Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- BS3395 - Provider product page
- Provider
- Bioworld Technology, Inc
- Proper citation
- Bioworld Technology Cat#BS3395, RRID:AB_1662257
- Product name
- PR48 (E394) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to amino acids 370-412 of Human PR48.
- Description
- The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions. The protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit, and a catalytic subunit. PR48 is a 48 kDa regulatory subunit of protein phosphatase 2A (PP2A). PP2A activity is required for the initiation of DNA replication in yeast, viral, and vertebrate systems. PR48 localizes to the nucleus and binds specifically to Cdc6, a highly conserved protein which is required for the formation of prereplicative complexes. PR48 is considered to be involved in the dephosphorylation of Cdc6 by PP2A, a process important to the control of DNA replication in mammalian cell.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of PR48 (E394) pAb at 1:500 dilutionLane1:HEK293T whole cell lysateLane2:Raw264.7 whole cell lysate