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- Product number
- 17776-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17776-1-AP, RRID:AB_2217085
- Product name
- VPS16 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated VPS16 antibody (Cat. #17776-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Autophagy supports PDGFRA-dependent brain tumor development by enhancing oncogenic signaling.
VPS41-mediated incomplete autophagy aggravates cadmium-induced apoptosis in mouse hepatocytes.
HOPS, CORVET and newly-identified Hybrid tethering complexes contribute differentially towards multiple modes of endocytosis.
C9orf72-catalyzed GTP loading of Rab39A enables HOPS-mediated membrane tethering and fusion in mammalian autophagy.
SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes.
Loss of Sirt1 promotes exosome secretion from podocytes by inhibiting lysosomal acidification in diabetic nephropathy.
AP2S1 regulates APP degradation through late endosome-lysosome fusion in cells and APP/PS1 mice.
Contribution of Hepatic Steatosis-Intensified Extracellular Vesicle Release to Aggravated Inflammatory Endothelial Injury in Liver-Specific Asah1 Gene Knockout Mice.
CUR5g, a novel autophagy inhibitor, exhibits potent synergistic anticancer effects with cisplatin against non-small-cell lung cancer.
Overexpression of VPS16 correlates with tumor progression and chemoresistance in colorectal cancer.
Acetylation of STX17 (syntaxin 17) controls autophagosome maturation.
Regulation of TRPML1 channel activity and inflammatory exosome release by endogenously produced reactive oxygen species in mouse podocytes.
Contribution of podocyte inflammatory exosome release to glomerular inflammation and sclerosis during hyperhomocysteinemia.
Abnormal podocyte TRPML1 channel activity and exosome release in mice with podocyte-specific Asah1 gene deletion.
Label-Free Quantitative Proteomic Profiling of LAD2 Mast Cell Releasates Reveals the Mechanism of Tween-80-Induced Anaphylactoid Reaction.
Control of lysosomal TRPML1 channel activity and exosome release by acid ceramidase in mouse podocytes.
Lysosomal regulation of extracellular vesicle excretion during d-ribose-induced NLRP3 inflammasome activation in podocytes.
Autophagosome maturation mediated by Rab7 contributes to neuroprotection of hypoxic preconditioning against global cerebral ischemia in rats.
Characterization of the Mammalian CORVET and HOPS Complexes and Their Modular Restructuring for Endosome Specificity.
Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy.
Late endosomal transport and tethering are coupled processes controlled by RILP and the cholesterol sensor ORP1L.
Distinct autophagosomal-lysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest.
Simpson JE, Muir MT, Lee M, Naughton C, Gilbert N, Pollard SM, Gammoh N
Developmental cell 2024 Jan 22;59(2):228-243.e7
Developmental cell 2024 Jan 22;59(2):228-243.e7
VPS41-mediated incomplete autophagy aggravates cadmium-induced apoptosis in mouse hepatocytes.
Wang T, Yan L, Wang L, Sun J, Qu H, Ma Y, Song R, Tong X, Zhu J, Yuan Y, Gu J, Bian J, Liu Z, Zou H
Journal of hazardous materials 2023 Oct 5;459:132243
Journal of hazardous materials 2023 Oct 5;459:132243
HOPS, CORVET and newly-identified Hybrid tethering complexes contribute differentially towards multiple modes of endocytosis.
Terawaki S, Vasilev F, Moriwaki T, Otomo T
Scientific reports 2023 Oct 31;13(1):18734
Scientific reports 2023 Oct 31;13(1):18734
C9orf72-catalyzed GTP loading of Rab39A enables HOPS-mediated membrane tethering and fusion in mammalian autophagy.
Zhang S, Tong M, Zheng D, Huang H, Li L, Ungermann C, Pan Y, Luo H, Lei M, Tang Z, Fu W, Chen S, Liu X, Zhong Q
Nature communications 2023 Oct 11;14(1):6360
Nature communications 2023 Oct 11;14(1):6360
SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes.
Zheng W, Chen Q, Liu H, Zeng L, Zhou Y, Liu X, Bai Y, Zhang J, Pan Y, Shao C
Autophagy 2023 Mar;19(3):839-857
Autophagy 2023 Mar;19(3):839-857
Loss of Sirt1 promotes exosome secretion from podocytes by inhibiting lysosomal acidification in diabetic nephropathy.
Ding L, Li ZL, Zhou Y, Liu NC, Liu SS, Zhang XJ, Liu CC, Zhang DJ, Wang GH, Ma RX
Molecular and cellular endocrinology 2023 Jun 1;568-569:111913
Molecular and cellular endocrinology 2023 Jun 1;568-569:111913
AP2S1 regulates APP degradation through late endosome-lysosome fusion in cells and APP/PS1 mice.
Wen QX, Luo B, Xie XY, Zhou GF, Chen J, Song L, Liu Y, Xie SQ, Chen L, Li KY, Xiang XJ, Chen GJ
Traffic (Copenhagen, Denmark) 2023 Jan;24(1):20-33
Traffic (Copenhagen, Denmark) 2023 Jan;24(1):20-33
Contribution of Hepatic Steatosis-Intensified Extracellular Vesicle Release to Aggravated Inflammatory Endothelial Injury in Liver-Specific Asah1 Gene Knockout Mice.
