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- Antibody Data
- Antigen structure
- References [88]
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- Product number
- 12225-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12225-1-AP, RRID:AB_2115832
- Product name
- STAR antibody
- Antibody type
- Polyclonal
- Description
- STAR antibody (Cat. #12225-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat, pig and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat, Porcine
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Metabolomic changes following PMSG-induced estrus synchronization in Qianbei Ma goats.
Cholecystokinin (CCK) mediates CCKBR to regulate androgen secretion via the steroid pathway in Bactrian camel Sertoli cells.
Exercise attenuates polycystic ovary syndrome development via improved mitochondrial proteostasis.
The β(2)-adrenoceptor agonist formoterol attenuates hallmarks of adrenal Cushing's syndrome.
Zinc Alleviates Oxidative Stress Injury of the Testis Induced by Zearalenone through Sirt3-Foxo3 Pathway in Mice.
NMN/NAD(+)/SIRT1 axis activates NAMPT to ameliorate H(2)O(2)-triggered the impairment of progesterone synthesis in ovarian granulosa cells.
Trimethylamine-N-oxide disrupts spermatogenesis by inducing mitochondrial oxidative stress injury through Hippo signaling.
Baicalin alleviates repeated superovulation induced ovarian dysfunction and oocyte impairment by suppressing excessive glycolysis.
Alpha-ketoglutarate alleviates Cadmium-induced ferroptosis in association with enhanced mitochondrial function in testes.
Molecular mechanism of testicular oxidative stress-induced ferroptosis in Leydig cells caused by cryptorchidism in yak.
Progressively diminished estrogen signaling concordant with increased fibrosis in ectopic endometrium.
The hypothalamic effects of PACAP on the hypothalamic-pituitary-gonadal axis in male mice.
Transcriptomic analysis of the effects exerted by curcumin on dihydrotestosterone-induced ovarian granulosa cells.
Isatin ameliorates ovarian inflammation and apoptosis caused by hormonal imbalances in PCOS mice.
Prepubertal Diabetes Stagnates Testicular Development by Skewing Autophagy Homeostasis in Leydig Cells.
Integrating network pharmacology and experimental validation to decipher the protective effect of icariin against testicular aging.
Overactivation of PERK-Mediated Endoplasmic Reticulum Stress-Induced Testis Damage in Chronically Stressed Mice.
Mechanistic insights into targeting APLN/APJ for ameliorating testosterone deficiency and reproductive disorders in diabetic mice.
circ_0000132 Regulates Chicken Granulosa Cell Proliferation Apoptosis and E2/P4 Synthesis via miR-206 E2F5 Signaling.
Single-cell transcriptomics uncovering a critical AKT-LONP1-STAR axis in ovarian hyperandrogenism of PCOS.
The ferroptosis of sertoli cells inducing blood-testis barrier damage is produced by oxidative stress in cryptorchidism.
LncRNA NEAT1 participates in diminished ovarian reserve by affecting granulosa cell apoptosis and estradiol synthesis via the miR-204-5p/ESR1 axis.
Polydatin, a derivative of resveratrol, ameliorates busulfan-induced oligozoospermia in mice by inhibiting NF-κB pathway activation and suppressing ferroptosis.
Acetaminophen overdose inhibits steroidogenic acute regulatory protein expression by reducing AKT-mediated SP1 expression in human granulosa-lutein cells.
Procyanidin B2 alleviates damage to mouse testicular tissue after freezing by inhibiting oxidative stress and apoptosis.
Development and evaluation of a microfluidic human testicular tissue chip: a novel in vitro platform for reproductive biology and pharmacology studies.
Genetic loss of Uchl1 leads to female infertility by affecting oocyte quality and follicular development.
miRNA-novel-216 regulated fatty acid composition and progesterone synthesis in goat granulosa cells by targeting the TPD52.
Sea Cucumber Peptides Promote Testosterone Synthesis in Male Mice: Possibly via Alistipes-Bile Acid-FXR Signaling Pathway.
Tanshinone IIA alleviates tri-ortho-cresyl phosphate-induced ovarian damage through Hippo signaling pathway activation in mice.
Effects of icariin as a feed additive on the reproductive function in bucks (Capra hircus).
Unraveling the impact of hyperleptinemia on female reproduction: insights from transgenic pig model.
Dysregulation of mitochondrial dynamics and mitophagy are involved in high-fat diet-induced steroidogenesis inhibition.
Exploring neuron-specific steroid synthesis and DHEAS therapy in Alzheimer's disease.
The senolytic drug ABT-263 accelerates ovarian aging in older female mice.
Higher Steroid Production in the Right Adrenal Gland Compared to the Left One in db/db Mice, a Model of Type 2 Diabetic Obesity.
ZnO NPs Impair the Viability and Function of Porcine Granulosa Cells Through Autophagy Regulated by ROS Production.
Acrylamide Exposure Impairs Ovarian Tricarboxylic Acid Cycle and Reduces Oocyte Quality in Mouse.
Acrolein exposure affects ovarian function by interfering with glycolysis and mitochondrial energy metabolism in mouse.
Effects of hyperhomocysteinemia on follicular development and oocytes quality.
Cordycepin suppresses steroidogenic acute regulatory protein expression by reducing SP1 in human granulosa-lutein cells.
Cyclophosphamide activates ferroptosis-induced dysfunction of Leydig cells via SMAD2 pathway†.
Androgen synthesis cell-specific CREBZF deficiency alters adrenal cortex steroid secretion and develops behavioral abnormalities in adult male mice.
