Antibody data
- Antibody Data
- Antigen structure
- References [10]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- AF1006 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Goat Polyclonal UNC5H2/UNC5B Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects rat UNC5H2 in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross-reactivity with recombinant rat UNC5H1 is observed.
- Reactivity
- Rat
- Host
- Goat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells.
Netrin 1 mediates protective effects exerted by insulin-like growth factor 1 on cochlear hair cells.
Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity.
Endothelial expression of guidance cues in vessel wall homeostasis dysregulation under proatherosclerotic conditions.
A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy.
The uncoordinated-5 homolog B receptor affects hepatic ischemia reperfusion injury.
Netrin-1 regulates Th1/Th2/Th17 cytokine production and inflammation through UNC5B receptor and protects kidney against ischemia-reperfusion injury.
Netrin-1 overexpression protects kidney from ischemia reperfusion injury by suppressing apoptosis.
Netrin-4 enhances angiogenesis and neurologic outcome after cerebral ischemia.
Netrin-1 inhibits leukocyte migration in vitro and in vivo.
Hadi T, Boytard L, Silvestro M, Alebrahim D, Jacob S, Feinstein J, Barone K, Spiro W, Hutchison S, Simon R, Rateri D, Pinet F, Fenyo D, Adelman M, Moore KJ, Eltzschig HK, Daugherty A, Ramkhelawon B
Nature communications 2018 Nov 27;9(1):5022
Nature communications 2018 Nov 27;9(1):5022
Netrin 1 mediates protective effects exerted by insulin-like growth factor 1 on cochlear hair cells.
Yamahara K, Nakagawa T, Ito J, Kinoshita K, Omori K, Yamamoto N
Neuropharmacology 2017 Jun;119:26-39
Neuropharmacology 2017 Jun;119:26-39
Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity.
Ramkhelawon B, Hennessy EJ, Ménager M, Ray TD, Sheedy FJ, Hutchison S, Wanschel A, Oldebeken S, Geoffrion M, Spiro W, Miller G, McPherson R, Rayner KJ, Moore KJ
Nature medicine 2014 Apr;20(4):377-84
Nature medicine 2014 Apr;20(4):377-84
Endothelial expression of guidance cues in vessel wall homeostasis dysregulation under proatherosclerotic conditions.
van Gils JM, Ramkhelawon B, Fernandes L, Stewart MC, Guo L, Seibert T, Menezes GB, Cara DC, Chow C, Kinane TB, Fisher EA, Balcells M, Alvarez-Leite J, Lacy-Hulbert A, Moore KJ
Arteriosclerosis, thrombosis, and vascular biology 2013 May;33(5):911-9
Arteriosclerosis, thrombosis, and vascular biology 2013 May;33(5):911-9
A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy.
Hägerling R, Pollmann C, Andreas M, Schmidt C, Nurmi H, Adams RH, Alitalo K, Andresen V, Schulte-Merker S, Kiefer F
The EMBO journal 2013 Mar 6;32(5):629-44
The EMBO journal 2013 Mar 6;32(5):629-44
The uncoordinated-5 homolog B receptor affects hepatic ischemia reperfusion injury.
König K, Köhler D, Granja T, Jennewein C, Tran N, Mirakaj V, Kröhnert F, Rosenberger P
PloS one 2012;7(7):e41085
PloS one 2012;7(7):e41085
Netrin-1 regulates Th1/Th2/Th17 cytokine production and inflammation through UNC5B receptor and protects kidney against ischemia-reperfusion injury.
Tadagavadi RK, Wang W, Ramesh G
Journal of immunology (Baltimore, Md. : 1950) 2010 Sep 15;185(6):3750-8
Journal of immunology (Baltimore, Md. : 1950) 2010 Sep 15;185(6):3750-8
Netrin-1 overexpression protects kidney from ischemia reperfusion injury by suppressing apoptosis.
Wang W, Reeves WB, Pays L, Mehlen P, Ramesh G
The American journal of pathology 2009 Sep;175(3):1010-8
The American journal of pathology 2009 Sep;175(3):1010-8
Netrin-4 enhances angiogenesis and neurologic outcome after cerebral ischemia.
Hoang S, Liauw J, Choi M, Choi M, Guzman RG, Steinberg GK
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2009 Feb;29(2):385-97
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2009 Feb;29(2):385-97
Netrin-1 inhibits leukocyte migration in vitro and in vivo.
Ly NP, Komatsuzaki K, Fraser IP, Tseng AA, Prodhan P, Moore KJ, Kinane TB
Proceedings of the National Academy of Sciences of the United States of America 2005 Oct 11;102(41):14729-34
Proceedings of the National Academy of Sciences of the United States of America 2005 Oct 11;102(41):14729-34
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Detection of Rat UNC5H2 by Western Blot. Detection of Rat UNC5H2 by Western Blot.