12704-1-AP

antibody from Proteintech Group

Targeting: SNAP29 CEDNIK, SNAP-29

Provider product page for 12704-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [44]
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Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 12704-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#12704-1-AP, RRID:AB_2192340
Product name: SNAP29 antibody
Antibody type: Polyclonal
Description: KD/KO validated SNAP29 antibody (Cat. #12704-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SNAP29 protein structure - 12704-1-AP shown in red.

Submitted references Knockout of Mucin 1 inhibits the proliferation, migration, and invasion of human MDA-MB-231 cells by blocking autophagy flow.

Huang Z, Zhao J, Zhang Q, Luo Y, Chen W, Liu Z, Liu X
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2026;59:e15075

Z-Guggulsterone Inhibits Triple-Negative Breast Cancer Progression by Blocking Autophagosome-Lysosome Fusion via OGT-Mediated SNAP29 O-GlcNAcylation.

Qian D, Mu Y, Liu H, Yang Z, Hu J, Zeng X, Liu K, He C, Liu X, Zhu L, Zhang J, Meng X
Phytotherapy research : PTR 2026 May;40(5):2364-2379

Electroacupuncture regulates neuronal ferroptosis and ferritinophagy through lysosomal-mediated TFEB activation in cerebral ischemia-reperfusion.

Tang B, Xu X, Zhao W, Zhou Q, Du G, Wang H
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2026 Apr;46(4):963-975

Poxvirus A52 protein subverts autophagy flux by blocking autophagosome-lysosome fusion to promote viral replication.

Niu K, Fang Y, Deng Y, Wang Z, Xie S, Zhu J, Song B, Wu W, Jing Z, Peng C
PLoS pathogens 2026 Apr;22(4):e1014137

Ulinastatin protects against cisplatin-induced ovarian damage via Nrf2/Keap1 pathway.

Zhao L, Wu Y, Zhang X, Li Y, Li Y, Fu Z
Journal of ovarian research 2025 Sep 29;18(1):207

METTL3-dependent m(6)A modification of SNAP29 induces "autophagy-mitochondrial crisis" in the ischemic microenvironment after soft tissue transplantation.

Yang N, Lai Y, Yu G, Zhang X, Shi J, Xiang L, Zhang J, Wu Y, Jiang X, Zhang X, Yang L, Gao W, Ding J, Wang X, Xiao J, Zhou K
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Matrine activates high xenophagy to inhibit enterovirus replication.

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British journal of pharmacology 2025 May;182(10):2287-2309

IGF2BP1-HAX-1 positive feedback loop-mediated HAX-1 overexpression blocks autophagic flux and promotes chemoresistance in nasopharyngeal carcinoma.

Zhang S, Gu M, Yin H, Pan S, Xie H, Chen W, Gul S, Zhao Y, Wang Z, Zheng W, You Y, You B
Cellular and molecular life sciences : CMLS 2025 Mar 7;82(1):105

Polystyrene nanoplastics trigger pyroptosis in dopaminergic neurons through TSC2/TFEB-mediated disruption of autophagosome-lysosome fusion in Parkinson's disease.

Liang X, Zeng Y, Zhang P, Zhu B, Feng J, Deng T, Fu Z, Liu C, Chen C, Zhang Y
Journal of translational medicine 2025 Jun 5;23(1):631

Dysfunction of Autophagy in Adipose Tissue Macrophages Regulated via FoxO1 in Obesity-Related Severe Acute Pancreatitis.

Ling X, Zhang Z, Lin L, Guo X, Ding Z
International journal of molecular sciences 2025 Jul 25;26(15)

Platycodin D2 Mediates Incomplete Autophagy and Ferroptosis in Breast Cancer Cells by Regulating Mitochondrial ROS.

Li Y, Lin H, Sun Y, Zhao R, Liu Y, Han J, Zhu Y, Jin N, Li X, Zhu G, Li Y
Phytotherapy research : PTR 2025 Feb;39(2):581-592

Pseudorabies virus gM protein and herpesvirus homologs block selective autophagy to enhance viral replication.

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Autophagy 2025 Dec;21(12):2597-2613

MiR-7 inhibits progression of glioblastoma by impairing autophagy resolution, energy metabolism and ECM remodeling.

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Journal of experimental & clinical cancer research : CR 2025 Aug 14;44(1):237

Impaired TFEB-mediated autophagy-lysosome fusion promotes tubular cell cycle G2/M arrest and renal fibrosis by suppressing ATP6V0C expression and interacting with SNAREs.

Ren X, Wang J, Wei H, Li X, Tian Y, Wang Z, Yin Y, Guo Z, Qin Z, Wu M, Zeng X
International journal of biological sciences 2024;20(5):1905-1926

Deapioplatycodin D promotes cell senescence induced by P21 through the mediation of incomplete mitophagy via BNIP3L.

