Antibody data
- Antibody Data
- Antigen structure
- References [9]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [6]
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Validation data
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- Product number
- NBP1-81018 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NBP1-81018, RRID:AB_11014635
- Product name
- Rabbit Polyclonal MX2 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Specificity of human MX2 antibody verified on a Protein Array containing target protein plus 383 other non-specific proteins.
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references The anti-viral dynamin family member MxB participates in mitochondrial integrity.
Human MxB Inhibits the Replication of Hepatitis C Virus.
SAMHD1 deficient human monocytes autonomously trigger type I interferon.
Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2.
Accumulation of MxB/Mx2-resistant HIV-1 Capsid Variants During Expansion of the HIV-1 Epidemic in Human Populations.
Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses.
MxB Is Not Responsible for the Blocking of HIV-1 Infection Observed in Alpha Interferon-Treated Cells.
Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression.
MX2 is an interferon-induced inhibitor of HIV-1 infection.
Cao H, Krueger EW, Chen J, Drizyte-Miller K, Schulz ME, McNiven MA
Nature communications 2020 Feb 26;11(1):1048
Nature communications 2020 Feb 26;11(1):1048
Human MxB Inhibits the Replication of Hepatitis C Virus.
Yi DR, An N, Liu ZL, Xu FW, Raniga K, Li QJ, Zhou R, Wang J, Zhang YX, Zhou JM, Zhang LL, An J, Qin CF, Guo F, Li XY, Liang C, Cen S
Journal of virology 2019 Jan 1;93(1)
Journal of virology 2019 Jan 1;93(1)
SAMHD1 deficient human monocytes autonomously trigger type I interferon.
Martinez-Lopez A, Martin-Fernandez M, Buta S, Kim B, Bogunovic D, Diaz-Griffero F
Molecular immunology 2018 Sep;101:450-460
Molecular immunology 2018 Sep;101:450-460
Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2.
Kane M, Rebensburg SV, Takata MA, Zang TM, Yamashita M, Kvaratskhelia M, Bieniasz PD
eLife 2018 Aug 7;7
eLife 2018 Aug 7;7
Accumulation of MxB/Mx2-resistant HIV-1 Capsid Variants During Expansion of the HIV-1 Epidemic in Human Populations.
Wei W, Guo H, Ma M, Markham R, Yu XF
EBioMedicine 2016 Jun;8:230-236
EBioMedicine 2016 Jun;8:230-236
Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses.
Sali TM, Pryke KM, Abraham J, Liu A, Archer I, Broeckel R, Staverosky JA, Smith JL, Al-Shammari A, Amsler L, Sheridan K, Nilsen A, Streblow DN, DeFilippis VR
PLoS pathogens 2015 Dec;11(12):e1005324
PLoS pathogens 2015 Dec;11(12):e1005324
MxB Is Not Responsible for the Blocking of HIV-1 Infection Observed in Alpha Interferon-Treated Cells.
Opp S, Vieira DA, Schulte B, Chanda SK, Diaz-Griffero F
Journal of virology 2015 Dec 30;90(6):3056-64
Journal of virology 2015 Dec 30;90(6):3056-64
Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression.
Sandler NG, Bosinger SE, Estes JD, Zhu RT, Tharp GK, Boritz E, Levin D, Wijeyesinghe S, Makamdop KN, del Prete GQ, Hill BJ, Timmer JK, Reiss E, Yarden G, Darko S, Contijoch E, Todd JP, Silvestri G, Nason M, Norgren RB Jr, Keele BF, Rao S, Langer JA, Lifson JD, Schreiber G, Douek DC
Nature 2014 Jul 31;511(7511):601-5
Nature 2014 Jul 31;511(7511):601-5
MX2 is an interferon-induced inhibitor of HIV-1 infection.
Kane M, Yadav SS, Bitzegeio J, Kutluay SB, Zang T, Wilson SJ, Schoggins JW, Rice CM, Yamashita M, Hatziioannou T, Bieniasz PD
Nature 2013 Oct 24;502(7472):563-6
Nature 2013 Oct 24;502(7472):563-6
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: MX2 Antibody [NBP1-81018] - Human glioma U87 cell lysate. WB image submitted by a verified customer review.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: MX2 Antibody [NBP1-81018] - Staining of human skin shows strong cytoplasmic positivity in epidermal cells.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: MX2 Antibody [NBP1-81018] - Staining of human liver shows no postivity in hepatocytes as expected.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: MX2 Antibody [NBP1-81018] - Staining of human colon shows moderate postivity in nuclear membrane in lymphoid cells in the lamina propria.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: MX2 Antibody [NBP1-81018] - Staining of human skeletal muscle shows no postivity in myocytes as expected.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: MX2 Antibody [NBP1-81018] - Staining of human lymph node shows moderate positivity in nuclear membrane in non-germinal center cells.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: MX2 Antibody [NBP1-81018] - Staining of human spleen shows strong positivity in nuclear membrane in cells in red pulp.