PKD1

gene product
PBP, Pc-1, TRPP1
This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described. [provided by RefSeq, Oct 2008]
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181 antibodies from 25 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
69 antibodies
LifeSpan BioSciences, Inc.
14 antibodies
Biorbyt
21 antibodies
Novus Biologicals
19 antibodies
NovoPro Bioscience Inc.
1 antibody
Everest Biotech
2 antibodies
OriGene
2 antibodies
Creative Diagnostics
8 antibodies
Abnova Corporation
1 antibody
Acris Antibodies GmbH
1 antibody
NSJ Bioreagents
1 antibody
R&D Systems
1 antibody
Creative Biolabs
3 antibodies
St John's Laboratory
3 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
EMD Millipore
1 antibody
Invitrogen Antibodies
2 antibodies
Proteintech Group
1 antibody
United States Biological
13 antibodies
MyBioSource
1 antibody
RayBiotech, Inc.
1 antibody
Sigma-Aldrich
1 antibody
Abgent
1 antibody
ProSci
1 antibody