Li Y, Xiao P, Sun Y, Li Y, Zhao H, Sun J, Wang X, Han X, Jin N, Li X, Bao Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117215

Insights into brominated flame retardant neurotoxicity: mechanisms of hippocampal neural cell death and brain region-specific transcriptomic shifts in mice.

Kramer NE, Fillmore CE, Slane EG, Barnett LMA, Wagner JJ, Cummings BS
Toxicological sciences : an official journal of the Society of Toxicology 2024 Oct 1;201(2):282-299

Migfilin promotes autophagic flux through direct interaction with SNAP29 and Vamp8.

Cai R, Bai P, Quan M, Ding Y, Wei W, Liu C, Yang A, Xiong Z, Li G, Li B, Deng Y, Tian R, Zhao YG, Wu C, Sun Y
The Journal of cell biology 2024 Nov 4;223(11)

BMAL1 upregulates STX17 levels to promote autophagosome-lysosome fusion in hippocampal neurons to ameliorate Alzheimer's disease.

Zhou X, Du K, Mao T, Wang N, Zhang L, Tian Y, Liu T, Wang L, Wang X
iScience 2024 Dec 20;27(12):111413

Migratory autolysosome disposal mitigates lysosome damage.

Sho T, Li Y, Jiao H, Yu L
The Journal of cell biology 2024 Dec 2;223(12)

Porphyromonas gingivalis, a periodontal pathogen, impairs post-infarcted myocardium by inhibiting autophagosome-lysosome fusion.

Shiheido-Watanabe Y, Maejima Y, Nakagama S, Fan Q, Tamura N, Sasano T
International journal of oral science 2023 Sep 18;15(1):42

TMEM175 downregulation participates in impairment of the autophagy related lysosomal dynamics following neonatal hypoxic-ischemic brain injury.

Zhang H, Tian Y, Yu W, Tong D, Ji Y, Qu X, Deng T, Li X, Xu Y
Journal of cellular physiology 2023 Oct;238(10):2512-2527

Neuronal SNAP-23 is critical for synaptic plasticity and spatial memory independently of NMDA receptor regulation.

Huang M, Bin NR, Rai J, Ma K, Chow CH, Eide S, Harada H, Xiao J, Feng D, Sun HS, Feng ZP, Gaisano HY, Pessin JE, Monnier PP, Okamoto K, Zhang L, Sugita S
iScience 2023 May 19;26(5):106664

SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes.

Zheng W, Chen Q, Liu H, Zeng L, Zhou Y, Liu X, Bai Y, Zhang J, Pan Y, Shao C
Autophagy 2023 Mar;19(3):839-857

Impaired autophagy flux by lncRNA NEAT1 is critical for inflammation factors production in human periodontal ligament stem cells with nicotine treatment.

Zhang T, Yang K, Chen Y, Jiang Y, Zhou Z, Liu J, Du Y, Wang L, Han X, Wu X, Wang X
Journal of periodontal research 2023 Feb;58(1):70-82

The ORF7a protein of SARS-CoV-2 initiates autophagy and limits autophagosome-lysosome fusion via degradation of SNAP29 to promote virus replication.

Hou P, Wang X, Wang H, Wang T, Yu Z, Xu C, Zhao Y, Wang W, Zhao Y, Chu F, Chang H, Zhu H, Lu J, Zhang F, Liang X, Li X, Wang S, Gao Y, He H
Autophagy 2023 Feb;19(2):551-569

NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8.

Anandhan A, Dodson M, Shakya A, Chen J, Liu P, Wei Y, Tan H, Wang Q, Jiang Z, Yang K, Garcia JG, Chambers SK, Chapman E, Ooi A, Yang-Hartwich Y, Stockwell BR, Zhang DD
Science advances 2023 Feb 3;9(5):eade9585

Doxorubicin induces cardiomyocyte death owing to the accumulation of dysfunctional mitochondria by inhibiting the autophagy fusion process.

Toda N, Sato T, Muraoka M, Lin D, Saito M, Li G, Song QC, Yanagisawa T, Yamauchi M
Free radical biology & medicine 2023 Feb 1;195:47-57

Hepatocyte-derived MASP1-enriched small extracellular vesicles activate HSCs to promote liver fibrosis.

Liu X, Tan S, Liu H, Jiang J, Wang X, Li L, Wu B
Hepatology (Baltimore, Md.) 2023 Apr 1;77(4):1181-1197

TFEB ameliorates autophagy flux disturbance induced by PBDE-47 via up-regulating autophagy-lysosome fusion.

