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Learn11979-1-AP
antibody from Proteintech Group
Targeting: EXOSC8
bA421P11.3, CIP3, EAP2, OIP2, p9, RRP43, Rrp43p
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [7]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [1]
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- Product number
- 11979-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11979-1-AP, RRID:AB_2101981
- Product name
- EXOSC8 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated EXOSC8 antibody (Cat. #11979-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references ZNF692 organizes a hub specialized in 40S ribosomal subunit maturation enhancing translation in rapidly proliferating cells.
Nucleolar URB1 ensures 3' ETS rRNA removal to prevent exosome surveillance.
Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication.
New subtype of PCH1C caused by novel EXOSC8 variants in a 16-year-old Spanish patient.
Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities.
EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia.
Exosome-bound WD repeat protein Monad inhibits breast cancer cell invasion by degrading amphiregulin mRNA.
Lafita-Navarro MC, Hao YH, Jiang C, Jang S, Chang TC, Brown IN, Venkateswaran N, Maurais E, Stachera W, Zhang Y, Mundy D, Han J, Tran VM, Mettlen M, Xu L, Woodruff JB, Grishin NV, Kinch L, Mendell JT, Buszczak M, Conacci-Sorrell M
Cell reports 2023 Oct 31;42(10):113280
Cell reports 2023 Oct 31;42(10):113280
Nucleolar URB1 ensures 3' ETS rRNA removal to prevent exosome surveillance.
Shan L, Xu G, Yao RW, Luan PF, Huang Y, Zhang PH, Pan YH, Zhang L, Gao X, Li Y, Cao SM, Gao SX, Yang ZH, Li S, Yang LZ, Wang Y, Wong CCL, Yu L, Li J, Yang L, Chen LL
Nature 2023 Mar;615(7952):526-534
Nature 2023 Mar;615(7952):526-534
Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication.
Moll T, Odon V, Harvey C, Collins MO, Peden A, Franklin J, Graves E, Marshall JN, Dos Santos Souza C, Zhang S, Castelli L, Hautbergue G, Azzouz M, Gordon D, Krogan N, Ferraiuolo L, Snyder MP, Shaw PJ, Rehwinkel J, Cooper-Knock J
Life science alliance 2023 Jan;6(1)
Life science alliance 2023 Jan;6(1)
New subtype of PCH1C caused by novel EXOSC8 variants in a 16-year-old Spanish patient.
Rodríguez-García ME, Cotrina-Vinagre FJ, Bellusci M, Merino-López A, Chumilla-Calzada S, García-Silva MT, Martínez-Azorín F
Neuromuscular disorders : NMD 2021 Aug;31(8):773-782
Neuromuscular disorders : NMD 2021 Aug;31(8):773-782
Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities.
Nichols CA, Gibson WJ, Brown MS, Kosmicki JA, Busanovich JP, Wei H, Urbanski LM, Curimjee N, Berger AC, Gao GF, Cherniack AD, Dhe-Paganon S, Paolella BR, Beroukhim R
Nature communications 2020 May 20;11(1):2517
Nature communications 2020 May 20;11(1):2517
EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia.
Boczonadi V, Müller JS, Pyle A, Munkley J, Dor T, Quartararo J, Ferrero I, Karcagi V, Giunta M, Polvikoski T, Birchall D, Princzinger A, Cinnamon Y, Lützkendorf S, Piko H, Reza M, Florez L, Santibanez-Koref M, Griffin H, Schuelke M, Elpeleg O, Kalaydjieva L, Lochmüller H, Elliott DJ, Chinnery PF, Edvardson S, Horvath R
Nature communications 2014 Jul 3;5:4287
Nature communications 2014 Jul 3;5:4287
Exosome-bound WD repeat protein Monad inhibits breast cancer cell invasion by degrading amphiregulin mRNA.
Saeki M, Egusa H, Kamano Y, Kakihara Y, Houry WA, Yatani H, Noguchi S, Kamisaki Y
PloS one 2013;8(7):e67326
PloS one 2013;8(7):e67326
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 11979-1-AP(EXOSC8 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of 4T1 cells, using EXOSC8 antibody 11979-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human pancreas cancer using 11979-1-AP(EXOSC8 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