Yuan X, Bhat OM, Zou Y, Zhang Y, Li PL
The American journal of pathology 2023 Apr;193(4):493-508
The American journal of pathology 2023 Apr;193(4):493-508
CUR5g, a novel autophagy inhibitor, exhibits potent synergistic anticancer effects with cisplatin against non-small-cell lung cancer.
Chen J, Shen Y, Wu B, Yang P, Sun G, Liu X, Qiang P, Gao Y, Sha F, Li Z, Zhang L
Cell death discovery 2022 Oct 31;8(1):435
Cell death discovery 2022 Oct 31;8(1):435
Overexpression of VPS16 correlates with tumor progression and chemoresistance in colorectal cancer.
Zhang B, Ma Y, Niu H, Liu Z
Biochemical and biophysical research communications 2022 Jun 4;607:81-88
Biochemical and biophysical research communications 2022 Jun 4;607:81-88
Acetylation of STX17 (syntaxin 17) controls autophagosome maturation.
Shen Q, Shi Y, Liu J, Su H, Huang J, Zhang Y, Peng C, Zhou T, Sun Q, Wan W, Liu W
Autophagy 2021 May;17(5):1157-1169
Autophagy 2021 May;17(5):1157-1169
Regulation of TRPML1 channel activity and inflammatory exosome release by endogenously produced reactive oxygen species in mouse podocytes.
Li G, Huang D, Li N, Ritter JK, Li PL
Redox biology 2021 Jul;43:102013
Redox biology 2021 Jul;43:102013
Contribution of podocyte inflammatory exosome release to glomerular inflammation and sclerosis during hyperhomocysteinemia.
Huang D, Li G, Zhang Q, Bhat OM, Zou Y, Ritter JK, Li PL
Biochimica et biophysica acta. Molecular basis of disease 2021 Jul 1;1867(7):166146
Biochimica et biophysica acta. Molecular basis of disease 2021 Jul 1;1867(7):166146
Abnormal podocyte TRPML1 channel activity and exosome release in mice with podocyte-specific Asah1 gene deletion.
Li G, Huang D, Bhat OM, Poklis JL, Zhang A, Zou Y, Kidd J, Gehr TWB, Li PL
Biochimica et biophysica acta. Molecular and cell biology of lipids 2021 Feb;1866(2):158856
Biochimica et biophysica acta. Molecular and cell biology of lipids 2021 Feb;1866(2):158856
Label-Free Quantitative Proteomic Profiling of LAD2 Mast Cell Releasates Reveals the Mechanism of Tween-80-Induced Anaphylactoid Reaction.
Mi YN, Yan PP, Di J, Cao L, Xiao X, Liu DZ, Cao YX
Proteomics. Clinical applications 2020 Jul;14(4):e1900065
Proteomics. Clinical applications 2020 Jul;14(4):e1900065
Control of lysosomal TRPML1 channel activity and exosome release by acid ceramidase in mouse podocytes.
Li G, Huang D, Hong J, Bhat OM, Yuan X, Li PL
American journal of physiology. Cell physiology 2019 Sep 1;317(3):C481-C491
American journal of physiology. Cell physiology 2019 Sep 1;317(3):C481-C491
Lysosomal regulation of extracellular vesicle excretion during d-ribose-induced NLRP3 inflammasome activation in podocytes.
Hong J, Bhat OM, Li G, Dempsey SK, Zhang Q, Ritter JK, Li W, Li PL
Biochimica et biophysica acta. Molecular cell research 2019 May;1866(5):849-860
Biochimica et biophysica acta. Molecular cell research 2019 May;1866(5):849-860
Autophagosome maturation mediated by Rab7 contributes to neuroprotection of hypoxic preconditioning against global cerebral ischemia in rats.
Zhan L, Chen S, Li K, Liang D, Zhu X, Liu L, Lu Z, Sun W, Xu E
Cell death & disease 2017 Jul 20;8(7):e2949
Cell death & disease 2017 Jul 20;8(7):e2949
Characterization of the Mammalian CORVET and HOPS Complexes and Their Modular Restructuring for Endosome Specificity.
van der Kant R, Jonker CT, Wijdeven RH, Bakker J, Janssen L, Klumperman J, Neefjes J
The Journal of biological chemistry 2015 Dec 18;290(51):30280-90
The Journal of biological chemistry 2015 Dec 18;290(51):30280-90
Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy.
Ulbricht A, Eppler FJ, Tapia VE, van der Ven PF, Hampe N, Hersch N, Vakeel P, Stadel D, Haas A, Saftig P, Behrends C, Fürst DO, Volkmer R, Hoffmann B, Kolanus W, Höhfeld J
Current biology : CB 2013 Mar 4;23(5):430-5
Current biology : CB 2013 Mar 4;23(5):430-5
Late endosomal transport and tethering are coupled processes controlled by RILP and the cholesterol sensor ORP1L.
van der Kant R, Fish A, Janssen L, Janssen H, Krom S, Ho N, Brummelkamp T, Carette J, Rocha N, Neefjes J
Journal of cell science 2013 Aug 1;126(Pt 15):3462-74
Journal of cell science 2013 Aug 1;126(Pt 15):3462-74
Distinct autophagosomal-lysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest.
Ganley IG, Wong PM, Gammoh N, Jiang X
Molecular cell 2011 Jun 24;42(6):731-43
Molecular cell 2011 Jun 24;42(6):731-43
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 17776-1-AP(VPS16 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 17776-1-AP(VPS16 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The VPS16 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human VPS16. This antibody recognizes human,mouse,rat antigen. The VPS16 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
