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- References [89]
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- Product number
- 13750-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13750-1-AP, RRID:AB_2266768
- Product name
- MX1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated MX1 antibody (Cat. #13750-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Overactivated MX1 Positive Natural Killer Cells Promote the Progression of Sepsis-Induced Acute Respiratory Distress Syndrome.
Identification of MUC1-C as a Target for Suppressing Progression of Head and Neck Squamous Cell Carcinomas.
cGAS suppresses hepatocellular carcinoma independent of its cGAMP synthase activity.
Cell fusion upregulates PD-L1 expression for evasion from immunosurveillance.
Targeted knockout of Mx in the DF-1 chicken fibroblast cell line impairs immune response against Newcastle disease virus.
Recombinant immunotoxin induces tumor intrinsic STING signaling against head and neck squamous cell carcinoma.
Capsaicin functions as a selective degrader of STAT3 to enhance host resistance to viral infection.
Transcriptomic and antiviral analyses of PoIFN-Delta5 against porcine enteric viruses in porcine intestinal epithelial cells.
Intranasal or airborne transmission-mediated delivery of an attenuated SARS-CoV-2 protects Syrian hamsters against new variants.
The antiviral activity of tripartite motif protein 38 in hepatitis B virus replication and gene expression and its association with treatment responses during PEG-IFN-α antiviral therapy.
Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria.
CCR4-NOT differentially controls host versus virus poly(a)-tail length and regulates HCMV infection.
The Type I Interferon Pathway Is Upregulated in the Cutaneous Lesions and Blood of Multibacillary Leprosy Patients With Erythema Nodosum Leprosum.
Proteomic Investigation Reveals Eukaryotic Translation Initiation Factor 5A Involvement in Porcine Reproductive and Respiratory Syndrome Virus Infection in vitro.
Marek's Disease Virus and Reticuloendotheliosis Virus Coinfection Enhances Viral Replication and Alters Cellular Protein Profiles.
Temporally integrated transcriptome analysis reveals ASFV pathology and host response dynamics.
LncRNA NEAT1 Potentiates SREBP2 Activity to Promote Inflammatory Macrophage Activation and Limit Hantaan Virus Propagation.
Single-cell profiling reveals distinct adaptive immune hallmarks in MDA5+ dermatomyositis with therapeutic implications.
Active and Passive Immunization of Syrian Hamsters with An Attenuated SARS-CoV-2 Protects against New Variants of Concern.
Acquired chemoresistance can lead to increased resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus.
Anti-inflammatory Properties of the Alpha-Melanocyte-Stimulating Hormone in Models of Granulomatous Inflammation.
Regulation of type I interferon signature by VGLL3 in the fibroblast-like synoviocytes of rheumatoid arthritis patients via targeting the Hippo pathway.
PIAS1-mediated SUMOylation of influenza A virus PB2 restricts viral replication and virulence.
RhoC Modulates Cell Junctions and Type I Interferon Response in Aggressive Breast Cancers.
Human parainfluenza virus type 1 regulates cholesterol biosynthesis and establishes quiescent infection in human airway cells.
Virus-inducible IGFALS facilitates innate immune responses by mediating IRAK1 and TRAF6 activation.
Interferon-induced degradation of the persistent hepatitis B virus cccDNA form depends on ISG20.
Inducible ATP1B1 Upregulates Antiviral Innate Immune Responses by the Ubiquitination of TRAF3 and TRAF6.
The Protein Kinase Receptor Modulates the Innate Immune Response against Tacaribe Virus.
Role of IL-6-IL-27 Complex in Host Antiviral Immune Response.
The ApoA-I mimetic peptide 4F attenuates in vitro replication of SARS-CoV-2, associated apoptosis, oxidative stress and inflammation in epithelial cells.
Large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting.
Exosomal miR-145-5p derived from orthohantavirus-infected endothelial cells inhibits HTNV infection.
Cross-talk between SUMOylation and ISGylation in response to interferon.
SFTSV Infection Induces BAK/BAX-Dependent Mitochondrial DNA Release to Trigger NLRP3 Inflammasome Activation.
A RIG-I-like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination.