Ursonic acid attenuates spermatogenesis in oligozoospermia mice through inhibiting ferroptosis.
Bone morphogenetic protein-9 downregulates StAR expression by inducing snail expression via SMAD1/5/8 signaling in human granulosa-lutein cells.
Artemisinins ameliorate polycystic ovarian syndrome by mediating LONP1-CYP11A1 interaction.
High-fat diet-induced L-saccharopine accumulation inhibits estradiol synthesis and damages oocyte quality by disturbing mitochondrial homeostasis.
TGF-β1 and TGF-β3, but not TGF-β2, are upregulated in the ovaries of ovarian hyperstimulation syndrome†.
Protective effect of TNFAIP3 on testosterone production in Leydig cells under an aging inflammatory microenvironment.
Sirtuin 1-mediated autophagy regulates testosterone synthesis in Leydig cells of piglets.
Luoshi Neiyi Prescription inhibits estradiol synthesis and inflammation in endometriosis through the HIF1A/EZH2/SF-1 pathway.
Apigenin improves testosterone synthesis by regulating endoplasmic reticulum stress.
Exosomes derived from BMSCs ameliorate cyclophosphamide-induced testosterone deficiency by enhancing the autophagy of Leydig cells via the AMPK-mTOR signaling pathway.
RNA sequencing profiles reveals progressively reduced spermatogenesis with progression in adult cryptorchidism.
Clinical and functional analyses of the novel STAR c.558C>A in a patient with classic lipoid congenital adrenal hyperplasia.
Knockdown of ZnT4 Induced Apoptosis, Inhibited Proliferation and testosterone synthesis of TM3 cells.
FDX1 regulates leydig cell ferroptosis mediates PM(2.5)-induced testicular dysfunction of mice.
Paternal cadmium exposure affects estradiol synthesis by impairing intracellular cholesterol homeostasis and mitochondrial function in offspring female mice.
Hypoxia activation attenuates progesterone synthesis in goat trophoblast cells via NR1D1 inhibition of StAR expression†.
Sea cucumber peptides positively regulate sexual hormones in male mice with acute exhaustive swimming: possibly through the Ca(2+)/PKA signaling pathway.
Expression Analysis of Lipocalin 2 (LCN2) in Reproductive and Non-Reproductive Tissues of Esr1-Deficient Mice.
Bisphenol S induces oxidative stress-mediated impairment of testosterone synthesis by inhibiting the Nrf2/HO-1 signaling pathway.
Mixed-Culture Propagation of Uterine-Tissue-Resident Macrophages and Their Expression Properties of Steroidogenic Molecules.
Casein Kinase 1α Regulates Testosterone Synthesis and Testis Development in Adult Mice.
HE4 overexpression in mice leads to leydig cell hyperplasia and spermatogensis impairment: Pathological implications for oligospermia.
Lactoferrin Restores the Deoxynivalenol-Impaired Spermatogenesis and Blood-Testis Barrier Integrity via Improving the Antioxidant Capacity and Modifying the Cell Adhesion and Inflammatory Response.
Asymmetries of Left and Right Adrenal Glands in Neural Innervation and Glucocorticoids Production.
Prepubertal exposure to copper oxide nanoparticles induces Leydig cell injury with steroidogenesis disorders in mouse testes.
Astragalus polysaccharide protects sepsis model rats after cecum ligation and puncture.
Paternal cadmium exposure affects testosterone synthesis by reducing the testicular cholesterol pool in offspring mice.
A Short Promoter Region Containing Conserved Regulatory Motifs Is Required for Steroidogenic Acute Regulatory Protein (Star) Gene Expression in the Mouse Testis.
Progesterone Induces Apoptosis and Steroidogenesis in Porcine Placental Trophoblasts.
Single-cell RNA-seq analysis of testicular somatic cell development in pigs.
Effects of 4-vinylcyclohexene diepoxide on the cell cycle, apoptosis, and steroid hormone secretion of goat ovarian granulosa cells.
Transcriptomic analysis of MA-10 tumor Leydig cells treated with adipose derived hormones adiponectin and resistin.
Effects of Bushen Yiyuan recipe on testosterone synthesis in Leydig cells of rats with exercise-induced low serum testosterone levels.
Chronic exposure to propylparaben at the humanly relevant dose triggers ovarian aging in adult mice.
Prenatal exposure to propylparaben at human-relevant doses accelerates ovarian aging in adult mice.
Propylparaben concentrations in the urine of women and adverse effects on ovarian function in mice in vivo and ovarian cells in vitro.
Isorhamnetin Promotes Estrogen Biosynthesis and Proliferation in Porcine Granulosa Cells via the PI3K/Akt Signaling Pathway.
Induction of autophagy by Beclin-1 in granulosa cells contributes to follicular progesterone elevation in ovarian endometriosis.
Cyclin-dependent kinase inhibitor 1B acts as a novel molecule to mediate testosterone synthesis and secretion in mouse Leydig cells by luteinizing hormone (LH) signaling pathway.
Single-cell transcriptomes reveal heterogeneity of high-grade serous ovarian carcinoma.
Effect of luteinizing hormone concentration on transcriptome and subcellular organelle phenotype of ovarian granulosa cells.
La(2)O(3) Nanoparticles Induce Reproductive Toxicity Mediated by the Nrf-2/ARE Signaling Pathway in Kunming Mice.
Oxidized-LDL inhibits testosterone biosynthesis by affecting mitochondrial function and the p38 MAPK/COX-2 signaling pathway in Leydig cells.
