Antibody data
- Antibody Data
- Antigen structure
- References [24]
- Comments [0]
- Validations [0]
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- Product number
- 15207-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- CHAC1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CHAC1 antibody (Cat. #15207-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat, hamster and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat, Hamster
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Novel insights into the protective effects of leonurine against acute kidney injury: Inhibition of ER stress-associated ferroptosis via regulating ATF4/CHOP/ACSL4 pathway.
ChaC1 upregulation reflects poor prognosis in a variety of cancers: analysis of the major missense SNPs of ChaC1 as an aid to refining prognosis.
Development and validation of an endoplasmic reticulum stress-related molecular prognostic model for breast cancer.
Autoregulatory control of mitochondrial glutathione homeostasis.
MIA3 promotes the degradation of GSH (glutathione) by binding to CHAC1, thereby promoting the progression of hepatocellular carcinoma.
p53 Activates the Lipoxygenase Activity of ALOX15B via Inhibiting SLC7A11 to Induce Ferroptosis in Bladder Cancer Cells.
Consequences of poly(ethylene oxide) and poloxamer P188 on transcription in healthy and stressed myoblasts.
Exosomes secreted from cardiomyocytes suppress the sensitivity of tumor ferroptosis in ischemic heart failure.
Anti-CHAC1 exosomes for nose-to-brain delivery of miR-760-3p in cerebral ischemia/reperfusion injury mice inhibiting neuron ferroptosis.
Treatment with paraquat affects the expression of ferroptosis-related genes.
Dual inhibition of thioredoxin reductase and proteasome is required for auranofin-induced paraptosis in breast cancer cells.
CHAC1 as a Novel Contributor of Ferroptosis in Retinal Pigment Epithelial Cells with Oxidative Damage.
ETS1 Ameliorates Hyperoxia-Induced Bronchopulmonary Dysplasia in Mice by Activating Nrf2/HO-1 Mediated Ferroptosis.
Intermittent dietary methionine deprivation facilitates tumoral ferroptosis and synergizes with checkpoint blockade.
Salidroside ameliorates acetaminophen-induced acute liver injury through the inhibition of endoplasmic reticulum stress-mediated ferroptosis by activating the AMPK/SIRT1 pathway.
Hepatic TGFβr1 Deficiency Attenuates Lipopolysaccharide/D-Galactosamine-Induced Acute Liver Failure Through Inhibiting GSK3β-Nrf2-Mediated Hepatocyte Apoptosis and Ferroptosis.
DJ-1 inhibits glutathione degradation by downregulating CHAC1 expression in astrocytes.
Glaucocalyxin A impairs tumor growth via amplification of the ATF4/CHOP/CHAC1 cascade in human oral squamous cell carcinoma.
Ferroptosis-related gene NOX4, CHAC1 and HIF1A are valid biomarkers for stomach adenocarcinoma.
Differences in cell death in methionine versus cysteine depletion.
Metabolomic analysis of spontaneous neutrophil apoptosis reveals the potential involvement of glutathione depletion.
High-fat diet aggravates colitis-associated carcinogenesis by evading ferroptosis in the ER stress-mediated pathway.
Ferroptosis-related gene CHAC1 is a valid indicator for the poor prognosis of kidney renal clear cell carcinoma.
Xylitol acts as an anticancer monosaccharide to induce selective cancer death via regulation of the glutathione level.
Cheng R, Wang X, Huang L, Lu Z, Wu A, Guo S, Li C, Mao W, Xie Y, Xu P, Tian R
Chemico-biological interactions 2024 May 25;395:111016
Chemico-biological interactions 2024 May 25;395:111016
ChaC1 upregulation reflects poor prognosis in a variety of cancers: analysis of the major missense SNPs of ChaC1 as an aid to refining prognosis.
Parande D, Suyal S, Bachhawat AK
Gene 2024 Jun 30;913:148386
Gene 2024 Jun 30;913:148386
Development and validation of an endoplasmic reticulum stress-related molecular prognostic model for breast cancer.
Fan P, Wang J, Li R, Chang K, Liu L, Wang Y, Wang Z, Zhang B, Ji C, Zhang J, Chen S, Ling R
Frontiers in oncology 2023;13:1178595
Frontiers in oncology 2023;13:1178595
Autoregulatory control of mitochondrial glutathione homeostasis.
