Antibody data
- Antibody Data
- Antigen structure
- References [42]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- 12225-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12225-1-AP, RRID:AB_2115832
- Product name
- STAR antibody
- Antibody type
- Polyclonal
- Description
- STAR antibody (Cat. #12225-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat, pig and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat, Porcine
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Cyclophosphamide activates ferroptosis-induced dysfunction of Leydig cells via SMAD2 pathway†.
Androgen synthesis cell-specific CREBZF deficiency alters adrenal cortex steroid secretion and develops behavioral abnormalities in adult male mice.
Ursonic acid attenuates spermatogenesis in oligozoospermia mice through inhibiting ferroptosis.
Bone morphogenetic protein-9 downregulates StAR expression by inducing snail expression via SMAD1/5/8 signaling in human granulosa-lutein cells.
TGF-β1 and TGF-β3, but not TGF-β2, are upregulated in the ovaries of ovarian hyperstimulation syndrome†.
Protective effect of TNFAIP3 on testosterone production in Leydig cells under an aging inflammatory microenvironment.
Exosomes derived from BMSCs ameliorate cyclophosphamide-induced testosterone deficiency by enhancing the autophagy of Leydig cells via the AMPK-mTOR signaling pathway.
RNA sequencing profiles reveals progressively reduced spermatogenesis with progression in adult cryptorchidism.
Clinical and functional analyses of the novel STAR c.558C>A in a patient with classic lipoid congenital adrenal hyperplasia.
Knockdown of ZnT4 Induced Apoptosis, Inhibited Proliferation and testosterone synthesis of TM3 cells.
FDX1 regulates leydig cell ferroptosis mediates PM(2.5)-induced testicular dysfunction of mice.
Paternal cadmium exposure affects estradiol synthesis by impairing intracellular cholesterol homeostasis and mitochondrial function in offspring female mice.
Hypoxia activation attenuates progesterone synthesis in goat trophoblast cells via NR1D1 inhibition of StAR expression†.
Sea cucumber peptides positively regulate sexual hormones in male mice with acute exhaustive swimming: possibly through the Ca(2+)/PKA signaling pathway.
Expression Analysis of Lipocalin 2 (LCN2) in Reproductive and Non-Reproductive Tissues of Esr1-Deficient Mice.
Bisphenol S induces oxidative stress-mediated impairment of testosterone synthesis by inhibiting the Nrf2/HO-1 signaling pathway.
Mixed-Culture Propagation of Uterine-Tissue-Resident Macrophages and Their Expression Properties of Steroidogenic Molecules.
Casein Kinase 1α Regulates Testosterone Synthesis and Testis Development in Adult Mice.
HE4 overexpression in mice leads to leydig cell hyperplasia and spermatogensis impairment: Pathological implications for oligospermia.
Lactoferrin Restores the Deoxynivalenol-Impaired Spermatogenesis and Blood-Testis Barrier Integrity via Improving the Antioxidant Capacity and Modifying the Cell Adhesion and Inflammatory Response.
Asymmetries of Left and Right Adrenal Glands in Neural Innervation and Glucocorticoids Production.
Prepubertal exposure to copper oxide nanoparticles induces Leydig cell injury with steroidogenesis disorders in mouse testes.
Astragalus polysaccharide protects sepsis model rats after cecum ligation and puncture.
Paternal cadmium exposure affects testosterone synthesis by reducing the testicular cholesterol pool in offspring mice.
A Short Promoter Region Containing Conserved Regulatory Motifs Is Required for Steroidogenic Acute Regulatory Protein (Star) Gene Expression in the Mouse Testis.
Progesterone Induces Apoptosis and Steroidogenesis in Porcine Placental Trophoblasts.
Single-cell RNA-seq analysis of testicular somatic cell development in pigs.
Effects of 4-vinylcyclohexene diepoxide on the cell cycle, apoptosis, and steroid hormone secretion of goat ovarian granulosa cells.
Transcriptomic analysis of MA-10 tumor Leydig cells treated with adipose derived hormones adiponectin and resistin.
Effects of Bushen Yiyuan recipe on testosterone synthesis in Leydig cells of rats with exercise-induced low serum testosterone levels.
Chronic exposure to propylparaben at the humanly relevant dose triggers ovarian aging in adult mice.
Prenatal exposure to propylparaben at human-relevant doses accelerates ovarian aging in adult mice.