Direct Antiviral Activity of IFN-Stimulated Genes Is Responsible for Resistance to Paramyxoviruses in ISG15-Deficient Cells.
The G Protein-Coupled Receptor FFAR2 Promotes Internalization during Influenza A Virus Entry.
Docosahexaenoic Acid Consumption Impedes Early Interferon- and Chemokine-Related Gene Expression While Suppressing Silica-Triggered Flaring of Murine Lupus.
Avian Flavivirus Infection of Monocytes/Macrophages by Extensive Subversion of Host Antiviral Innate Immune Responses.
Long Noncoding RNA Lnc-MxA Inhibits Beta Interferon Transcription by Forming RNA-DNA Triplexes at Its Promoter.
Induction of interleukin 6 impairs the anti-HBV efficiency of IFN-α in human hepatocytes through upregulation of SOCS3.
Molecular cloning and transcriptional regulation of Indian peafowl (Pavo cristatus) IFN-α gene.
The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infection.
Comparative Analysis of the Antiviral Effects Mediated by Type I and III Interferons in Hepatitis B Virus-Infected Hepatocytes.
Characterization, functional and signaling elucidation of pigeon (Columba livia) interferon-α: Knockdown p53 negatively modulates antiviral response.
Interferon-alpha promotes immunosuppression through IFNAR1/STAT1 signalling in head and neck squamous cell carcinoma.
Inducible LGALS3BP/90K activates antiviral innate immune responses by targeting TRAF6 and TRAF3 complex.
Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques.
NAC1 Potentiates Cellular Antiviral Signaling by Bridging MAVS and TBK1.
Bexarotene protects against neurotoxicity partially through a PPARγ-dependent mechanism in mice following traumatic brain injury.
Alcohol attenuates anti-HCV function of IFN-λ1 through up-regulation of PLASy expression in human hepatic cells.
Myxovirus resistance protein A inhibits hepatitis C virus replication through JAK-STAT pathway activation.
TBK1: A key regulator and potential treatment target for interferon positive Sjögren's syndrome, systemic lupus erythematosus and systemic sclerosis.
Characterization of Whooper Swan (Cygnus cygnus) Interferon α: Prokaryotic Expression, Biological Activities, and Physicochemical Characteristics.
Phospholipid scramblase 1 interacts with influenza A virus NP, impairing its nuclear import and thereby suppressing virus replication.
Distinct temporal roles for the promyelocytic leukaemia (PML) protein in the sequential regulation of intracellular host immunity to HSV-1 infection.
Type I IFN signature in childhood-onset systemic lupus erythematosus: a conspiracy of DNA- and RNA-sensing receptors?
Interferon-alpha enhances the antitumour activity of EGFR-targeted therapies by upregulating RIG-I in head and neck squamous cell carcinoma.
The large GTPase Mx1 binds Kif5B for cargo transport along microtubules.
Inducible TAP1 Negatively Regulates the Antiviral Innate Immune Response by Targeting the TAK1 Complex.
Inducible Rubicon facilitates viral replication by antagonizing interferon production.
Matrix Metalloproteinase 9 Facilitates Hepatitis B Virus Replication through Binding with Type I Interferon (IFN) Receptor 1 To Repress IFN/JAK/STAT Signaling.
Soluble IL-6 Receptor and IL-27 Subunit p28 Protein Complex Mediate the Antiviral Response through the Type III IFN Pathway.
Comparative Proteome Analysis of Porcine Jejunum Tissues in Response to a Virulent Strain of Porcine Epidemic Diarrhea Virus and Its Attenuated Strain.
STAT1 and NF-κB Inhibitors Diminish Basal Interferon-Stimulated Gene Expression and Improve the Productive Infection of Oncolytic HSV in MPNST Cells.
Association of Increased Treg Cell Levels With Elevated Indoleamine 2,3-Dioxygenase Activity and an Imbalanced Kynurenine Pathway in Interferon-Positive Primary Sjögren's Syndrome.
MxA Mediates SUMO-Induced Resistance to Vesicular Stomatitis Virus.
Complex Interplay between HIV-1 Capsid and MX2-Independent Alpha Interferon-Induced Antiviral Factors.
Human hepatitis B virus surface and e antigens inhibit major vault protein signaling in interferon induction pathways.
