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- Antigen structure
- References [12]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
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- Product number
- 15975-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15975-1-AP, RRID:AB_2203337
- Product name
- TELO2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TELO2 antibody (Cat. #15975-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Structure of the Human TELO2-TTI1-TTI2 Complex.
The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma.
Synthetic lethality by targeting the RUVBL1/2-TTT complex in mTORC1-hyperactive cancer cells.
RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer.
The effects of Tel2 on cardiomyocyte survival.
MNK Controls mTORC1:Substrate Association through Regulation of TELO2 Binding with mTORC1.
A Syndromic Intellectual Disability Disorder Caused by Variants in TELO2, a Gene Encoding a Component of the TTT Complex.
A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling.
Fructose supplementation impairs rat liver autophagy through mTORC activation without inducing endoplasmic reticulum stress.
SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma.
Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.
A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.
Kim Y, Park J, Joo SY, Kim BG, Jo A, Lee H, Cho Y
Journal of molecular biology 2022 Jan 30;434(2):167370
Journal of molecular biology 2022 Jan 30;434(2):167370
The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma.
Heider M, Eichner R, Stroh J, Morath V, Kuisl A, Zecha J, Lawatscheck J, Baek K, Garz AK, Rudelius M, Deuschle FC, Keller U, Lemeer S, Verbeek M, Götze KS, Skerra A, Weber WA, Buchner J, Schulman BA, Kuster B, Fernández-Sáiz V, Bassermann F
Molecular cell 2021 Mar 18;81(6):1170-1186.e10
Molecular cell 2021 Mar 18;81(6):1170-1186.e10
Synthetic lethality by targeting the RUVBL1/2-TTT complex in mTORC1-hyperactive cancer cells.
Shin SH, Lee JS, Zhang JM, Choi S, Boskovic ZV, Zhao R, Song M, Wang R, Tian J, Lee MH, Kim JH, Jeong M, Lee JH, Petukhov M, Lee SW, Kim SG, Zou L, Byun S
Science advances 2020 Jul;6(31):eaay9131
Science advances 2020 Jul;6(31):eaay9131
RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer.
Yenerall P, Das AK, Wang S, Kollipara RK, Li LS, Villalobos P, Flaming J, Lin YF, Huffman K, Timmons BC, Gilbreath C, Sonavane R, Kinch LN, Rodriguez-Canales J, Moran C, Behrens C, Hirasawa M, Takata T, Murakami R, Iwanaga K, Chen BPC, Grishin NV, Raj GV, Wistuba II, Minna JD, Kittler R
Cell chemical biology 2020 Jan 16;27(1):105-121.e14
Cell chemical biology 2020 Jan 16;27(1):105-121.e14
The effects of Tel2 on cardiomyocyte survival.
Yorichika N, Baba Y, Shimada BK, Thakore M, Wong SM, Kobayashi M, Higa JK, Matsui T
Life sciences 2019 Sep 1;232:116665
Life sciences 2019 Sep 1;232:116665
MNK Controls mTORC1:Substrate Association through Regulation of TELO2 Binding with mTORC1.
Brown MC, Gromeier M
Cell reports 2017 Feb 7;18(6):1444-1457
Cell reports 2017 Feb 7;18(6):1444-1457
A Syndromic Intellectual Disability Disorder Caused by Variants in TELO2, a Gene Encoding a Component of the TTT Complex.
You J, Sobreira NL, Gable DL, Jurgens J, Grange DK, Belnap N, Siniard A, Szelinger S, Schrauwen I, Richholt RF, Vallee SE, Dinulos MBP, Valle D, Armanios M, Hoover-Fong J
American journal of human genetics 2016 May 5;98(5):909-918
American journal of human genetics 2016 May 5;98(5):909-918
A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling.
Wang Y, Xu Q, Sack L, Kang C, Elledge SJ
Genes & development 2016 Feb 1;30(3):293-306
Genes & development 2016 Feb 1;30(3):293-306
Fructose supplementation impairs rat liver autophagy through mTORC activation without inducing endoplasmic reticulum stress.
Baena M, Sangüesa G, Hutter N, Sánchez RM, Roglans N, Laguna JC, Alegret M
Biochimica et biophysica acta 2015 Feb;1851(2):107-16
Biochimica et biophysica acta 2015 Feb;1851(2):107-16
SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma.
Fernández-Sáiz V, Targosz BS, Lemeer S, Eichner R, Langer C, Bullinger L, Reiter C, Slotta-Huspenina J, Schroeder S, Knorn AM, Kurutz J, Peschel C, Pagano M, Kuster B, Bassermann F
Nature cell biology 2013 Jan;15(1):72-81
Nature cell biology 2013 Jan;15(1):72-81
Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.
Kim SG, Hoffman GR, Poulogiannis G, Buel GR, Jang YJ, Lee KW, Kim BY, Erikson RL, Cantley LC, Choo AY, Blenis J
Molecular cell 2013 Jan 10;49(1):172-85
Molecular cell 2013 Jan 10;49(1):172-85
A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.
Hurov KE, Cotta-Ramusino C, Elledge SJ
Genes & development 2010 Sep 1;24(17):1939-50
Genes & development 2010 Sep 1;24(17):1939-50
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Y79 cells were subjected to SDS PAGE followed by western blot with 15975-1-AP(TELO2 antibody) at dilution of 1:1500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TELO2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TELO2. This antibody recognizes human,mouse,rat antigen. The TELO2 antibody has been validated for the following applications: ELISA, WB, IP, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-TELO2 (IP:15975-1-AP, 3ug; Detection:15975-1-AP 1:1000) with Y79 cells lysate 2000ug.
- Sample type
- cell line
