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- Antibody Data
- Antigen structure
- References [16]
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- Validations
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- Product number
- AF1817 - Provider product page
- Provider
- R&D Systems
- Product name
- Mouse TIM-1/KIM-1/HAVCR Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects mouse TIM-1/KIM-1/HAVCR in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant human TIM-1, recombinant mouse (rm) TIM-2, rmTIM-3, rmTIM-4, rmTIM-6, and rmTIM-7 is observed.
- Reactivity
- Mouse
- Host
- Goat
- Conjugate
- Unconjugated
- Antigen sequence
NP_001160104- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Lack of Cathepsin D in the Renal Proximal Tubular Cells Resulted in Increased Sensitivity against Renal Ischemia/Reperfusion Injury.
PINK1-PRKN/PARK2 pathway of mitophagy is activated to protect against renal ischemia-reperfusion injury.
Control release of mitochondria-targeted antioxidant by injectable self-assembling peptide hydrogel ameliorated persistent mitochondrial dysfunction and inflammation after acute kidney injury.
Uromodulin deficiency alters tubular injury and interstitial inflammation but not fibrosis in experimental obstructive nephropathy.
Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury.
Molecular characterization of the transition from acute to chronic kidney injury following ischemia/reperfusion.
Elevated urinary CRELD2 is associated with endoplasmic reticulum stress-mediated kidney disease.
Forkhead box O3 (FoxO3) regulates kidney tubular autophagy following urinary tract obstruction.
Wnt4 is a novel biomarker for the early detection of kidney tubular injury after ischemia/reperfusion injury.
Rescue therapy with Tanshinone IIA hinders transition of acute kidney injury to chronic kidney disease via targeting GSK3β.
Kidney-specific Sonoporation-mediated Gene Transfer.
Rapid Renal Regulation of Peroxisome Proliferator-activated Receptor γ Coactivator-1α by Extracellular Signal-Regulated Kinase 1/2 in Physiological and Pathological Conditions.
Characterizing functional domains for TIM-mediated enveloped virus entry.
Long-term rescue of dystrophin expression and improvement in muscle pathology and function in dystrophic mdx mice by peptide-conjugated morpholino.
Repair of injured proximal tubule does not involve specialized progenitors.
TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells.
Suzuki C, Tanida I, Ohmuraya M, Oliva Trejo JA, Kakuta S, Sunabori T, Uchiyama Y
International journal of molecular sciences 2019 Apr 5;20(7)
International journal of molecular sciences 2019 Apr 5;20(7)
PINK1-PRKN/PARK2 pathway of mitophagy is activated to protect against renal ischemia-reperfusion injury.
Tang C, Han H, Yan M, Zhu S, Liu J, Liu Z, He L, Tan J, Liu Y, Liu H, Sun L, Duan S, Peng Y, Liu F, Yin XM, Zhang Z, Dong Z
Autophagy 2018;14(5):880-897
Autophagy 2018;14(5):880-897
Control release of mitochondria-targeted antioxidant by injectable self-assembling peptide hydrogel ameliorated persistent mitochondrial dysfunction and inflammation after acute kidney injury.
Zhao M, Zhou Y, Liu S, Li L, Chen Y, Cheng J, Lu Y, Liu J
Drug delivery 2018 Nov;25(1):546-554
Drug delivery 2018 Nov;25(1):546-554
Uromodulin deficiency alters tubular injury and interstitial inflammation but not fibrosis in experimental obstructive nephropathy.
Maydan O, McDade PG, Liu Y, Wu XR, Matsell DG, Eddy AA
Physiological reports 2018 Mar;6(6):e13654
Physiological reports 2018 Mar;6(6):e13654
Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury.
Lazzeri E, Angelotti ML, Peired A, Conte C, Marschner JA, Maggi L, Mazzinghi B, Lombardi D, Melica ME, Nardi S, Ronconi E, Sisti A, Antonelli G, Becherucci F, De Chiara L, Guevara RR, Burger A, Schaefer B, Annunziato F, Anders HJ, Lasagni L, Romagnani P
Nature communications 2018 Apr 9;9(1):1344
Nature communications 2018 Apr 9;9(1):1344
Molecular characterization of the transition from acute to chronic kidney injury following ischemia/reperfusion.