Propylparaben concentrations in the urine of women and adverse effects on ovarian function in mice in vivo and ovarian cells in vitro.
Isorhamnetin Promotes Estrogen Biosynthesis and Proliferation in Porcine Granulosa Cells via the PI3K/Akt Signaling Pathway.
Induction of autophagy by Beclin-1 in granulosa cells contributes to follicular progesterone elevation in ovarian endometriosis.
Cyclin-dependent kinase inhibitor 1B acts as a novel molecule to mediate testosterone synthesis and secretion in mouse Leydig cells by luteinizing hormone (LH) signaling pathway.
Single-cell transcriptomes reveal heterogeneity of high-grade serous ovarian carcinoma.
Effect of luteinizing hormone concentration on transcriptome and subcellular organelle phenotype of ovarian granulosa cells.
La(2)O(3) Nanoparticles Induce Reproductive Toxicity Mediated by the Nrf-2/ARE Signaling Pathway in Kunming Mice.
Oxidized-LDL inhibits testosterone biosynthesis by affecting mitochondrial function and the p38 MAPK/COX-2 signaling pathway in Leydig cells.
The ovarian estrogen synthesis function was impaired in Y123F mouse and partly restored by exogenous FSH supplement.
STMN1 Promotes Progesterone Production Via StAR Up-regulation in Mouse Granulosa Cells.
Liao S, Wei C, Wei G, Liang H, Peng F, Zhao L, Li Z, Liu C, Zhou Q
Biology of reproduction 2024 May 9;110(5):1012-1024
Biology of reproduction 2024 May 9;110(5):1012-1024
Androgen synthesis cell-specific CREBZF deficiency alters adrenal cortex steroid secretion and develops behavioral abnormalities in adult male mice.
Niu H, Li C, Zhang H, Liu H, Shang C, Jia Y, Wuenjiya, Li Z, Wang A, Jin Y, Lin P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 15;38(9):e23650
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 15;38(9):e23650
Ursonic acid attenuates spermatogenesis in oligozoospermia mice through inhibiting ferroptosis.
Dong J, Dong Y, Chen H, Ye T, Chen G, Fan B, Wang X, Shi J, Wang C
Bioorganic chemistry 2024 Mar;144:107174
Bioorganic chemistry 2024 Mar;144:107174
Bone morphogenetic protein-9 downregulates StAR expression by inducing snail expression via SMAD1/5/8 signaling in human granulosa-lutein cells.
Liu B, Fu B, Zhou S, Wang H, Bi B, Guo M, Cheng JC, Fang L
Molecular and cellular endocrinology 2024 Mar 1;582:112126
Molecular and cellular endocrinology 2024 Mar 1;582:112126
TGF-β1 and TGF-β3, but not TGF-β2, are upregulated in the ovaries of ovarian hyperstimulation syndrome†.
Liu B, Jia Q, Hong IS, Dang X, Wu Z, Wang H, Cheng JC, Fang L
Biology of reproduction 2024 Jan 13;110(1):116-129
Biology of reproduction 2024 Jan 13;110(1):116-129
Protective effect of TNFAIP3 on testosterone production in Leydig cells under an aging inflammatory microenvironment.
Xing D, Jin Y, Sun D, Liu Y, Cai B, Gao C, Cui Y, Jin B
Archives of gerontology and geriatrics 2024 Feb;117:105274
Archives of gerontology and geriatrics 2024 Feb;117:105274
Exosomes derived from BMSCs ameliorate cyclophosphamide-induced testosterone deficiency by enhancing the autophagy of Leydig cells via the AMPK-mTOR signaling pathway.
Liang HY, Peng F, Pan MJ, Liao SL, Wei C, Wei GY, Xie X, Xue KY, Chen MK, Yang JK, Guo WB, Liu CD, Zhou QZ
Asian journal of andrology 2023;25(4):474-483
Asian journal of andrology 2023;25(4):474-483
RNA sequencing profiles reveals progressively reduced spermatogenesis with progression in adult cryptorchidism.
Sun W, Zhang X, Wang L, Ren G, Piao S, Yang C, Liu Z
Frontiers in endocrinology 2023;14:1271724
Frontiers in endocrinology 2023;14:1271724
Clinical and functional analyses of the novel STAR c.558C>A in a patient with classic lipoid congenital adrenal hyperplasia.
