FAB1859P-100
antibody from R&D Systems
Targeting: CLEC7A
CD369, CLECSF12, dectin-1, hDectin-1, SCARE2
Antibody data
- Antibody Data
- Antigen structure
- References [8]
- Comments [0]
- Validations
- Flow cytometry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- FAB1859P-100 - Provider product page
- Provider
- R&D Systems
- Product name
- Human Dectin-1/CLEC7A PE-conjugated Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human Dectin-1/CLEC7A in direct ELISAs. In directs ELISAs, less than 10% cross-reactivity with recombinant human (rh) DLEC and no cross-reactivity with recombinant mouse Dectin-1 or rhDectin-2 is observed.
- Reactivity
- Human
- Host
- Mouse
- Antigen sequence
NP_072092
- Isotype
- IgG
- Antibody clone number
- 259931
- Vial size
- 100 Tests
- Storage
- Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied.
Submitted references Dexamethasone induced inhibition of Dectin-1 activation of antigen presenting cells is mediated via STAT-3 and NF-κB signaling pathways.
Correction: A chitin-like component on sclerotic cells of fonsecaea pedrosoi inhibits dectin-1-mediated murine Th17 development by masking β-glucans.
Opposite regulatory effects of IFN-β and IL-3 on C-type lectin receptors, antigen uptake, and phagocytosis in human macrophages.
Ex vivo cytokine release and pattern recognition receptor expression of subjects exposed to dampness: pilot study to assess the outcome of mould exposure to the innate immune system.
MBL-mediated opsonophagocytosis of Candida albicans by human neutrophils is coupled with intracellular Dectin-1-triggered ROS production.
Expression profiles of novel cell surface molecules on B-cell subsets and plasma cells as analyzed by flow cytometry.
Vitamin D(3) down-regulates proinflammatory cytokine response to Mycobacterium tuberculosis through pattern recognition receptors while inducing protective cathelicidin production.
Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity.
Kotthoff P, Heine A, Held SAE, Brossart P
Scientific reports 2017 Jul 3;7(1):4522
Scientific reports 2017 Jul 3;7(1):4522
Correction: A chitin-like component on sclerotic cells of fonsecaea pedrosoi inhibits dectin-1-mediated murine Th17 development by masking β-glucans.
PLOS ONE Staff.
PloS one 2015;10(3):e0119244
PloS one 2015;10(3):e0119244
Opposite regulatory effects of IFN-β and IL-3 on C-type lectin receptors, antigen uptake, and phagocytosis in human macrophages.
Cardone M, Ikeda KN, Varano B, Belardelli F, Millefiorini E, Gessani S, Conti L
Journal of leukocyte biology 2014 Jan;95(1):161-8
Journal of leukocyte biology 2014 Jan;95(1):161-8
Ex vivo cytokine release and pattern recognition receptor expression of subjects exposed to dampness: pilot study to assess the outcome of mould exposure to the innate immune system.
Punsmann S, Liebers V, Lotz A, Brüning T, Raulf M
PloS one 2013;8(12):e82734
PloS one 2013;8(12):e82734
MBL-mediated opsonophagocytosis of Candida albicans by human neutrophils is coupled with intracellular Dectin-1-triggered ROS production.
Li D, Dong B, Tong Z, Wang Q, Liu W, Wang Y, Liu W, Chen J, Xu L, Chen L, Duan Y
PloS one 2012;7(12):e50589
PloS one 2012;7(12):e50589
Expression profiles of novel cell surface molecules on B-cell subsets and plasma cells as analyzed by flow cytometry.
Llinàs L, Lázaro A, de Salort J, Matesanz-Isabel J, Sintes J, Engel P
Immunology letters 2011 Jan 30;134(2):113-21
Immunology letters 2011 Jan 30;134(2):113-21
Vitamin D(3) down-regulates proinflammatory cytokine response to Mycobacterium tuberculosis through pattern recognition receptors while inducing protective cathelicidin production.
Khoo AL, Chai LY, Koenen HJ, Oosting M, Steinmeyer A, Zuegel U, Joosten I, Netea MG, van der Ven AJ
Cytokine 2011 Aug;55(2):294-300
Cytokine 2011 Aug;55(2):294-300
Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity.
Cunha C, Di Ianni M, Bozza S, Giovannini G, Zagarella S, Zelante T, D'Angelo C, Pierini A, Pitzurra L, Falzetti F, Carotti A, Perruccio K, Latgé JP, Rodrigues F, Velardi A, Aversa F, Romani L, Carvalho A
Blood 2010 Dec 9;116(24):5394-402
Blood 2010 Dec 9;116(24):5394-402
No comments: Submit comment
Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of Dectin-1/CLEC7A in Human Blood Monocytes by Flow Cytometry. Human peripheral blood monocytes were stained with Mouse Anti-Human Dectin-1/CLEC7A PE-conjugated Monoclonal Antibody (Catalog # FAB1859P, filled histogram) or isotype control antibody (Catalog # IC0041P, open histogram). View our protocol for Staining Membrane-associated Proteins.