AGTO-G017D

antibody from Creative Biolabs
Targeting: EEF2 EEF-2, EF2
Provider product page for AGTO-G017D
No application information provided.

Antibody data

Product number
AGTO-G017D - Provider product page
Provider
Creative Biolabs
Product name
Anti-EEF2 immunotoxin G4S (scFv)-DT
Antibody type
Monoclonal
Description
This immunotoxin was achieved by conjugating/fusing the Anti-EEF2 scFv to Diphtheria toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to leukemia cells and the toxin enters cells by receptor-mediated endocytosis. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death. It was designed for treatment of T cell leukemia.
Reactivity
Human
Host
Mouse
EEF2 protein structure - AGTO-G017D shown in red.