Liu Y, Liu S, Tomar A, Yen FS, Unlu G, Ropek N, Weber RA, Wang Y, Khan A, Gad M, Peng J, Terzi E, Alwaseem H, Pagano AE, Heissel S, Molina H, Allwein B, Kenny TC, Possemato RL, Zhao L, Hite RK, Vinogradova EV, Mansy SS, Birsoy K
Science (New York, N.Y.) 2023 Nov 17;382(6672):820-828
Science (New York, N.Y.) 2023 Nov 17;382(6672):820-828
MIA3 promotes the degradation of GSH (glutathione) by binding to CHAC1, thereby promoting the progression of hepatocellular carcinoma.
Wanbiao Z, Jing M, Shi Z, Tengxiang C, Xueke Z, Haiyang L
Molecular and cellular biochemistry 2023 Nov 10;
Molecular and cellular biochemistry 2023 Nov 10;
p53 Activates the Lipoxygenase Activity of ALOX15B via Inhibiting SLC7A11 to Induce Ferroptosis in Bladder Cancer Cells.
Li X, Xiong W, Wang Y, Li Y, Cheng X, Liu W
Laboratory investigation; a journal of technical methods and pathology 2023 May;103(5):100058
Laboratory investigation; a journal of technical methods and pathology 2023 May;103(5):100058
Consequences of poly(ethylene oxide) and poloxamer P188 on transcription in healthy and stressed myoblasts.
Crabtree AA, Boehnke N, Bates FS, Hackel BJ
Proceedings of the National Academy of Sciences of the United States of America 2023 May 2;120(18):e2219885120
Proceedings of the National Academy of Sciences of the United States of America 2023 May 2;120(18):e2219885120
Exosomes secreted from cardiomyocytes suppress the sensitivity of tumor ferroptosis in ischemic heart failure.
Yuan Y, Mei Z, Qu Z, Li G, Yu S, Liu Y, Liu K, Shen Z, Pu J, Wang Y, Wang C, Sun Z, Liu Q, Pang X, Wang A, Ren Z, Wang T, Liu Y, Hong J, Xie J, Li X, Wang Z, Du W, Yang B
Signal transduction and targeted therapy 2023 Mar 27;8(1):121
Signal transduction and targeted therapy 2023 Mar 27;8(1):121
Anti-CHAC1 exosomes for nose-to-brain delivery of miR-760-3p in cerebral ischemia/reperfusion injury mice inhibiting neuron ferroptosis.
Wang Y, Niu H, Li L, Han J, Liu Z, Chu M, Sha X, Zhao J
Journal of nanobiotechnology 2023 Mar 27;21(1):109
Journal of nanobiotechnology 2023 Mar 27;21(1):109
Treatment with paraquat affects the expression of ferroptosis-related genes.
Ge X, Cai Q, Zhang S, Wu X, Ying P, Ke J, Yang Z
Human & experimental toxicology 2023 Jan-Dec;42:9603271231167585
Human & experimental toxicology 2023 Jan-Dec;42:9603271231167585
Dual inhibition of thioredoxin reductase and proteasome is required for auranofin-induced paraptosis in breast cancer cells.
Seo MJ, Kim IY, Lee DM, Park YJ, Cho MY, Jin HJ, Choi KS
Cell death & disease 2023 Jan 19;14(1):42
Cell death & disease 2023 Jan 19;14(1):42
CHAC1 as a Novel Contributor of Ferroptosis in Retinal Pigment Epithelial Cells with Oxidative Damage.
Liu Y, Wu D, Fu Q, Hao S, Gu Y, Zhao W, Chen S, Sheng F, Xu Y, Chen Z, Yao K
International journal of molecular sciences 2023 Jan 13;24(2)
International journal of molecular sciences 2023 Jan 13;24(2)
ETS1 Ameliorates Hyperoxia-Induced Bronchopulmonary Dysplasia in Mice by Activating Nrf2/HO-1 Mediated Ferroptosis.
Yang M, Chen Y, Huang X, Shen F, Meng Y
Lung 2023 Aug;201(4):425-441
Lung 2023 Aug;201(4):425-441
Intermittent dietary methionine deprivation facilitates tumoral ferroptosis and synergizes with checkpoint blockade.
