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- References [7]
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- Product number
- AF1859 - Provider product page
- Provider
- R&D Systems
- Product name
- Human Dectin-1/CLEC7A Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Detects human Dectin-1/CLEC7A in direct ELISAs and Western blots. In this format, less than 2% cross-reactivity with recombinant mouse Dectin-1 and recombinant human Dectin-2 is observed.
- Reactivity
- Human
- Host
- Goat
- Conjugate
- Unconjugated
- Antigen sequence
NP_072092- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Differential susceptibility of Dectin-1 isoforms to functional inactivation by neutrophil and fungal proteases.
Osteopontin contributes to effective neutrophil recruitment, IL-1β production and apoptosis in Aspergillus fumigatus keratitis.
Enhanced immunogenicity of a tricomponent mannan tetanus toxoid conjugate vaccine targeted to dendritic cells via Dectin-1 by incorporating β-glucan.
The modular nature of dendritic cell responses to commensal and pathogenic fungi.
Protein kinase Cδ is a critical component of Dectin-1 signaling in primary human monocytes.
Costimulation of dectin-1 and DC-SIGN triggers the arachidonic acid cascade in human monocyte-derived dendritic cells.
Costimulation of dectin-1 and DC-SIGN triggers the arachidonic acid cascade in human monocyte-derived dendritic cells.
Griffiths JS, Thompson A, Stott M, Benny A, Lewis NA, Taylor PR, Forton J, Herrick S, Orr SJ, McGreal EP
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun;32(6):3385-3397
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun;32(6):3385-3397
Osteopontin contributes to effective neutrophil recruitment, IL-1β production and apoptosis in Aspergillus fumigatus keratitis.
Zhao G, Hu M, Li C, Lee J, Yuan K, Zhu G, Che C
Immunology and cell biology 2018 Apr;96(4):401-412
Immunology and cell biology 2018 Apr;96(4):401-412
Enhanced immunogenicity of a tricomponent mannan tetanus toxoid conjugate vaccine targeted to dendritic cells via Dectin-1 by incorporating β-glucan.
Lipinski T, Fitieh A, St Pierre J, Ostergaard HL, Bundle DR, Touret N
Journal of immunology (Baltimore, Md. : 1950) 2013 Apr 15;190(8):4116-28
Journal of immunology (Baltimore, Md. : 1950) 2013 Apr 15;190(8):4116-28
The modular nature of dendritic cell responses to commensal and pathogenic fungi.
Rizzetto L, Buschow SI, Beltrame L, Figdor CG, Schierer S, Schuler G, Cavalieri D
PloS one 2012;7(8):e42430
PloS one 2012;7(8):e42430
Protein kinase Cδ is a critical component of Dectin-1 signaling in primary human monocytes.
Elsori DH, Yakubenko VP, Roome T, Thiagarajan PS, Bhattacharjee A, Yadav SP, Cathcart MK
Journal of leukocyte biology 2011 Sep;90(3):599-611
Journal of leukocyte biology 2011 Sep;90(3):599-611
Costimulation of dectin-1 and DC-SIGN triggers the arachidonic acid cascade in human monocyte-derived dendritic cells.
Valera I, Fernández N, Trinidad AG, Alonso S, Brown GD, Alonso A, Crespo MS
Journal of immunology (Baltimore, Md. : 1950) 2008 Apr 15;180(8):5727-36
Journal of immunology (Baltimore, Md. : 1950) 2008 Apr 15;180(8):5727-36
Costimulation of dectin-1 and DC-SIGN triggers the arachidonic acid cascade in human monocyte-derived dendritic cells.
Valera I, Fernández N, Trinidad AG, Alonso S, Brown GD, Alonso A, Crespo MS
Journal of immunology (Baltimore, Md. : 1950) 2008 Apr 15;180(8):5727-36
Journal of immunology (Baltimore, Md. : 1950) 2008 Apr 15;180(8):5727-36
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