tissue.
Liu M, He L
Cellular and molecular life sciences : CMLS 2024 Apr 22;81(1):190
Cellular and molecular life sciences : CMLS 2024 Apr 22;81(1):190
TDCPP and TiO(2) NPs aggregates synergistically induce SH-SY5Y cell neurotoxicity by excessive mitochondrial fission and mitophagy inhibition.
Wang L, Wang B, Zhang X, Yang Z, Zhang X, Gong H, Song Y, Zhang K, Sun M
Environmental pollution (Barking, Essex : 1987) 2024 Apr 15;347:123740
Environmental pollution (Barking, Essex : 1987) 2024 Apr 15;347:123740
Phosphoglycerate mutase 5 exacerbates liver ischemia-reperfusion injury by activating mitochondrial fission.
Tang H, Yu Q, Chen X, Zhang J, Guo D, Guo W, Zhang S, Shi X
Scientific reports 2024 Apr 12;14(1):8535
Scientific reports 2024 Apr 12;14(1):8535
Early Mitochondrial Defects in the 5xFAD Mouse Model of Alzheimer's Disease.
Sharma N, Banerjee R, Davis RL
Journal of Alzheimer's disease : JAD 2023;91(4):1323-1338
Journal of Alzheimer's disease : JAD 2023;91(4):1323-1338
Nanocurcumin Reduces High Glucose and Particulate Matter-Induced Endothelial Inflammation: Mitochondrial Function and Involvement of miR-221/222.
Lai TC, Lee CW, Hsu MH, Chen YC, Lin SR, Lin SW, Lee TL, Lin SY, Hsu SH, Tsai JS, Chen YL
International journal of nanomedicine 2023;18:7379-7402
International journal of nanomedicine 2023;18:7379-7402
Selenium-enriched Cardamine violifolia protects against sepsis-induced intestinal injury by regulating mitochondrial fusion in weaned pigs.
Wang D, Kuang Y, Lv Q, Xie W, Xu X, Zhu H, Zhang Y, Cong X, Cheng S, Liu Y
Science China. Life sciences 2023 Sep;66(9):2099-2111
Science China. Life sciences 2023 Sep;66(9):2099-2111
Hypoxia-induced GPCPD1 depalmitoylation triggers mitophagy via regulating PRKN-mediated ubiquitination of VDAC1.
Liu Y, Zhang H, Liu Y, Zhang S, Su P, Wang L, Li Y, Liang Y, Wang X, Zhao W, Chen B, Luo D, Zhang N, Yang Q
Autophagy 2023 Sep;19(9):2443-2463
Autophagy 2023 Sep;19(9):2443-2463
Aerobic exercise enhances mitochondrial homeostasis to counteract D-galactose-induced sarcopenia in zebrafish.
Chen ZL, Guo C, Zou YY, Feng C, Yang DX, Sun CC, Wen W, Jian ZJ, Zhao Z, Xiao Q, Zheng L, Peng XY, Zhou ZQ, Tang CF
Experimental gerontology 2023 Sep;180:112265
Experimental gerontology 2023 Sep;180:112265
Photobiomodulation provides neuroprotection through regulating mitochondrial fission imbalance in the subacute phase of spinal cord injury.
Li X, Wang XK, Zhu ZJ, Liang ZW, Li PH, Ma YG, Ding T, Li K, Zuo XS, Ju C, Zhang ZH, Song ZW, Quan HL, Zhang JW, Luo L, Wang Z, Hu XY
Neural regeneration research 2023 Sep;18(9):2005-2010
Neural regeneration research 2023 Sep;18(9):2005-2010
Mitochondrial miR-12294-5p regulated copper-induced mitochondrial oxidative stress and mitochondrial quality control imbalance by targeted inhibition of CISD1 in chicken livers.
Zhong G, Li Y, Li L, Huo Y, Zhang W, Li T, Ma F, Liao J, Li Y, Zhang H, Guo J, Pan J, Yu W, Hu L, Tang Z
Journal of hazardous materials 2023 Sep 15;458:131908
Journal of hazardous materials 2023 Sep 15;458:131908
High-resolution visualization and assessment of basal and OXPHOS-induced mitophagy in H9c2 cardiomyoblasts.
Godtliebsen G, Larsen KB, Bhujabal Z, Opstad IS, Nager M, Punnakkal AR, Kalstad TB, Olsen R, Lund T, Prasad DK, Agarwal K, Myrmel T, Birgisdottir AB
Autophagy 2023 Oct;19(10):2769-2788
Autophagy 2023 Oct;19(10):2769-2788
Histone deacetylase inhibitor pracinostat suppresses colorectal cancer by inducing CDK5-Drp1 signaling-mediated peripheral mitofission.
Liang XL, Ouyang L, Yu NN, Sun ZH, Gui ZK, Niu YL, He QY, Zhang J, Wang Y
Journal of pharmaceutical analysis 2023 Oct;13(10):1168-1182
Journal of pharmaceutical analysis 2023 Oct;13(10):1168-1182
Polydatin improves vascular endothelial function by maintaining mitochondrial homeostasis under high glucose conditions.
Shah W, Zhao Q, Wang S, Zhang M, Ma H, Guan Y, Zhang Y, Liu Y, Zhu C, Wang S, Zhang X, Dong J, Ma H
Scientific reports 2023 Oct 2;13(1):16550
Scientific reports 2023 Oct 2;13(1):16550
A conserved, noncanonical insert in FIS1 mediates TBC1D15 and DRP1 recruitment for mitochondrial fission.
Ihenacho UK, Toro R, Mansour RH, Hill RB
The Journal of biological chemistry 2023 Nov;299(11):105303
The Journal of biological chemistry 2023 Nov;299(11):105303
The mystery of phospho-Drp1 with four adaptors in cell cycle: when mitochondrial fission couples to cell fate decisions.
Wu NS, Ma IC, Lin YF, Ko HJ, Loh JK, Hong YR
Cell cycle (Georgetown, Tex.) 2023 Nov;22(21-22):2485-2503
Cell cycle (Georgetown, Tex.) 2023 Nov;22(21-22):2485-2503
The poxvirus F17 protein counteracts mitochondrially orchestrated antiviral responses.
Meade N, Toreev HK, Chakrabarty RP, Hesser CR, Park C, Chandel NS, Walsh D
Nature communications 2023 Nov 30;14(1):7889
Nature communications 2023 Nov 30;14(1):7889
CCDC127 regulates lipid droplet homeostasis by enhancing mitochondria-ER contacts.
Xia Y, Zhang Y, Sun Y, He L
Biochemical and biophysical research communications 2023 Nov 26;683:149116
Biochemical and biophysical research communications 2023 Nov 26;683:149116
Sodium Sulfite-Triggered Hepatocyte Ferroptosis via mtROS/Lysosomal Membrane Permeabilization-Mediated Lysosome Iron Efflux.
Liu M, Lu J, Chen Y, Zhang S, Guo J, Guan S
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16310-16322
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16310-16322
miR-27a-3p relieves heat stress-induced mitochondrial damage and aberrant milk protein synthesis through MEK/ERK pathway in BMECs.
Wang Y, Wu J, Xia SW, Zhao F, Ding Q, Ye XM, Zhong JF, Chen KL, Wang HL
Cell stress & chaperones 2023 May;28(3):265-274
Cell stress & chaperones 2023 May;28(3):265-274
Heme oxygenase-1 prevents non-alcoholic steatohepatitis through modulating mitochondrial quality control.
Li D, Yuan X, Dong S, Al-Dhamin Z, Du J, Fu N, Nan Y
Acta physiologica (Oxford, England) 2023 Mar;237(3):e13918
Acta physiologica (Oxford, England) 2023 Mar;237(3):e13918
HC067047 as a potent TRPV4 inhibitor repairs endotoxemia colonic injury.
Chen L, Mao M, Liu D, Liu W, Wang Y, Xie L, Deng Y, Lin Y, Xu Y, Zhong X, Cao W
International immunopharmacology 2023 Mar;116:109648
International immunopharmacology 2023 Mar;116:109648
Empagliflozin ameliorates cardiac dysfunction in heart failure mice via regulating mitochondrial dynamics.
Lyu Y, Huo J, Jiang W, Yang W, Wang S, Zhang S, Cheng Y, Jiang Z, Shan Q
European journal of pharmacology 2023 Mar 5;942:175531
European journal of pharmacology 2023 Mar 5;942:175531
Macrophage Inactivation by Small Molecule Wedelolactone via Targeting sEH for the Treatment of LPS-Induced Acute Lung Injury.
Zhang J, Zhang M, Huo XK, Ning J, Yu ZL, Morisseau C, Sun CP, Hammock BD, Ma XC
ACS central science 2023 Mar 22;9(3):440-456
ACS central science 2023 Mar 22;9(3):440-456
MFN1 augmentation prevents retinal degeneration in a Charcot-Marie-Tooth type 2A mouse model.
Shahin S, Lu B, Zhou Y, Xu H, Chetsawang J, Baloh RH, Wang S
iScience 2023 Mar 17;26(3):106270
iScience 2023 Mar 17;26(3):106270
miR-484 mediates oxidative stress-induced ovarian dysfunction and promotes granulosa cell apoptosis via SESN2 downregulation.
Wang X, Yang J, Li H, Mu H, Zeng L, Cai S, Su P, Li H, Zhang L, Xiang W
Redox biology 2023 Jun;62:102684
Redox biology 2023 Jun;62:102684
Senomorphic effect of diphenyleneiodonium through AMPK/MFF/DRP1 mediated mitochondrial fission.
Liao KM, Chen CJ, Luo WJ, Hsu CW, Yu SL, Yang PC, Su KY
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jun;162:114616
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jun;162:114616
Paraquat-induced neurogenesis abnormalities via Drp1-mediated mitochondrial fission.
Zhang B, Zhang Y, Zuo Z, Xiong G, Luo H, Song B, Zhao L, Zhou Z, Chang X
Ecotoxicology and environmental safety 2023 Jun 1;257:114939
Ecotoxicology and environmental safety 2023 Jun 1;257:114939
Pseudolaric acid B triggers cell apoptosis by activating AMPK/JNK/DRP1/mitochondrial fission pathway in hepatocellular carcinoma.
Liu Z, Wang N, Meng Z, Lu S, Peng G
Toxicology 2023 Jul;493:153556
Toxicology 2023 Jul;493:153556
Myricetin improves pathological changes in 3×Tg-AD mice by regulating the mitochondria-NLRP3 inflammasome-microglia channel by targeting P38 MAPK signaling pathway.
Liu P, Zhou Y, Shi J, Wang F, Yang X, Zheng X, Wang Y, He Y, Xie X, Pang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul;115:154801
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul;115:154801
Hydrogen sulfide alleviates mitochondrial damage and ferroptosis by regulating OPA3-NFS1 axis in doxorubicin-induced cardiotoxicity.
Wang Y, Ying X, Wang Y, Zou Z, Yuan A, Xiao Z, Geng N, Qiao Z, Li W, Lu X, Pu J
Cellular signalling 2023 Jul;107:110655
Cellular signalling 2023 Jul;107:110655
Parkin regulates amino acid homeostasis at mitochondria-lysosome (M/L) contact sites in Parkinson's disease.
Peng W, Schröder LF, Song P, Wong YC, Krainc D
Science advances 2023 Jul 21;9(29):eadh3347
Science advances 2023 Jul 21;9(29):eadh3347
Targeting an allosteric site in dynamin-related protein 1 to inhibit Fis1-mediated mitochondrial dysfunction.
Rios L, Pokhrel S, Li SJ, Heo G, Haileselassie B, Mochly-Rosen D
Nature communications 2023 Jul 19;14(1):4356
Nature communications 2023 Jul 19;14(1):4356
High-intensity interval training induces renal injury and fibrosis in type 2 diabetic mice.