Xue Y, Lu F, Chang Z, Li J, Gao Y, Zhou J, Luo Y, Lai Y, Cao S, Li X, Zhou Y, Li Y, Tan Z, Cheng X, Li X, Chen J, Wang W
Nature communications 2023 Aug 8;14(1):4758
Nature communications 2023 Aug 8;14(1):4758
Salidroside ameliorates acetaminophen-induced acute liver injury through the inhibition of endoplasmic reticulum stress-mediated ferroptosis by activating the AMPK/SIRT1 pathway.
Xu J, Zhao L, Zhang X, Ying K, Zhou R, Cai W, Wu X, Jiang H, Xu Q, Miao D, Zeng Y, Yu F
Ecotoxicology and environmental safety 2023 Aug 7;262:115331
Ecotoxicology and environmental safety 2023 Aug 7;262:115331
Hepatic TGFβr1 Deficiency Attenuates Lipopolysaccharide/D-Galactosamine-Induced Acute Liver Failure Through Inhibiting GSK3β-Nrf2-Mediated Hepatocyte Apoptosis and Ferroptosis.
Huang S, Wang Y, Xie S, Lai Y, Mo C, Zeng T, Kuang S, Deng G, Zhou C, Chen Y, Huang S, Gao L, Lv Z
Cellular and molecular gastroenterology and hepatology 2022;13(6):1649-1672
Cellular and molecular gastroenterology and hepatology 2022;13(6):1649-1672
DJ-1 inhibits glutathione degradation by downregulating CHAC1 expression in astrocytes.
Ge Y, Zheng X, Mao S, Zhang Q, Hu G, Wei Y
Neuroscience research 2022 Nov;184:62-69
Neuroscience research 2022 Nov;184:62-69
Glaucocalyxin A impairs tumor growth via amplification of the ATF4/CHOP/CHAC1 cascade in human oral squamous cell carcinoma.
Wang X, He MJ, Chen XJ, Bai YT, Zhou G
Journal of ethnopharmacology 2022 May 23;290:115100
Journal of ethnopharmacology 2022 May 23;290:115100
Ferroptosis-related gene NOX4, CHAC1 and HIF1A are valid biomarkers for stomach adenocarcinoma.
Xiao R, Wang S, Guo J, Liu S, Ding A, Wang G, Li W, Zhang Y, Bian X, Zhao S, Qiu W
Journal of cellular and molecular medicine 2022 Feb;26(4):1183-1193
Journal of cellular and molecular medicine 2022 Feb;26(4):1183-1193
Differences in cell death in methionine versus cysteine depletion.
Wallis KF, Morehead LC, Bird JT, Byrum SD, Miousse IR
Environmental and molecular mutagenesis 2021 Mar;62(3):216-226
Environmental and molecular mutagenesis 2021 Mar;62(3):216-226
Metabolomic analysis of spontaneous neutrophil apoptosis reveals the potential involvement of glutathione depletion.
Yuyun X, Fan Y, Weiping W, Qing Y, Bingwei S
Innate immunity 2021 Jan;27(1):31-40
Innate immunity 2021 Jan;27(1):31-40
High-fat diet aggravates colitis-associated carcinogenesis by evading ferroptosis in the ER stress-mediated pathway.
Zhang X, Li W, Ma Y, Zhao X, He L, Sun P, Wang H
Free radical biology & medicine 2021 Dec;177:156-166
Free radical biology & medicine 2021 Dec;177:156-166
Ferroptosis-related gene CHAC1 is a valid indicator for the poor prognosis of kidney renal clear cell carcinoma.
Li D, Liu S, Xu J, Chen L, Xu C, Chen F, Xu Z, Zhang Y, Xia S, Shao Y, Wang Y
Journal of cellular and molecular medicine 2021 Apr;25(7):3610-3621
Journal of cellular and molecular medicine 2021 Apr;25(7):3610-3621
Xylitol acts as an anticancer monosaccharide to induce selective cancer death via regulation of the glutathione level.
Tomonobu N, Komalasari NLGY, Sumardika IW, Jiang F, Chen Y, Yamamoto KI, Kinoshita R, Murata H, Inoue Y, Sakaguchi M
Chemico-biological interactions 2020 Jun 1;324:109085
Chemico-biological interactions 2020 Jun 1;324:109085
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