MOCS2

Eukaryotic molybdoenzymes use a unique molybdenum cofactor (MoCo) consisting of a pterin, termed molybdopterin, and the catalytically active metal molybdenum. MoCo is synthesized from precursor Z by the heterodimeric enzyme molybdopterin synthase. The large and small subunits of molybdopterin synthase are both encoded from this gene by overlapping open reading frames. The proteins were initially thought to be encoded from a bicistronic transcript. They are now thought to be encoded from monocistronic transcripts. Alternatively spliced transcripts have been found for this locus that encode the large and small subunits. [provided by RefSeq, Jul 2008]

Description

Molybdenum cofactor synthesis 2

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nuclear speckles, Cytosol

Predicted location

Intracellular

Protein family

Disease related genes
Enzymes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Potential drug targets
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

5:q11.2 (53095679 - 53110063)

Ensembl ID

ENSG00000164172  (ver. 103.38)

Orthologs

Mouse Mocs2: ENSMUSG00000015536

UniProt

O96033, O96007

neXtProt

NX_O96033, NX_O96007

Human splice variants
Mouse splice variants