Zheng L, Qin R, Rao Z, Xiao W
Life sciences 2023 Jul 1;324:121740
Life sciences 2023 Jul 1;324:121740
Bavachin and Corylifol A Improve Muscle Atrophy by Enhancing Mitochondria Quality Control in Type 2 Diabetic Mice.
Yeon MH, Seo E, Lee JH, Jun HS
Antioxidants (Basel, Switzerland) 2023 Jan 6;12(1)
Antioxidants (Basel, Switzerland) 2023 Jan 6;12(1)
N-acetyl-L-cysteine alleviates FUNDC1-mediated mitophagy by regulating mitochondrial dynamics in type 1 diabetic nephropathy canine.
Ma F, Li H, Huo H, Han Q, Liao J, Zhang H, Li Y, Pan J, Hu L, Guo J, Tang Z
Life sciences 2023 Jan 15;313:121278
Life sciences 2023 Jan 15;313:121278
Endoplasmic reticulum stress mediated by ROS participates in cadmium exposure-induced MC3T3-E1 cell apoptosis.
Jia L, Ma T, Lv L, Yu Y, Zhao M, Chen H, Gao L
Ecotoxicology and environmental safety 2023 Feb;251:114517
Ecotoxicology and environmental safety 2023 Feb;251:114517
Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis.
Zhou Y, Tang J, Lan J, Zhang Y, Wang H, Chen Q, Kang Y, Sun Y, Feng X, Wu L, Jin H, Chen S, Peng Y
Acta pharmaceutica Sinica. B 2023 Feb;13(2):577-597
Acta pharmaceutica Sinica. B 2023 Feb;13(2):577-597
PKM2-mediated neuronal hyperglycolysis enhances the risk of Parkinson's disease in diabetic rats.
Zhao Y, Wang Y, Wu Y, Tao C, Xu R, Chen Y, Qian L, Xu T, Lian X
Journal of pharmaceutical analysis 2023 Feb;13(2):187-200
Journal of pharmaceutical analysis 2023 Feb;13(2):187-200
Osthole: A potential AMPK agonist that inhibits NLRP3 inflammasome activation by regulating mitochondrial homeostasis for combating rheumatoid arthritis.
Jiang X, Lu Z, Zhang Q, Yu J, Han D, Liu J, Li P, Li F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154640
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154640
METTL14-dependent maturation of pri-miR-17 regulates mitochondrial homeostasis and induces chemoresistance in colorectal cancer.
Sun K, Chen L, Li Y, Huang B, Yan Q, Wu C, Lai Q, Fang Y, Cai J, Liu Y, Chen J, Wang X, Zhu Y, Dong S, Tan J, Li A, Liu S, Zhang Y
Cell death & disease 2023 Feb 21;14(2):148
Cell death & disease 2023 Feb 21;14(2):148
Selenium alleviates cadmium-induced mitophagy through FUNDC1-mediated mitochondrial quality control pathway in the lungs of sheep.
Lin S, Yang F, Hu M, Chen J, Chen G, Hu A, Li X, Fu D, Xing C, Xiong Z, Wu Y, Cao H
Environmental pollution (Barking, Essex : 1987) 2023 Feb 15;319:120954
Environmental pollution (Barking, Essex : 1987) 2023 Feb 15;319:120954
SIRT3-dependent mitochondrial redox homeostasis mitigates CHK1 inhibition combined with gemcitabine treatment induced cardiotoxicity in hiPSC-CMs and mice.
Chen JW, Shan TK, Wei TW, Jiang QQ, Du C, Gu LF, Yang TT, Zhou LH, Wang SB, Bao YL, Wang H, Ji Y, Xie LP, Gu AH, Sun CQ, Wang QM, Wang LS
Archives of toxicology 2023 Dec;97(12):3209-3226
Archives of toxicology 2023 Dec;97(12):3209-3226
Nogo-B mediates endothelial oxidative stress and inflammation to promote coronary atherosclerosis in pressure-overloaded mouse hearts.
Zhang Y, Li JJ, Xu R, Wang XP, Zhao XY, Fang Y, Chen YP, Ma S, Di XH, Wu W, She G, Pang ZD, Wang YD, Zhang X, Xie W, Deng XL, Du XJ, Zhang Y
Redox biology 2023 Dec;68:102944
Redox biology 2023 Dec;68:102944
Mitochondrial fission drives neuronal metabolic burden to promote stress susceptibility in male mice.
Dong WT, Long LH, Deng Q, Liu D, Wang JL, Wang F, Chen JG
Nature metabolism 2023 Dec;5(12):2220-2236
Nature metabolism 2023 Dec;5(12):2220-2236
Zinc Overload Induces Damage to H9c2 Cardiomyocyte Through Mitochondrial Dysfunction and ROS-Mediated Mitophagy.
Yang Y, Wang P, Guo J, Ma T, Hu Y, Huang L, Xing B, He Y, Xi J
Cardiovascular toxicology 2023 Dec;23(11-12):388-405
Cardiovascular toxicology 2023 Dec;23(11-12):388-405
Zearalenone promotes porcine ESCs apoptosis by enhancing Drp1-mediated mitochondrial fragmentation and activating the JNK pathway.
Hai S, Zhao J, Chen C, Wang C, Ma L, Rahman SU, Zhao C, Feng S, Wu J, Wang X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Dec;182:114110
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Dec;182:114110
Ramelteon attenuates renal ischemia and reperfusion injury through reducing mitochondrial fission and fusion and inflammation.
Chen P, Liu W, Wei Y
Translational andrology and urology 2023 Dec 31;12(12):1859-1870
Translational andrology and urology 2023 Dec 31;12(12):1859-1870
The Binding of HSPA8 and Mitochondrial ALDH2 Mediates Oxygen-Glucose Deprivation-Induced Fibroblast Senescence.
Hui W, Song T, Yu L, Chen X
Antioxidants (Basel, Switzerland) 2023 Dec 25;13(1)
Antioxidants (Basel, Switzerland) 2023 Dec 25;13(1)
CircRNA SCAR Improves High-Glucose-Induced Mitochondrial Dysfunction and Permeability Damage in Retinal Microvascular Endothelial Cells.
Wu R, Huang S, Xie JF, Wen NL, Wen M, Zhong SE
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2023 Aug;55(8):555-562
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2023 Aug;55(8):555-562
Loganin alleviated cognitive impairment in 3×Tg-AD mice through promoting mitophagy mediated by optineurin.
Zhou Y, Luo D, Shi J, Yang X, Xu W, Gao W, Guo Y, Zhao Q, Xie X, He Y, Du G, Pang X
Journal of ethnopharmacology 2023 Aug 10;312:116455
Journal of ethnopharmacology 2023 Aug 10;312:116455
LDLR heterozygous deletion reduces hamster testicular cholesterol toxicity via AMPK/Sirt1/PGC-1α pathway.
Bai Y, Hei N, Gao M, Dong X, Li M, Jiang S, Zhang L
Toxicology letters 2023 Aug 1;384:30-43
Toxicology letters 2023 Aug 1;384:30-43
Aristolochic acid I exposure triggers ovarian dysfunction by activating NLRP3 inflammasome and affecting mitochondrial homeostasis.
Sun MX, Qiao FX, Xu ZR, Liu YC, Xu CL, Wang HL, Qi ZQ, Liu Y
Free radical biology & medicine 2023 Aug 1;204:313-324
Free radical biology & medicine 2023 Aug 1;204:313-324
A single dose of exercise stimulates skeletal muscle mitochondrial plasticity in myotonic dystrophy type 1.
Mikhail AI, Manta A, Ng SY, Osborne AK, Mattina SR, Mackie MR, Ljubicic V
Acta physiologica (Oxford, England) 2023 Apr;237(4):e13943
Acta physiologica (Oxford, England) 2023 Apr;237(4):e13943
Possible frequent multiple mitochondrial DNA copies in a single nucleoid in HeLa cells.
Pavluch V, Špaček T, Engstová H, Dlasková A, Ježek P
Scientific reports 2023 Apr 8;13(1):5788
Scientific reports 2023 Apr 8;13(1):5788
Molybdenum and Cadmium Co-induce Mitochondrial Quality Control Disorder via FUNDC1-Mediated Mitophagy in Sheep Kidney.
Wu Y, Yang F, Zhou G, Wang Q, Xing C, Bai H, Yi X, Xiong Z, Yang S, Cao H
Frontiers in veterinary science 2022;9:842259
Frontiers in veterinary science 2022;9:842259
Impact of UCP2 depletion on heat stroke-induced mitochondrial function in human umbilical vein endothelial cells.
Huang W, Mao L, Xie W, Cai S, Huang Q, Liu Y, Chen Z
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2022;39(1):287-296
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2022;39(1):287-296
Selenium Attenuates TBHP-Induced Apoptosis of Nucleus Pulposus Cells by Suppressing Mitochondrial Fission through Activating Nuclear Factor Erythroid 2-Related Factor 2.
Wang P, Zhang S, Liu W, Chen S, Lv X, Hu B, Shao Z
Oxidative medicine and cellular longevity 2022;2022:7531788
Oxidative medicine and cellular longevity 2022;2022:7531788
Dynamin-Related Protein 1 Is Involved in Mitochondrial Damage, Defective Mitophagy, and NLRP3 Inflammasome Activation Induced by MSU Crystals.
Jiang H, Chen F, Song D, Zhou X, Ren L, Zeng M
Oxidative medicine and cellular longevity 2022;2022:5064494
Oxidative medicine and cellular longevity 2022;2022:5064494
Change in Oxidative Stress and Mitochondrial Dynamics in Response to Elevated Cold-Inducible RNA-Binding Protein in Cardiac Surgery-Associated Acute Kidney Injury.
Zheng X, Fan Y, Li J, Ma T, Li Y, Wang Q, Yan Y, Liu W
Oxidative medicine and cellular longevity 2022;2022:3576892
Oxidative medicine and cellular longevity 2022;2022:3576892
Intracellular Ca(2+) Signaling and Calcium Release-Activated Calcium Modulator ORAI1 Are Associated With CD4(+) T Lymphocytes in Dairy Cows.
Li M, Zhang B, Yin Y, Wen J, Wang J, He Y, Jiang Q, Loor JJ, Wang S, Yang W, Xu C
Frontiers in immunology 2022;13:835936
Frontiers in immunology 2022;13:835936
COA3 overexpression promotes non-small cell lung cancer metastasis by reprogramming glucose metabolism.
Lin H, Gao Y, Sun K, Zhang Q, Li Y, Chen M, Jin F
American journal of cancer research 2022;12(8):3662-3678
American journal of cancer research 2022;12(8):3662-3678
Non-invasive photobiomodulation treatment in an Alzheimer Disease-like transgenic rat model.
Yang L, Wu C, Parker E, Li Y, Dong Y, Tucker L, Brann DW, Lin HW, Zhang Q
Theranostics 2022;12(5):2205-2231
Theranostics 2022;12(5):2205-2231
Mannose inhibits the growth of prostate cancer through a mitochondrial mechanism.
Deng YL, Liu R, Cai ZD, Han ZD, Feng YF, Cai SH, Chen QB, Zhu JG, Zhong WD
Asian journal of andrology 2022 Sep-Oct;24(5):540-548
Asian journal of andrology 2022 Sep-Oct;24(5):540-548
Empagliflozin Preserves Skeletal Muscle Function in a HFpEF Rat Model.
Winzer EB, Schauer A, Langner E, Augstein A, Goto K, Männel A, Barthel P, Jannasch A, Labeit S, Mangner N, Linke A, Adams V
International journal of molecular sciences 2022 Sep 20;23(19)
International journal of molecular sciences 2022 Sep 20;23(19)
Depletion of serum-derived exosomes aggravates heat stress-induced damage of bovine mammary epithelial cells.
