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- Antibody Data
- Antigen structure
- References [12]
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- Validations
- Immunohistochemistry [1]
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- Product number
- AF3689 - Provider product page
- Provider
- R&D Systems
- Product name
- Rat TIM-1/KIM-1/HAVCR Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Detects rat TIM-1/KIM-1/HAVCR in direct ELISAs and Western blots. In direct ELISAs, approximately 5% cross-reactivity with recombinant mouse (rm) TIM-1 is observed, and less than 1% cross-reactivity with recombinant human TIM-1, recombinant rat TIM-2, rmTIM-3, rmTIM-4, rmTIM-6, and rmTIM-7 is observed.
- Reactivity
- Rat
- Host
- Goat
- Conjugate
- Unconjugated
- Antigen sequence
O54947- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Canagliflozin, a sodium-glucose cotransporter 2 inhibitor, normalizes renal susceptibility to type 1 cardiorenal syndrome through reduction of renal oxidative stress in diabetic rats.
High fructose diet feeding accelerates diabetic nephropathy in Spontaneously Diabetic Torii (SDT) rats.
Osteopontin deficiency ameliorates Alport pathology by preventing tubular metabolic deficits.
Wnt4 is significantly upregulated during the early phases of cisplatin-induced acute kidney injury.
Combined therapy with melatonin and exendin-4 effectively attenuated the deterioration of renal function in rat cardiorenal syndrome.
Combination therapy of exendin-4 and allogenic adipose-derived mesenchymal stem cell preserved renal function in a chronic kidney disease and sepsis syndrome setting in rats.
Endocytosis of Albumin Induces Matrix Metalloproteinase-9 by Activating the ERK Signaling Pathway in Renal Tubule Epithelial Cells.
An Atherogenic Paigen-Diet Aggravates Nephropathy in Type 2 Diabetic OLETF Rats.
Altered expression profile of renal α(1D)-adrenergic receptor in diabetes and its modulation by PPAR agonists.
The uremic toxin adsorbent AST-120 abrogates cardiorenal injury following myocardial infarction.
Urinary levels of regenerating islet-derived protein III β and gelsolin differentiate gentamicin from cisplatin-induced acute kidney injury in rats.
Sub-nephrotoxic doses of gentamicin predispose animals to developing acute kidney injury and to excrete ganglioside M2 activator protein.
Kimura Y, Kuno A, Tanno M, Sato T, Ohno K, Shibata S, Nakata K, Sugawara H, Abe K, Igaki Y, Yano T, Miki T, Miura T
Journal of diabetes investigation 2019 Jul;10(4):933-946
Journal of diabetes investigation 2019 Jul;10(4):933-946
High fructose diet feeding accelerates diabetic nephropathy in Spontaneously Diabetic Torii (SDT) rats.
Toyoda K, Suzuki Y, Muta K, Masuyama T, Kakimoto K, Kobayashi A, Shoda T, Sugai S
The Journal of toxicological sciences 2018;43(1):45-58
The Journal of toxicological sciences 2018;43(1):45-58
Osteopontin deficiency ameliorates Alport pathology by preventing tubular metabolic deficits.
Ding W, Yousefi K, Goncalves S, Goldstein BJ, Sabater AL, Kloosterboer A, Ritter P, Lambert G, Mendez AJ, Shehadeh LA
JCI insight 2018 Mar 22;3(6)
JCI insight 2018 Mar 22;3(6)
Wnt4 is significantly upregulated during the early phases of cisplatin-induced acute kidney injury.
He YX, Diao TT, Song SM, Wang CC, Wang Y, Zhou CL, Bai YB, Yu SS, Mi X, Yang XY, Wei QJ, Li B
Scientific reports 2018 Jul 12;8(1):10555
Scientific reports 2018 Jul 12;8(1):10555
Combined therapy with melatonin and exendin-4 effectively attenuated the deterioration of renal function in rat cardiorenal syndrome.
Chen KH, Chen CH, Wallace CG, Chen YT, Yang CC, Sung PH, Chiang HJ, Chen YL, Chua S, Yip HK, Cheng JT
American journal of translational research 2017;9(2):214-229
American journal of translational research 2017;9(2):214-229
Combination therapy of exendin-4 and allogenic adipose-derived mesenchymal stem cell preserved renal function in a chronic kidney disease and sepsis syndrome setting in rats.
Chen CH, Cheng BC, Chen KH, Shao PL, Sung PH, Chiang HJ, Yang CC, Lin KC, Sun CK, Sheu JJ, Chang HW, Lee MS, Yip HK
Oncotarget 2017 Nov 21;8(59):100002-100020
Oncotarget 2017 Nov 21;8(59):100002-100020
Endocytosis of Albumin Induces Matrix Metalloproteinase-9 by Activating the ERK Signaling Pathway in Renal Tubule Epithelial Cells.
Chen X, Cobbs A, George J, Chima A, Tuyishime F, Zhao X
International journal of molecular sciences 2017 Aug 12;18(8)
International journal of molecular sciences 2017 Aug 12;18(8)
An Atherogenic Paigen-Diet Aggravates Nephropathy in Type 2 Diabetic OLETF Rats.
Nozako M, Koyama T, Nagano C, Sato M, Matsumoto S, Mitani K, Yasufuku R, Kohashi M, Yoshikawa T
PloS one 2015;10(11):e0143979
PloS one 2015;10(11):e0143979
Altered expression profile of renal α(1D)-adrenergic receptor in diabetes and its modulation by PPAR agonists.
Zhao X, Zhang Y, Leander M, Li L, Wang G, Emmett N
Journal of diabetes research 2014;2014:725634
Journal of diabetes research 2014;2014:725634
The uremic toxin adsorbent AST-120 abrogates cardiorenal injury following myocardial infarction.
Lekawanvijit S, Kumfu S, Wang BH, Manabe M, Nishijima F, Kelly DJ, Krum H, Kompa AR
PloS one 2013;8(12):e83687
PloS one 2013;8(12):e83687
Urinary levels of regenerating islet-derived protein III β and gelsolin differentiate gentamicin from cisplatin-induced acute kidney injury in rats.
Ferreira L, Quiros Y, Sancho-Martínez SM, García-Sánchez O, Raposo C, López-Novoa JM, González-Buitrago JM, López-Hernández FJ
Kidney international 2011 Mar;79(5):518-28
Kidney international 2011 Mar;79(5):518-28
Sub-nephrotoxic doses of gentamicin predispose animals to developing acute kidney injury and to excrete ganglioside M2 activator protein.
Quiros Y, Ferreira L, Sancho-Martínez SM, González-Buitrago JM, López-Novoa JM, López-Hernández FJ
Kidney international 2010 Nov;78(10):1006-15
Kidney international 2010 Nov;78(10):1006-15
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Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- TIM-1/KIM-1/HAVCR in Rat Kidney. TIM-1/KIM-1/HAVCR was detected in perfusion fixed frozen sections of rat kidney using 15 µg/mL Rat TIM-1/KIM-1/HAVCR Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3689) overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.
