PPP2R3C

This gene encodes a regulatory subunit of the serine/threonine phosphatase, protein phosphatase 2. This protein is localized to both nuclear and cytoplasmic regions depending on cell cycle phase. Homozygous conditional knockout mice for this gene exhibit reduced numbers and impaired proliferation of immune system B cells. This protein may regulate the expression of the P-glycoprotein ATP-binding cassette transporter through its phosphatase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Description

Protein phosphatase 2 regulatory subunit B''gamma

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Golgi apparatus, Cytosol

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

14 (35085467 - 35122517)

Ensembl ID

ENSG00000092020  (ver. 103.38)

Orthologs

Mouse Ppp2r3c: ENSMUSG00000021022

UniProt

Q969Q6

neXtProt

NX_Q969Q6

Human splice variants
Mouse splice variants

Protein structure