Wang Y, Wang HL, Lin ZP, Zhong JF, Chen KL, Duan X
Molecular biology reports 2022 Oct;49(10):9297-9305
Molecular biology reports 2022 Oct;49(10):9297-9305
Blocking exosomal secretion aggravates 1,4-benzoquinone-induced mitochondrial fission activated by the AMPK/MFF/Drp1 pathway in HL-60 cells.
Lu F, Zhang Q, Zhang M, Sun S, Yang X, Yan H
Journal of applied toxicology : JAT 2022 Oct;42(10):1618-1627
Journal of applied toxicology : JAT 2022 Oct;42(10):1618-1627
Integrated Analysis of Transcriptome and microRNA Profile Reveals the Toxicity of Euphorbia Factors toward Human Colon Adenocarcinoma Cell Line Caco-2.
Zou L, Bao W, Gao Y, Chen M, Wu Y, Wang S, Li C, Zhang J, Zhang D, Wang Q, Zhu A
Molecules (Basel, Switzerland) 2022 Oct 16;27(20)
Molecules (Basel, Switzerland) 2022 Oct 16;27(20)
The Endoplasmic Reticulum ATP13A1 is Essential for MAVS-Mediated Antiviral Innate Immunity.
Zhang R, Hou X, Wang C, Li J, Zhu J, Jiang Y, Hou F
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Nov;9(33):e2203831
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Nov;9(33):e2203831
Cadmium-induced apoptosis of Leydig cells is mediated by excessive mitochondrial fission and inhibition of mitophagy.
Yi L, Shang XJ, Lv L, Wang Y, Zhang J, Quan C, Shi Y, Liu Y, Zhang L
Cell death & disease 2022 Nov 5;13(11):928
Cell death & disease 2022 Nov 5;13(11):928
Sirt3 deficiency accelerates ovarian senescence without affecting spermatogenesis in aging mice.
Zhu J, Yang Q, Li H, Wang Y, Jiang Y, Wang H, Cong L, Xu J, Shen Z, Chen W, Zeng X, Wang M, Lei M, Sun Y
Free radical biology & medicine 2022 Nov 20;193(Pt 2):511-525
Free radical biology & medicine 2022 Nov 20;193(Pt 2):511-525
Dihydromyricetin contributes to weight loss via pro-browning mediated by mitochondrial fission in white adipose.
Xiong X, Xia M, Niu A, Zhang Y, Yin T, Huang Q
European journal of pharmacology 2022 Nov 15;935:175345
European journal of pharmacology 2022 Nov 15;935:175345
AMPK/MFF Activation: Role in Mitochondrial Fission and Mitophagy in Dry Eye.
Peng F, Jiang D, Xu W, Sun Y, Zha Z, Tan X, Yu J, Pan C, Zheng Q, Chen W
Investigative ophthalmology & visual science 2022 Nov 1;63(12):18
Investigative ophthalmology & visual science 2022 Nov 1;63(12):18
SIRT4 Expression Ameliorates the Detrimental Effect of Heat Stress via AMPK/mTOR Signaling Pathway in BMECs.
Ding Q, Wang Y, Xia SW, Zhao F, Zhong JF, Wang HL, Chen KL
International journal of molecular sciences 2022 Nov 1;23(21)
International journal of molecular sciences 2022 Nov 1;23(21)
Heat shock protein 60 couples an oxidative stress-responsive p38/MK2 signaling and NF-κB survival machinery in cancer cells.
Min S, Kim JY, Cho HM, Park S, Hwang JM, You H, Chan Chae Y, Lee WJ, Sun W, Kang D, Lee S, Kang SW
Redox biology 2022 May;51:102293
Redox biology 2022 May;51:102293
PACS-2 Ameliorates Tubular Injury by Facilitating Endoplasmic Reticulum-Mitochondria Contact and Mitophagy in Diabetic Nephropathy.
Li C, Li L, Yang M, Yang J, Zhao C, Han Y, Zhao H, Jiang N, Wei L, Xiao Y, Liu Y, Xiong X, Xi Y, Luo S, Deng F, Chen W, Yuan S, Zhu X, Xiao L, Sun L
Diabetes 2022 May 1;71(5):1034-1050
Diabetes 2022 May 1;71(5):1034-1050
HSP70 attenuates compression-induced apoptosis of nucleus pulposus cells by suppressing mitochondrial fission via upregulating the expression of SIRT3.
Hu B, Wang P, Zhang S, Liu W, Lv X, Shi D, Zhao L, Liu H, Wang B, Chen S, Shao Z
Experimental & molecular medicine 2022 Mar;54(3):309-323
Experimental & molecular medicine 2022 Mar;54(3):309-323
PINK1 regulates mitochondrial fission/fusion and neuroinflammation in β-amyloid-induced Alzheimer's disease models.
Wang X, Xue Y, Yao Y, Li Y, Ji X, Chi T, Liu P, Zou L
Neurochemistry international 2022 Mar;154:105298
Neurochemistry international 2022 Mar;154:105298
Chicoric Acid Attenuated Renal Tubular Injury in HFD-Induced Chronic Kidney Disease Mice through the Promotion of Mitophagy via the Nrf2/PINK/Parkin Pathway.
Ding XQ, Jian TY, Gai YN, Niu GT, Liu Y, Meng XH, Li J, Lyu H, Ren BR, Chen J
Journal of agricultural and food chemistry 2022 Mar 9;70(9):2923-2935
Journal of agricultural and food chemistry 2022 Mar 9;70(9):2923-2935
PINK1/TAX1BP1-directed mitophagy attenuates vascular endothelial injury induced by copper oxide nanoparticles.
Fan Y, Cheng Z, Mao L, Xu G, Li N, Zhang M, Weng P, Zheng L, Dong X, Hu S, Wang B, Qin X, Jiang X, Chen C, Zhang J, Zou Z
Journal of nanobiotechnology 2022 Mar 19;20(1):149
Journal of nanobiotechnology 2022 Mar 19;20(1):149
Carbon tetrachloride induced mitochondrial division, respiratory chain damage, abnormal intracellular [H(+)] and apoptosis are due to the activation of 5-HT degradation system in hepatocytes.
Zhang Y, Liang X, Guan J, Jin J, Zhang Y, Xu F, Fu J
Toxicology and applied pharmacology 2022 Mar 15;439:115929
Toxicology and applied pharmacology 2022 Mar 15;439:115929
Autophagy and mitochondrial dynamics contribute to the protective effect of diosgenin against 3-MCPD induced kidney injury.
Zhong Y, Sun D, Yao Y, Liu Q, Guo T, Wang X, Peng X
Chemico-biological interactions 2022 Mar 1;355:109850
Chemico-biological interactions 2022 Mar 1;355:109850
Long-term exercise pre-training attenuates Alzheimer's disease-related pathology in a transgenic rat model of Alzheimer's disease.
Yang L, Wu C, Li Y, Dong Y, Wu CY, Lee RH, Brann DW, Lin HW, Zhang Q
GeroScience 2022 Jun;44(3):1457-1477
GeroScience 2022 Jun;44(3):1457-1477
Regulatory roles of external cholesterol in human airway epithelial mitochondrial function through STARD3 signalling.
Li L, Liu Y, Liu X, Zheng N, Gu Y, Song Y, Wang X
Clinical and translational medicine 2022 Jun;12(6):e902
Clinical and translational medicine 2022 Jun;12(6):e902
Effects of amyloid-β on protein SUMOylation and levels of mitochondrial proteins in primary cortical neurons.
Soares ES, de Souza ACG, Zanella CA, Carmichael RE, Henley JM, Wilkinson KA, Cimarosti HI
IBRO neuroscience reports 2022 Jun;12:142-148
IBRO neuroscience reports 2022 Jun;12:142-148
Novel Thermosensitive Hydrogel Promotes Spinal Cord Repair by Regulating Mitochondrial Function.
Li Y, Yang L, Hu F, Xu J, Ye J, Liu S, Wang L, Zhuo M, Ran B, Zhang H, Ye J, Xiao J
ACS applied materials & interfaces 2022 Jun 8;14(22):25155-25172
ACS applied materials & interfaces 2022 Jun 8;14(22):25155-25172
Breast Cancer Selective Disruption of Actin Cytoskeleton by Diallyl Trisulfide.
Hahm ER, Mathan SV, Singh RP, Singh SV
Journal of cancer prevention 2022 Jun 30;27(2):101-111
Journal of cancer prevention 2022 Jun 30;27(2):101-111
Myosin II proteins are required for organization of calcium-induced actin networks upstream of mitochondrial division.
Kage F, Vicente-Manzanares M, McEwan BC, Kettenbach AN, Higgs HN
Molecular biology of the cell 2022 Jun 1;33(7):ar63
Molecular biology of the cell 2022 Jun 1;33(7):ar63
Aldehyde dehydrogenase 2 deficiency promotes skeletal muscle atrophy in aged mice.
Kasai A, Jee E, Tamura Y, Kouzaki K, Kotani T, Nakazato K
American journal of physiology. Regulatory, integrative and comparative physiology 2022 Jun 1;322(6):R511-R525
American journal of physiology. Regulatory, integrative and comparative physiology 2022 Jun 1;322(6):R511-R525
Inhibition of nuclear deacetylase Sirtuin-1 induces mitochondrial acetylation and calcium overload leading to cell death.
Sun Y, Yang YM, Hu YY, Ouyang L, Sun ZH, Yin XF, Li N, He QY, Wang Y
Redox biology 2022 Jul;53:102334
Redox biology 2022 Jul;53:102334
Selenium alleviates cadmium-induced aging via mitochondrial quality control in the livers of sheep.
Xiong Z, Yang F, Xu T, Yang Y, Wang F, Zhou G, Wang Q, Guo X, Xing C, Bai H, Chen J, Wu Y, Yang S, Cao H
Journal of inorganic biochemistry 2022 Jul;232:111818
Journal of inorganic biochemistry 2022 Jul;232:111818
PEX11β and FIS1 cooperate in peroxisome division independently of mitochondrial fission factor.
Schrader TA, Carmichael RE, Islinger M, Costello JL, Hacker C, Bonekamp NA, Weishaupt JH, Andersen PM, Schrader M
Journal of cell science 2022 Jul 1;135(13)
Journal of cell science 2022 Jul 1;135(13)
Herceptin induces ferroptosis and mitochondrial dysfunction in H9c2 cells.
Sun L, Wang H, Yu S, Zhang L, Jiang J, Zhou Q
International journal of molecular medicine 2022 Feb;49(2)
International journal of molecular medicine 2022 Feb;49(2)
The SUMO protease SENP3 regulates mitochondrial autophagy mediated by Fis1.
Waters E, Wilkinson KA, Harding AL, Carmichael RE, Robinson D, Colley HE, Guo C
EMBO reports 2022 Feb 3;23(2):e48754
EMBO reports 2022 Feb 3;23(2):e48754
Attenuates of NAD(+) impair BMSC osteogenesis and fracture repair through OXPHOS.
Li B, Shi Y, Liu M, Wu F, Hu X, Yu F, Wang C, Ye L
Stem cell research & therapy 2022 Feb 22;13(1):77
Stem cell research & therapy 2022 Feb 22;13(1):77
Protective Effects of Chaya against Mitochondrial and Synaptic Toxicities in the Type 2 Diabetes Mouse Model TallyHO.
Ramasubramanian B, Griffith C, Hanson M, Bunquin LE, Reddy AP, Hegde V, Reddy PH
Cells 2022 Feb 21;11(4)
Cells 2022 Feb 21;11(4)
Early Cellular, Molecular, Morphological and Behavioral Changes in the Humanized Amyloid-Beta-Knock-In Mouse Model of Late-Onset Alzheimer's Disease.
