Antibody data
- Antibody Data
- Antigen structure
- References [25]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 10171-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10171-1-AP, RRID:AB_10644158
- Product name
- Beta Arrestin 2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Beta Arrestin 2 antibody (Cat. #10171-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Differential toxic and antiepileptic features of Vigabatrin raceme and its enantiomers.
Structure-based design of non-hypertrophic apelin receptor modulator.
Thrombin receptor activating peptide-6 decreases acute graft-versus-host disease through activating GPR15.
Cholinergic signaling via muscarinic M1 receptor confers resistance to docetaxel in prostate cancer.
Microglial Ffar4 deficiency promotes cognitive impairment in the context of metabolic syndrome.
PRL-mediated STAT5B/ARRB2 pathway promotes the progression of prostate cancer through the activation of MAPK signaling.
Monoclonal antibody targeting mu-opioid receptor attenuates morphine tolerance via enhancing morphine-induced receptor endocytosis.
WDR4 promotes the progression and lymphatic metastasis of bladder cancer via transcriptional down-regulation of ARRB2.
NE-activated β(2)-AR/β-arrestin 2/Src pathway mediates duodenal hyperpermeability induced by water-immersion restraint stress.
Chemokine receptor CXCR7 activates Aurora Kinase A and promotes neuroendocrine prostate cancer growth.
CXCL12/CXCR7/β-arrestin1 biased signal promotes epithelial-to-mesenchymal transition of colorectal cancer by repressing miRNAs through YAP1 nuclear translocation.
β-Arrestin2-biased Drd2 agonist UNC9995 alleviates astrocyte inflammatory injury via interaction between β-arrestin2 and STAT3 in mouse model of depression.
Sympathetic Denervation Ameliorates Renal Fibrosis via Inhibition of Cellular Senescence.
An ionic lock and a hydrophobic zipper mediate the coupling between an insect pheromone receptor BmOR3 and downstream effectors.
Autophagy and post-ischemic conditioning in retinal ischemia.
Activation of GPR120 in podocytes ameliorates kidney fibrosis and inflammation in diabetic nephropathy.
Bioactive peptide apelin rescues acute kidney injury by protecting the function of renal tubular mitochondria.
Lactate enhances Arc/arg3.1 expression through hydroxycarboxylic acid receptor 1-β-arrestin2 pathway in astrocytes.
Dopamine Uses the DRD5-ARRB2-PP2A Signaling Axis to Block the TRAF6-Mediated NF-κB Pathway and Suppress Systemic Inflammation.
BBSome trains remove activated GPCRs from cilia by enabling passage through the transition zone.
β-Arrestin-1 deficiency ameliorates renal interstitial fibrosis by blocking Wnt1/β-catenin signaling in mice.
The phosphatase Pgam5 antagonizes Wnt/β-Catenin signaling in embryonic anterior-posterior axis patterning.
Arrestins contribute to amyloid beta-induced cell death via modulation of autophagy and the α7nAch receptor in SH-SY5Y cells.
β-Arrestins promote podocyte injury by inhibition of autophagy in diabetic nephropathy.
β-Arrestin interacts with the beta/gamma subunits of trimeric G-proteins and dishevelled in the Wnt/Ca(2+) pathway in xenopus gastrulation.
Xu SL, Fan M, Ma MD, Zheng Q, Chen PQ, Wei YD, Sun HM, Sun HZ, Ge JF
Brain research 2024 Sep 1;1838:148991
Brain research 2024 Sep 1;1838:148991
Structure-based design of non-hypertrophic apelin receptor modulator.
Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y
Cell 2024 Mar 14;187(6):1460-1475.e20
Cell 2024 Mar 14;187(6):1460-1475.e20
Thrombin receptor activating peptide-6 decreases acute graft-versus-host disease through activating GPR15.
Liu C, Lan Q, Cao S, Zheng F, Liang Y, Shen J, Wang Y, Ikezoe T, Xu K, Pan B
Leukemia 2024 Jun;38(6):1390-1402
Leukemia 2024 Jun;38(6):1390-1402
Cholinergic signaling via muscarinic M1 receptor confers resistance to docetaxel in prostate cancer.