Liu J, Kumar S, Dolzhenko E, Alvarado GF, Guo J, Lu C, Chen Y, Li M, Dessing MC, Parvez RK, Cippà PE, Krautzberger AM, Saribekyan G, Smith AD, McMahon AP
JCI insight 2017 Sep 21;2(18)
JCI insight 2017 Sep 21;2(18)
Elevated urinary CRELD2 is associated with endoplasmic reticulum stress-mediated kidney disease.
Kim Y, Park SJ, Manson SR, Molina CA, Kidd K, Thiessen-Philbrook H, Perry RJ, Liapis H, Kmoch S, Parikh CR, Bleyer AJ, Chen YM
JCI insight 2017 Dec 7;2(23)
JCI insight 2017 Dec 7;2(23)
Forkhead box O3 (FoxO3) regulates kidney tubular autophagy following urinary tract obstruction.
Li L, Zviti R, Ha C, Wang ZV, Hill JA, Lin F
The Journal of biological chemistry 2017 Aug 18;292(33):13774-13783
The Journal of biological chemistry 2017 Aug 18;292(33):13774-13783
Wnt4 is a novel biomarker for the early detection of kidney tubular injury after ischemia/reperfusion injury.
Zhao SL, Wei SY, Wang YX, Diao TT, Li JS, He YX, Yu J, Jiang XY, Cao Y, Mao XY, Wei QJ, Wang Y, Li B
Scientific reports 2016 Sep 7;6:32610
Scientific reports 2016 Sep 7;6:32610
Rescue therapy with Tanshinone IIA hinders transition of acute kidney injury to chronic kidney disease via targeting GSK3β.
Jiang C, Zhu W, Yan X, Shao Q, Xu B, Zhang M, Gong R
Scientific reports 2016 Nov 18;6:36698
Scientific reports 2016 Nov 18;6:36698
Kidney-specific Sonoporation-mediated Gene Transfer.
Ishida R, Kami D, Kusaba T, Kirita Y, Kishida T, Mazda O, Adachi T, Gojo S
Molecular therapy : the journal of the American Society of Gene Therapy 2016 Feb;24(1):125-34
Molecular therapy : the journal of the American Society of Gene Therapy 2016 Feb;24(1):125-34
Rapid Renal Regulation of Peroxisome Proliferator-activated Receptor γ Coactivator-1α by Extracellular Signal-Regulated Kinase 1/2 in Physiological and Pathological Conditions.
Collier JB, Whitaker RM, Eblen ST, Schnellmann RG
The Journal of biological chemistry 2016 Dec 23;291(52):26850-26859
The Journal of biological chemistry 2016 Dec 23;291(52):26850-26859
Characterizing functional domains for TIM-mediated enveloped virus entry.
Moller-Tank S, Albritton LM, Rennert PD, Maury W
Journal of virology 2014 Jun;88(12):6702-13
Journal of virology 2014 Jun;88(12):6702-13
Long-term rescue of dystrophin expression and improvement in muscle pathology and function in dystrophic mdx mice by peptide-conjugated morpholino.
Wu B, Lu P, Cloer C, Shaban M, Grewal S, Milazi S, Shah SN, Moulton HM, Lu QL
The American journal of pathology 2012 Aug;181(2):392-400
The American journal of pathology 2012 Aug;181(2):392-400
Repair of injured proximal tubule does not involve specialized progenitors.
Humphreys BD, Czerniak S, DiRocco DP, Hasnain W, Cheema R, Bonventre JV
Proceedings of the National Academy of Sciences of the United States of America 2011 May 31;108(22):9226-31
Proceedings of the National Academy of Sciences of the United States of America 2011 May 31;108(22):9226-31
TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells.
Nakae S, Iikura M, Suto H, Akiba H, Umetsu DT, Dekruyff RH, Saito H, Galli SJ
Blood 2007 Oct 1;110(7):2565-8
Blood 2007 Oct 1;110(7):2565-8
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Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of Mouse TIM-1/KIM-1/HAVCR by Western Blot. Western blot shows lysates of NIH-3T3 mouse embryonic fibroblast cell line. PVDF membrane was probed with 0.25 µg/mL of Goat Anti-Mouse TIM-1/KIM-1/HAVCR Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1817) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). A specific band was detected for TIM-1/KIM-1/HAVCR at approximately 70-80 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.