Kshirsagar S, Alvir RV, Hindle A, Kumar S, Vijayan M, Pradeepkiran JA, Reddy AP, Ramasubramanian B, Reddy PH
Cells 2022 Feb 19;11(4)
Cells 2022 Feb 19;11(4)
Protein C receptor maintains cancer stem cell properties via activating lipid synthesis in nasopharyngeal carcinoma.
Zhang P, He Q, Wang Y, Zhou G, Chen Y, Tang L, Zhang Y, Hong X, Mao Y, He Q, Yang X, Liu N, Ma J
Signal transduction and targeted therapy 2022 Feb 16;7(1):46
Signal transduction and targeted therapy 2022 Feb 16;7(1):46
Myricetin Restores Aβ-Induced Mitochondrial Impairments in N2a-SW Cells.
Yao X, Zhang J, Lu Y, Deng Y, Zhao R, Xiao S
ACS chemical neuroscience 2022 Feb 16;13(4):454-463
ACS chemical neuroscience 2022 Feb 16;13(4):454-463
CHCHD2 and CHCHD10 regulate mitochondrial dynamics and integrated stress response.
Ruan Y, Hu J, Che Y, Liu Y, Luo Z, Cheng J, Han Q, He H, Zhou Q
Cell death & disease 2022 Feb 16;13(2):156
Cell death & disease 2022 Feb 16;13(2):156
Generation of a homozygous FIS1 knockout human embryonic stem cell line GIBHe015-B by CRISPR/Cas9 system.
Wang M, Tang J, Zhou T, Mai Y, Zhu Y
Stem cell research 2022 Dec;65:102980
Stem cell research 2022 Dec;65:102980
Cdk5 Promotes Mitochondrial Fission via Drp1 Phosphorylation at S616 in Chronic Ethanol Exposure-Induced Cognitive Impairment.
Liu D, Li J, Rong X, Li J, Peng Y, Shen Q
Molecular neurobiology 2022 Dec;59(12):7075-7094
Molecular neurobiology 2022 Dec;59(12):7075-7094
SARS-CoV-2 mitochondriopathy in COVID-19 pneumonia exacerbates hypoxemia.
Archer SL, Dasgupta A, Chen KH, Wu D, Baid K, Mamatis JE, Gonzalez V, Read A, Bentley RE, Martin AY, Mewburn JD, Dunham-Snary KJ, Evans GA, Levy G, Jones O, Al-Qazazi R, Ring B, Alizadeh E, Hindmarch CC, Rossi J, Lima PD, Falzarano D, Banerjee A, Colpitts CC
Redox biology 2022 Dec;58:102508
Redox biology 2022 Dec;58:102508
Perinatal exposure to glyphosate-based herbicides impairs progeny health and placental angiogenesis by disturbing mitochondrial function.
Bai G, Jiang X, Qin J, Zou Y, Zhang W, Teng T, Shi B, Sun H
Environment international 2022 Dec;170:107579
Environment international 2022 Dec;170:107579
Protective Effect and Mechanism of Melatonin on Cisplatin-Induced Ovarian Damage in Mice.
Xing F, Wang M, Ding Z, Zhang J, Ding S, Shi L, Xie Q, Ahmad MJ, Wei Z, Tang L, Liang D, Cao Y, Liu Y
Journal of clinical medicine 2022 Dec 12;11(24)
Journal of clinical medicine 2022 Dec 12;11(24)
A Combination Therapy of Urolithin A+EGCG Has Stronger Protective Effects than Single Drug Urolithin A in a Humanized Amyloid Beta Knockin Mice for Late-Onset Alzheimer's Disease.
Kshirsagar S, Alvir RV, Pradeepkiran JA, Hindle A, Vijayan M, Ramasubramaniam B, Kumar S, Reddy AP, Reddy PH
Cells 2022 Aug 27;11(17)
Cells 2022 Aug 27;11(17)
A pivotal role of selective autophagy in mitochondrial quality control: Implications for zinc oxide nanoparticles induced neurotoxicity.
Wang L, Duan Z, Liang M, Wang C, Liang T, Sun L, Yan C, Li Q, Liang T
Chemico-biological interactions 2022 Aug 25;363:110003
Chemico-biological interactions 2022 Aug 25;363:110003
N(6)-adenomethylation of GsdmC is essential for Lgr5(+) stem cell survival to maintain normal colonic epithelial morphogenesis.
Du J, Sarkar R, Li Y, He L, Kang W, Liao W, Liu W, Nguyen T, Zhang L, Deng Z, Dougherty U, Kupfer SS, Chen M, Pekow J, Bissonnette M, He C, Li YC
Developmental cell 2022 Aug 22;57(16):1976-1994.e8
Developmental cell 2022 Aug 22;57(16):1976-1994.e8
Chrono-Aerobic Exercise Optimizes Metabolic State in DB/DB Mice through CLOCK-Mitophagy-Apoptosis.
Zhang Z, Li X, Zhang J, Du J, Zhang Q, Ge Z, Ding S
International journal of molecular sciences 2022 Aug 18;23(16)
International journal of molecular sciences 2022 Aug 18;23(16)
Nicotinamide mononucleotide alleviates heat stress-induced oxidative stress and apoptosis in BMECs through reducing mitochondrial damage and endoplasmic reticulum stress.
Zeng HF, Xu J, Wang XL, Li SJ, Han ZY
Ecotoxicology and environmental safety 2022 Apr 15;235:113441
Ecotoxicology and environmental safety 2022 Apr 15;235:113441
CLOCK regulates Drp1 mRNA stability and mitochondrial homeostasis by interacting with PUF60.
Xu L, Lin J, Liu Y, Hua B, Cheng Q, Lin C, Yan Z, Wang Y, Sun N, Qian R, Lu C
Cell reports 2022 Apr 12;39(2):110635
Cell reports 2022 Apr 12;39(2):110635
BNIP3 (BCL2 interacting protein 3) regulates pluripotency by modulating mitochondrial homeostasis via mitophagy.
Liu K, Zhao Q, Sun H, Liu L, Wang C, Li Z, Xu Y, Wang L, Zhang L, Zhang H, Chen Q, Zhao T
Cell death & disease 2022 Apr 11;13(4):334
Cell death & disease 2022 Apr 11;13(4):334
Phosphorylation of Dynamin-Related Protein 1 (DRP1) Regulates Mitochondrial Dynamics and Skeletal Muscle Wasting in Cancer Cachexia.
Mao X, Gu Y, Sui X, Shen L, Han J, Wang H, Xi Q, Zhuang Q, Meng Q, Wu G
Frontiers in cell and developmental biology 2021;9:673618
Frontiers in cell and developmental biology 2021;9:673618
KCa3.1 Mediates Dysregulation of Mitochondrial Quality Control in Diabetic Kidney Disease.
Huang C, Yi H, Shi Y, Cao Q, Shi Y, Cheng D, Braet F, Chen XM, Pollock CA
Frontiers in cell and developmental biology 2021;9:573814
Frontiers in cell and developmental biology 2021;9:573814
PP2 Ameliorates Renal Fibrosis by Regulating the NF-κB/COX-2 and PPARγ/UCP2 Pathway in Diabetic Mice.
Wei J, Deng X, Li Y, Li R, Yang Z, Li X, Song S, Shi Y, Duan H, Wu H
Oxidative medicine and cellular longevity 2021;2021:7394344
Oxidative medicine and cellular longevity 2021;2021:7394344
RNA-Seq Profiling to Investigate the Mechanism of Qishen Granules on Regulating Mitochondrial Energy Metabolism of Heart Failure in Rats.
He H, Li C, Lu X, Li Y, Li X, Sun X, Tang B, Wu Y, Li C
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5779307
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5779307
Tortoise Plastron and Deer Antler Gelatin Prevents Against Neuronal Mitochondrial Dysfunction In Vitro: Implication for a Potential Therapy of Alzheimer's Disease.
Cheng D, Yang XJ, Zhang L, Qin ZS, Li WQ, Xu HC, Zhang ZJ
Frontiers in pharmacology 2021;12:690256
Frontiers in pharmacology 2021;12:690256
Elevated Lactate by High-Intensity Interval Training Regulates the Hippocampal BDNF Expression and the Mitochondrial Quality Control System.
Hu J, Cai M, Shang Q, Li Z, Feng Y, Liu B, Xue X, Lou S
Frontiers in physiology 2021;12:629914
Frontiers in physiology 2021;12:629914
Antioxidant activity of mesenchymal stem cell-derived extracellular vesicles restores hippocampal neurons following seizure damage.
Luo Q, Xian P, Wang T, Wu S, Sun T, Wang W, Wang B, Yang H, Yang Y, Wang H, Liu W, Long Q
Theranostics 2021;11(12):5986-6005
Theranostics 2021;11(12):5986-6005
Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington's disease.
Hu D, Sun X, Magpusao A, Fedorov Y, Thompson M, Wang B, Lundberg K, Adams DJ, Qi X
Nature communications 2021 Sep 6;12(1):5305
Nature communications 2021 Sep 6;12(1):5305
Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity.
Xiao X, Yeghiazaryan G, Hess S, Klemm P, Sieben A, Kleinridders A, Morgan DA, Wunderlich FT, Rahmouni K, Kong D, Scammell TE, Lowell BB, Kloppenburg P, Brüning JC, Hausen AC
Nature communications 2021 Sep 2;12(1):5249
Nature communications 2021 Sep 2;12(1):5249
Effects of andrographolide on renal tubulointersticial injury and fibrosis. Evidence of its mechanism of action.
Liu W, Liang L, Zhang Q, Li Y, Yan S, Tang T, Ren Y, Mo J, Liu F, Chen X, Lan T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct;91:153650
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct;91:153650
Calcium chelator BAPTA‑AM protects against iron overload‑induced chondrocyte mitochondrial dysfunction and cartilage degeneration.
Jing X, Wang Q, Du T, Zhang W, Liu X, Liu Q, Li T, Wang G, Chen F, Cui X
International journal of molecular medicine 2021 Oct;48(4)
International journal of molecular medicine 2021 Oct;48(4)
Mechanisms of impaired mitochondrial homeostasis and NAD(+) metabolism in a model of mitochondrial heart disease exhibiting redox active iron accumulation.
Chiang S, Braidy N, Maleki S, Lal S, Richardson DR, Huang ML
Redox biology 2021 Oct;46:102038
Redox biology 2021 Oct;46:102038
Inhibition of ER stress attenuates kidney injury and apoptosis induced by 3-MCPD via regulating mitochondrial fission/fusion and Ca(2+) homeostasis.
Zhong Y, Jin C, Han J, Zhu J, Liu Q, Sun D, Xia X, Peng X
Cell biology and toxicology 2021 Oct;37(5):795-809
Cell biology and toxicology 2021 Oct;37(5):795-809
SIRT3 protects bovine mammary epithelial cells from heat stress damage by activating the AMPK signaling pathway.
Sun XC, Wang Y, Zeng HF, Xi YM, Lin H, Han ZY, Chen KL
Cell death discovery 2021 Oct 21;7(1):304
Cell death discovery 2021 Oct 21;7(1):304
Melatonin protects against excessive autophagy-induced mitochondrial and ovarian reserve function deficiency though ERK signaling pathway in Chinese hamster ovary (CHO) cells.
Xie QE, Wang MY, Cao ZP, Du X, Ji DM, Liang D, Cao YX, Liu YJ
Mitochondrion 2021 Nov;61:44-53
Mitochondrion 2021 Nov;61:44-53
Distinct fission signatures predict mitochondrial degradation or biogenesis.
Kleele T, Rey T, Winter J, Zaganelli S, Mahecic D, Perreten Lambert H, Ruberto FP, Nemir M, Wai T, Pedrazzini T, Manley S
Nature 2021 May;593(7859):435-439
Nature 2021 May;593(7859):435-439
Protective effects of a mitochondria-targeted small peptide SS31 against hyperglycemia-induced mitochondrial abnormalities in the liver tissues of diabetic mice, Tallyho/JngJ mice.