Interferon inducible antiviral MxA is inversely associated with prostate cancer and regulates cell cycle, invasion and Docetaxel induced apoptosis.
Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice.
Hepatitis B virus hijacks CTHRC1 to evade host immunity and maintain replication.
The large GTPase Mx1 is involved in apical transport in MDCK cells.
NRAV, a long noncoding RNA, modulates antiviral responses through suppression of interferon-stimulated gene transcription.
Interferon induction of IFITM proteins promotes infection by human coronavirus OC43.
Epicutaneous application of toll-like receptor 7 agonists leads to systemic autoimmunity in wild-type mice: a new model of systemic Lupus erythematosus.
MxA as a clinically applicable biomarker for identifying systemic interferon type I in primary Sjogren's syndrome.
IL-27, a cytokine, and IFN-λ1, a type III IFN, are coordinated to regulate virus replication through type I IFN.
Vpx rescue of HIV-1 from the antiviral state in mature dendritic cells is independent of the intracellular deoxynucleotide concentration.
Quantitative proteomic analysis reveals that transmissible gastroenteritis virus activates the JAK-STAT1 signaling pathway.
Influenza A virus-induced degradation of eukaryotic translation initiation factor 4B contributes to viral replication by suppressing IFITM3 protein expression.
Serial cervicovaginal exposures with replication-deficient SIVsm induce higher dendritic cell (pDC) and CD4+ T-cell infiltrates not associated with prevention but a more severe SIVmac251 infection of rhesus macaques.
MxA inhibits hepatitis B virus replication by interaction with hepatitis B core antigen.
IFITM3 restricts the morbidity and mortality associated with influenza.
IFITM3 inhibits influenza A virus infection by preventing cytosolic entry.
Vpx rescues HIV-1 transduction of dendritic cells from the antiviral state established by type 1 interferon.
Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections.
Rac1 is required for oncolytic NDV replication in human cancer cells and establishes a link between tumorigenesis and sensitivity to oncolytic virus.
Liu Q, Peng F, Liu H, Sun Q, Chen H, Xu X, Hu Z, Zhou X, Jin K, Xie J, Huang Y, Huang W, Yang Y
Journal of inflammation research 2024;17:3187-3200
Journal of inflammation research 2024;17:3187-3200
Identification of MUC1-C as a Target for Suppressing Progression of Head and Neck Squamous Cell Carcinomas.
Nakashoji A, Haratake N, Bhattacharya A, Mao W, Xu K, Wang K, Daimon T, Ozawa H, Shigeta K, Fushimi A, Yamashita N, Morimoto Y, Shimokawa M, Saito S, Egloff AM, Uppaluri R, Long MD, Kufe D
Cancer research communications 2024 May 14;4(5):1268-1281
Cancer research communications 2024 May 14;4(5):1268-1281
cGAS suppresses hepatocellular carcinoma independent of its cGAMP synthase activity.
Ma D, Yang M, Sun C, Cui X, Xiong G, Wang Q, Jing W, Chen H, Lv X, Liu S, Li T, Zhao Y, Han L
Cell death and differentiation 2024 Jun;31(6):722-737
Cell death and differentiation 2024 Jun;31(6):722-737
Cell fusion upregulates PD-L1 expression for evasion from immunosurveillance.
Tajima Y, Shibasaki F, Masai H
Cancer gene therapy 2024 Jan;31(1):158-173
Cancer gene therapy 2024 Jan;31(1):158-173
Targeted knockout of Mx in the DF-1 chicken fibroblast cell line impairs immune response against Newcastle disease virus.
Wang L, Xue Z, Wang J, Jian Y, Lu H, Ma H, Wang S, Zeng W, Zhang T
Poultry science 2023 Sep;102(9):102855
Poultry science 2023 Sep;102(9):102855
Recombinant immunotoxin induces tumor intrinsic STING signaling against head and neck squamous cell carcinoma.
Xie G, Shan L, Yang C, Liu Y, Pang X, Teng S, Wu TC, Gu X
Scientific reports 2023 Oct 28;13(1):18476
Scientific reports 2023 Oct 28;13(1):18476
Capsaicin functions as a selective degrader of STAT3 to enhance host resistance to viral infection.
