MAB1817-100

antibody from R&D Systems

Targeting: HAVCR1 CD365, HAVCR, HAVCR-1, KIM1, TIM-1, TIM1, TIMD1

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Antibody Data

Product number

MAB1817-100

Provider

R&D Systems

Product name

Mouse TIM-1/KIM-1/HAVCR Antibody

Antibody type

Monoclonal

Description

Protein A or G purified from hybridoma culture supernatant. Detects mouse TIM-1/KIM-1/HAVCR in ELISAs and Western blots. This antibody does not cross-react with recombinant human (rh) TIM-1, rmTIM-2, or rmTIM-3.

Reactivity

Mouse

Host

Rat

Conjugate

Unconjugated

Antigen sequence

NP_001160104


Isotype

IgG

Antibody clone number

222414

Vial size

100 ug

Concentration

LYOPH

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

References

Submitted references

Renal immune surveillance and dipeptidase-1 contribute to contrast-induced acute kidney injury.

Lau A, Chung H, Komada T, Platnich JM, Sandall CF, Choudhury SR, Chun J, Naumenko V, Surewaard BG, Nelson MC, Ulke-Lemée A, Beck PL, Benediktsson H, Jevnikar AM, Snelgrove SL, Hickey MJ, Senger DL, James MT, Macdonald JA, Kubes P, Jenne CN, Muruve DA
The Journal of clinical investigation 2018 Jul 2;128(7):2894-2913

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The pathological role of IL-18Rα in renal ischemia/reperfusion injury.

Yano T, Nozaki Y, Kinoshita K, Hino S, Hirooka Y, Niki K, Shimazu H, Kishimoto K, Funauch M, Matsumura I
Laboratory investigation; a journal of technical methods and pathology 2015 Jan;95(1):78-91

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Proximal tubule-derived colony stimulating factor-1 mediates polarization of renal macrophages and dendritic cells, and recovery in acute kidney injury.

Wang Y, Chang J, Yao B, Niu A, Kelly E, Breeggemann MC, Abboud Werner SL, Harris RC, Zhang MZ
Kidney international 2015 Dec;88(6):1274-1282

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HAVCR/KIM-1 activates the IL-6/STAT-3 pathway in clear cell renal cell carcinoma and determines tumor progression and patient outcome.

Cuadros T, Trilla E, Sarró E, Vilà MR, Vilardell J, de Torres I, Salcedo M, López-Hellin J, Sánchez A, Ramón y Cajal S, Itarte E, Morote J, Meseguer A
Cancer research 2014 Mar 1;74(5):1416-28

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Endogenous Tim-1 (Kim-1) promotes T-cell responses and cell-mediated injury in experimental crescentic glomerulonephritis.

Nozaki Y, Nikolic-Paterson DJ, Snelgrove SL, Akiba H, Yagita H, Holdsworth SR, Kitching AR
Kidney international 2012 May;81(9):844-55

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T cell Ig domain and mucin domain 1 engagement on invariant NKT cells in the presence of TCR stimulation enhances IL-4 production but inhibits IFN-gamma production.

Kim HS, Kim HS, Lee CW, Chung DH
Journal of immunology (Baltimore, Md. : 1950) 2010 Apr 15;184(8):4095-106

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TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells.

Nakae S, Iikura M, Suto H, Akiba H, Umetsu DT, Dekruyff RH, Saito H, Galli SJ
Blood 2007 Oct 1;110(7):2565-8