Wang J, Wei J, Pu T, Zeng A, Karthikeyan V, Bechtold B, Vo K, Chen J, Lin TP, Chang AP, Corey E, Puhr M, Klocker H, Culig Z, Bland T, Wu BJ
Cell reports. Medicine 2024 Feb 20;5(2):101388
Cell reports. Medicine 2024 Feb 20;5(2):101388
Microglial Ffar4 deficiency promotes cognitive impairment in the context of metabolic syndrome.
Wang W, Li J, Cui S, Li J, Ye X, Wang Z, Zhang T, Jiang X, Kong Y, Chen X, Chen YQ, Zhu S
Science advances 2024 Feb 2;10(5):eadj7813
Science advances 2024 Feb 2;10(5):eadj7813
PRL-mediated STAT5B/ARRB2 pathway promotes the progression of prostate cancer through the activation of MAPK signaling.
Yang T, Chi Y, Wang X, Xu C, Chen X, Liu Y, Huang S, Zhu X, Zhang H, Zhuo H, Wu D
Cell death & disease 2024 Feb 10;15(2):128
Cell death & disease 2024 Feb 10;15(2):128
Monoclonal antibody targeting mu-opioid receptor attenuates morphine tolerance via enhancing morphine-induced receptor endocytosis.
Zhang JJ, Song CG, Wang M, Zhang GQ, Wang B, Chen X, Lin P, Zhu YM, Sun ZC, Wang YZ, Jiang JL, Li L, Yang XM, Chen ZN
Journal of pharmaceutical analysis 2023 Oct;13(10):1135-1152
Journal of pharmaceutical analysis 2023 Oct;13(10):1135-1152
WDR4 promotes the progression and lymphatic metastasis of bladder cancer via transcriptional down-regulation of ARRB2.
Wang G, He X, Dai H, Lin L, Cao W, Fu Y, Diao W, Ding M, Zhang Q, Chen W, Guo H
Oncogenesis 2023 Oct 2;12(1):47
Oncogenesis 2023 Oct 2;12(1):47
NE-activated β(2)-AR/β-arrestin 2/Src pathway mediates duodenal hyperpermeability induced by water-immersion restraint stress.
Yan JT, Zhu YZ, Liang L, Feng XY
American journal of physiology. Cell physiology 2023 Jan 1;324(1):C133-C141
American journal of physiology. Cell physiology 2023 Jan 1;324(1):C133-C141
Chemokine receptor CXCR7 activates Aurora Kinase A and promotes neuroendocrine prostate cancer growth.
Gritsina G, Fong KW, Lu X, Lin Z, Xie W, Agarwal S, Lin D, Schiltz GE, Beltran H, Corey E, Morrissey C, Wang Y, Zhao JC, Hussain M, Yu J
The Journal of clinical investigation 2023 Aug 1;133(15)
The Journal of clinical investigation 2023 Aug 1;133(15)
CXCL12/CXCR7/β-arrestin1 biased signal promotes epithelial-to-mesenchymal transition of colorectal cancer by repressing miRNAs through YAP1 nuclear translocation.
Si M, Song Y, Wang X, Wang D, Liu X, Qu X, Song Z, Yu X
Cell & bioscience 2022 Oct 9;12(1):171
Cell & bioscience 2022 Oct 9;12(1):171
β-Arrestin2-biased Drd2 agonist UNC9995 alleviates astrocyte inflammatory injury via interaction between β-arrestin2 and STAT3 in mouse model of depression.
Liu Y, Song N, Yao H, Jiang S, Wang Y, Zheng Y, Zhou Y, Ding J, Hu G, Lu M
Journal of neuroinflammation 2022 Oct 1;19(1):240
Journal of neuroinflammation 2022 Oct 1;19(1):240
Sympathetic Denervation Ameliorates Renal Fibrosis via Inhibition of Cellular Senescence.
Li Q, Deng Y, Liu L, Zhang C, Cai Y, Zhang T, Han M, Xu G
Frontiers in immunology 2021;12:823935
Frontiers in immunology 2021;12:823935
An ionic lock and a hydrophobic zipper mediate the coupling between an insect pheromone receptor BmOR3 and downstream effectors.
Lin JY, Yang Z, Yang C, Du JX, Yang F, Cheng J, Pan W, Zhang SJ, Yan X, Wang J, Wang J, Tie L, Yu X, Chen X, Sun JP
The Journal of biological chemistry 2021 Oct;297(4):101160
The Journal of biological chemistry 2021 Oct;297(4):101160
Autophagy and post-ischemic conditioning in retinal ischemia.