Zhang MQ, Jia X, Cheng CQ, Wang YX, Li YY, Kong LD, Li QQ, Xie F, Yu YL, He YT, Dong QT, Jia ZH, Wang Y, Xu AL
Acta pharmacologica Sinica 2023 Nov;44(11):2253-2264
Acta pharmacologica Sinica 2023 Nov;44(11):2253-2264
Transcriptomic and antiviral analyses of PoIFN-Delta5 against porcine enteric viruses in porcine intestinal epithelial cells.
Zhu X, Fan B, Song S, Gao J, Zhou J, Zhao Y, Guo W, Zhang X, Qian J, Zhu M, Li J, Li Y, Guo R, Fan H, Dong H, Zhang X, Li B
Veterinary microbiology 2023 May;280:109718
Veterinary microbiology 2023 May;280:109718
Intranasal or airborne transmission-mediated delivery of an attenuated SARS-CoV-2 protects Syrian hamsters against new variants.
Stauft CB, Selvaraj P, D'Agnillo F, Meseda CA, Liu S, Pedro CL, Sangare K, Lien CZ, Weir JP, Starost MF, Wang TT
Nature communications 2023 Jun 9;14(1):3393
Nature communications 2023 Jun 9;14(1):3393
The antiviral activity of tripartite motif protein 38 in hepatitis B virus replication and gene expression and its association with treatment responses during PEG-IFN-α antiviral therapy.
Luo H, Hu X, Li Y, Lei D, Tan G, Zeng Y, Qin B
Virology 2023 Feb;579:84-93
Virology 2023 Feb;579:84-93
Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria.
Rosain J, Neehus AL, Manry J, Yang R, Le Pen J, Daher W, Liu Z, Chan YH, Tahuil N, Türel Ö, Bourgey M, Ogishi M, Doisne JM, Izquierdo HM, Shirasaki T, Le Voyer T, Guérin A, Bastard P, Moncada-Vélez M, Han JE, Khan T, Rapaport F, Hong SH, Cheung A, Haake K, Mindt BC, Pérez L, Philippot Q, Lee D, Zhang P, Rinchai D, Al Ali F, Ahmad Ata MM, Rahman M, Peel JN, Heissel S, Molina H, Kendir-Demirkol Y, Bailey R, Zhao S, Bohlen J, Mancini M, Seeleuthner Y, Roelens M, Lorenzo L, Soudée C, Paz MEJ, González ML, Jeljeli M, Soulier J, Romana S, L'Honneur AS, Materna M, Martínez-Barricarte R, Pochon M, Oleaga-Quintas C, Michev A, Migaud M, Lévy R, Alyanakian MA, Rozenberg F, Croft CA, Vogt G, Emile JF, Kremer L, Ma CS, Fritz JH, Lemon SM, Spaan AN, Manel N, Abel L, MacDonald MR, Boisson-Dupuis S, Marr N, Tangye SG, Di Santo JP, Zhang Q, Zhang SY, Rice CM, Béziat V, Lachmann N, Langlais D, Casanova JL, Gros P, Bustamante J
Cell 2023 Feb 2;186(3):621-645.e33
Cell 2023 Feb 2;186(3):621-645.e33
CCR4-NOT differentially controls host versus virus poly(a)-tail length and regulates HCMV infection.
Burgess HM, Grande R, Riccio S, Dinesh I, Winkler GS, Depledge DP, Mohr I
EMBO reports 2023 Dec 6;24(12):e56327
EMBO reports 2023 Dec 6;24(12):e56327
The Type I Interferon Pathway Is Upregulated in the Cutaneous Lesions and Blood of Multibacillary Leprosy Patients With Erythema Nodosum Leprosum.
Rosa TLSA, Mendes MA, Linhares NRC, Rodrigues TF, Dias AA, Leal-Calvo T, Gandini M, Ferreira H, Costa FDMR, Sales AM, Amadeu TP, Schmitz V, Pinheiro RO, Rodrigues LS, Moraes MO, Pessolani MCV
Frontiers in medicine 2022;9:899998
Frontiers in medicine 2022;9:899998
Proteomic Investigation Reveals Eukaryotic Translation Initiation Factor 5A Involvement in Porcine Reproductive and Respiratory Syndrome Virus Infection in vitro.
