ABIN115698

antibody from antibodies-online

Targeting: ENG CD105, END, HHT1, ORW, ORW1

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Antibody Data

Product number

ABIN115698

Provider

antibodies-online

Product name

anti-CD105 (Endoglin / TGF-Beta1/3 Receptor) (AA 26-586) antibody

Antibody type

Polyclonal

Antigen

Highly pure recombinant Human soluble CD105/Endoglin produced in Insect Cells. Remarks: It consists of amino acid 26 (Glu) to 586 (Leu) and is fused to a C-terminal His-tag (6xHis).

Description

Antigen-Affinity Chromatography.

Reactivity

Human

Host

Rabbit

Epitope

AA 26-586

Vial size

0.05 mg

Storage

Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.

Handling

Avoid repeated freezing and thawing.

References

Submitted references

Endoglin is expressed on human chondrocytes and forms a heteromeric complex with betaglycan in a ligand and type II TGFbeta receptor independent manner.

Parker WL, Goldring MB, Philip A
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2003 Feb;18(2):289-302

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Endoglin: An accessory component of the TGF-beta-binding receptor-complex with diagnostic, prognostic, and bioimmunotherapeutic potential in human malignancies.

Fonsatti E, Del Vecchio L, Altomonte M, Sigalotti L, Nicotra MR, Coral S, Natali PG, Maio M
Journal of cellular physiology 2001 Jul;188(1):1-7

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Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development.

Arthur HM, Ure J, Smith AJ, Renforth G, Wilson DI, Torsney E, Charlton R, Parums DV, Jowett T, Marchuk DA, Burn J, Diamond AG
Developmental biology 2000 Jan 1;217(1):42-53

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Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily.

Barbara NP, Wrana JL, Letarte M
The Journal of biological chemistry 1999 Jan 8;274(2):584-94

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Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1.

McAllister KA, Grogg KM, Johnson DW, Gallione CJ, Baldwin MA, Jackson CE, Helmbold EA, Markel DS, McKinnon WC, Murrell J
Nature genetics 1994 Dec;8(4):345-51

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Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells.

Cheifetz S, Bellón T, Calés C, Vera S, Bernabeu C, Massagué J, Letarte M
The Journal of biological chemistry 1992 Sep 25;267(27):19027-30