CABT-BL7388

antibody from Creative Diagnostics

Targeting: CLEC9A CD370, DNGR-1, HEEE9341, UNQ9341

Flow cytometry (Recommended by provider)

Antibody Data

Product number

CABT-BL7388

Provider

Creative Diagnostics

Product name

Anti-Clec9A Monoclonal antibody, clone 53E3 [PE]

Antibody type

Monoclonal

Description

CLEC9A is a group V CTLR (C-type lectin-like receptor) that functions as an activation receptor and is expressed on myeloid lineage cells. This protein is also expressed at the cell surface and acts as glycosylated dimers which mediate endocytosis, but not phagocytosis (Poulin LF et al, 2010). It facilitates antigen uptake and presentation, and may provide a suitable target for antibody-mediated antigen delivery. CLEC9A is important for conveying information from necrotic cells to T-cells and defines a pathway by which adaptive immune responses can be initiated in the absence of infection. It recruits Syk to mediate sensing of necrosis by the principal DC subset involved in regulating cross priming to cell-associated antigens. Signaling via this kinase occurs through a novel pathway involving CARD9 which induce a variety of cellular responses including the induction of cytokines (such as TNF, IL-6, IL-10, IL-23, and IL-2), the respiratory burst, and the production of Arachidonic acid. In addition, it also induces TH17 (T-helper type 17) adaptive responses in vivo. Expression of CLEC9A is highly restricted in peripheral blood, being detected only on BDCA3+ DCs and on a small subset of CD14+ CD16- monocytes. CLEC9A serves as a new marker to distinguish subtypes of DCs.

Reactivity

Mouse

Host

Rat

Conjugate

Yellow dye

Isotype

IgG

Antibody clone number

5.30E+04

Vial size

25 ug