The ovarian estrogen synthesis function was impaired in Y123F mouse and partly restored by exogenous FSH supplement.
STMN1 Promotes Progesterone Production Via StAR Up-regulation in Mouse Granulosa Cells.
Qiao FX, Ju YH, Wang XD, An PC, Ji Q, Li RY, Zeng TJ, Liu Q, Zhang DY, Feng ZH, Cao MS, Chen X
Animal reproduction science 2026 May;288:108145
Animal reproduction science 2026 May;288:108145
Cholecystokinin (CCK) mediates CCKBR to regulate androgen secretion via the steroid pathway in Bactrian camel Sertoli cells.
Wang Q, Wang W, Nan J, Zhang Y, Zhao X
The Journal of steroid biochemistry and molecular biology 2026 Mar;257:106922
The Journal of steroid biochemistry and molecular biology 2026 Mar;257:106922
Exercise attenuates polycystic ovary syndrome development via improved mitochondrial proteostasis.
Shin C, Chen LW, Hossain MN, Li X, Islam S, Kou Z, Cui Q, de Avila JM, Zhu MJ, Du M
American journal of physiology. Endocrinology and metabolism 2026 Mar 1;330(3):E390-E400
American journal of physiology. Endocrinology and metabolism 2026 Mar 1;330(3):E390-E400
The β(2)-adrenoceptor agonist formoterol attenuates hallmarks of adrenal Cushing's syndrome.
Cleveland KH, Lee KS, Ponnalagu D, Vicente JJ, Parker ED, Lee JYE, Wordeman L, Scott JD
British journal of pharmacology 2026 Jun;183(11):3129-3145
British journal of pharmacology 2026 Jun;183(11):3129-3145
Zinc Alleviates Oxidative Stress Injury of the Testis Induced by Zearalenone through Sirt3-Foxo3 Pathway in Mice.
Zhao Z, Yao J, Guo Z, Song L, Ma J, Song Y, Ma Y, Zhao J
Biological trace element research 2026 Feb;204(2):769-785
Biological trace element research 2026 Feb;204(2):769-785
NMN/NAD(+)/SIRT1 axis activates NAMPT to ameliorate H(2)O(2)-triggered the impairment of progesterone synthesis in ovarian granulosa cells.
Wang Y, Li Q, Li Y, Ma Z, Xu H, Chen K, Li J, Lan D, Fu W
Journal of ovarian research 2026 Feb 28;19(1)
Journal of ovarian research 2026 Feb 28;19(1)
Trimethylamine-N-oxide disrupts spermatogenesis by inducing mitochondrial oxidative stress injury through Hippo signaling.
Wang S, Ma G, Qi C, Cheng S, Lai H, Zhou L, Wu G, Chen Z, Mao X, Jing T, He Y, Zhou H
Free radical biology & medicine 2026 Feb 1;243:452-465
Free radical biology & medicine 2026 Feb 1;243:452-465
Baicalin alleviates repeated superovulation induced ovarian dysfunction and oocyte impairment by suppressing excessive glycolysis.
Li LF, Shen H, Qi ZM, Luo T, Liu SM, Ou LL, Xu CL, Liu Y
Theriogenology 2026 Aug;260:117934
Theriogenology 2026 Aug;260:117934
Alpha-ketoglutarate alleviates Cadmium-induced ferroptosis in association with enhanced mitochondrial function in testes.
Wang X, Dong W, Zhao J, Chen N, Zheng T, Liu Y, Li Q, Ye H, Li H, Xie L
Reproductive toxicology (Elmsford, N.Y.) 2026 Apr 16;143:109249
Reproductive toxicology (Elmsford, N.Y.) 2026 Apr 16;143:109249
Molecular mechanism of testicular oxidative stress-induced ferroptosis in Leydig cells caused by cryptorchidism in yak.
Zeng J, Yuan L, Qi Y, Chen G, Chen Y, Li H, Song Y, Zhang Y
Theriogenology 2026 Apr 15;261:117946
Theriogenology 2026 Apr 15;261:117946
Progressively diminished estrogen signaling concordant with increased fibrosis in ectopic endometrium.
Nie J, Yi Y, Liu X, Guo SW
Human reproduction open 2025;2025(3):hoaf028
Human reproduction open 2025;2025(3):hoaf028
The hypothalamic effects of PACAP on the hypothalamic-pituitary-gonadal axis in male mice.
Faludi P, Barabás K, Lengyel F, Udvarácz I, Pham D, Kisjós O, Nagy Z, Reglődi D, Kovács G
Frontiers in endocrinology 2025;16:1677085
Frontiers in endocrinology 2025;16:1677085
Transcriptomic analysis of the effects exerted by curcumin on dihydrotestosterone-induced ovarian granulosa cells.
Chen D, Yu Q, Sheng S, Cai L, Zheng J, Zhang Y
Frontiers in endocrinology 2025;16:1522269
Frontiers in endocrinology 2025;16:1522269
Isatin ameliorates ovarian inflammation and apoptosis caused by hormonal imbalances in PCOS mice.
Li X, Ye T, Zhu W, Gu J, Zheng Z, Wang C, Zhang X, Geng H, Zhou W, Tan X, Ma Y, Zhang H, Wang X
Biochemical pharmacology 2025 Sep;239:117083
Biochemical pharmacology 2025 Sep;239:117083
Prepubertal Diabetes Stagnates Testicular Development by Skewing Autophagy Homeostasis in Leydig Cells.
Tang Z, Zheng Y
Cells 2025 Sep 4;14(17)
Cells 2025 Sep 4;14(17)
Integrating network pharmacology and experimental validation to decipher the protective effect of icariin against testicular aging.
