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- References [13]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 55222-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#55222-1-AP, RRID:AB_11182929
- Product name
- HCN1 antibody
- Antibody type
- Polyclonal
- Description
- HCN1 antibody (Cat. #55222-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The Kv4.3 channel on c-low threshold mechanoreceptors in DRG is a key mediator transforming tactile stimuli into nociceptive signals in chemotherapy-induced neuropathy.
Maternal cadmium exposure promotes amyloid-beta pathology by interrupting the interaction of AQP1 and HCN1 in male offspring.
HCN2 deficiency correlates with memory deficits and hyperexcitability of dCA1 pyramidal neurons in Alzheimer's disease.
CDK5-Induced HCN2 Channel Dysfunction in the Prelimbic Cortex Drives Allodynia and Anxiety-Like Behaviors in Neuropathic Pain.
HCN2 promotes neurodevelopmental and synaptic function repair through the CaMKII/CREB pathway to alleviate general anesthesia-induced cognitive impairment.
High-fat diet disrupts a septal control on feeding to promote obesity in male mice.
Investigating the role of hyperexpressed HCN1 in inducing myocardial infarction through activation of the NF-κB signaling pathway.
HCN channels in the lateral habenula regulate pain and comorbid depressive-like behaviors in mice.
Cellular and circuit architecture of the lateral septum for reward processing.
Thalamocortical Circuit Controls Neuropathic Pain via Up-regulation of HCN2 in the Ventral Posterolateral Thalamus.
Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.
Prenatal alcohol exposure enhanced alcohol preference and susceptibility to PTSD in a sex-dependent manner through the synaptic HCN1 channel.
Optogenetic Activation of Striatopallidal Neurons Reveals Altered HCN Gating in DYT1 Dystonia.
Zhang J, Wang X, Liu X, Li J, Qiao K, Sun J, Zuo J, Zhao W, He T, Li X, Guan Z, Zhang Y, Xu Y, Jia Q
Acta pharmaceutica Sinica. B 2026 Feb;16(2):854-878
Acta pharmaceutica Sinica. B 2026 Feb;16(2):854-878
Maternal cadmium exposure promotes amyloid-beta pathology by interrupting the interaction of AQP1 and HCN1 in male offspring.
Mai W, Peng D, Wu L, Gao N, Zhang X, Zhang R, Chen R, Zhong X, Chen H, Xie Q, Zhang Q
Ecotoxicology and environmental safety 2025 Oct 15;305:119238
Ecotoxicology and environmental safety 2025 Oct 15;305:119238
HCN2 deficiency correlates with memory deficits and hyperexcitability of dCA1 pyramidal neurons in Alzheimer's disease.
Zhang X, Zhang Y, Zhang T, Wang J, Liu C, Shang Q, Wei X, Zhu H, Shen H, Sun B
Alzheimer's research & therapy 2025 Feb 27;17(1):55
Alzheimer's research & therapy 2025 Feb 27;17(1):55
CDK5-Induced HCN2 Channel Dysfunction in the Prelimbic Cortex Drives Allodynia and Anxiety-Like Behaviors in Neuropathic Pain.
Chen L, Cao S, Liu YZ, Yang QF, Yang JY, Zhang DY, Xie GG, Yin XS, Zhang Y, Wang Y
Neuroscience bulletin 2025 Dec;41(12):2254-2271
Neuroscience bulletin 2025 Dec;41(12):2254-2271
HCN2 promotes neurodevelopmental and synaptic function repair through the CaMKII/CREB pathway to alleviate general anesthesia-induced cognitive impairment.
Yang L, Cheng X, Ye L, Shi Y, Ye C, Wei F
Cellular signalling 2025 Dec;136:112113
Cellular signalling 2025 Dec;136:112113
High-fat diet disrupts a septal control on feeding to promote obesity in male mice.
Jiang S, Lai S, Jing H, Wu X, Li F, Chen B, Bao J, Wang L, Chen G, Zhu Y
Nature communications 2025 Dec 27;17(1):1248
Nature communications 2025 Dec 27;17(1):1248
Investigating the role of hyperexpressed HCN1 in inducing myocardial infarction through activation of the NF-κB signaling pathway.
Liang X, Zhang J, Luo Y
Open life sciences 2024;19(1):20220967
Open life sciences 2024;19(1):20220967
HCN channels in the lateral habenula regulate pain and comorbid depressive-like behaviors in mice.
Cao XZ, Zhu MY, Xu G, Li F, Yan Y, Zhang JJ, Wang J, Zeng F, Bao Y, Zhang XX, Liu T, Zhang DY
CNS neuroscience & therapeutics 2024 Jul;30(7):e14831
CNS neuroscience & therapeutics 2024 Jul;30(7):e14831
Cellular and circuit architecture of the lateral septum for reward processing.
Chen G, Lai S, Jiang S, Li F, Sun K, Wu X, Zhou K, Liu Y, Deng X, Chen Z, Xu F, Xu Y, Wang K, Cao G, Xu F, Bi GQ, Zhu Y
Neuron 2024 Aug 21;112(16):2783-2798.e9
Neuron 2024 Aug 21;112(16):2783-2798.e9
Thalamocortical Circuit Controls Neuropathic Pain via Up-regulation of HCN2 in the Ventral Posterolateral Thalamus.
Yan Y, Zhu M, Cao X, Xu G, Shen W, Li F, Zhang J, Luo L, Zhang X, Zhang D, Liu T
Neuroscience bulletin 2023 May;39(5):774-792
Neuroscience bulletin 2023 May;39(5):774-792
Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.
Hsu YH, Pintacuda G, Liu R, Nacu E, Kim A, Tsafou K, Petrossian N, Crotty W, Suh JM, Riseman J, Martin JM, Biagini JC, Mena D, Ching JKT, Malolepsza E, Li T, Singh T, Ge T, Egri SB, Tanenbaum B, Stanclift CR, Apffel AM, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Stanley Global Asia Initiatives, Carr SA, Schenone M, Jaffe J, Fornelos N, Huang H, Eggan KC, Lage K
iScience 2023 May 19;26(5):106701
iScience 2023 May 19;26(5):106701
Prenatal alcohol exposure enhanced alcohol preference and susceptibility to PTSD in a sex-dependent manner through the synaptic HCN1 channel.
Yao H, Wang C, Xia Z
Journal of affective disorders 2023 Mar 1;324:143-152
Journal of affective disorders 2023 Mar 1;324:143-152
Optogenetic Activation of Striatopallidal Neurons Reveals Altered HCN Gating in DYT1 Dystonia.
Sciamanna G, Ponterio G, Vanni V, Laricchiuta D, Martella G, Bonsi P, Meringolo M, Tassone A, Mercuri NB, Pisani A
Cell reports 2020 May 19;31(7):107644
Cell reports 2020 May 19;31(7):107644
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 55222-1-AP(HCN1 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human heart using 55222-1-AP(HCN1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The HCN1 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human HCN1. This antibody recognizes human,mouse,rat antigen. The HCN1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
