AGTO-G017E

antibody from Creative Biolabs
Targeting: EEF2 EEF-2, EF2
Provider product page for AGTO-G017E
No application information provided.

Antibody data

Product number
AGTO-G017E - Provider product page
Provider
Creative Biolabs
Product name
Anti-EEF2 immunotoxin G4S (scFv)-PE
Antibody type
Monoclonal
Description
This immunotoxin was achieved by conjugating/fusing the Anti-EEF2 scFv to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to leukemia cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating T cell leukemia.
Reactivity
Human
Host
Mouse
EEF2 protein structure - AGTO-G017E shown in red.