Li H, Wan B, Jiang D, Ji P, Zhao M, Li X, Li R, Qiao S
Frontiers in veterinary science 2022;9:861137
Frontiers in veterinary science 2022;9:861137
Marek's Disease Virus and Reticuloendotheliosis Virus Coinfection Enhances Viral Replication and Alters Cellular Protein Profiles.
Du X, Zhou D, Zhou J, Xue J, Cheng Z
Frontiers in veterinary science 2022;9:854007
Frontiers in veterinary science 2022;9:854007
Temporally integrated transcriptome analysis reveals ASFV pathology and host response dynamics.
Lv L, Zhang T, Jia H, Zhang Y, Ahsan A, Zhao X, Chen T, Shen Z, Shen N
Frontiers in immunology 2022;13:995998
Frontiers in immunology 2022;13:995998
LncRNA NEAT1 Potentiates SREBP2 Activity to Promote Inflammatory Macrophage Activation and Limit Hantaan Virus Propagation.
Yang Y, Li M, Ma Y, Ye W, Si Y, Zheng X, Liu H, Cheng L, Zhang L, Zhang H, Zhang X, Lei Y, Shen L, Zhang F, Ma H
Frontiers in microbiology 2022;13:849020
Frontiers in microbiology 2022;13:849020
Single-cell profiling reveals distinct adaptive immune hallmarks in MDA5+ dermatomyositis with therapeutic implications.
Ye Y, Chen Z, Jiang S, Jia F, Li T, Lu X, Xue J, Lian X, Ma J, Hao P, Lu L, Ye S, Shen N, Bao C, Fu Q, Zhang X
Nature communications 2022 Oct 29;13(1):6458
Nature communications 2022 Oct 29;13(1):6458
Active and Passive Immunization of Syrian Hamsters with An Attenuated SARS-CoV-2 Protects against New Variants of Concern.
Wang T, Stauft C, Selvaraj P, D'agnillo F, Meseda C, Sangare K, Pedro C, Liu S, Lien C, Weir J, Starost M
Research square 2022 Nov 11;
Research square 2022 Nov 11;
Acquired chemoresistance can lead to increased resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus.
Goad DW, Bressy C, Holbrook MC, Grdzelishvili VZ
Molecular therapy oncolytics 2022 Mar 17;24:59-76
Molecular therapy oncolytics 2022 Mar 17;24:59-76
Anti-inflammatory Properties of the Alpha-Melanocyte-Stimulating Hormone in Models of Granulomatous Inflammation.
Shahraki AH, Tian R, Zhang C, Fregien NL, Bejarano P, Mirsaeidi M
Lung 2022 Aug;200(4):463-472
Lung 2022 Aug;200(4):463-472
Regulation of type I interferon signature by VGLL3 in the fibroblast-like synoviocytes of rheumatoid arthritis patients via targeting the Hippo pathway.
Du Y, Cui R, Tian N, Chen M, Zhang XL, Dai SM
Arthritis research & therapy 2022 Aug 8;24(1):188
Arthritis research & therapy 2022 Aug 8;24(1):188
PIAS1-mediated SUMOylation of influenza A virus PB2 restricts viral replication and virulence.
Wang G, Zhao Y, Zhou Y, Jiang L, Liang L, Kong F, Yan Y, Wang X, Wang Y, Wen X, Zeng X, Tian G, Deng G, Shi J, Liu L, Chen H, Li C
PLoS pathogens 2022 Apr;18(4):e1010446
PLoS pathogens 2022 Apr;18(4):e1010446
RhoC Modulates Cell Junctions and Type I Interferon Response in Aggressive Breast Cancers.
Abraham HG, Ulintz PJ, Goo L, Yates JA, Little AC, Bao L, Wu Z, Merajver SD
Frontiers in oncology 2021;11:712041
Frontiers in oncology 2021;11:712041
Human parainfluenza virus type 1 regulates cholesterol biosynthesis and establishes quiescent infection in human airway cells.