Sun J, Lv C, Lin Z, Luo S, Liao S, Lian X, Liu Y, Luo L, Zheng M, Zhang D, Wang X, Wang S
Ecotoxicology and environmental safety 2025 Sep 15;303:119063
Ecotoxicology and environmental safety 2025 Sep 15;303:119063
Overactivation of PERK-Mediated Endoplasmic Reticulum Stress-Induced Testis Damage in Chronically Stressed Mice.
Peng L, Tang X, Tang P, Zhou C, Xiang Y, Cao W, Li Y, Peng C, Xu Y, Li S
ACS omega 2025 Oct 7;10(39):44937-44947
ACS omega 2025 Oct 7;10(39):44937-44947
Mechanistic insights into targeting APLN/APJ for ameliorating testosterone deficiency and reproductive disorders in diabetic mice.
Song K, Jing T, Yang X, Xia J, Wang Z, Luo F, Qiu C, Liu Z, Zhao XY, Wang G, Ou X
Cell communication and signaling : CCS 2025 Oct 30;23(1):469
Cell communication and signaling : CCS 2025 Oct 30;23(1):469
circ_0000132 Regulates Chicken Granulosa Cell Proliferation Apoptosis and E2/P4 Synthesis via miR-206 E2F5 Signaling.
Yang H, Li W, Fu G, Liu S, Ma T
International journal of molecular sciences 2025 Nov 5;26(21)
International journal of molecular sciences 2025 Nov 5;26(21)
Single-cell transcriptomics uncovering a critical AKT-LONP1-STAR axis in ovarian hyperandrogenism of PCOS.
Zhang C, Lin Z, Lin Y, Ma H
Journal of ovarian research 2025 Nov 19;18(1):275
Journal of ovarian research 2025 Nov 19;18(1):275
The ferroptosis of sertoli cells inducing blood-testis barrier damage is produced by oxidative stress in cryptorchidism.
Zeng J, Yuan L, Chen G, Qi Y, Qie X, Jin Y, Chen Y, Li H
Free radical biology & medicine 2025 May;232:97-106
Free radical biology & medicine 2025 May;232:97-106
LncRNA NEAT1 participates in diminished ovarian reserve by affecting granulosa cell apoptosis and estradiol synthesis via the miR-204-5p/ESR1 axis.
Dong L, Wu H, Qi F, Chen W, Xu Y, Li M, Wang Y, Yan R, Cai P
Journal of ovarian research 2025 May 16;18(1):102
Journal of ovarian research 2025 May 16;18(1):102
Polydatin, a derivative of resveratrol, ameliorates busulfan-induced oligozoospermia in mice by inhibiting NF-κB pathway activation and suppressing ferroptosis.
Wang C, Li X, Ye T, Gu J, Zheng Z, Chen G, Dong J, Zhou W, Shi J, Zhang L
Bioorganic chemistry 2025 Mar;156:108170
Bioorganic chemistry 2025 Mar;156:108170
Acetaminophen overdose inhibits steroidogenic acute regulatory protein expression by reducing AKT-mediated SP1 expression in human granulosa-lutein cells.
Cheng JC, Zhang Q, Zhang L, Bi B, Wang H, Fang L, Chang HM, Sun YP
Reproductive toxicology (Elmsford, N.Y.) 2025 Mar;132:108764
Reproductive toxicology (Elmsford, N.Y.) 2025 Mar;132:108764
Procyanidin B2 alleviates damage to mouse testicular tissue after freezing by inhibiting oxidative stress and apoptosis.
Cao G, Li C, Zhang J, Deng L, Li R, Xu C
Cryobiology 2025 Mar;118:105196
Cryobiology 2025 Mar;118:105196
Development and evaluation of a microfluidic human testicular tissue chip: a novel in vitro platform for reproductive biology and pharmacology studies.
Shen J, Wang X, Yang C, Ren G, Wang L, Piao S, Zhang B, Sun W, Ge X, Jing J, Xiang Y, He Z, Wang L, Yao B, Liu Z
Lab on a chip 2025 Feb 11;25(4):577-589
Lab on a chip 2025 Feb 11;25(4):577-589
Genetic loss of Uchl1 leads to female infertility by affecting oocyte quality and follicular development.
Luo J, Zhang J, Zhang Y, Li M, Yu L, Song D, Sun Z
Molecular and cellular endocrinology 2025 Feb 1;597:112440
Molecular and cellular endocrinology 2025 Feb 1;597:112440
miRNA-novel-216 regulated fatty acid composition and progesterone synthesis in goat granulosa cells by targeting the TPD52.
Jia Y, Xu Q, Wang P, Liu Z, Zhang R, Liu K, Ling Y, Liu Y, Chu M
Reproduction (Cambridge, England) 2025 Feb 1;169(2)
Reproduction (Cambridge, England) 2025 Feb 1;169(2)
Sea Cucumber Peptides Promote Testosterone Synthesis in Male Mice: Possibly via Alistipes-Bile Acid-FXR Signaling Pathway.
Pan R, Min Z, Li K, Feng F, Zheng B, Luo X
Molecular nutrition & food research 2025 Dec;69(24):e70286
Molecular nutrition & food research 2025 Dec;69(24):e70286
Tanshinone IIA alleviates tri-ortho-cresyl phosphate-induced ovarian damage through Hippo signaling pathway activation in mice.
