322804

antibody from BioLegend
Targeting: CRLF2 CRL2, TSLPR
Provider product page for 322804

Antibody data

Product number
322804 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#322804, RRID:AB_604160
Product name
Biotin anti-human TSLPR (TSLP-R)
Antibody type
Monoclonal
Antigen
Human TSLP-R:Fc protein
Description
TSLP-R, also known as thymic stromal lymphopoietin protein receptor, cytokine receptor-like 2, CRL2, and IL-XR, is a type I membrane receptor that forms a functional heterodimeric complex with IL-7R to bind TSLP. The TSLP-R contains a WSXWS motif required for proper protein folding and a box1 motif important for association with the JAKs. TSLP-R has a predicted molecular weight approximately 40 kD, and two isoforms have been reported that are produced by alternative splicing. The TSLP-R is expressed preferentially in myeloid cells including dendritic cells and activated monocytes, and is weakly expressed in T cells. Expression has also been reported in heart, skeletal muscle, and kidney tissues. TSLP binding to the heterodimeric functional receptor (TSLP-R and IL-7R) activates JAK2, STAT3 and STAT5 to stimulate cell proliferation. Ligand receptor interactions haves been implicated in the development of the hematopoietic system, dendritic cell maturation, and the maintenance and polarization of human Th2 memory T cells in allergic diseases.
Reactivity
Human
Host
Mouse
Conjugate
Biotin
Isotype
IgG
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
The antibody solution should be stored undiluted at 4°C. Do not freeze.
CRLF2 protein structure - 322804 shown in red.