15187-1-AP

antibody from Proteintech Group

Targeting: RBPMS HERMES

Provider product page for 15187-1-AP

Western blot

ELISA

Immunocytochemistry

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Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [50]
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Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 15187-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#15187-1-AP, RRID:AB_2238431
Product name: RBPMS antibody
Antibody type: Polyclonal
Description: RBPMS antibody (Cat. #15187-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

RBPMS protein structure - 15187-1-AP shown in red.

Submitted references Oriented porous microtubules combined with CNTF-delivery directional guide axonal regeneration after traumatic optic neuropathy.

Ren X, Huang Q, Xie Z, Liu Z, Wei J, Zheng J, Li Z, Wang Z, Li T, Chen Z, Yao Q, Wu W
Biomaterials 2026 Mar;326:123654

Self-amplifying RNA therapy encoding CNTF with disulfiram co-delivery promotes optic nerve repair through microglial pyroptosis inhibition and RGC axonal regeneration.

Zhang Q, Liu Y, Wei Q, Song M, Liu S, Zhang H, Deng T, Zhang C, Tan K, Huang R, Ni N, Zhang J, Gu P, Du G, Li J, Chen Y, Zhou H, Fan X
Journal of nanobiotechnology 2026 Mar 13;24(1)

Synapses and dendritic spines are eliminated in the primary visual cortex of mice subjected to chronic intraocular pressure elevation.

Zhang X, Li D, Zeng W, Huang Y, Zhan Z, Zhang Y, Hu Q, Huang L, Yu M
Neural regeneration research 2026 Mar 1;21(3):1236-1248

A novel optic nerve demyelination mouse model: Insights into secondary impairment of the visual cortical circuit.

Zhang Z, Zhang X, Wang Y, Li Y, Ding G, Tong H, Xu J, Li C, Wang X, Gu H
Experimental eye research 2026 Jun;267:110999

Ethambutol induces optic neuropathy through SDHB-mediated ferroptosis in retinal ganglion cells via Smad4 pathway.

Li Q, Ge W, Zhang Y, Xu Q, Xu J, Zhang Y, Guo X, Sheng W, Zhu L
Human cell 2026 Jan 21;39(2):37

Afadin sorts different retinal neuron types into accurate cellular layers.

Lum MR, Patel S, Graham HK, Zhao M, Yi Y, Li L, Yao M, La Torre A, Della Santina L, Han Y, Hu Y, Welsbie DS, Duan X
eLife 2026 Jan 14;14

Ptbp1 is not required for retinal neurogenesis and cell fate specification.

Appel H, Carmen-Orozco RP, Santiago CP, Hoang T, Blackshaw S
bioRxiv : the preprint server for biology 2025 Sep 29;

RBPMS and RBPMS2 Cooperate to Safeguard Cardiac Splicing.

Wu T, Chen Z, Gao C, Stanley EV, Zhang Z, Gu Y, Zhou X, Chen J
Circulation research 2025 Sep 12;137(7):1027-1044

Mapping cellular cytosolic pH in vivo under physiological and pathophysiological conditions.

Zhang S, Hu X, Zhang B, Liu J, Feng H, Liu C, Hui Y, Fang Y, Liu L, Zhang X
The Journal of biological chemistry 2025 Oct;301(10):110637

Molecular and spatial analysis of ganglion cells on retinal flatmounts identifies perivascular neurons resilient to glaucoma.

Nimkar K, Tsai NY, Zhao M, Yi Y, Lum MR, Garrett TR, Wang Y, Toma K, Caval-Holme F, Reddy N, Ehrlich AT, Kriegstein AR, Do MTH, Hu Y, Sivyer B, Shekhar K, Duan X
Neuron 2025 Oct 15;113(20):3390-3407.e8

Reln-Dab1 pathway mitigates retinal ganglion cell apoptosis in retinal ischemia-reperfusion injury.

Xu N, Li Z, Zeng X, Jiang Y, Sun T, Liu S, Li N, Li Z, Huang Y, Wang L
Cell death & disease 2025 May 29;16(1):423

A Facile Strategy to Restore the Optic Nerve Functionality Using an Injectable Conducting Hydrogel.

Yu C, Zhou Y, Yao S, Wang Z, Ye S, Qi R, Hu H, Liu K, Wu Y, Lawson T, Yan L, Liu Y, Wu W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(21):e2415601

Temporally-segregated dual functions for Gfi1 in the development of retinal direction-selectivity.