Bhatti JS, Tamarai K, Kandimalla R, Manczak M, Yin X, Ramasubramanian B, Sawant N, Pradeepkiran JA, Vijayan M, Kumar S, Reddy PH
Mitochondrion 2021 May;58:49-58
Mitochondrion 2021 May;58:49-58
Dihydromyricetin attenuates heat stress-induced apoptosis in dairy cow mammary epithelial cells through suppressing mitochondrial dysfunction.
Wang HL, Xing GD, Qian Y, Sun XF, Zhong JF, Chen KL
Ecotoxicology and environmental safety 2021 May;214:112078
Ecotoxicology and environmental safety 2021 May;214:112078
Protective effects of antidepressant citalopram against abnormal APP processing and amyloid beta-induced mitochondrial dynamics, biogenesis, mitophagy and synaptic toxicities in Alzheimer's disease.
Reddy AP, Yin X, Sawant N, Reddy PH
Human molecular genetics 2021 May 29;30(10):847-864
Human molecular genetics 2021 May 29;30(10):847-864
Effects of photoperiod on morphology and function in testis and epididymis of Cricetulus barabensis.
Mou J, Xu J, Wang Z, Wang C, Yang X, Wang X, Xue H, Wu M, Xu L
Journal of cellular physiology 2021 Mar;236(3):2109-2125
Journal of cellular physiology 2021 Mar;236(3):2109-2125
Haemodynamic-directed cardiopulmonary resuscitation promotes mitochondrial fusion and preservation of mitochondrial mass after successful resuscitation in a pediatric porcine model.
Senthil K, Morgan RW, Hefti MM, Karlsson M, Lautz AJ, Mavroudis CD, Ko T, Nadkarni VM, Ehinger J, Berg RA, Sutton RM, McGowan FX, Kilbaugh TJ
Resuscitation plus 2021 Jun;6:100124
Resuscitation plus 2021 Jun;6:100124
The detrimental effect of iron on OA chondrocytes: Importance of pro-inflammatory cytokines induced iron influx and oxidative stress.
Jing X, Du T, Li T, Yang X, Wang G, Liu X, Jiang Z, Cui X
Journal of cellular and molecular medicine 2021 Jun;25(12):5671-5680
Journal of cellular and molecular medicine 2021 Jun;25(12):5671-5680
ALS/FTD mutations in UBQLN2 are linked to mitochondrial dysfunction through loss-of-function in mitochondrial protein import.
Lin BC, Phung TH, Higgins NR, Greenslade JE, Prado MA, Finley D, Karbowski M, Polster BM, Monteiro MJ
Human molecular genetics 2021 Jun 17;30(13):1230-1246
Human molecular genetics 2021 Jun 17;30(13):1230-1246
Effect of the interference with DRP1 expression on the biological characteristics of glioma stem cells.
Zhang L, Cao H, Tao H, Yang J, Gong W, Hu Q
Experimental and therapeutic medicine 2021 Jul;22(1):696
Experimental and therapeutic medicine 2021 Jul;22(1):696
Resveratrol and exercise combined to treat functional limitations in late life: A pilot randomized controlled trial.
Harper SA, Bassler JR, Peramsetty S, Yang Y, Roberts LM, Drummer D, Mankowski RT, Leeuwenburgh C, Ricart K, Patel RP, Bamman MM, Anton SD, Jaeger BC, Buford TW
Experimental gerontology 2021 Jan;143:111111
Experimental gerontology 2021 Jan;143:111111
ATPIF1 maintains normal mitochondrial structure which is impaired by CCM3 deficiency in endothelial cells.
Wang K, Chen H, Zhou Z, Zhang H, Zhou HJ, Min W
Cell & bioscience 2021 Jan 9;11(1):11
Cell & bioscience 2021 Jan 9;11(1):11
Selonsertib, a potential drug for liver failure therapy by rescuing the mitochondrial dysfunction of macrophage via ASK1-JNK-DRP1 pathway.
Lou G, Li A, Cen Y, Yang Q, Zhang T, Qi J, Chen Z, Liu Y
Cell & bioscience 2021 Jan 7;11(1):9
Cell & bioscience 2021 Jan 7;11(1):9
Mesenchymal stem cells ameliorate lipid metabolism through reducing mitochondrial damage of hepatocytes in the treatment of post-hepatectomy liver failure.
Wang JL, Ding HR, Pan CY, Shi XL, Ren HZ
Cell death & disease 2021 Jan 21;12(1):111
Cell death & disease 2021 Jan 21;12(1):111
CHIP protects against MPP(+)/MPTP-induced damage by regulating Drp1 in two models of Parkinson's disease.
Hu Z, Mao C, Wang H, Zhang Z, Zhang S, Luo H, Tang M, Yang J, Yuan Y, Wang Y, Liu Y, Fan L, Zhang Q, Yao D, Liu F, Schisler JC, Shi C, Xu Y
Aging 2021 Jan 2;13(1):1458-1472
Aging 2021 Jan 2;13(1):1458-1472
Restoring metabolism of myeloid cells reverses cognitive decline in ageing.
Minhas PS, Latif-Hernandez A, McReynolds MR, Durairaj AS, Wang Q, Rubin A, Joshi AU, He JQ, Gauba E, Liu L, Wang C, Linde M, Sugiura Y, Moon PK, Majeti R, Suematsu M, Mochly-Rosen D, Weissman IL, Longo FM, Rabinowitz JD, Andreasson KI
Nature 2021 Feb;590(7844):122-128
Nature 2021 Feb;590(7844):122-128
The XBP1‒MARCH5‒MFN2 Axis Confers Endoplasmic Reticulum Stress Resistance by Coordinating Mitochondrial Fission and Mitophagy in Melanoma.
Wang H, Yi X, Guo S, Wang S, Ma J, Zhao T, Shi Q, Tian Y, Wang H, Jia L, Gao T, Li C, Guo W
The Journal of investigative dermatology 2021 Dec;141(12):2932-2943.e12
The Journal of investigative dermatology 2021 Dec;141(12):2932-2943.e12
Carnosol alleviates nonalcoholic fatty liver disease by inhibiting mitochondrial dysfunction and apoptosis through targeting of PRDX3.
Geng Y, Wang Y, Sun R, Kang X, Zhao H, Zhu M, Sun Y, Hu Y, Wang Z, Tian X, Zhao Y, Yao J
Toxicology and applied pharmacology 2021 Dec 1;432:115758
Toxicology and applied pharmacology 2021 Dec 1;432:115758
Chronic hypoxia alters cardiac mitochondrial complex protein expression and activity in fetal guinea pigs in a sex-selective manner.
Song H, Polster BM, Thompson LP
American journal of physiology. Regulatory, integrative and comparative physiology 2021 Dec 1;321(6):R912-R924
American journal of physiology. Regulatory, integrative and comparative physiology 2021 Dec 1;321(6):R912-R924
Intranasal administration of DHED protects against exhaustive exercise-induced brain injury in rats.
Peng G, Zheng H, Wu C, Wu C, Ma X, Xiong J, Hou J, Zhang L, Yang L, Pan H
Brain research 2021 Dec 1;1772:147665
Brain research 2021 Dec 1;1772:147665
Targeting P2RX1 alleviates renal ischemia/reperfusion injury by preserving mitochondrial dynamics.
Zhuang S, Xia S, Huang P, Wu J, Qu J, Chen R, Sun N, Li D, Wu H, Zhang M, Zhang J, Yuan X, Wang X
Pharmacological research 2021 Aug;170:105712
Pharmacological research 2021 Aug;170:105712
LKB1/AMPKα signaling pathway and mitochondrial fission/fusion dynamics regulate apoptosis induced by 3-chlorpropane-1,2-diol in HEK293 cells.
Jin C, Xue W, Liu Q, Han J, Luo R, Feng J, Liu J, Guo T, Peng X, Hu T
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Aug;154:112350
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Aug;154:112350
Extract of Cynomorium songaricum ameliorates mitochondrial ultrastructure impairments and dysfunction in two different in vitro models of Alzheimer's disease.
Cheng D, Su L, Wang X, Li X, Li L, Hu M, Lu Y
BMC complementary medicine and therapies 2021 Aug 9;21(1):206
BMC complementary medicine and therapies 2021 Aug 9;21(1):206
Fis1 ablation in the male germline disrupts mitochondrial morphology and mitophagy, and arrests spermatid maturation.
Varuzhanyan G, Ladinsky MS, Yamashita SI, Abe M, Sakimura K, Kanki T, Chan DC
Development (Cambridge, England) 2021 Aug 15;148(16)
Development (Cambridge, England) 2021 Aug 15;148(16)
Change on apoptosis, autophagy and mitochondria of the Harderian gland in Cricetulus barabensis during age.
Kong XT, Wang Z, Mou JJ, Li CS, Xue HL, Wu M, Chen L, Xu JH, Xu LX
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2021 Apr-May;253:110547
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2021 Apr-May;253:110547
Mst1 Knockout Alleviates Mitochondrial Fission and Mitigates Left Ventricular Remodeling in the Development of Diabetic Cardiomyopathy.
Feng X, Wang S, Yang X, Lin J, Man W, Dong Y, Zhang Y, Zhao Z, Wang H, Sun D
Frontiers in cell and developmental biology 2020;8:628842
Frontiers in cell and developmental biology 2020;8:628842
Deletion of Bmal1 Impairs Pancreatic β-Cell Function via Mitochondrial Signaling Pathway.
Ye L, Wu H, Xu W
BioMed research international 2020;2020:9803024
BioMed research international 2020;2020:9803024
Proteomic Profile of Mouse Brain Aging Contributions to Mitochondrial Dysfunction, DNA Oxidative Damage, Loss of Neurotrophic Factor, and Synaptic and Ribosomal Proteins.
Li Y, Yu H, Chen C, Li S, Zhang Z, Xu H, Zhu F, Liu J, Spencer PS, Dai Z, Yang X
Oxidative medicine and cellular longevity 2020;2020:5408452
Oxidative medicine and cellular longevity 2020;2020:5408452
Drp1-mediated mitochondrial fission contributes to baicalein-induced apoptosis and autophagy in lung cancer via activation of AMPK signaling pathway.
Deng X, Liu J, Liu L, Sun X, Huang J, Dong J
International journal of biological sciences 2020;16(8):1403-1416
International journal of biological sciences 2020;16(8):1403-1416
The effect of autophagy and mitochondrial fission on Harderian gland is greater than apoptosis in male hamsters during different photoperiods.
Xu JH, Wang Z, Mou JJ, Zhao XY, Geng XC, Wu M, Xue HL, Chen L, Xu LX
PloS one 2020;15(11):e0241561
PloS one 2020;15(11):e0241561
Bu-Yin-Qian-Zheng Formula Ameliorates MPP(+)-Induced Mitochondrial Dysfunction in Parkinson's Disease via Parkin.
Ma HJ, Gai C, Chai Y, Feng WD, Cheng CC, Zhang JK, Zhang YX, Yang LP, Guo ZY, Gao YS, Sun HM
Frontiers in pharmacology 2020;11:577017
Frontiers in pharmacology 2020;11:577017
High-Intensity Interval Training Restores Glycolipid Metabolism and Mitochondrial Function in Skeletal Muscle of Mice With Type 2 Diabetes.
Zheng L, Rao Z, Guo Y, Chen P, Xiao W
Frontiers in endocrinology 2020;11:561
Frontiers in endocrinology 2020;11:561
Photoperiod Affects Harderian Gland Morphology and Secretion in Female Cricetulus barabensis: Autophagy, Apoptosis, and Mitochondria.
Wang Z, Xu JH, Mou JJ, Kong XT, Wu M, Xue HL, Xu LX
Frontiers in physiology 2020;11:408
Frontiers in physiology 2020;11:408
Promotion of mitochondrial fusion protects against developmental PBDE-47 neurotoxicity by restoring mitochondrial homeostasis and suppressing excessive apoptosis.