Kurebayashi Y, Bajimaya S, Watanabe M, Lim N, Lutz M, Dunagan M, Takimoto T
PLoS pathogens 2021 Sep;17(9):e1009908
PLoS pathogens 2021 Sep;17(9):e1009908
Virus-inducible IGFALS facilitates innate immune responses by mediating IRAK1 and TRAF6 activation.
Xu G, Deng F, Zuo Q, Liu L, Dou K, Cheng Z, Cao W, Luo C, Yu C, Liu S, Zhu Y
Cellular & molecular immunology 2021 Jun;18(6):1587-1589
Cellular & molecular immunology 2021 Jun;18(6):1587-1589
Interferon-induced degradation of the persistent hepatitis B virus cccDNA form depends on ISG20.
Stadler D, Kächele M, Jones AN, Hess J, Urban C, Schneider J, Xia Y, Oswald A, Nebioglu F, Bester R, Lasitschka F, Ringelhan M, Ko C, Chou WM, Geerlof A, van de Klundert MA, Wettengel JM, Schirmacher P, Heikenwälder M, Schreiner S, Bartenschlager R, Pichlmair A, Sattler M, Unger K, Protzer U
EMBO reports 2021 Jun 4;22(6):e49568
EMBO reports 2021 Jun 4;22(6):e49568
Inducible ATP1B1 Upregulates Antiviral Innate Immune Responses by the Ubiquitination of TRAF3 and TRAF6.
Cao W, Guo Y, Cheng Z, Xu G, Zuo Q, Nie L, Huang Y, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2021 Jun 1;206(11):2668-2681
Journal of immunology (Baltimore, Md. : 1950) 2021 Jun 1;206(11):2668-2681
The Protein Kinase Receptor Modulates the Innate Immune Response against Tacaribe Virus.
Moreno H, Kunz S
Viruses 2021 Jul 7;13(7)
Viruses 2021 Jul 7;13(7)
Role of IL-6-IL-27 Complex in Host Antiviral Immune Response.
Zuo Q, Cheng Z, Zhang G, Xia Y, Xu G, Cao W, Yang X, Fu Y, He R, Fang P, Guo Y, Nie L, Huang Y, Liu L, Zhan J, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2021 Jul 15;207(2):577-589
Journal of immunology (Baltimore, Md. : 1950) 2021 Jul 15;207(2):577-589
The ApoA-I mimetic peptide 4F attenuates in vitro replication of SARS-CoV-2, associated apoptosis, oxidative stress and inflammation in epithelial cells.
Kelesidis T, Madhav S, Petcherski A, Cristelle H, O'Connor E, Hultgren NW, Ritou E, Williams DS, Shirihai OS, Reddy ST
Virulence 2021 Dec;12(1):2214-2227
Virulence 2021 Dec;12(1):2214-2227
Large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting.
Liu W, Xie L, He YH, Wu ZY, Liu LX, Bai XF, Deng DX, Xu XE, Liao LD, Lin W, Heng JH, Xu X, Peng L, Huang QF, Li CY, Zhang ZD, Wang W, Zhang GR, Gao X, Wang SH, Li CQ, Xu LY, Liu W, Li EM
Nature communications 2021 Aug 16;12(1):4961
Nature communications 2021 Aug 16;12(1):4961
Exosomal miR-145-5p derived from orthohantavirus-infected endothelial cells inhibits HTNV infection.
Wang X, Chen QZ, Zan YX, Wang MR, Yan J, Guo WW, Li KJ, Liu YY, Luo F, Feng Y, Hou W, Xiong HR
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Oct;34(10):13809-13825
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Oct;34(10):13809-13825
Cross-talk between SUMOylation and ISGylation in response to interferon.
El-Asmi F, McManus FP, Brantis-de-Carvalho CE, Valle-Casuso JC, Thibault P, Chelbi-Alix MK
Cytokine 2020 May;129:155025
Cytokine 2020 May;129:155025
SFTSV Infection Induces BAK/BAX-Dependent Mitochondrial DNA Release to Trigger NLRP3 Inflammasome Activation.
Li S, Li H, Zhang YL, Xin QL, Guan ZQ, Chen X, Zhang XA, Li XK, Xiao GF, Lozach PY, Cui J, Liu W, Zhang LK, Peng K
Cell reports 2020 Mar 31;30(13):4370-4385.e7
Cell reports 2020 Mar 31;30(13):4370-4385.e7
A RIG-I-like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination.