Chaudhari K, Guzman-Clavel LE, Kolodkin AL
bioRxiv : the preprint server for biology 2025 Jun 6;

Suppression of CDK1/Drp1-Mediated Mitochondrial Fission Attenuates Dexamethasone-Induced Extracellular Matrix Deposition in the Trabecular Meshwork.

Deng X, Zhu M, Liu Y, Zhang N, Zhang P, Zeng W, Ke M
Antioxidants & redox signaling 2025 Feb;42(4-6):249-264

Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury.

Li T, Xing HM, Qian HD, Gao Q, Xu SL, Ma H, Chi ZL
Neural regeneration research 2025 Feb 1;20(2):587-597

Ptbp1 is not required for retinal neurogenesis and cell fate specification.

Appel H, Carmen-Orozco RP, Santiago CP, Hoang T, Blackshaw S
eLife 2025 Dec 4;14

Novel Roles of Sonic Hedgehog Signaling in Retinal Patterning and Neurogenesis During Mammalian Eye Development.

Krueger MR, Cheema SK, Simo S, Levine EM, Brown NL, La Torre A
bioRxiv : the preprint server for biology 2025 Aug 21;

A TLK2-mediated calcium-driven cell death pathway links neuronal degeneration to nuclear envelope disruption.

Li Y, Huang H, Gao J, Lu J, Kang G, Ge Y, Jiang W, Cai X, Zhang G, Liu L
Nature communications 2025 Apr 10;16(1):3419

Astrocyte-Derived Extracellular Vesicles Alleviate Optic Nerve Injury Through Remodeling of Retinal Microenvironmental Homeostasis.

Chen L, Yu Z, Zhu S, Song S, He G, Chi ZL, Wu W
Investigative ophthalmology & visual science 2025 Apr 1;66(4):16

Retinal ganglion cell type-specific expression of synuclein family members revealed by scRNA-sequencing.

Yang Q, Liu L, He F, Zhao W, Chen Z, Wu X, Rao B, Lin X, Mao F, Qu J, Zhang J
International journal of medical sciences 2024;21(8):1472-1490

RTA408 alleviates retinal ganglion cells damage in mouse glaucoma by inhibiting excessive autophagy.

Qian H, Chen W, Yuan G, Luo M, Zhang L, Wu B, Huang H, Xu J, Wang Q, Li M
PloS one 2024;19(11):e0313446

Human iPSC-derived retinal organoids develop robust Alzheimer's disease neuropathology.

James E, Vielle A, Cusato K, Li H, Lee B, Parween S, Howell A, Johnson NR, Chial HJ, Potter H, Vergara MN
Frontiers in cellular neuroscience 2024;18:1340448

Role of caspase-11 non-canonical inflammasomes in retinal ischemia/reperfusion injury.

Wan Y, Li J, Pu J, Yang J, Pei C, Qi Y
Molecular medicine (Cambridge, Mass.) 2024 Sep 27;30(1):159

RBPMS and RBPMS2 Cooperate to Safeguard Cardiac Splicing.

Wu T, Chen Z, Zhang Z, Zhou X, Gu Y, Dinenno FA, Chen J
bioRxiv : the preprint server for biology 2024 Nov 9;

Perivascular neurons instruct 3D vascular lattice formation via neurovascular contact.

Toma K, Zhao M, Zhang S, Wang F, Graham HK, Zou J, Modgil S, Shang WH, Tsai NY, Cai Z, Liu L, Hong G, Kriegstein AR, Hu Y, Körbelin J, Zhang R, Liao YJ, Kim TN, Ye X, Duan X
Cell 2024 May 23;187(11):2767-2784.e23

CRISPR-CasRx-mediated disruption of Aqp1/Adrb2/Rock1/Rock2 genes reduces intraocular pressure and retinal ganglion cell damage in mice.

Yao M, Zeng Z, Li S, Zou Z, Chen Z, Chen X, Gao Q, Zhao G, Chen A, Li Z, Wang Y, Ning R, McAlinden C, Zhou X, Huang J
Nature communications 2024 Jul 30;15(1):6395

Comparative transcriptomic profiling reveals a role for Olig1 in promoting axon regeneration.

