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- Antigen structure
- References [8]
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- Product number
- 17169-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17169-1-AP, RRID:AB_2137150
- Product name
- LOH12CR1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated LOH12CR1 antibody (Cat. #17169-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references BLOC1S1 variants cause lysosomal and autophagic defects resulting in a hypomyelinating leukodystrophy with epileptic encephalopathy.
BLOC1S1 variants cause lysosomal and autophagic defects resulting in a hypomyelinating leukodystrophy with epileptic encephalopathy.
Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration.
Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders.
Consecutive functions of small GTPases guide HOPS-mediated tethering of late endosomes and lysosomes.
HIV-1 Vpr protein impairs lysosome clearance causing SNCA/alpha-synuclein accumulation in neurons.
Synaptic Vesicle Precursors and Lysosomes Are Transported by Different Mechanisms in the Axon of Mammalian Neurons.
BORC, a multisubunit complex that regulates lysosome positioning.
De Pace R, Dominguez Gonzalez CA, Williamson CD, Helman G, Sanderson LE, Disanza B, Hsiao-Sánchez N, Pizzino A, Muirhead K, Bonkowsky JL, Taft RJ, Sannaa NA, Dias P, Quintas AS, Mutlu MB, Bas H, Oztürk H, Mojarrad M, Alerasool M, Sheikhani S, Jabbar HK, Issa AH, Houlden H, Zonic E, Barakat TS, Tripolski K, Romito A, Teferedegn E, Vossough A, Whitehead MT, Bhoj E, Ahrens-Nicklas RC, Simons C, Wolvetang E, van Ham TJ, Bertoli-Avella AM, Maroofian R, Bonifacino JS, Vanderver A
American journal of human genetics 2026 Apr 2;113(4):736-753
American journal of human genetics 2026 Apr 2;113(4):736-753
BLOC1S1 variants cause lysosomal and autophagic defects resulting in a hypomyelinating leukodystrophy with epileptic encephalopathy.
De Pace R, Gonzalez CD, Williamson CD, Helman G, Sanderson LE, Disanza B, Hsiao-Sánchez N, Pizzino A, Muirhead K, Bonkowsky JL, Taft RJ, Sannaa NA, Dias P, Quintas AS, Mutlu MB, Bas H, Oztürk H, Mojarrad M, Alerasool M, Sheikhani S, Jabbar HK, Issa AH, Houlden H, Zonic E, Barakat TS, Tripolski K, Romito A, Teferedegn E, Vossough A, Whitehead MT, Bhoj E, Ahrens-Nicklas RC, Simons C, Wolvetang E, van Ham TJ, Bertoli-Avella AM, Maroofian R, Bonifacino JS, Vanderver A
medRxiv : the preprint server for health sciences 2025 Jul 17;
medRxiv : the preprint server for health sciences 2025 Jul 17;
Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration.
De Pace R, Ghosh S, Ryan VH, Sohn M, Jarnik M, Rezvan Sangsari P, Morgan NY, Dale RK, Ward ME, Bonifacino JS
Nature neuroscience 2024 Jun;27(6):1087-1102
Nature neuroscience 2024 Jun;27(6):1087-1102
Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders.
Pintacuda G, Hsu YH, Tsafou K, Li KW, Martín JM, Riseman J, Biagini JC, Ching JKT, Mena D, Gonzalez-Lozano MA, Egri SB, Jaffe J, Smit AB, Fornelos N, Eggan KC, Lage K
Cell genomics 2023 Mar 8;3(3):100250
Cell genomics 2023 Mar 8;3(3):100250
Consecutive functions of small GTPases guide HOPS-mediated tethering of late endosomes and lysosomes.
Schleinitz A, Pöttgen LA, Keren-Kaplan T, Pu J, Saftig P, Bonifacino JS, Haas A, Jeschke A
Cell reports 2023 Jan 31;42(1):111969
Cell reports 2023 Jan 31;42(1):111969
HIV-1 Vpr protein impairs lysosome clearance causing SNCA/alpha-synuclein accumulation in neurons.
Santerre M, Arjona SP, Allen CN, Callen S, Buch S, Sawaya BE
Autophagy 2021 Jul;17(7):1768-1782
Autophagy 2021 Jul;17(7):1768-1782
Synaptic Vesicle Precursors and Lysosomes Are Transported by Different Mechanisms in the Axon of Mammalian Neurons.
De Pace R, Britt DJ, Mercurio J, Foster AM, Djavaherian L, Hoffmann V, Abebe D, Bonifacino JS
Cell reports 2020 Jun 16;31(11):107775
Cell reports 2020 Jun 16;31(11):107775
BORC, a multisubunit complex that regulates lysosome positioning.
Pu J, Schindler C, Jia R, Jarnik M, Backlund P, Bonifacino JS
Developmental cell 2015 Apr 20;33(2):176-88
Developmental cell 2015 Apr 20;33(2):176-88
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The LOH12CR1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human LOH12CR1. This antibody recognizes human,mouse,rat antigen. The LOH12CR1 antibody has been validated for the following applications: ELISA, WB analysis.