Mathew B, Chennakesavalu M, Sharma M, Torres LA, Stelman CR, Tran S, Patel R, Burg N, Salkovski M, Kadzielawa K, Seiler F, Aldrich LN, Roth S
Autophagy 2021 Jun;17(6):1479-1499
Autophagy 2021 Jun;17(6):1479-1499
Activation of GPR120 in podocytes ameliorates kidney fibrosis and inflammation in diabetic nephropathy.
Wei TT, Yang LT, Guo F, Tao SB, Cheng L, Huang RS, Ma L, Fu P
Acta pharmacologica Sinica 2021 Feb;42(2):252-263
Acta pharmacologica Sinica 2021 Feb;42(2):252-263
Bioactive peptide apelin rescues acute kidney injury by protecting the function of renal tubular mitochondria.
Guan YM, Diao ZL, Huang HD, Zheng JF, Zhang QD, Wang LY, Liu WH
Amino acids 2021 Aug;53(8):1229-1240
Amino acids 2021 Aug;53(8):1229-1240
Lactate enhances Arc/arg3.1 expression through hydroxycarboxylic acid receptor 1-β-arrestin2 pathway in astrocytes.
Ma K, Ding X, Song Q, Han Z, Yao H, Ding J, Hu G
Neuropharmacology 2020 Jul;171:108084
Neuropharmacology 2020 Jul;171:108084
Dopamine Uses the DRD5-ARRB2-PP2A Signaling Axis to Block the TRAF6-Mediated NF-κB Pathway and Suppress Systemic Inflammation.
Wu Y, Hu Y, Wang B, Li S, Ma C, Liu X, Moynagh PN, Zhou J, Yang S
Molecular cell 2020 Apr 2;78(1):42-56.e6
Molecular cell 2020 Apr 2;78(1):42-56.e6
BBSome trains remove activated GPCRs from cilia by enabling passage through the transition zone.
Ye F, Nager AR, Nachury MV
The Journal of cell biology 2018 May 7;217(5):1847-1868
The Journal of cell biology 2018 May 7;217(5):1847-1868
β-Arrestin-1 deficiency ameliorates renal interstitial fibrosis by blocking Wnt1/β-catenin signaling in mice.
Xu H, Li Q, Liu J, Zhu J, Li L, Wang Z, Zhang Y, Sun Y, Sun J, Wang R, Yi F
Journal of molecular medicine (Berlin, Germany) 2018 Jan;96(1):97-109
Journal of molecular medicine (Berlin, Germany) 2018 Jan;96(1):97-109
The phosphatase Pgam5 antagonizes Wnt/β-Catenin signaling in embryonic anterior-posterior axis patterning.
Rauschenberger V, Bernkopf DB, Krenn S, Jalal K, Heller J, Behrens J, Gentzel M, Schambony A
Development (Cambridge, England) 2017 Jun 15;144(12):2234-2247
Development (Cambridge, England) 2017 Jun 15;144(12):2234-2247
Arrestins contribute to amyloid beta-induced cell death via modulation of autophagy and the α7nAch receptor in SH-SY5Y cells.
Liu YQ, Jia MQ, Xie ZH, Liu XF, Hui-Yang, Zheng XL, Yuan HQ, Bi JZ
Scientific reports 2017 Jun 13;7(1):3446
Scientific reports 2017 Jun 13;7(1):3446
β-Arrestins promote podocyte injury by inhibition of autophagy in diabetic nephropathy.
Liu J, Li QX, Wang XJ, Zhang C, Duan YQ, Wang ZY, Zhang Y, Yu X, Li NJ, Sun JP, Yi F
Cell death & disease 2016 Apr 7;7(4):e2183
Cell death & disease 2016 Apr 7;7(4):e2183
β-Arrestin interacts with the beta/gamma subunits of trimeric G-proteins and dishevelled in the Wnt/Ca(2+) pathway in xenopus gastrulation.
Seitz K, Dürsch V, Harnoš J, Bryja V, Gentzel M, Schambony A
PloS one 2014;9(1):e87132
PloS one 2014;9(1):e87132
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- RAW264.7 cells were subjected to SDS PAGE followed by western blot with 10171-1-AP(Beta Arrestin 2 antibody) at dilution of 1:2000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human spleen using 10171-1-AP(Beta Arrestin 2 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human spleen using 10171-1-AP(Beta Arrestin 2 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue