10171-1-AP

antibody from Proteintech Group

Targeting: ARRB2 ARR2, BARR2, DKFZp686L0365

Provider product page for 10171-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [36]
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Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 10171-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10171-1-AP, RRID:AB_10644158
Product name: Beta Arrestin 2 antibody
Antibody type: Polyclonal
Description: KD/KO validated Beta Arrestin 2 antibody (Cat. #10171-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ARRB2 protein structure - 10171-1-AP shown in red.

Submitted references Cytoplasmic tail diversity determines the effector bias of the adhesion GPCR ADGRL2.

Garbett KA, Zheng C, Drube J, Hoffmann C, Gurevich VV, Sando RC
Cell chemical biology 2026 Mar 19;33(3):364-378.e6

Identification of oxidative stress-responsive genes in recurrent miscarriage and their role in disease pathogenesis.

Wang M, Zhu L, Cheng X
PloS one 2025;20(12):e0337362

Insufficient BK channel function enhances NF-κB nuclear translocation and promotes IL-6 synthesis in vascular smooth muscle cells induced by AT1-AA.

Li Y, Xue L, Feng J, Wang Z, Long Y, Liu W, Zhang S, Zhi X, Hao H, Wang X, Liu H, Wang L
Biochemical pharmacology 2025 Sep;239:117000

Myocardial delivery of miR30d with peptide-functionalized milk-derived extracellular vesicles for targeted treatment of hypertrophic heart failure.

Tong L, Wang Q, Zhang Y, Lai F, Xu J, Yin W, Zhang S, Wei G, Yin J, Yi H, Storm G, Wang Z, Huang R, Xu T, Wang JW
Biomaterials 2025 May;316:122976

GPR120 internalization: a key mechanism for EPA in antidepressant action.

Yu Q, Li H, Chen M, Pan Y, Zhou L, An L, Zhao J, Bai S, Liang Q, Zhang R, Deng D
Food & function 2025 Mar 31;16(7):2893-2908

Cytoplasmic tail composition modulates the G protein and arrestin-3 signaling bias of the adhesion GPCR LPHN2.

Garbett K, Zheng C, Drube J, Hoffmann C, Gurevich VV, Sando RC
bioRxiv : the preprint server for biology 2025 Jul 6;

Free fatty acid receptor-4 regulates T-cell-mediated allogeneic reaction through activating an aryl hydrocarbon receptor pathway.

Duah M, Zheng F, Shen J, Xu Y, Cao S, Yan Z, Lan Q, Wang Y, Xu K, Pan B
Acta pharmaceutica Sinica. B 2025 Jan;15(1):224-238

REG3A promotes gemcitabine resistance in pancreatic cancer via the GPR54/ARRB2/ERK1/2 ligand-directed signaling pathway.

Liu J, Li S, Zhou H, Wang M, Zhang C, Tian C, Xu Y, Wang M, Li X, Li Q, Xiang M
Biochemical pharmacology 2025 Dec;242(Pt 2):117322

Interleukin-1/Toll-like receptor signaling potentiates macrophage olfactory receptor 2-driven atherosclerosis.

Zhang L, Fu J, Hu Z, Zhao Y, Cao Y, Yao M, Liu F, Du J, Ran H, Wang Z, Li Y, Liang L, Su W, Melgiri ND, Liu D, Jiang L, Hu T, Huang R, Sun Y
Cell reports 2025 Dec 23;44(12):116639

Melatonin alleviates retinal injury induced by vigabatrin and partially enhances its antiepileptic effects.

Ma M, Fan M, Xu S, Zheng Q, Wang C, Chen P, Wei Y, Ge J
International immunopharmacology 2025 Apr 24;153:114516

MiR-483-3p promotes dental pulp stem cells osteogenic differentiation via the MAPK signaling pathway by targeting ARRB2.

Yu X, Ge J, Xie H, Qian J, Xia W, Wang Q, Zhou X, Zhou Y
In vitro cellular & developmental biology. Animal 2024 Sep;60(8):879-887

Differential toxic and antiepileptic features of Vigabatrin raceme and its enantiomers.

Xu SL, Fan M, Ma MD, Zheng Q, Chen PQ, Wei YD, Sun HM, Sun HZ, Ge JF
Brain research 2024 Sep 1;1838:148991

Structure-based design of non-hypertrophic apelin receptor modulator.

Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y
Cell 2024 Mar 14;187(6):1460-1475.e20

Thrombin receptor activating peptide-6 decreases acute graft-versus-host disease through activating GPR15.

Liu C, Lan Q, Cao S, Zheng F, Liang Y, Shen J, Wang Y, Ikezoe T, Xu K, Pan B
Leukemia 2024 Jun;38(6):1390-1402

Cholinergic signaling via muscarinic M1 receptor confers resistance to docetaxel in prostate cancer.

Wang J, Wei J, Pu T, Zeng A, Karthikeyan V, Bechtold B, Vo K, Chen J, Lin TP, Chang AP, Corey E, Puhr M, Klocker H, Culig Z, Bland T, Wu BJ
Cell reports. Medicine 2024 Feb 20;5(2):101388

Microglial Ffar4 deficiency promotes cognitive impairment in the context of metabolic syndrome.

Wang W, Li J, Cui S, Li J, Ye X, Wang Z, Zhang T, Jiang X, Kong Y, Chen X, Chen YQ, Zhu S
Science advances 2024 Feb 2;10(5):eadj7813

PRL-mediated STAT5B/ARRB2 pathway promotes the progression of prostate cancer through the activation of MAPK signaling.

Yang T, Chi Y, Wang X, Xu C, Chen X, Liu Y, Huang S, Zhu X, Zhang H, Zhuo H, Wu D
Cell death & disease 2024 Feb 10;15(2):128

Monoclonal antibody targeting mu-opioid receptor attenuates morphine tolerance via enhancing morphine-induced receptor endocytosis.

Zhang JJ, Song CG, Wang M, Zhang GQ, Wang B, Chen X, Lin P, Zhu YM, Sun ZC, Wang YZ, Jiang JL, Li L, Yang XM, Chen ZN
Journal of pharmaceutical analysis 2023 Oct;13(10):1135-1152

WDR4 promotes the progression and lymphatic metastasis of bladder cancer via transcriptional down-regulation of ARRB2.

Wang G, He X, Dai H, Lin L, Cao W, Fu Y, Diao W, Ding M, Zhang Q, Chen W, Guo H
Oncogenesis 2023 Oct 2;12(1):47

NE-activated β(2)-AR/β-arrestin 2/Src pathway mediates duodenal hyperpermeability induced by water-immersion restraint stress.

Yan JT, Zhu YZ, Liang L, Feng XY
American journal of physiology. Cell physiology 2023 Jan 1;324(1):C133-C141

Chemokine receptor CXCR7 activates Aurora Kinase A and promotes neuroendocrine prostate cancer growth.

Gritsina G, Fong KW, Lu X, Lin Z, Xie W, Agarwal S, Lin D, Schiltz GE, Beltran H, Corey E, Morrissey C, Wang Y, Zhao JC, Hussain M, Yu J
The Journal of clinical investigation 2023 Aug 1;133(15)

CXCL12/CXCR7/β-arrestin1 biased signal promotes epithelial-to-mesenchymal transition of colorectal cancer by repressing miRNAs through YAP1 nuclear translocation.

Si M, Song Y, Wang X, Wang D, Liu X, Qu X, Song Z, Yu X
Cell & bioscience 2022 Oct 9;12(1):171

β-Arrestin2-biased Drd2 agonist UNC9995 alleviates astrocyte inflammatory injury via interaction between β-arrestin2 and STAT3 in mouse model of depression.

Liu Y, Song N, Yao H, Jiang S, Wang Y, Zheng Y, Zhou Y, Ding J, Hu G, Lu M
Journal of neuroinflammation 2022 Oct 1;19(1):240

Sympathetic Denervation Ameliorates Renal Fibrosis via Inhibition of Cellular Senescence.

Li Q, Deng Y, Liu L, Zhang C, Cai Y, Zhang T, Han M, Xu G
Frontiers in immunology 2021;12:823935

An ionic lock and a hydrophobic zipper mediate the coupling between an insect pheromone receptor BmOR3 and downstream effectors.