Liu J, Dai HM, Guang GP, Hu WM, Jin P
Frontiers in genetics 2023;14:1096454
Frontiers in genetics 2023;14:1096454
Knockdown of ZnT4 Induced Apoptosis, Inhibited Proliferation and testosterone synthesis of TM3 cells.
Li H, Li Y, Liu J, Liu X, Li Y, Wang S, Ma J
In vitro cellular & developmental biology. Animal 2023 Sep;59(8):565-574
In vitro cellular & developmental biology. Animal 2023 Sep;59(8):565-574
FDX1 regulates leydig cell ferroptosis mediates PM(2.5)-induced testicular dysfunction of mice.
Li L, Pei Z, Wu R, Zhang Y, Pang Y, Hu H, Hu W, Geng Z, Feng T, Niu Y, Hao G, Zhang R
Ecotoxicology and environmental safety 2023 Sep 15;263:115309
Ecotoxicology and environmental safety 2023 Sep 15;263:115309
Paternal cadmium exposure affects estradiol synthesis by impairing intracellular cholesterol homeostasis and mitochondrial function in offspring female mice.
Zhang Y, Zhou J, Zeng L, Xiong Y, Wang X, Xiang W, Su P
Ecotoxicology and environmental safety 2023 Sep 15;263:115280
Ecotoxicology and environmental safety 2023 Sep 15;263:115280
Hypoxia activation attenuates progesterone synthesis in goat trophoblast cells via NR1D1 inhibition of StAR expression†.
Li C, Yang D, Yang W, Wang Y, Li D, Li Y, Xiao B, Zhang H, Zhao H, Dong H, Zhang J, Chu G, Wang A, Jin Y, Liu Y, Chen H
Biology of reproduction 2023 Nov 15;109(5):720-735
Biology of reproduction 2023 Nov 15;109(5):720-735
Sea cucumber peptides positively regulate sexual hormones in male mice with acute exhaustive swimming: possibly through the Ca(2+)/PKA signaling pathway.
Luo X, Liu W, Zheng B, Zheng Y, Zhao M, Feng F, Liu L
Food & function 2023 Nov 13;14(22):10188-10203
Food & function 2023 Nov 13;14(22):10188-10203
Expression Analysis of Lipocalin 2 (LCN2) in Reproductive and Non-Reproductive Tissues of Esr1-Deficient Mice.
Kessel JC, Weiskirchen R, Schröder SK
International journal of molecular sciences 2023 May 25;24(11)
International journal of molecular sciences 2023 May 25;24(11)
Bisphenol S induces oxidative stress-mediated impairment of testosterone synthesis by inhibiting the Nrf2/HO-1 signaling pathway.
Wang YX, Dai W, Li YZ, Wu ZY, Kan YQ, Zeng HC, He QZ
Journal of biochemical and molecular toxicology 2023 Mar;37(3):e23273
Journal of biochemical and molecular toxicology 2023 Mar;37(3):e23273
Mixed-Culture Propagation of Uterine-Tissue-Resident Macrophages and Their Expression Properties of Steroidogenic Molecules.
Ogawa K, Tanida T
Biomedicines 2023 Mar 22;11(3)
Biomedicines 2023 Mar 22;11(3)
Casein Kinase 1α Regulates Testosterone Synthesis and Testis Development in Adult Mice.
Guo H, Zhang D, Zhou Y, Sun L, Li C, Luo X, Liu J, Cui S
Endocrinology 2023 Mar 13;164(5)
Endocrinology 2023 Mar 13;164(5)
HE4 overexpression in mice leads to leydig cell hyperplasia and spermatogensis impairment: Pathological implications for oligospermia.
Ling P, Tang L, Lin M, Bu C, Yin Y, Wang F, Chen D, Jiang SW
Molecular and cellular endocrinology 2023 Jun 1;568-569:111916
Molecular and cellular endocrinology 2023 Jun 1;568-569:111916
Lactoferrin Restores the Deoxynivalenol-Impaired Spermatogenesis and Blood-Testis Barrier Integrity via Improving the Antioxidant Capacity and Modifying the Cell Adhesion and Inflammatory Response.
Li Z, Zhao Y, Zong Q, Hu P, Bao W, Liu HY, Cai D
Antioxidants (Basel, Switzerland) 2023 Jan 9;12(1)
Antioxidants (Basel, Switzerland) 2023 Jan 9;12(1)
Asymmetries of Left and Right Adrenal Glands in Neural Innervation and Glucocorticoids Production.
