Antibody data
- Antibody Data
- Antigen structure
- References [7]
- Comments [0]
- Validations
- Flow cytometry [1]
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- Product number
- FAB138G-025 - Provider product page
- Provider
- R&D Systems
- Product name
- Human NKG2C/CD159c Alexa Fluor® 488-conjugated Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human NKG2C/CD159c heterodimer with CD94 in flow cytometry. It does not cross-react with the human NKG2A/CD94 heterodimer or with the human CD94 homodimer.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Green dye
- Isotype
- IgG
- Antibody clone number
- 134591
- Vial size
- 25 Tests
- Storage
- Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied.
Submitted references Human M2 Macrophages Limit NK Cell Effector Functions through Secretion of TGF-β and Engagement of CD85j.
Systems Vaccinology Identifies an Early Innate Immune Signature as a Correlate of Antibody Responses to the Ebola Vaccine rVSV-ZEBOV.
KIR2DL3 and KIR2DL1 show similar impact on licensing of human NK cells.
Regulatory Dendritic Cells Restrain NK Cell IFN-γ Production through Mechanisms Involving NKp46, IL-10, and MHC Class I-Specific Inhibitory Receptors.
2DL1, 2DL2 and 2DL3 all contribute to KIR phenotype variability on human NK cells.
Predominant development of mature and functional human NK cells in a novel human IL-2-producing transgenic NOG mouse.
Modulation of the natural killer cell KIR repertoire by cytomegalovirus infection.
Nuñez SY, Ziblat A, Secchiari F, Torres NI, Sierra JM, Raffo Iraolagoitia XL, Araya RE, Domaica CI, Fuertes MB, Zwirner NW
Journal of immunology (Baltimore, Md. : 1950) 2018 Feb 1;200(3):1008-1015
Journal of immunology (Baltimore, Md. : 1950) 2018 Feb 1;200(3):1008-1015
Systems Vaccinology Identifies an Early Innate Immune Signature as a Correlate of Antibody Responses to the Ebola Vaccine rVSV-ZEBOV.
Rechtien A, Richert L, Lorenzo H, Martrus G, Hejblum B, Dahlke C, Kasonta R, Zinser M, Stubbe H, Matschl U, Lohse A, Krähling V, Eickmann M, Becker S, VEBCON Consortium., Thiébaut R, Altfeld M, Addo MM
Cell reports 2017 Aug 29;20(9):2251-2261
Cell reports 2017 Aug 29;20(9):2251-2261
KIR2DL3 and KIR2DL1 show similar impact on licensing of human NK cells.
Sim MJ, Stowell J, Sergeant R, Altmann DM, Long EO, Boyton RJ
European journal of immunology 2016 Jan;46(1):185-91
European journal of immunology 2016 Jan;46(1):185-91
Regulatory Dendritic Cells Restrain NK Cell IFN-γ Production through Mechanisms Involving NKp46, IL-10, and MHC Class I-Specific Inhibitory Receptors.
Spallanzani RG, Torres NI, Avila DE, Ziblat A, Iraolagoitia XL, Rossi LE, Domaica CI, Fuertes MB, Rabinovich GA, Zwirner NW
Journal of immunology (Baltimore, Md. : 1950) 2015 Sep 1;195(5):2141-8
Journal of immunology (Baltimore, Md. : 1950) 2015 Sep 1;195(5):2141-8
2DL1, 2DL2 and 2DL3 all contribute to KIR phenotype variability on human NK cells.
Dunphy SE, Guinan KJ, Chorcora CN, Jayaraman J, Traherne JA, Trowsdale J, Pende D, Middleton D, Gardiner CM
Genes and immunity 2015 Jul-Aug;16(5):301-10
Genes and immunity 2015 Jul-Aug;16(5):301-10
Predominant development of mature and functional human NK cells in a novel human IL-2-producing transgenic NOG mouse.
Katano I, Takahashi T, Ito R, Kamisako T, Mizusawa T, Ka Y, Ogura T, Suemizu H, Kawakami Y, Ito M
Journal of immunology (Baltimore, Md. : 1950) 2015 Apr 1;194(7):3513-25
Journal of immunology (Baltimore, Md. : 1950) 2015 Apr 1;194(7):3513-25
Modulation of the natural killer cell KIR repertoire by cytomegalovirus infection.
Charoudeh HN, Terszowski G, Czaja K, Gonzalez A, Schmitter K, Stern M
European journal of immunology 2013 Feb;43(2):480-7
European journal of immunology 2013 Feb;43(2):480-7
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Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of NKG2C/CD159c in Human PBMC lymphocytes by Flow Cytometry. Human peripheral blood mononuclear cell (PBMC) lymphocytes were stained with Mouse Anti-Human NCAM-1/CD56 PE-conjugated Monoclonal Antibody (Catalog # FAB2408P) and either (A) Mouse Anti-Human NKG2C/CD159c Alexa Fluor® 488-conjugated Monoclonal Antibody (Catalog # FAB138G) or (B) Mouse IgG1 Alexa Fluor 488 Isotype Control (Catalog # IC002G). View our protocol for Staining Membrane-associated Proteins.