AF3457

antibody from Novus Biologicals

Targeting: SORCS1

Western blot (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunoprecipitation (Supportive data in Antibodypedia)

Antibody Data

Product number

AF3457

Provider

Novus Biologicals

Product name

Goat Polyclonal SorCS1 Antibody

Antibody type

Polyclonal

Description

Immunogen affinity purified. Detects human SorCS1 in direct ELISAs and Western blots. In direct ELISAs, approximately 20% cross-reactivity with recombinant mouse SorCS1 is observed and less than 1% cross-reactivity with recombinant human (rh) SorCS2 and rhSorCS3 is observed.

Reactivity

Human

Host

Goat

Isotype

IgG

Vial size

100 ug

Concentration

LYOPH

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.

References

Submitted references

Prions amplify through degradation of the VPS10P sorting receptor sortilin.

Uchiyama K, Tomita M, Yano M, Chida J, Hara H, Das NR, Nykjaer A, Sakaguchi S
PLoS pathogens 2017 Jun;13(6):e1006470

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SORCS1 alters amyloid precursor protein processing and variants may increase Alzheimer's disease risk.

Reitz C, Tokuhiro S, Clark LN, Conrad C, Vonsattel JP, Hazrati LN, Palotás A, Lantigua R, Medrano M, Z Jiménez-Velázquez I, Vardarajan B, Simkin I, Haines JL, Pericak-Vance MA, Farrer LA, Lee JH, Rogaeva E, George-Hyslop PS, Mayeux R
Annals of neurology 2011 Jan;69(1):47-64

Immunoprecipitation

Supportive validation

Submitted by

Novus Biologicals (provider)

Main image

Experimental details

Immunoprecipitation: SorCS1 Antibody [AF3457] - IP of human SorCS1 transfected into HEK293 cells. Lane 4 is lysate of untransfected cells. Image courtesy of pAbmAbs.