Fu XQ, Zhan WR, Tian WY, Zeng PM, Luo ZG
Cell reports 2024 Jul 23;43(7):114514

Protective Effect of Nicotinamide Riboside on Glucocorticoid-Induced Glaucoma: Mitigating Mitochondrial Damage and Extracellular Matrix Deposition.

Zhang N, Zhang P, Deng X, Zhu M, Hu Y, Ji D, Li L, Liu Y, Zeng W, Ke M
Investigative ophthalmology & visual science 2024 Jul 1;65(8):1

SH3RF2 contributes to cisplatin resistance in ovarian cancer cells by promoting RBPMS degradation.

Gong TT, Liu FH, Xiao Q, Li YZ, Wei YF, Xu HL, Cao F, Sun ML, Jiang FL, Tao T, Ma QP, Qin X, Song Y, Gao S, Wu L, Zhao YH, Huang DH, Wu QJ
Communications biology 2024 Jan 9;7(1):67

Ripa-56 protects retinal ganglion cells in glutamate-induced retinal excitotoxic model of glaucoma.

Feng L, Dai S, Zhang C, Zhang W, Zhu W, Wang C, He Y, Song W
Scientific reports 2024 Feb 15;14(1):3834

Design, green synthesis, and anti-glutamate damage screening of chalcone derivatives with spiro-heterocyclic structures as potential anti-ischemic brain and eye damage agents.

Wu J, Huang C, Ren S, Wu T, Li Y, Zhong H, Su T, Chen Y, Tan X, Wu W, Wang J, Li W
Bioorganic chemistry 2024 Dec;153:107870

Afadin Sorts Different Retinal Neuron Types into Accurate Cellular Layers.

Lum MR, Patel SH, Graham HK, Zhao M, Yi Y, Li L, Yao M, La Torre A, Santina LD, Han Y, Hu Y, Welsbie DS, Duan X
bioRxiv : the preprint server for biology 2024 Dec 25;

Molecular and spatial analysis of ganglion cells on retinal flatmounts: diversity, topography, and perivascularity.

Tsai NY, Nimkar K, Zhao M, Lum MR, Yi Y, Garrett TR, Wang Y, Toma K, Caval-Holme F, Reddy N, Ehrlich AT, Kriegstein AR, Do MTH, Sivyer B, Shekhar K, Duan X
bioRxiv : the preprint server for biology 2024 Dec 17;

Distribution and synaptic organization of substance P-like immunoreactive neurons in the mouse retina.

Wang F, Zhong W, Yang Q, Zhao W, Liu X, Rao B, Lin X, Zhang J
Brain structure & function 2023 Sep;228(7):1703-1724

Osteopontin drives retinal ganglion cell resiliency in glaucomatous optic neuropathy.

Zhao M, Toma K, Kinde B, Li L, Patel AK, Wu KY, Lum MR, Tan C, Hooper JE, Kriegstein AR, La Torre A, Liao YJ, Welsbie DS, Hu Y, Han Y, Duan X
Cell reports 2023 Sep 26;42(9):113038

Proteogenomics of different urothelial bladder cancer stages reveals distinct molecular features for papillary cancer and carcinoma in situ.

Yao Z, Xu N, Shang G, Wang H, Tao H, Wang Y, Qin Z, Tan S, Feng J, Zhu J, Ma F, Tian S, Zhang Q, Qu Y, Hou J, Guo J, Zhao J, Hou Y, Ding C
Nature communications 2023 Sep 13;14(1):5670

Schwann cell-derived extracellular vesicles as a potential therapy for retinal ganglion cell degeneration.

Zhu S, Chen L, Wang M, Zhang J, Chen G, Yao Y, Song S, Li T, Xu S, Yu Z, Shen B, Xu D, Chi ZL, Wu W
Journal of controlled release : official journal of the Controlled Release Society 2023 Nov;363:641-656

Pan-cancer tRNA-derived fragment CAT1 coordinates RBPMS to stabilize NOTCH2 mRNA to promote tumorigenesis.

Yu M, Yi J, Qiu Q, Yao D, Li J, Yang J, Mi C, Zhou L, Lu B, Lu W, Ying K, Chen W, Chen E, Zhang H, Lu Z, Lu Y, Liu P
Cell reports 2023 Nov 28;42(11):113408

Deferoxamine attenuates visual impairment in retinal ischemia‒reperfusion via inhibiting ferroptosis.