Saxu R, Yang Y, Gu HF
International journal of molecular sciences 2023 Dec 14;24(24)
International journal of molecular sciences 2023 Dec 14;24(24)
Prepubertal exposure to copper oxide nanoparticles induces Leydig cell injury with steroidogenesis disorders in mouse testes.
Zheng X, Chen J, Kang L, Wei Y, Wu Y, Hong Y, Wang X, Li D, Shen L, Long C, Wei G, Wu S
Biochemical and biophysical research communications 2023 Apr 30;654:62-72
Biochemical and biophysical research communications 2023 Apr 30;654:62-72
Astragalus polysaccharide protects sepsis model rats after cecum ligation and puncture.
Li J, Zhao J, Chai Y, Li W, Liu X, Chen Y
Frontiers in bioengineering and biotechnology 2022;10:1020300
Frontiers in bioengineering and biotechnology 2022;10:1020300
Paternal cadmium exposure affects testosterone synthesis by reducing the testicular cholesterol pool in offspring mice.
Zhou J, Zhang Y, Zeng L, Wang X, Mu H, Wang M, Pan H, Su P
Ecotoxicology and environmental safety 2022 Sep 1;242:113947
Ecotoxicology and environmental safety 2022 Sep 1;242:113947
A Short Promoter Region Containing Conserved Regulatory Motifs Is Required for Steroidogenic Acute Regulatory Protein (Star) Gene Expression in the Mouse Testis.
Bouchard MF, Picard J, Tremblay JJ, Viger RS
International journal of molecular sciences 2022 Oct 9;23(19)
International journal of molecular sciences 2022 Oct 9;23(19)
Progesterone Induces Apoptosis and Steroidogenesis in Porcine Placental Trophoblasts.
Liu Y, Ding H, Yang Y, Liu Y, Cao X, Feng T
Animals : an open access journal from MDPI 2022 Oct 8;12(19)
Animals : an open access journal from MDPI 2022 Oct 8;12(19)
Single-cell RNA-seq analysis of testicular somatic cell development in pigs.
Zhang L, Guo M, Liu Z, Liu R, Zheng Y, Yu T, Lv Y, Lu H, Zeng W, Zhang T, Pan C
Journal of genetics and genomics = Yi chuan xue bao 2022 Nov;49(11):1016-1028
Journal of genetics and genomics = Yi chuan xue bao 2022 Nov;49(11):1016-1028
Effects of 4-vinylcyclohexene diepoxide on the cell cycle, apoptosis, and steroid hormone secretion of goat ovarian granulosa cells.
Miao Y, Wan W, Zhu K, Pan M, Zhao X, Ma B, Wei Q
In vitro cellular & developmental biology. Animal 2022 Mar;58(3):220-231
In vitro cellular & developmental biology. Animal 2022 Mar;58(3):220-231
Transcriptomic analysis of MA-10 tumor Leydig cells treated with adipose derived hormones adiponectin and resistin.
Nguyen HT, Martin LJ
Reproductive biology 2022 Mar;22(1):100598
Reproductive biology 2022 Mar;22(1):100598
Effects of Bushen Yiyuan recipe on testosterone synthesis in Leydig cells of rats with exercise-induced low serum testosterone levels.
Wang Y, Peng X, Zhou Z, Tang C, Liu W
Pharmaceutical biology 2022 Dec;60(1):1670-1678
Pharmaceutical biology 2022 Dec;60(1):1670-1678
Chronic exposure to propylparaben at the humanly relevant dose triggers ovarian aging in adult mice.
Yan W, Li M, Guo Q, Li X, Zhou S, Dai J, Zhang J, Wu M, Tang W, Wen J, Xue L, Jin Y, Luo A, Wang S
Ecotoxicology and environmental safety 2022 Apr 15;235:113432
Ecotoxicology and environmental safety 2022 Apr 15;235:113432
Prenatal exposure to propylparaben at human-relevant doses accelerates ovarian aging in adult mice.
Li M, Zhou S, Wu Y, Li Y, Yan W, Guo Q, Xi Y, Chen Y, Li Y, Wu M, Zhang J, Wei J, Wang S
Environmental pollution (Barking, Essex : 1987) 2021 Sep 15;285:117254
Environmental pollution (Barking, Essex : 1987) 2021 Sep 15;285:117254
Propylparaben concentrations in the urine of women and adverse effects on ovarian function in mice in vivo and ovarian cells in vitro.