Min YQ, Ning YJ, Wang H, Deng F
The Journal of biological chemistry 2020 Jul 10;295(28):9691-9711
The Journal of biological chemistry 2020 Jul 10;295(28):9691-9711
Direct Antiviral Activity of IFN-Stimulated Genes Is Responsible for Resistance to Paramyxoviruses in ISG15-Deficient Cells.
Holthaus D, Vasou A, Bamford CGG, Andrejeva J, Paulus C, Randall RE, McLauchlan J, Hughes DJ
Journal of immunology (Baltimore, Md. : 1950) 2020 Jul 1;205(1):261-271
Journal of immunology (Baltimore, Md. : 1950) 2020 Jul 1;205(1):261-271
The G Protein-Coupled Receptor FFAR2 Promotes Internalization during Influenza A Virus Entry.
Wang G, Jiang L, Wang J, Zhang J, Kong F, Li Q, Yan Y, Huang S, Zhao Y, Liang L, Li J, Sun N, Hu Y, Shi W, Deng G, Chen P, Liu L, Zeng X, Tian G, Bu Z, Chen H, Li C
Journal of virology 2020 Jan 6;94(2)
Journal of virology 2020 Jan 6;94(2)
Docosahexaenoic Acid Consumption Impedes Early Interferon- and Chemokine-Related Gene Expression While Suppressing Silica-Triggered Flaring of Murine Lupus.
Benninghoff AD, Bates MA, Chauhan PS, Wierenga KA, Gilley KN, Holian A, Harkema JR, Pestka JJ
Frontiers in immunology 2019;10:2851
Frontiers in immunology 2019;10:2851
Avian Flavivirus Infection of Monocytes/Macrophages by Extensive Subversion of Host Antiviral Innate Immune Responses.
Ma Y, Liang Y, Wang N, Cui L, Chen Z, Wu H, Zhu C, Wang Z, Liu S, Li H
Journal of virology 2019 Nov 15;93(22)
Journal of virology 2019 Nov 15;93(22)
Long Noncoding RNA Lnc-MxA Inhibits Beta Interferon Transcription by Forming RNA-DNA Triplexes at Its Promoter.
Li X, Guo G, Lu M, Chai W, Li Y, Tong X, Li J, Jia X, Liu W, Qi D, Ye X
Journal of virology 2019 Nov 1;93(21)
Journal of virology 2019 Nov 1;93(21)
Induction of interleukin 6 impairs the anti-HBV efficiency of IFN-α in human hepatocytes through upregulation of SOCS3.
Yang K, Guan S, Zhang H, Chen Z
Journal of medical virology 2019 May;91(5):803-812
Journal of medical virology 2019 May;91(5):803-812
Molecular cloning and transcriptional regulation of Indian peafowl (Pavo cristatus) IFN-α gene.
Wang Y, Zhao H, Liu J, Shao Y, Xing M
Cell stress & chaperones 2019 Mar;24(2):323-332
Cell stress & chaperones 2019 Mar;24(2):323-332
The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infection.
McFarlane S, Orr A, Roberts APE, Conn KL, Iliev V, Loney C, da Silva Filipe A, Smollett K, Gu Q, Robertson N, Adams PD, Rai TS, Boutell C
PLoS pathogens 2019 Mar;15(3):e1007667
PLoS pathogens 2019 Mar;15(3):e1007667
Comparative Analysis of the Antiviral Effects Mediated by Type I and III Interferons in Hepatitis B Virus-Infected Hepatocytes.
Bockmann JH, Stadler D, Xia Y, Ko C, Wettengel JM, Schulze Zur Wiesch J, Dandri M, Protzer U
The Journal of infectious diseases 2019 Jul 19;220(4):567-577
The Journal of infectious diseases 2019 Jul 19;220(4):567-577
Characterization, functional and signaling elucidation of pigeon (Columba livia) interferon-α: Knockdown p53 negatively modulates antiviral response.