Ma Z, Hu N, Zheng L, Xue Y, Zhou C, Wang W, Cheng X, Luo T, Yu J, Hu L
Journal of ovarian research 2025 Apr 26;18(1):85
Journal of ovarian research 2025 Apr 26;18(1):85
Effects of icariin as a feed additive on the reproductive function in bucks (Capra hircus).
Zhao FE, Chen H, Wang S, Zhang X, Chen N, Chen H, Fu J, Liu H, Liu J, Liu T
Frontiers in veterinary science 2024;11:1467947
Frontiers in veterinary science 2024;11:1467947
Unraveling the impact of hyperleptinemia on female reproduction: insights from transgenic pig model.
Jamal MA, Cheng Y, Jiao D, Cheng W, Zou D, Wang X, Wei T, Guo J, Xu K, Zhao H, Pu S, Yang C, Qing Y, Jia B, Li H, Zhao R, Zhao HY, Wei HJ
Biological research 2024 Sep 4;57(1):60
Biological research 2024 Sep 4;57(1):60
Dysregulation of mitochondrial dynamics and mitophagy are involved in high-fat diet-induced steroidogenesis inhibition.
Lv ZM, Liu C, Wang P, Chen YH
Journal of lipid research 2024 Oct;65(10):100639
Journal of lipid research 2024 Oct;65(10):100639
Exploring neuron-specific steroid synthesis and DHEAS therapy in Alzheimer's disease.
Lin HY, Feng YH, Kao TJ, Chen HC, Chen GY, Ko CY, Hsu TI
The Journal of steroid biochemistry and molecular biology 2024 Oct;243:106585
The Journal of steroid biochemistry and molecular biology 2024 Oct;243:106585
The senolytic drug ABT-263 accelerates ovarian aging in older female mice.
Xia X, Yang Y, Liu P, Chen L, Dai X, Xue P, Wang Y
Scientific reports 2024 Oct 5;14(1):23178
Scientific reports 2024 Oct 5;14(1):23178
Higher Steroid Production in the Right Adrenal Gland Compared to the Left One in db/db Mice, a Model of Type 2 Diabetic Obesity.
Saxu R, Luo Q, Yang Y, Gu HF
International journal of molecular sciences 2024 Oct 3;25(19)
International journal of molecular sciences 2024 Oct 3;25(19)
ZnO NPs Impair the Viability and Function of Porcine Granulosa Cells Through Autophagy Regulated by ROS Production.
Wang Y, Lv J, Liu G, Yao Q, Wang Z, Liu N, He Y, Il D, Tusupovich JI, Jiang Z
Antioxidants (Basel, Switzerland) 2024 Oct 25;13(11)
Antioxidants (Basel, Switzerland) 2024 Oct 25;13(11)
Acrylamide Exposure Impairs Ovarian Tricarboxylic Acid Cycle and Reduces Oocyte Quality in Mouse.
Liu YC, Li RC, Wang WK, Chen YZ, He QK, Xu ZR, Yang YF, Cheng SY, Wang HL, Qi ZQ, Xu CL, Liu Y
Environmental toxicology 2024 Nov;39(11):5074-5085
Environmental toxicology 2024 Nov;39(11):5074-5085
Acrolein exposure affects ovarian function by interfering with glycolysis and mitochondrial energy metabolism in mouse.
Chen YZ, Wang WK, Yang YF, Cheng SY, Li LF, Shen H, Qi ZM, Liu Y
Environmental pollution (Barking, Essex : 1987) 2024 Nov 15;361:124776
Environmental pollution (Barking, Essex : 1987) 2024 Nov 15;361:124776
Effects of hyperhomocysteinemia on follicular development and oocytes quality.
Wang L, Gao J, Ma J, Sun J, Wang Y, Luo J, Wang Z, Wang H, Li J, Yang D, Wang J, Hu R
iScience 2024 Nov 15;27(11):111241
iScience 2024 Nov 15;27(11):111241
Cordycepin suppresses steroidogenic acute regulatory protein expression by reducing SP1 in human granulosa-lutein cells.
Zhang L, Zhou S, Bi B, Wang H, Fu B, Guo M, Luo S, Cheng JC, Fang L
Reproduction (Cambridge, England) 2024 Nov 1;168(5)
Reproduction (Cambridge, England) 2024 Nov 1;168(5)
Cyclophosphamide activates ferroptosis-induced dysfunction of Leydig cells via SMAD2 pathway†.
Liao S, Wei C, Wei G, Liang H, Peng F, Zhao L, Li Z, Liu C, Zhou Q
Biology of reproduction 2024 May 9;110(5):1012-1024
Biology of reproduction 2024 May 9;110(5):1012-1024
Androgen synthesis cell-specific CREBZF deficiency alters adrenal cortex steroid secretion and develops behavioral abnormalities in adult male mice.
Niu H, Li C, Zhang H, Liu H, Shang C, Jia Y, Wuenjiya, Li Z, Wang A, Jin Y, Lin P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 15;38(9):e23650
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 15;38(9):e23650
Ursonic acid attenuates spermatogenesis in oligozoospermia mice through inhibiting ferroptosis.
Dong J, Dong Y, Chen H, Ye T, Chen G, Fan B, Wang X, Shi J, Wang C
Bioorganic chemistry 2024 Mar;144:107174
Bioorganic chemistry 2024 Mar;144:107174
Bone morphogenetic protein-9 downregulates StAR expression by inducing snail expression via SMAD1/5/8 signaling in human granulosa-lutein cells.