Jiao L, Li S, Zhai J, Wang D, Li H, Chu W, Geng X, Du Y
Journal of applied toxicology : JAT 2021 Nov;41(11):1719-1731
Journal of applied toxicology : JAT 2021 Nov;41(11):1719-1731
Isorhamnetin Promotes Estrogen Biosynthesis and Proliferation in Porcine Granulosa Cells via the PI3K/Akt Signaling Pathway.
Li X, Chen H, Zhang Z, Xu D, Duan J, Li X, Yang L, Hua R, Cheng J, Li Q
Journal of agricultural and food chemistry 2021 Jun 16;69(23):6535-6542
Journal of agricultural and food chemistry 2021 Jun 16;69(23):6535-6542
Induction of autophagy by Beclin-1 in granulosa cells contributes to follicular progesterone elevation in ovarian endometriosis.
Ding Y, Zhu Q, He Y, Lu Y, Wang Y, Qi J, Wu H, Xu R, Li J, Li X, Sun Y
Translational research : the journal of laboratory and clinical medicine 2021 Jan;227:15-29
Translational research : the journal of laboratory and clinical medicine 2021 Jan;227:15-29
Cyclin-dependent kinase inhibitor 1B acts as a novel molecule to mediate testosterone synthesis and secretion in mouse Leydig cells by luteinizing hormone (LH) signaling pathway.
Guo H, Luo X, Sun L, Li J, Cui S
In vitro cellular & developmental biology. Animal 2021 Aug;57(7):742-752
In vitro cellular & developmental biology. Animal 2021 Aug;57(7):742-752
Single-cell transcriptomes reveal heterogeneity of high-grade serous ovarian carcinoma.
Hao Q, Li J, Zhang Q, Xu F, Xie B, Lu H, Wu X, Zhou X
Clinical and translational medicine 2021 Aug;11(8):e500
Clinical and translational medicine 2021 Aug;11(8):e500
Effect of luteinizing hormone concentration on transcriptome and subcellular organelle phenotype of ovarian granulosa cells.
Wan YT, Liu S, Zhao SK, Luo YY, Lv YS, Qu DN, Liu MH, Li Y
Journal of assisted reproduction and genetics 2021 Apr;38(4):809-824
Journal of assisted reproduction and genetics 2021 Apr;38(4):809-824
La(2)O(3) Nanoparticles Induce Reproductive Toxicity Mediated by the Nrf-2/ARE Signaling Pathway in Kunming Mice.
Yuan L, Li Q, Bai D, Shang X, Hu F, Chen Z, An T, Chen Y, Zhang X
International journal of nanomedicine 2020;15:3415-3431
International journal of nanomedicine 2020;15:3415-3431
Oxidized-LDL inhibits testosterone biosynthesis by affecting mitochondrial function and the p38 MAPK/COX-2 signaling pathway in Leydig cells.
Jing J, Ding N, Wang D, Ge X, Ma J, Ma R, Huang X, Jueraitetibaike K, Liang K, Wang S, Cao S, Zhao AZ, Yao B
Cell death & disease 2020 Aug 14;11(8):626
Cell death & disease 2020 Aug 14;11(8):626
The ovarian estrogen synthesis function was impaired in Y123F mouse and partly restored by exogenous FSH supplement.
Tu X, Liu M, Tang J, Zhang Y, Shi Y, Yu L, Sun Z
Reproductive biology and endocrinology : RB&E 2018 May 4;16(1):44
Reproductive biology and endocrinology : RB&E 2018 May 4;16(1):44
STMN1 Promotes Progesterone Production Via StAR Up-regulation in Mouse Granulosa Cells.
Dou YD, Zhao H, Huang T, Zhao SG, Liu XM, Yu XC, Ma ZX, Zhang YC, Liu T, Gao X, Li L, Lu G, Chan WY, Gao F, Liu HB, Chen ZJ
Scientific reports 2016 Jun 8;6:26691
Scientific reports 2016 Jun 8;6:26691
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The STAR antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human STAR. This antibody recognizes human,mouse,rat antigen. The STAR antibody has been validated for the following applications: ELISA, WB analysis.