Wang X, Li M, Diao K, Wang Y, Chen H, Zhao Z, Li Y, Jia X, Wang H, Zheng F, Xia Z, Han L, Zhang M
Scientific reports 2023 Nov 17;13(1):20145

MAP4Ks inhibition promotes retinal neuron regeneration from Müller glia in adult mice.

Zhang H, Guo Y, Yang Y, Wang Y, Zhang Y, Zhuang J, Zhang Y, Shen M, Zhao J, Zhang R, Qiu Y, Li S, Hu J, Li W, Wu J, Xu H, Fliesler SJ, Liao Y, Liu Z
NPJ Regenerative medicine 2023 Jul 13;8(1):36

Use of a tissue clearing technique combined with retrograde trans-synaptic viral tracing to evaluate changes in mouse retinorecipient brain regions following optic nerve crush.

Zhan ZY, Huang YR, Zhao LW, Quan YD, Li ZJ, Sun DF, Wu YL, Wu HY, Liu ZT, Wu KL, Lan YQ, Yu MB
Neural regeneration research 2023 Apr;18(4):913-921

Genetic loss of function of Ptbp1 does not induce glia-to-neuron conversion in retina.

Hoang T, Kim DW, Appel H, Pannullo NA, Leavey P, Ozawa M, Zheng S, Yu M, Peachey NS, Blackshaw S
Cell reports 2022 Jun 14;39(11):110849

Loss of RBPMS in ovarian cancer compromises the efficacy of EGFR inhibitor gefitinib through activating HER2/AKT/mTOR/P70S6K signaling.

Li M, Hu M, Wang Y, Xia Z, Li Z, Li J, Zheng D, Zheng X, Xi M
Biochemical and biophysical research communications 2022 Dec 31;637:348-357

Develop an efficient and specific AAV-based labeling system for Muller glia in mice.

Gao Y, Fang K, Yan Z, Zhang H, Geng G, Wu W, Xu D, Zhang H, Zhong N, Wang Q, Cai M, Zuo E, Yang H
Scientific reports 2022 Dec 27;12(1):22410

Gene regulatory networks controlling temporal patterning, neurogenesis, and cell-fate specification in mammalian retina.

Lyu P, Hoang T, Santiago CP, Thomas ED, Timms AE, Appel H, Gimmen M, Le N, Jiang L, Kim DW, Chen S, Espinoza DF, Telger AE, Weir K, Clark BS, Cherry TJ, Qian J, Blackshaw S
Cell reports 2021 Nov 16;37(7):109994

Optic nerve regeneration screen identifies multiple genes restricting adult neural repair.

Lindborg JA, Tran NM, Chenette DM, DeLuca K, Foli Y, Kannan R, Sekine Y, Wang X, Wollan M, Kim IJ, Sanes JR, Strittmatter SM
Cell reports 2021 Mar 2;34(9):108777

SP1-mediated upregulation of LINGO-1 promotes degeneration of retinal ganglion cells in optic nerve injury.

Wu Y, Zhan Z, Quan Y, Yang Y, Chen X, Liu L, Wu K, Yu M
CNS neuroscience & therapeutics 2020 Oct;26(10):1010-1020

α-synuclein overexpression in the retina leads to vision impairment and degeneration of dopaminergic amacrine cells.

Marrocco E, Indrieri A, Esposito F, Tarallo V, Carboncino A, Alvino FG, De Falco S, Franco B, De Risi M, De Leonibus E
Scientific reports 2020 Jun 15;10(1):9619

Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice.

Zhou H, Su J, Hu X, Zhou C, Li H, Chen Z, Xiao Q, Wang B, Wu W, Sun Y, Zhou Y, Tang C, Liu F, Wang L, Feng C, Liu M, Li S, Zhang Y, Xu H, Yao H, Shi L, Yang H
Cell 2020 Apr 30;181(3):590-603.e16

Expression of TGF-β Signaling Regulator RBPMS (RNA-Binding Protein With Multiple Splicing) Is Regulated by IL-1β and TGF-β Superfamily Members, and Decreased in Aged and Osteoarthritic Cartilage.

Shanmugaapriya S, van Caam A, de Kroon L, Vitters EL, Walgreen B, van Beuningen H, Davidson EB, van der Kraan PM
Cartilage 2016 Oct;7(4):333-45

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse heart tissue were subjected to SDS PAGE followed by western blot with 15187-1-AP(RBPMS antibody) at dilution of 1:400
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of Hela cells, using RBPMS antibody 15187-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line