Dong L, Li P, Yang K, Liu L, Gao H, Zhou G, Zhao Q, Xia T, Wang A, Zhang S
Theranostics 2020;10(3):1245-1261
Theranostics 2020;10(3):1245-1261
Exercise enhances mitochondrial fission and mitophagy to improve myopathy following critical limb ischemia in elderly mice via the PGC1a/FNDC5/irisin pathway.
He W, Wang P, Chen Q, Li C
Skeletal muscle 2020 Sep 15;10(1):25
Skeletal muscle 2020 Sep 15;10(1):25
PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth.
Guo L, Cui C, Wang J, Yuan J, Yang Q, Zhang P, Su W, Bao R, Ran J, Wu C
Nature communications 2020 Oct 1;11(1):4913
Nature communications 2020 Oct 1;11(1):4913
HIF-1α ameliorates tubular injury in diabetic nephropathy via HO-1-mediated control of mitochondrial dynamics.
Jiang N, Zhao H, Han Y, Li L, Xiong S, Zeng L, Xiao Y, Wei L, Xiong X, Gao P, Yang M, Liu Y, Sun L
Cell proliferation 2020 Nov;53(11):e12909
Cell proliferation 2020 Nov;53(11):e12909
Novel ultrastructural findings on cardiac mitochondria of huddling Brandt's voles in mild cold environment.
Wang Z, Xu JH, Mou JJ, Kong XT, Zou JW, Xue HL, Wu M, Xu LX
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2020 Nov;249:110766
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2020 Nov;249:110766
Hypoxia induces pulmonary artery smooth muscle dysfunction through mitochondrial fragmentation-mediated endoplasmic reticulum stress.
Zhuan B, Wang X, Wang MD, Li ZC, Yuan Q, Xie J, Yang Z
Aging 2020 Nov 18;12(23):23684-23697
Aging 2020 Nov 18;12(23):23684-23697
Formation of colorectal liver metastases induces musculoskeletal and metabolic abnormalities consistent with exacerbated cachexia.
Huot JR, Novinger LJ, Pin F, Narasimhan A, Zimmers TA, O'Connell TM, Bonetto A
JCI insight 2020 May 7;5(9)
JCI insight 2020 May 7;5(9)
AIM2 promotes the development of non-small cell lung cancer by modulating mitochondrial dynamics.
Qi M, Dai D, Liu J, Li Z, Liang P, Wang Y, Cheng L, Zhan Y, An Z, Song Y, Yang Y, Yan X, Xiao H, Shao H
Oncogene 2020 Mar;39(13):2707-2723
Oncogene 2020 Mar;39(13):2707-2723
PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway.
Yao X, Yu S, Jing X, Guo J, Sun K, Guo F, Ye Y
Stem cell research & therapy 2020 Mar 30;11(1):140
Stem cell research & therapy 2020 Mar 30;11(1):140
Mitochondrial Dynamics Regulation in Skin Fibroblasts from Mitochondrial Disease Patients.
Tokuyama T, Hirai A, Shiiba I, Ito N, Matsuno K, Takeda K, Saito K, Mii K, Matsushita N, Fukuda T, Inatome R, Yanagi S
Biomolecules 2020 Mar 13;10(3)
Biomolecules 2020 Mar 13;10(3)
ChREBP-β regulates thermogenesis in brown adipose tissue.
Wei C, Ma X, Su K, Qi S, Zhu Y, Lin J, Wang C, Yang R, Chen X, Wang W, Zhang WJ
The Journal of endocrinology 2020 Jun;245(3):343-356
The Journal of endocrinology 2020 Jun;245(3):343-356
Drp1/Mff signaling pathway is involved in fluoride-induced abnormal fission of hepatocyte mitochondria in mice.
Zhou BH, Wei SS, Jia LS, Zhang Y, Miao CY, Wang HW
The Science of the total environment 2020 Jul 10;725:138192
The Science of the total environment 2020 Jul 10;725:138192
FKBP8 LIRL-dependent mitochondrial fragmentation facilitates mitophagy under stress conditions.
Yoo SM, Yamashita SI, Kim H, Na D, Lee H, Kim SJ, Cho DH, Kanki T, Jung YK
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Feb;34(2):2944-2957
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Feb;34(2):2944-2957
PKM2 suppresses osteogenesis and facilitates adipogenesis by regulating β-catenin signaling and mitochondrial fusion and fission.
Guo J, Ren R, Yao X, Ye Y, Sun K, Lin J, Wang G, Guo F, Xiao J, Xu T
Aging 2020 Feb 25;12(4):3976-3992
Aging 2020 Feb 25;12(4):3976-3992
Microcystin-leucine-arginine induced neurotoxicity by initiating mitochondrial fission in hippocampal neurons.
Zhang C, Wang J, Zhu J, Chen Y, Han X
The Science of the total environment 2020 Feb 10;703:134702
The Science of the total environment 2020 Feb 10;703:134702
Genome-wide synthetic lethal CRISPR screen identifies FIS1 as a genetic interactor of ALS-linked C9ORF72.
Chai N, Haney MS, Couthouis J, Morgens DW, Benjamin A, Wu K, Ousey J, Fang S, Finer S, Bassik MC, Gitler AD
Brain research 2020 Feb 1;1728:146601
Brain research 2020 Feb 1;1728:146601
Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease.
Zhang X, Wang R, Hu D, Sun X, Fujioka H, Lundberg K, Chan ER, Wang Q, Xu R, Flanagan ME, Pieper AA, Qi X
Science advances 2020 Dec;6(49)
Science advances 2020 Dec;6(49)
Desferoxamine protects against glucocorticoid-induced osteonecrosis of the femoral head via activating HIF-1α expression.
Jing X, Du T, Yang X, Zhang W, Wang G, Liu X, Li T, Jiang Z
Journal of cellular physiology 2020 Dec;235(12):9864-9875
Journal of cellular physiology 2020 Dec;235(12):9864-9875
Mitochondrial Safeguard: a stress response that offsets extreme fusion and protects respiratory function via flickering-induced Oma1 activation.
Murata D, Yamada T, Tokuyama T, Arai K, Quirós PM, López-Otín C, Iijima M, Sesaki H
The EMBO journal 2020 Dec 15;39(24):e105074
The EMBO journal 2020 Dec 15;39(24):e105074
PRCC-TFE3 regulates migration and invasion of translocation renal cell carcinomas via activation of Drp1-dependent mitochondrial fission.
Wang B, Gan W, Han X, Li D
Cell biology international 2020 Aug;44(8):1727-1733
Cell biology international 2020 Aug;44(8):1727-1733
USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation.
Rusilowicz-Jones EV, Jardine J, Kallinos A, Pinto-Fernandez A, Guenther F, Giurrandino M, Barone FG, McCarron K, Burke CJ, Murad A, Martinez A, Marcassa E, Gersch M, Buckmelter AJ, Kayser-Bricker KJ, Lamoliatte F, Gajbhiye A, Davis S, Scott HC, Murphy E, England K, Mortiboys H, Komander D, Trost M, Kessler BM, Ioannidis S, Ahlijanian MK, Urbé S, Clague MJ
Life science alliance 2020 Aug;3(8)
Life science alliance 2020 Aug;3(8)
Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission.
Ma D, Zheng B, Liu HL, Zhao YB, Liu X, Zhang XH, Li Q, Shi WB, Suzuki T, Wen JK
PLoS biology 2020 Aug;18(8):e3000808
PLoS biology 2020 Aug;18(8):e3000808
Heat stress induces apoptosis through disruption of dynamic mitochondrial networks in dairy cow mammary epithelial cells.
Chen KL, Wang HL, Jiang LZ, Qian Y, Yang CX, Chang WW, Zhong JF, Xing GD
In vitro cellular & developmental biology. Animal 2020 Apr;56(4):322-331
In vitro cellular & developmental biology. Animal 2020 Apr;56(4):322-331
An epigenetic increase in mitochondrial fission by MiD49 and MiD51 regulates the cell cycle in cancer: Diagnostic and therapeutic implications.
Dasgupta A, Chen KH, Wu D, Hoskin V, Mewburn J, Lima PDA, Parlow LRG, Hindmarch CCT, Martin A, Sykes EA, Tayade C, Lightbody ED, Madarnas Y, SenGupta SK, Elliott BE, Nicol CJB, Archer SL
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):5106-5127
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):5106-5127
Exogenous H(2)S Promoted USP8 Sulfhydration to Regulate Mitophagy in the Hearts of db/db Mice.
Sun Y, Lu F, Yu X, Wang B, Chen J, Lu F, Peng S, Sun X, Yu M, Chen H, Wang Y, Zhang L, Liu N, Du H, Zhao D, Zhang W
Aging and disease 2020 Apr;11(2):269-285
Aging and disease 2020 Apr;11(2):269-285
DsbA-L deficiency exacerbates mitochondrial dysfunction of tubular cells in diabetic kidney disease.
Gao P, Yang M, Chen X, Xiong S, Liu J, Sun L
Clinical science (London, England : 1979) 2020 Apr 17;134(7):677-694
Clinical science (London, England : 1979) 2020 Apr 17;134(7):677-694
SIRT3-Dependent Mitochondrial Dynamics Remodeling Contributes to Oxidative Stress-Induced Melanocyte Degeneration in Vitiligo.
Yi X, Guo W, Shi Q, Yang Y, Zhang W, Chen X, Kang P, Chen J, Cui T, Ma J, Wang H, Guo S, Chang Y, Liu L, Jian Z, Wang L, Xiao Q, Li S, Gao T, Li C
Theranostics 2019;9(6):1614-1633
Theranostics 2019;9(6):1614-1633
Spermidine Prevents Heart Injury in Neonatal Rats Exposed to Intrauterine Hypoxia by Inhibiting Oxidative Stress and Mitochondrial Fragmentation.
Chai N, Zhang H, Li L, Yu X, Liu Y, Lin Y, Wang L, Yan J, Nikolaevna SE, Zhao Y
Oxidative medicine and cellular longevity 2019;2019:5406468
Oxidative medicine and cellular longevity 2019;2019:5406468
Impaired Mitochondrial Fusion and Oxidative Phosphorylation Triggered by High Glucose Is Mediated by Tom22 in Endothelial Cells.
Zeng Y, Pan Q, Wang X, Li D, Lin Y, Man F, Xiao F, Guo L
Oxidative medicine and cellular longevity 2019;2019:4508762
Oxidative medicine and cellular longevity 2019;2019:4508762
Parkin-mediated ubiquitination contributes to the constitutive turnover of mitochondrial fission factor (Mff).
Lee L, Seager R, Nakamura Y, Wilkinson KA, Henley JM
PloS one 2019;14(5):e0213116
PloS one 2019;14(5):e0213116
Propofol Ameliorates H9c2 Cells Apoptosis Induced by Oxygen Glucose Deprivation and Reperfusion Injury via Inhibiting High Levels of Mitochondrial Fusion and Fission.
Zhao L, Zhuang J, Wang Y, Zhou D, Zhao D, Zhu S, Pu J, Zhang H, Yin M, Zhao W, Wang Z, Hong J
Frontiers in pharmacology 2019;10:61
Frontiers in pharmacology 2019;10:61
Da-Bu-Yin-Wan and Qian-Zheng-San Ameliorate Mitochondrial Dynamics in the Parkinson's Disease Cell Model Induced by MPP().
Gai C, Feng WD, Qiang TY, Ma HJ, Chai Y, Zhang SJ, Guo ZY, Hu JH, Sun HM
Frontiers in pharmacology 2019;10:372
Frontiers in pharmacology 2019;10:372
Icariin Protects Bone Marrow Mesenchymal Stem Cells Against Iron Overload Induced Dysfunction Through Mitochondrial Fusion and Fission, PI3K/AKT/mTOR and MAPK Pathways.