Liu B, Fu B, Zhou S, Wang H, Bi B, Guo M, Cheng JC, Fang L
Molecular and cellular endocrinology 2024 Mar 1;582:112126
Molecular and cellular endocrinology 2024 Mar 1;582:112126
Artemisinins ameliorate polycystic ovarian syndrome by mediating LONP1-CYP11A1 interaction.
Liu Y, Jiang JJ, Du SY, Mu LS, Fan JJ, Hu JC, Ye Y, Ding M, Zhou WY, Yu QH, Xia YF, Xu HY, Shi YJ, Qian SW, Tang Y, Li W, Dang YJ, Dong X, Li XY, Xu CJ, Tang QQ
Science (New York, N.Y.) 2024 Jun 14;384(6701):eadk5382
Science (New York, N.Y.) 2024 Jun 14;384(6701):eadk5382
High-fat diet-induced L-saccharopine accumulation inhibits estradiol synthesis and damages oocyte quality by disturbing mitochondrial homeostasis.
Wen J, Feng Y, Xue L, Yuan S, Chen Q, Luo A, Wang S, Zhang J
Gut microbes 2024 Jan-Dec;16(1):2412381
Gut microbes 2024 Jan-Dec;16(1):2412381
TGF-β1 and TGF-β3, but not TGF-β2, are upregulated in the ovaries of ovarian hyperstimulation syndrome†.
Liu B, Jia Q, Hong IS, Dang X, Wu Z, Wang H, Cheng JC, Fang L
Biology of reproduction 2024 Jan 13;110(1):116-129
Biology of reproduction 2024 Jan 13;110(1):116-129
Protective effect of TNFAIP3 on testosterone production in Leydig cells under an aging inflammatory microenvironment.
Xing D, Jin Y, Sun D, Liu Y, Cai B, Gao C, Cui Y, Jin B
Archives of gerontology and geriatrics 2024 Feb;117:105274
Archives of gerontology and geriatrics 2024 Feb;117:105274
Sirtuin 1-mediated autophagy regulates testosterone synthesis in Leydig cells of piglets.
Zhang Y, Yu L, He Y, Liu C, Abouelfetouh MM, Ju S, Zhou Z, Li Q
Theriogenology 2024 Dec;230:130-141
Theriogenology 2024 Dec;230:130-141
Luoshi Neiyi Prescription inhibits estradiol synthesis and inflammation in endometriosis through the HIF1A/EZH2/SF-1 pathway.
Wu L, Lan D, Sun B, Su R, Pei F, Kuang Z, Su Y, Lin S, Wang X, Zhang S, Chen X, Jia J, Zeng C
Journal of ethnopharmacology 2024 Dec 5;335:118659
Journal of ethnopharmacology 2024 Dec 5;335:118659
Apigenin improves testosterone synthesis by regulating endoplasmic reticulum stress.
Wu L, Qu J, Mou L, Liu C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117075
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117075
Exosomes derived from BMSCs ameliorate cyclophosphamide-induced testosterone deficiency by enhancing the autophagy of Leydig cells via the AMPK-mTOR signaling pathway.
Liang HY, Peng F, Pan MJ, Liao SL, Wei C, Wei GY, Xie X, Xue KY, Chen MK, Yang JK, Guo WB, Liu CD, Zhou QZ
Asian journal of andrology 2023;25(4):474-483
Asian journal of andrology 2023;25(4):474-483
RNA sequencing profiles reveals progressively reduced spermatogenesis with progression in adult cryptorchidism.
Sun W, Zhang X, Wang L, Ren G, Piao S, Yang C, Liu Z
Frontiers in endocrinology 2023;14:1271724
Frontiers in endocrinology 2023;14:1271724
Clinical and functional analyses of the novel STAR c.558C>A in a patient with classic lipoid congenital adrenal hyperplasia.
Liu J, Dai HM, Guang GP, Hu WM, Jin P
Frontiers in genetics 2023;14:1096454
Frontiers in genetics 2023;14:1096454
Knockdown of ZnT4 Induced Apoptosis, Inhibited Proliferation and testosterone synthesis of TM3 cells.
Li H, Li Y, Liu J, Liu X, Li Y, Wang S, Ma J
In vitro cellular & developmental biology. Animal 2023 Sep;59(8):565-574
In vitro cellular & developmental biology. Animal 2023 Sep;59(8):565-574
FDX1 regulates leydig cell ferroptosis mediates PM(2.5)-induced testicular dysfunction of mice.
Li L, Pei Z, Wu R, Zhang Y, Pang Y, Hu H, Hu W, Geng Z, Feng T, Niu Y, Hao G, Zhang R
Ecotoxicology and environmental safety 2023 Sep 15;263:115309
Ecotoxicology and environmental safety 2023 Sep 15;263:115309
Paternal cadmium exposure affects estradiol synthesis by impairing intracellular cholesterol homeostasis and mitochondrial function in offspring female mice.
Zhang Y, Zhou J, Zeng L, Xiong Y, Wang X, Xiang W, Su P
Ecotoxicology and environmental safety 2023 Sep 15;263:115280
Ecotoxicology and environmental safety 2023 Sep 15;263:115280
Hypoxia activation attenuates progesterone synthesis in goat trophoblast cells via NR1D1 inhibition of StAR expression†.
Li C, Yang D, Yang W, Wang Y, Li D, Li Y, Xiao B, Zhang H, Zhao H, Dong H, Zhang J, Chu G, Wang A, Jin Y, Liu Y, Chen H
Biology of reproduction 2023 Nov 15;109(5):720-735
Biology of reproduction 2023 Nov 15;109(5):720-735
Sea cucumber peptides positively regulate sexual hormones in male mice with acute exhaustive swimming: possibly through the Ca(2+)/PKA signaling pathway.