Tang H, Huang H, Wang D, Li P, Tian Z, Li D, Wang S, Ma R, Xia T, Wang A
Journal of hazardous materials 2022 May 15;430:128483

Weakened interaction of ATG14 and the SNARE complex blocks autophagosome-lysosome fusion contributes to fluoride-induced developmental neurotoxicity.

Zhang Y, Han X, Tang Y, Zhang J, Hu Z, Xu W, Yao P, Niu Q
Ecotoxicology and environmental safety 2022 Jan 15;230:113108

Kansl1 haploinsufficiency impairs autophagosome-lysosome fusion and links autophagic dysfunction with Koolen-de Vries syndrome in mice.

Li T, Lu D, Yao C, Li T, Dong H, Li Z, Xu G, Chen J, Zhang H, Yi X, Zhu H, Liu G, Wen K, Zhao H, Gao J, Zhang Y, Han Q, Li T, Zhang W, Zhao J, Li T, Bai Z, Song M, He X, Zhou T, Xia Q, Li A, Pan X
Nature communications 2022 Feb 17;13(1):931

CHML is an NRF2 target gene that regulates mTOR function.

Dodson M, Dai W, Anandhan A, Schmidlin CJ, Liu P, Wilson NC, Wei Y, Kitamura N, Galligan JJ, Ooi A, Chapman E, Zhang DD
Molecular oncology 2022 Apr;16(8):1714-1727

Decreased neuronal synaptosome associated protein 29 contributes to poststroke cognitive impairment by disrupting presynaptic maintenance.

Yan W, Fan J, Zhang X, Song H, Wan R, Wang W, Yin Y
Theranostics 2021;11(10):4616-4636

Autophagy impairment as a key feature for acetaminophen-induced ototoxicity.

Zhao T, Zheng T, Yu H, Hu BH, Hu B, Ma P, Yang Y, Yang N, Hu J, Cao T, Chen G, Yan B, Peshoff M, Hatzoglou M, Geng R, Li B, Zheng QY
Cell death & disease 2021 Jan 4;12(1):3

Mild hypothermia pretreatment extenuates liver ischemia-reperfusion injury through Rab7-mediated autophagosomes-lysosomes fusion.

Liu A, Wang W, Lu Z, Liu Z, Zhou W, Zhong Z, Ye Q
Biochemical and biophysical research communications 2021 Apr 23;550:15-21

DDRGK1, a crucial player of ufmylation system, is indispensable for autophagic degradation by regulating lysosomal function.

Cao Y, Li R, Shen M, Li C, Zou Y, Jiang Q, Liu S, Lu C, Li H, Liu H, Cai Y
Cell death & disease 2021 Apr 20;12(5):416

Microtubule destabilization caused by silicate via HDAC6 activation contributes to autophagic dysfunction in bone mesenchymal stem cells.

Li Z, Liu S, Fu T, Peng Y, Zhang J
Stem cell research & therapy 2019 Nov 27;10(1):351

KRAS regulation by small non-coding RNAs and SNARE proteins.

Che Y, Siprashvili Z, Kovalski JR, Jiang T, Wozniak G, Elcavage L, Khavari PA
Nature communications 2019 Nov 11;10(1):5118

The Glycoprotein and Nucleocapsid Protein of Hantaviruses Manipulate Autophagy Flux to Restrain Host Innate Immune Responses.

Wang K, Ma H, Liu H, Ye W, Li Z, Cheng L, Zhang L, Lei Y, Shen L, Zhang F
Cell reports 2019 May 14;27(7):2075-2091.e5

Syntaxin 17 promotes lipid droplet formation by regulating the distribution of acyl-CoA synthetase 3.

Kimura H, Arasaki K, Ohsaki Y, Fujimoto T, Ohtomo T, Yamada J, Tagaya M
Journal of lipid research 2018 May;59(5):805-819

Quantitative proteomics study of host response to virulent and attenuated pseudorabies virus infection in mouse brain.

Zeng HL, Yu FL, Zhang Z, Yang Q, Jin S, He X, Chen X, Shen Y, Cheng L, Guo L, Xu F
Biochimica et biophysica acta. Proteins and proteomics 2018 Feb;1866(2):307-315

Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation.

Lu Q, Insinna C, Ott C, Stauffer J, Pintado PA, Rahajeng J, Baxa U, Walia V, Cuenca A, Hwang YS, Daar IO, Lopes S, Lippincott-Schwartz J, Jackson PK, Caplan S, Westlake CJ
Nature cell biology 2015 Mar;17(3):228-240

Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation.

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human kidney tissue were subjected to SDS PAGE followed by western blot with 12704-1-AP(SNAP29 antibody) at dilution of 1:500
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The SNAP29 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SNAP29. This antibody recognizes human,mouse,rat antigen. The SNAP29 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 12704-1-AP.pdf

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