Yao X, Jing X, Guo J, Sun K, Deng Y, Zhang Y, Guo F, Ye Y
Frontiers in pharmacology 2019;10:163
Frontiers in pharmacology 2019;10:163
Mitochondrial dysfunction in endothelial cells induced by airborne fine particulate matter (<2.5 μm).
Miao X, Li W, Niu B, Li J, Sun J, Qin M, Zhou Z
Journal of applied toxicology : JAT 2019 Oct;39(10):1424-1432
Journal of applied toxicology : JAT 2019 Oct;39(10):1424-1432
Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae.
Yuan J, Chen C, Cui J, Lu J, Yan C, Wei X, Zhao X, Li N, Li S, Xue G, Cheng W, Li B, Li H, Lin W, Tian C, Zhao J, Han J, An D, Zhang Q, Wei H, Zheng M, Ma X, Li W, Chen X, Zhang Z, Zeng H, Ying S, Wu J, Yang R, Liu D
Cell metabolism 2019 Oct 1;30(4):675-688.e7
Cell metabolism 2019 Oct 1;30(4):675-688.e7
SS-31 reduces inflammation and oxidative stress through the inhibition of Fis1 expression in lipopolysaccharide-stimulated microglia.
Mo Y, Deng S, Zhang L, Huang Y, Li W, Peng Q, Liu Z, Ai Y
Biochemical and biophysical research communications 2019 Nov 26;520(1):171-178
Biochemical and biophysical research communications 2019 Nov 26;520(1):171-178
Proteomic Analysis and Biochemical Correlates of Mitochondrial Dysfunction after Low-Intensity Primary Blast Exposure.
Song H, Chen M, Chen C, Cui J, Johnson CE, Cheng J, Wang X, Swerdlow RH, DePalma RG, Xia W, Gu Z
Journal of neurotrauma 2019 May 15;36(10):1591-1605
Journal of neurotrauma 2019 May 15;36(10):1591-1605
A maternal high-fat, high-sucrose diet induces transgenerational cardiac mitochondrial dysfunction independently of maternal mitochondrial inheritance.
Ferey JLA, Boudoures AL, Reid M, Drury A, Scheaffer S, Modi Z, Kovacs A, Pietka T, DeBosch BJ, Thompson MD, Diwan A, Moley KH
American journal of physiology. Heart and circulatory physiology 2019 May 1;316(5):H1202-H1210
American journal of physiology. Heart and circulatory physiology 2019 May 1;316(5):H1202-H1210
Low-dose oral copper treatment changes the hippocampal phosphoproteomic profile and perturbs mitochondrial function in a mouse model of Alzheimer's disease.
Chen C, Jiang X, Li Y, Yu H, Li S, Zhang Z, Xu H, Yang Y, Liu G, Zhu F, Ren X, Zou L, Xu B, Liu J, Spencer PS, Yang X
Free radical biology & medicine 2019 May 1;135:144-156
Free radical biology & medicine 2019 May 1;135:144-156
Roles of mitochondrial fission inhibition in developmental fluoride neurotoxicity: mechanisms of action in vitro and associations with cognition in rats and children.
Zhao Q, Niu Q, Chen J, Xia T, Zhou G, Li P, Dong L, Xu C, Tian Z, Luo C, Liu L, Zhang S, Wang A
Archives of toxicology 2019 Mar;93(3):709-726
Archives of toxicology 2019 Mar;93(3):709-726
ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects.
Zhao Y, Sun X, Hu D, Prosdocimo DA, Hoppel C, Jain MK, Ramachandran R, Qi X
Nature communications 2019 Mar 26;10(1):1371
Nature communications 2019 Mar 26;10(1):1371
Angiotensin II suppresses autophagy and disrupts ultrastructural morphology and function of mitochondria in mouse skeletal muscle.
Silva KAS, Ghiarone T, Schreiber K, Grant D, White T, Frisard MI, Sukhanov S, Chandrasekar B, Delafontaine P, Yoshida T
Journal of applied physiology (Bethesda, Md. : 1985) 2019 Jun 1;126(6):1550-1562
Journal of applied physiology (Bethesda, Md. : 1985) 2019 Jun 1;126(6):1550-1562
Oxidative pathophysiology following volumetric muscle loss injury in a porcine model.
Chao T, Burmeister DM, Corona BT, Greising SM
Journal of applied physiology (Bethesda, Md. : 1985) 2019 Jun 1;126(6):1541-1549
Journal of applied physiology (Bethesda, Md. : 1985) 2019 Jun 1;126(6):1541-1549
Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations.
Li H, Ham A, Ma TC, Kuo SH, Kanter E, Kim D, Ko HS, Quan Y, Sardi SP, Li A, Arancio O, Kang UJ, Sulzer D, Tang G
Autophagy 2019 Jan;15(1):113-130
Autophagy 2019 Jan;15(1):113-130
Fibroblast growth factor 18 exerts anti-osteoarthritic effects through PI3K-AKT signaling and mitochondrial fusion and fission.
Yao X, Zhang J, Jing X, Ye Y, Guo J, Sun K, Guo F
Pharmacological research 2019 Jan;139:314-324
Pharmacological research 2019 Jan;139:314-324
Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy.
Sprenger HG, Wani G, Hesseling A, König T, Patron M, MacVicar T, Ahola S, Wai T, Barth E, Rugarli EI, Bergami M, Langer T
EMBO molecular medicine 2019 Jan;11(1)
EMBO molecular medicine 2019 Jan;11(1)
Two separate functions of NME3 critical for cell survival underlie a neurodegenerative disorder.
Chen CW, Wang HL, Huang CW, Huang CY, Lim WK, Tu IC, Koorapati A, Hsieh ST, Kan HW, Tzeng SR, Liao JC, Chong WM, Naroditzky I, Kidron D, Eran A, Nijim Y, Sela E, Feldman HB, Kalfon L, Raveh-Barak H, Falik-Zaccai TC, Elpeleg O, Mandel H, Chang ZF
Proceedings of the National Academy of Sciences of the United States of America 2019 Jan 8;116(2):566-574
Proceedings of the National Academy of Sciences of the United States of America 2019 Jan 8;116(2):566-574
Mitochondrial division inhibitor 1 reduces dynamin-related protein 1 and mitochondrial fission activity.
Manczak M, Kandimalla R, Yin X, Reddy PH
Human molecular genetics 2019 Jan 15;28(2):177-199
Human molecular genetics 2019 Jan 15;28(2):177-199
Hepatic HKDC1 Expression Contributes to Liver Metabolism.
Pusec CM, De Jesus A, Khan MW, Terry AR, Ludvik AE, Xu K, Giancola N, Pervaiz H, Daviau Smith E, Ding X, Harrison S, Chandel NS, Becker TC, Hay N, Ardehali H, Cordoba-Chacon J, Layden BT
Endocrinology 2019 Feb 1;160(2):313-330
Endocrinology 2019 Feb 1;160(2):313-330
Burn-induced reductions in mitochondrial abundance and efficiency are more pronounced with small volumes of colloids in swine.
Chao T, Gómez BI, Heard TC, Smith BW, Dubick MA, Burmeister DM
American journal of physiology. Cell physiology 2019 Dec 1;317(6):C1229-C1238
American journal of physiology. Cell physiology 2019 Dec 1;317(6):C1229-C1238
Novel findings on ultrastructural protection of skeletal muscle fibers during hibernation of Daurian ground squirrels: Mitochondria, nuclei, cytoskeleton, glycogen.
Wang Z, Jiang SF, Cao J, Liu K, Xu SH, Arfat Y, Guo QL, Chang H, Goswami N, Hinghofer-Szalkay H, Gao YF
Journal of cellular physiology 2019 Aug;234(8):13318-13331
Journal of cellular physiology 2019 Aug;234(8):13318-13331
Pyridostigmine regulates glucose metabolism and mitochondrial homeostasis to reduce myocardial vulnerability to injury in diabetic mice.
Yang Y, Zhao M, Yu XJ, Liu LZ, He X, Deng J, Zang WJ
American journal of physiology. Endocrinology and metabolism 2019 Aug 1;317(2):E312-E326
American journal of physiology. Endocrinology and metabolism 2019 Aug 1;317(2):E312-E326
Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells.
Zhong X, Cui P, Cai Y, Wang L, He X, Long P, Lu K, Yan R, Zhang Y, Pan X, Zhao X, Li W, Zhang H, Zhou Q, Gao P
Cell metabolism 2019 Apr 2;29(4):979-992.e4
Cell metabolism 2019 Apr 2;29(4):979-992.e4
Polybrene induces neural degeneration by bidirectional Ca(2+) influx-dependent mitochondrial and ER-mitochondrial dynamics.
Bao F, Shi H, Gao M, Yang L, Zhou L, Zhao Q, Wu Y, Chen K, Xiang G, Long Q, Guo J, Zhang J, Liu X
Cell death & disease 2018 Sep 20;9(10):966
Cell death & disease 2018 Sep 20;9(10):966
In Vivo Deletion of β-Cell Drp1 Impairs Insulin Secretion Without Affecting Islet Oxygen Consumption.
Hennings TG, Chopra DG, DeLeon ER, VanDeusen HR, Sesaki H, Merrins MJ, Ku GM
Endocrinology 2018 Sep 1;159(9):3245-3256
Endocrinology 2018 Sep 1;159(9):3245-3256
A high-fat diet impairs mitochondrial biogenesis, mitochondrial dynamics, and the respiratory chain complex in rat myocardial tissues.
Chen D, Li X, Zhang L, Zhu M, Gao L
Journal of cellular biochemistry 2018 Nov;119(11):9602
Journal of cellular biochemistry 2018 Nov;119(11):9602
Aerobic Exercise Preconception and During Pregnancy Enhances Oxidative Capacity in the Hindlimb Muscles of Mice Offspring.
Liu J, Lee I, Feng HZ, Galen SS, Hüttemann PP, Perkins GA, Jin JP, Hüttemann M, Malek MH
Journal of strength and conditioning research 2018 May;32(5):1391-1403
Journal of strength and conditioning research 2018 May;32(5):1391-1403
AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells.
Pei S, Minhajuddin M, Adane B, Khan N, Stevens BM, Mack SC, Lai S, Rich JN, Inguva A, Shannon KM, Kim H, Tan AC, Myers JR, Ashton JM, Neff T, Pollyea DA, Smith CA, Jordan CT
Cell stem cell 2018 Jul 5;23(1):86-100.e6
Cell stem cell 2018 Jul 5;23(1):86-100.e6
Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer's disease.
Reddy PH, Yin X, Manczak M, Kumar S, Pradeepkiran JA, Vijayan M, Reddy AP
Human molecular genetics 2018 Jul 15;27(14):2502-2516
Human molecular genetics 2018 Jul 15;27(14):2502-2516
INF2-mediated actin polymerization at the ER stimulates mitochondrial calcium uptake, inner membrane constriction, and division.
Chakrabarti R, Ji WK, Stan RV, de Juan Sanz J, Ryan TA, Higgs HN
The Journal of cell biology 2018 Jan 2;217(1):251-268
The Journal of cell biology 2018 Jan 2;217(1):251-268
GLUT10 maintains the integrity of major arteries through regulation of redox homeostasis and mitochondrial function.
Syu YW, Lai HW, Jiang CL, Tsai HY, Lin CC, Lee YC
Human molecular genetics 2018 Jan 15;27(2):307-321
Human molecular genetics 2018 Jan 15;27(2):307-321
Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer's disease.
Kandimalla R, Manczak M, Yin X, Wang R, Reddy PH
Human molecular genetics 2018 Jan 1;27(1):30-40
Human molecular genetics 2018 Jan 1;27(1):30-40
Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer's disease.
