322811

antibody from BioLegend
Targeting: CRLF2 CRL2, TSLPR
Provider product page for 322811

Antibody data

Product number
322811 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#322811, RRID:AB_2564354
Product name
PerCP/Cy5.5 anti-human TSLPR (TSLP-R)
Antibody type
Monoclonal
Antigen
Human TSLP-R:Fc protein
Description
TSLP-R, also known as the thymic stromal lymphopoietin protein receptor, cytokine receptor-like 2, CRL2, and IL-XR, is a type I membrane receptor that forms a functional heterodimeric complex with IL-7R to bind with TSLP. The TSLP-R contains a WSXWS motif required for proper protein folding and a box1 motif important for association with the JAKs. TSLP-R has a predicted molecular weight approximately 40 kD, and has two isoforms reported that are produced by alternative splicing. The TSLP-R is expressed preferentially in myeloid cells, dendritic cells, and activated monocytes. It is weakly expressed in T cells. Expression has also been reported in heart, skeletal, muscle, and kidney tissues. TSLP binding to the heterodimeric functional receptor (TSLP-R and IL-7R) activates JAK2, STAT3, and STAT5 to stimulate cell proliferation. Ligand receptor interactions have been implicated in the development of the hematopoietic system, dendritic cell maturation, and the maintenance and polarization of human Th2 memory T cells in allergy diseases.
Reactivity
Human
Host
Mouse
Antibody clone number
1B4
Vial size
25 tests
Storage
2°C-8°C
Handling
Ambient RT
CRLF2 protein structure - 322811 shown in red.