ARAP2

The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008]

Description

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2

Tissue specificity

Tissue enhanced (bone marrow, brain)

Subcell location

Actin filaments, Focal adhesion sites

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

4 (35948221 - 36244514)

Ensembl ID

ENSG00000047365  (ver. 103.38)

Orthologs

Mouse Arap2: ENSMUSG00000037999

UniProt

Q8WZ64

neXtProt

NX_Q8WZ64

Human splice variants
Mouse splice variants

Protein structure