Manczak M, Kandimalla R, Yin X, Reddy PH
Human molecular genetics 2018 Apr 15;27(8):1332-1342
Human molecular genetics 2018 Apr 15;27(8):1332-1342
Neuroprotective Effect and Mechanism of Thiazolidinedione on Dopaminergic Neurons In Vivo and In Vitro in Parkinson's Disease.
Wang Y, Zhao W, Li G, Chen J, Guan X, Chen X, Guan Z
PPAR research 2017;2017:4089214
PPAR research 2017;2017:4089214
Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission.
Wang L, Zhang T, Wang L, Cai Y, Zhong X, He X, Hu L, Tian S, Wu M, Hui L, Zhang H, Gao P
The EMBO journal 2017 May 15;36(10):1330-1347
The EMBO journal 2017 May 15;36(10):1330-1347
Salvianolic acid B inhibits mitochondrial dysfunction by up-regulating mortalin.
Liu Y, Hu Y, E Q, Zuo J, Yang L, Liu W
Scientific reports 2017 Mar 2;7:43097
Scientific reports 2017 Mar 2;7:43097
Mitochondrial dynamics changes with age in an APPsw/PS1dE9 mouse model of Alzheimer's disease.
Xu LL, Shen Y, Wang X, Wei LF, Wang P, Yang H, Wang CF, Xie ZH, Bi JZ
Neuroreport 2017 Mar 1;28(4):222-228
Neuroreport 2017 Mar 1;28(4):222-228
Phosphorylation of dynamin-related protein 1 at Ser616 regulates mitochondrial fission and is involved in mitochondrial calcium uniporter-mediated neutrophil polarization and chemotaxis.
Zheng X, Chen M, Meng X, Chu X, Cai C, Zou F
Molecular immunology 2017 Jul;87:23-32
Molecular immunology 2017 Jul;87:23-32
p62-Mediated mitochondrial clustering attenuates apoptosis induced by mitochondrial depolarization.
Xiao B, Deng X, Lim GGY, Zhou W, Saw WT, Zhou ZD, Lim KL, Tan EK
Biochimica et biophysica acta. Molecular cell research 2017 Jul;1864(7):1308-1317
Biochimica et biophysica acta. Molecular cell research 2017 Jul;1864(7):1308-1317
Low-level laser therapy for beta amyloid toxicity in rat hippocampus.
Lu Y, Wang R, Dong Y, Tucker D, Zhao N, Ahmed ME, Zhu L, Liu TC, Cohen RM, Zhang Q
Neurobiology of aging 2017 Jan;49:165-182
Neurobiology of aging 2017 Jan;49:165-182
Sirtuin 5 protects mitochondria from fragmentation and degradation during starvation.
Guedouari H, Daigle T, Scorrano L, Hebert-Chatelain E
Biochimica et biophysica acta. Molecular cell research 2017 Jan;1864(1):169-176
Biochimica et biophysica acta. Molecular cell research 2017 Jan;1864(1):169-176
Hydrogen Sulphide modulating mitochondrial morphology to promote mitophagy in endothelial cells under high-glucose and high-palmitate.
Liu N, Wu J, Zhang L, Gao Z, Sun Y, Yu M, Zhao Y, Dong S, Lu F, Zhang W
Journal of cellular and molecular medicine 2017 Dec;21(12):3190-3203
Journal of cellular and molecular medicine 2017 Dec;21(12):3190-3203
Receptor-mediated Drp1 oligomerization on endoplasmic reticulum.
Ji WK, Chakrabarti R, Fan X, Schoenfeld L, Strack S, Higgs HN
The Journal of cell biology 2017 Dec 4;216(12):4123-4139
The Journal of cell biology 2017 Dec 4;216(12):4123-4139
Ischemia-induced Drp1 and Fis1-mediated mitochondrial fission and right ventricular dysfunction in pulmonary hypertension.
Tian L, Neuber-Hess M, Mewburn J, Dasgupta A, Dunham-Snary K, Wu D, Chen KH, Hong Z, Sharp WW, Kutty S, Archer SL
Journal of molecular medicine (Berlin, Germany) 2017 Apr;95(4):381-393
Journal of molecular medicine (Berlin, Germany) 2017 Apr;95(4):381-393
AP39, a Mitochondria-Targeted Hydrogen Sulfide Donor, Supports Cellular Bioenergetics and Protects against Alzheimer's Disease by Preserving Mitochondrial Function in APP/PS1 Mice and Neurons.
Zhao FL, Fang F, Qiao PF, Yan N, Gao D, Yan Y
Oxidative medicine and cellular longevity 2016;2016:8360738
Oxidative medicine and cellular longevity 2016;2016:8360738
Autophagy plays a role in skeletal muscle mitochondrial biogenesis in an endurance exercise-trained condition.
Ju JS, Jeon SI, Park JY, Lee JY, Lee SC, Cho KJ, Jeong JM
The journal of physiological sciences : JPS 2016 Sep;66(5):417-30
The journal of physiological sciences : JPS 2016 Sep;66(5):417-30
Dysfunctional tubular endoplasmic reticulum constitutes a pathological feature of Alzheimer's disease.
Sharoar MG, Shi Q, Ge Y, He W, Hu X, Perry G, Zhu X, Yan R
Molecular psychiatry 2016 Sep;21(9):1263-71
Molecular psychiatry 2016 Sep;21(9):1263-71
Quantification and Characterization of UVB-Induced Mitochondrial Fragmentation in Normal Primary Human Keratinocytes.
Jugé R, Breugnot J, Da Silva C, Bordes S, Closs B, Aouacheria A
Scientific reports 2016 Oct 12;6:35065
Scientific reports 2016 Oct 12;6:35065
Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease.
Yin X, Manczak M, Reddy PH
Human molecular genetics 2016 May 1;25(9):1739-53
Human molecular genetics 2016 May 1;25(9):1739-53
Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology.
Zhang C, Shi Z, Zhang L, Zhou Z, Zheng X, Liu G, Bu G, Fraser PE, Xu H, Zhang YW
Journal of cell science 2016 Mar 1;129(5):994-1002
Journal of cell science 2016 Mar 1;129(5):994-1002
FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions.
Wu W, Lin C, Wu K, Jiang L, Wang X, Li W, Zhuang H, Zhang X, Chen H, Li S, Yang Y, Lu Y, Wang J, Zhu R, Zhang L, Sui S, Tan N, Zhao B, Zhang J, Li L, Feng D
The EMBO journal 2016 Jul 1;35(13):1368-84
The EMBO journal 2016 Jul 1;35(13):1368-84
Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria.
Korwitz A, Merkwirth C, Richter-Dennerlein R, Tröder SE, Sprenger HG, Quirós PM, López-Otín C, Rugarli EI, Langer T
The Journal of cell biology 2016 Jan 18;212(2):157-66
The Journal of cell biology 2016 Jan 18;212(2):157-66
Resveratrol Induces Cancer Cell Apoptosis through MiR-326/PKM2-Mediated ER Stress and Mitochondrial Fission.
Wu H, Wang Y, Wu C, Yang P, Li H, Li Z
Journal of agricultural and food chemistry 2016 Dec 14;64(49):9356-9367
Journal of agricultural and food chemistry 2016 Dec 14;64(49):9356-9367
Protective effects of reduced dynamin-related protein 1 against amyloid beta-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease.
Manczak M, Kandimalla R, Fry D, Sesaki H, Reddy PH
Human molecular genetics 2016 Dec 1;25(23):5148-5166
Human molecular genetics 2016 Dec 1;25(23):5148-5166
Mitochondrial division inhibitor 1 protects against mutant huntingtin-induced abnormal mitochondrial dynamics and neuronal damage in Huntington's disease.
Manczak M, Reddy PH
Human molecular genetics 2015 Dec 20;24(25):7308-25
Human molecular genetics 2015 Dec 20;24(25):7308-25
The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission.
Anand R, Wai T, Baker MJ, Kladt N, Schauss AC, Rugarli E, Langer T
The Journal of cell biology 2014 Mar 17;204(6):919-29
The Journal of cell biology 2014 Mar 17;204(6):919-29
Mutations in Fis1 disrupt orderly disposal of defective mitochondria.
Shen Q, Yamano K, Head BP, Kawajiri S, Cheung JT, Wang C, Cho JH, Hattori N, Youle RJ, van der Bliek AM
Molecular biology of the cell 2014 Jan;25(1):145-59
Molecular biology of the cell 2014 Jan;25(1):145-59
RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway.
Wang X, Jiang W, Yan Y, Gong T, Han J, Tian Z, Zhou R
Nature immunology 2014 Dec;15(12):1126-33
Nature immunology 2014 Dec;15(12):1126-33
PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation.
Furuya N, Ikeda S, Sato S, Soma S, Ezaki J, Oliva Trejo JA, Takeda-Ezaki M, Fujimura T, Arikawa-Hirasawa E, Tada N, Komatsu M, Tanaka K, Kominami E, Hattori N, Ueno T
Autophagy 2014 Apr;10(4):631-41
Autophagy 2014 Apr;10(4):631-41
Loss of Yme1L perturbates mitochondrial dynamics.
Ruan Y, Li H, Zhang K, Jian F, Tang J, Song Z
Cell death & disease 2013 Oct 31;4(10):e896
Cell death & disease 2013 Oct 31;4(10):e896
Mitochondrial abnormalities in temporal lobe of autistic brain.
Tang G, Gutierrez Rios P, Kuo SH, Akman HO, Rosoklija G, Tanji K, Dwork A, Schon EA, Dimauro S, Goldman J, Sulzer D
Neurobiology of disease 2013 Jun;54:349-61
Neurobiology of disease 2013 Jun;54:349-61
A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity.
Qi X, Qvit N, Su YC, Mochly-Rosen D
Journal of cell science 2013 Feb 1;126(Pt 3):789-802
Journal of cell science 2013 Feb 1;126(Pt 3):789-802
Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration.
Guo X, Disatnik MH, Monbureau M, Shamloo M, Mochly-Rosen D, Qi X
The Journal of clinical investigation 2013 Dec;123(12):5371-88
The Journal of clinical investigation 2013 Dec;123(12):5371-88
Dynamin-related protein 1 heterozygote knockout mice do not have synaptic and mitochondrial deficiencies.
Manczak M, Sesaki H, Kageyama Y, Reddy PH
Biochimica et biophysica acta 2012 Jun;1822(6):862-74
Biochimica et biophysica acta 2012 Jun;1822(6):862-74
Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage.
Manczak M, Calkins MJ, Reddy PH
Human molecular genetics 2011 Jul 1;20(13):2495-509
Human molecular genetics 2011 Jul 1;20(13):2495-509
Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease.
Calkins MJ, Manczak M, Mao P, Shirendeb U, Reddy PH
Human molecular genetics 2011 Dec 1;20(23):4515-29
Human molecular genetics 2011 Dec 1;20(23):4515-29
Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage.
Shirendeb U, Reddy AP, Manczak M, Calkins MJ, Mao P, Tagle DA, Reddy PH
Human molecular genetics 2011 Apr 1;20(7):1438-55
Human molecular genetics 2011 Apr 1;20(7):1438-55
Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons.
Manczak M, Mao P, Calkins MJ, Cornea A, Reddy AP, Murphy MP, Szeto HH, Park B, Reddy PH
Journal of Alzheimer's disease : JAD 2010;20 Suppl 2(Suppl 2):S609-31
Journal of Alzheimer's disease : JAD 2010;20 Suppl 2(Suppl 2):S609-31
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 10956-1-AP( FIS1 Antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-FIS1 (IP:10956-1-AP, 3ug; Detection:10956-1-AP 1:500) with HeLa cells lysate 3000ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 10956-1-AP(FIS1 antibody) at dilution of 1:25 (under 40x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 10956-1-AP(FIS1 antibody) at dilution of 1:25 (under 10x lens)
- Sample type
- tissue