Lin JY, Yang Z, Yang C, Du JX, Yang F, Cheng J, Pan W, Zhang SJ, Yan X, Wang J, Wang J, Tie L, Yu X, Chen X, Sun JP
The Journal of biological chemistry 2021 Oct;297(4):101160

Autophagy and post-ischemic conditioning in retinal ischemia.

Mathew B, Chennakesavalu M, Sharma M, Torres LA, Stelman CR, Tran S, Patel R, Burg N, Salkovski M, Kadzielawa K, Seiler F, Aldrich LN, Roth S
Autophagy 2021 Jun;17(6):1479-1499

Activation of GPR120 in podocytes ameliorates kidney fibrosis and inflammation in diabetic nephropathy.

Wei TT, Yang LT, Guo F, Tao SB, Cheng L, Huang RS, Ma L, Fu P
Acta pharmacologica Sinica 2021 Feb;42(2):252-263

Bioactive peptide apelin rescues acute kidney injury by protecting the function of renal tubular mitochondria.

Guan YM, Diao ZL, Huang HD, Zheng JF, Zhang QD, Wang LY, Liu WH
Amino acids 2021 Aug;53(8):1229-1240

Lactate enhances Arc/arg3.1 expression through hydroxycarboxylic acid receptor 1-β-arrestin2 pathway in astrocytes.

Ma K, Ding X, Song Q, Han Z, Yao H, Ding J, Hu G
Neuropharmacology 2020 Jul;171:108084

Dopamine Uses the DRD5-ARRB2-PP2A Signaling Axis to Block the TRAF6-Mediated NF-κB Pathway and Suppress Systemic Inflammation.

Wu Y, Hu Y, Wang B, Li S, Ma C, Liu X, Moynagh PN, Zhou J, Yang S
Molecular cell 2020 Apr 2;78(1):42-56.e6

BBSome trains remove activated GPCRs from cilia by enabling passage through the transition zone.

Ye F, Nager AR, Nachury MV
The Journal of cell biology 2018 May 7;217(5):1847-1868

β-Arrestin-1 deficiency ameliorates renal interstitial fibrosis by blocking Wnt1/β-catenin signaling in mice.

Xu H, Li Q, Liu J, Zhu J, Li L, Wang Z, Zhang Y, Sun Y, Sun J, Wang R, Yi F
Journal of molecular medicine (Berlin, Germany) 2018 Jan;96(1):97-109

The phosphatase Pgam5 antagonizes Wnt/β-Catenin signaling in embryonic anterior-posterior axis patterning.

Rauschenberger V, Bernkopf DB, Krenn S, Jalal K, Heller J, Behrens J, Gentzel M, Schambony A
Development (Cambridge, England) 2017 Jun 15;144(12):2234-2247

Arrestins contribute to amyloid beta-induced cell death via modulation of autophagy and the α7nAch receptor in SH-SY5Y cells.

Liu YQ, Jia MQ, Xie ZH, Liu XF, Hui-Yang, Zheng XL, Yuan HQ, Bi JZ
Scientific reports 2017 Jun 13;7(1):3446

β-Arrestins promote podocyte injury by inhibition of autophagy in diabetic nephropathy.

Liu J, Li QX, Wang XJ, Zhang C, Duan YQ, Wang ZY, Zhang Y, Yu X, Li NJ, Sun JP, Yi F
Cell death & disease 2016 Apr 7;7(4):e2183

β-Arrestin interacts with the beta/gamma subunits of trimeric G-proteins and dishevelled in the Wnt/Ca(2+) pathway in xenopus gastrulation.

Seitz K, Dürsch V, Harnoš J, Bryja V, Gentzel M, Schambony A
PloS one 2014;9(1):e87132

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: RAW264.7 cells were subjected to SDS PAGE followed by western blot with 10171-1-AP(Beta Arrestin 2 antibody) at dilution of 1:2000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human spleen using 10171-1-AP(Beta Arrestin 2 antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human spleen using 10171-1-AP(Beta Arrestin 2 antibody) at dilution of 1:100 (under 40x lens)
Sample type: tissue