RA0816

antibody from Oursmab

Targeting: VSIR B7-H5, B7H5, C10orf54, Dies1, GI24, PD-1H, SISP1, VISTA

Western blot (Supportive data in Antibodypedia)

ELISA (Supportive data in Antibodypedia)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

RA0816

Provider

Oursmab

Product name

Onvatilimab (Biosimilar Reference Antibody) (VSIR)

Antibody type

Monoclonal

Description

Onvatilimab (also known as JNJ-61610588 or CI-8993) is a humanized IgG1-kappa monoclonal antibody that targets V-domain Ig suppressor of T-cell activation (VISTA), an inhibitory immune checkpoint protein. As an IgG1 isotype, it is designed to potentially engage immune effector functions such as antibody-dependent cellular cytotoxicity (ADCC). By binding to VISTA, onvatilimab blocks its interaction with ligands (e.g., VSIG3, PSGL-1), thereby reversing VISTA-mediated suppression of T-cell activation and cytokine production. It is being developed as an immune checkpoint inhibitor for the treatment of advanced solid tumors, with the aim of restoring anti-tumor immunity, particularly in combination with other immunotherapies.

Reactivity

Human

Isotype

IgG

Vial size

100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg

Concentration

Bottled at the concentration indicated on the vial.

Storage

Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.

Western blot

Supportive validation

Submitted by

Oursmab (provider)

Main image

Experimental details

Onvatilimab (Biosimilar Reference Antibody) (VSIR)-RA0816-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.

ELISA

Supportive validation

Submitted by

Oursmab (provider)

Main image

Experimental details

ELISA plate pre-coated Antigen protein, can bind Onvatilimab (Biosimilar Reference Antibody) (VSIR)-RA0816 in a linear range of 0.18¨C15 ng/mL.