Luo X, Liu W, Zheng B, Zheng Y, Zhao M, Feng F, Liu L
Food & function 2023 Nov 13;14(22):10188-10203
Food & function 2023 Nov 13;14(22):10188-10203
Expression Analysis of Lipocalin 2 (LCN2) in Reproductive and Non-Reproductive Tissues of Esr1-Deficient Mice.
Kessel JC, Weiskirchen R, Schröder SK
International journal of molecular sciences 2023 May 25;24(11)
International journal of molecular sciences 2023 May 25;24(11)
Bisphenol S induces oxidative stress-mediated impairment of testosterone synthesis by inhibiting the Nrf2/HO-1 signaling pathway.
Wang YX, Dai W, Li YZ, Wu ZY, Kan YQ, Zeng HC, He QZ
Journal of biochemical and molecular toxicology 2023 Mar;37(3):e23273
Journal of biochemical and molecular toxicology 2023 Mar;37(3):e23273
Mixed-Culture Propagation of Uterine-Tissue-Resident Macrophages and Their Expression Properties of Steroidogenic Molecules.
Ogawa K, Tanida T
Biomedicines 2023 Mar 22;11(3)
Biomedicines 2023 Mar 22;11(3)
Casein Kinase 1α Regulates Testosterone Synthesis and Testis Development in Adult Mice.
Guo H, Zhang D, Zhou Y, Sun L, Li C, Luo X, Liu J, Cui S
Endocrinology 2023 Mar 13;164(5)
Endocrinology 2023 Mar 13;164(5)
HE4 overexpression in mice leads to leydig cell hyperplasia and spermatogensis impairment: Pathological implications for oligospermia.
Ling P, Tang L, Lin M, Bu C, Yin Y, Wang F, Chen D, Jiang SW
Molecular and cellular endocrinology 2023 Jun 1;568-569:111916
Molecular and cellular endocrinology 2023 Jun 1;568-569:111916
Lactoferrin Restores the Deoxynivalenol-Impaired Spermatogenesis and Blood-Testis Barrier Integrity via Improving the Antioxidant Capacity and Modifying the Cell Adhesion and Inflammatory Response.
Li Z, Zhao Y, Zong Q, Hu P, Bao W, Liu HY, Cai D
Antioxidants (Basel, Switzerland) 2023 Jan 9;12(1)
Antioxidants (Basel, Switzerland) 2023 Jan 9;12(1)
Asymmetries of Left and Right Adrenal Glands in Neural Innervation and Glucocorticoids Production.
Saxu R, Yang Y, Gu HF
International journal of molecular sciences 2023 Dec 14;24(24)
International journal of molecular sciences 2023 Dec 14;24(24)
Prepubertal exposure to copper oxide nanoparticles induces Leydig cell injury with steroidogenesis disorders in mouse testes.
Zheng X, Chen J, Kang L, Wei Y, Wu Y, Hong Y, Wang X, Li D, Shen L, Long C, Wei G, Wu S
Biochemical and biophysical research communications 2023 Apr 30;654:62-72
Biochemical and biophysical research communications 2023 Apr 30;654:62-72
Astragalus polysaccharide protects sepsis model rats after cecum ligation and puncture.
Li J, Zhao J, Chai Y, Li W, Liu X, Chen Y
Frontiers in bioengineering and biotechnology 2022;10:1020300
Frontiers in bioengineering and biotechnology 2022;10:1020300
Paternal cadmium exposure affects testosterone synthesis by reducing the testicular cholesterol pool in offspring mice.
Zhou J, Zhang Y, Zeng L, Wang X, Mu H, Wang M, Pan H, Su P
Ecotoxicology and environmental safety 2022 Sep 1;242:113947
Ecotoxicology and environmental safety 2022 Sep 1;242:113947
A Short Promoter Region Containing Conserved Regulatory Motifs Is Required for Steroidogenic Acute Regulatory Protein (Star) Gene Expression in the Mouse Testis.
Bouchard MF, Picard J, Tremblay JJ, Viger RS
International journal of molecular sciences 2022 Oct 9;23(19)
International journal of molecular sciences 2022 Oct 9;23(19)
Progesterone Induces Apoptosis and Steroidogenesis in Porcine Placental Trophoblasts.
Liu Y, Ding H, Yang Y, Liu Y, Cao X, Feng T
Animals : an open access journal from MDPI 2022 Oct 8;12(19)
Animals : an open access journal from MDPI 2022 Oct 8;12(19)
Single-cell RNA-seq analysis of testicular somatic cell development in pigs.
Zhang L, Guo M, Liu Z, Liu R, Zheng Y, Yu T, Lv Y, Lu H, Zeng W, Zhang T, Pan C
Journal of genetics and genomics = Yi chuan xue bao 2022 Nov;49(11):1016-1028
Journal of genetics and genomics = Yi chuan xue bao 2022 Nov;49(11):1016-1028
Effects of 4-vinylcyclohexene diepoxide on the cell cycle, apoptosis, and steroid hormone secretion of goat ovarian granulosa cells.
Miao Y, Wan W, Zhu K, Pan M, Zhao X, Ma B, Wei Q
In vitro cellular & developmental biology. Animal 2022 Mar;58(3):220-231
In vitro cellular & developmental biology. Animal 2022 Mar;58(3):220-231
Transcriptomic analysis of MA-10 tumor Leydig cells treated with adipose derived hormones adiponectin and resistin.
