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- Antibody Data
- Antigen structure
- References [2]
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- Product number
- AF3457 - Provider product page
- Provider
- R&D Systems
- Product name
- Human SorCS1 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Detects human SorCS1 in direct ELISAs and Western blots. In direct ELISAs, approximately 20% cross-reactivity with recombinant mouse SorCS1 is observed and less than 1% cross-reactivity with recombinant human (rh) SorCS2 and rhSorCS3 is observed.
- Reactivity
- Human
- Host
- Goat
- Conjugate
- Unconjugated
- Antigen sequence
Q8WY21.3- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Prions amplify through degradation of the VPS10P sorting receptor sortilin.
SORCS1 alters amyloid precursor protein processing and variants may increase Alzheimer's disease risk.
Uchiyama K, Tomita M, Yano M, Chida J, Hara H, Das NR, Nykjaer A, Sakaguchi S
PLoS pathogens 2017 Jun;13(6):e1006470
PLoS pathogens 2017 Jun;13(6):e1006470
SORCS1 alters amyloid precursor protein processing and variants may increase Alzheimer's disease risk.
Reitz C, Tokuhiro S, Clark LN, Conrad C, Vonsattel JP, Hazrati LN, Palotás A, Lantigua R, Medrano M, Z Jiménez-Velázquez I, Vardarajan B, Simkin I, Haines JL, Pericak-Vance MA, Farrer LA, Lee JH, Rogaeva E, George-Hyslop PS, Mayeux R
Annals of neurology 2011 Jan;69(1):47-64
Annals of neurology 2011 Jan;69(1):47-64
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