Nguyen HT, Martin LJ
Reproductive biology 2022 Mar;22(1):100598
Reproductive biology 2022 Mar;22(1):100598
Effects of Bushen Yiyuan recipe on testosterone synthesis in Leydig cells of rats with exercise-induced low serum testosterone levels.
Wang Y, Peng X, Zhou Z, Tang C, Liu W
Pharmaceutical biology 2022 Dec;60(1):1670-1678
Pharmaceutical biology 2022 Dec;60(1):1670-1678
Chronic exposure to propylparaben at the humanly relevant dose triggers ovarian aging in adult mice.
Yan W, Li M, Guo Q, Li X, Zhou S, Dai J, Zhang J, Wu M, Tang W, Wen J, Xue L, Jin Y, Luo A, Wang S
Ecotoxicology and environmental safety 2022 Apr 15;235:113432
Ecotoxicology and environmental safety 2022 Apr 15;235:113432
Prenatal exposure to propylparaben at human-relevant doses accelerates ovarian aging in adult mice.
Li M, Zhou S, Wu Y, Li Y, Yan W, Guo Q, Xi Y, Chen Y, Li Y, Wu M, Zhang J, Wei J, Wang S
Environmental pollution (Barking, Essex : 1987) 2021 Sep 15;285:117254
Environmental pollution (Barking, Essex : 1987) 2021 Sep 15;285:117254
Propylparaben concentrations in the urine of women and adverse effects on ovarian function in mice in vivo and ovarian cells in vitro.
Jiao L, Li S, Zhai J, Wang D, Li H, Chu W, Geng X, Du Y
Journal of applied toxicology : JAT 2021 Nov;41(11):1719-1731
Journal of applied toxicology : JAT 2021 Nov;41(11):1719-1731
Isorhamnetin Promotes Estrogen Biosynthesis and Proliferation in Porcine Granulosa Cells via the PI3K/Akt Signaling Pathway.
Li X, Chen H, Zhang Z, Xu D, Duan J, Li X, Yang L, Hua R, Cheng J, Li Q
Journal of agricultural and food chemistry 2021 Jun 16;69(23):6535-6542
Journal of agricultural and food chemistry 2021 Jun 16;69(23):6535-6542
Induction of autophagy by Beclin-1 in granulosa cells contributes to follicular progesterone elevation in ovarian endometriosis.
Ding Y, Zhu Q, He Y, Lu Y, Wang Y, Qi J, Wu H, Xu R, Li J, Li X, Sun Y
Translational research : the journal of laboratory and clinical medicine 2021 Jan;227:15-29
Translational research : the journal of laboratory and clinical medicine 2021 Jan;227:15-29
Cyclin-dependent kinase inhibitor 1B acts as a novel molecule to mediate testosterone synthesis and secretion in mouse Leydig cells by luteinizing hormone (LH) signaling pathway.
Guo H, Luo X, Sun L, Li J, Cui S
In vitro cellular & developmental biology. Animal 2021 Aug;57(7):742-752
In vitro cellular & developmental biology. Animal 2021 Aug;57(7):742-752
Single-cell transcriptomes reveal heterogeneity of high-grade serous ovarian carcinoma.
Hao Q, Li J, Zhang Q, Xu F, Xie B, Lu H, Wu X, Zhou X
Clinical and translational medicine 2021 Aug;11(8):e500
Clinical and translational medicine 2021 Aug;11(8):e500
Effect of luteinizing hormone concentration on transcriptome and subcellular organelle phenotype of ovarian granulosa cells.
Wan YT, Liu S, Zhao SK, Luo YY, Lv YS, Qu DN, Liu MH, Li Y
Journal of assisted reproduction and genetics 2021 Apr;38(4):809-824
Journal of assisted reproduction and genetics 2021 Apr;38(4):809-824
La(2)O(3) Nanoparticles Induce Reproductive Toxicity Mediated by the Nrf-2/ARE Signaling Pathway in Kunming Mice.
Yuan L, Li Q, Bai D, Shang X, Hu F, Chen Z, An T, Chen Y, Zhang X
International journal of nanomedicine 2020;15:3415-3431
International journal of nanomedicine 2020;15:3415-3431
Oxidized-LDL inhibits testosterone biosynthesis by affecting mitochondrial function and the p38 MAPK/COX-2 signaling pathway in Leydig cells.
Jing J, Ding N, Wang D, Ge X, Ma J, Ma R, Huang X, Jueraitetibaike K, Liang K, Wang S, Cao S, Zhao AZ, Yao B
Cell death & disease 2020 Aug 14;11(8):626
Cell death & disease 2020 Aug 14;11(8):626
The ovarian estrogen synthesis function was impaired in Y123F mouse and partly restored by exogenous FSH supplement.
Tu X, Liu M, Tang J, Zhang Y, Shi Y, Yu L, Sun Z
Reproductive biology and endocrinology : RB&E 2018 May 4;16(1):44
Reproductive biology and endocrinology : RB&E 2018 May 4;16(1):44
STMN1 Promotes Progesterone Production Via StAR Up-regulation in Mouse Granulosa Cells.
Dou YD, Zhao H, Huang T, Zhao SG, Liu XM, Yu XC, Ma ZX, Zhang YC, Liu T, Gao X, Li L, Lu G, Chan WY, Gao F, Liu HB, Chen ZJ
Scientific reports 2016 Jun 8;6:26691
Scientific reports 2016 Jun 8;6:26691
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The STAR antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human STAR. This antibody recognizes human,mouse,rat antigen. The STAR antibody has been validated for the following applications: ELISA, WB analysis.