Li S, Wang Y, Zhao H, Shao Y, Liu J, Xing M
Developmental and comparative immunology 2019 Jan;90:29-40
Developmental and comparative immunology 2019 Jan;90:29-40
Interferon-alpha promotes immunosuppression through IFNAR1/STAT1 signalling in head and neck squamous cell carcinoma.
Ma H, Yang W, Zhang L, Liu S, Zhao M, Zhou G, Wang L, Jin S, Zhang Z, Hu J
British journal of cancer 2019 Feb;120(3):317-330
British journal of cancer 2019 Feb;120(3):317-330
Inducible LGALS3BP/90K activates antiviral innate immune responses by targeting TRAF6 and TRAF3 complex.
Xu G, Xia Z, Deng F, Liu L, Wang Q, Yu Y, Wang F, Zhu C, Liu W, Cheng Z, Zhu Y, Zhou L, Zhang Y, Lu M, Liu S
PLoS pathogens 2019 Aug;15(8):e1008002
PLoS pathogens 2019 Aug;15(8):e1008002
Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques.
Abdulhaqq SA, Martinez M, Kang G, Rodriguez IV, Nichols SM, Beaumont D, Joseph J, Azzoni L, Yin X, Wise M, Weiner D, Liu Q, Foulkes A, Münch J, Kirchhoff F, Coutifaris C, Tomaras GD, Sariol C, Marx PA, Li Q, Kraiselburd EN, Montaner LJ
Nature communications 2019 Aug 21;10(1):3753
Nature communications 2019 Aug 21;10(1):3753
NAC1 Potentiates Cellular Antiviral Signaling by Bridging MAVS and TBK1.
Xia Z, Xu G, Nie L, Liu L, Peng N, He Q, Zuo Q, Zhou Y, Cao Z, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2019 Aug 15;203(4):1001-1011
Journal of immunology (Baltimore, Md. : 1950) 2019 Aug 15;203(4):1001-1011
Bexarotene protects against neurotoxicity partially through a PPARγ-dependent mechanism in mice following traumatic brain injury.
He J, Liu H, Zhong J, Guo Z, Wu J, Zhang H, Huang Z, Jiang L, Li H, Zhang Z, Liu L, Wu Y, Qi L, Sun X, Cheng C
Neurobiology of disease 2018 Sep;117:114-124
Neurobiology of disease 2018 Sep;117:114-124
Alcohol attenuates anti-HCV function of IFN-λ1 through up-regulation of PLASy expression in human hepatic cells.
Ran M, Huang J, Liang H, Jiang J, Liang B, Ning C, Zang N, Liao W, Liu H, Qin F, Yang Q, Ho W, Ye L, Chen H
Journal of medical virology 2018 Jun;90(6):1112-1120
Journal of medical virology 2018 Jun;90(6):1112-1120
Myxovirus resistance protein A inhibits hepatitis C virus replication through JAK-STAT pathway activation.
Wang H, Xin X, Wang M, Han L, Li J, Hao Y, Zheng C, Shen C
Archives of virology 2018 Jun;163(6):1429-1438
Archives of virology 2018 Jun;163(6):1429-1438
TBK1: A key regulator and potential treatment target for interferon positive Sjögren's syndrome, systemic lupus erythematosus and systemic sclerosis.
Bodewes ILA, Huijser E, van Helden-Meeuwsen CG, Tas L, Huizinga R, Dalm VASH, van Hagen PM, Groot N, Kamphuis S, van Daele PLA, Versnel MA
Journal of autoimmunity 2018 Jul;91:97-102
Journal of autoimmunity 2018 Jul;91:97-102
Characterization of Whooper Swan (Cygnus cygnus) Interferon α: Prokaryotic Expression, Biological Activities, and Physicochemical Characteristics.
Zhao H, Wang Y, Shao Y, Liu J, Li J, Zong H, Xing M
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2018 Jan;38(1):20-28
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2018 Jan;38(1):20-28
Phospholipid scramblase 1 interacts with influenza A virus NP, impairing its nuclear import and thereby suppressing virus replication.
Luo W, Zhang J, Liang L, Wang G, Li Q, Zhu P, Zhou Y, Li J, Zhao Y, Sun N, Huang S, Zhou C, Chang Y, Cui P, Chen P, Jiang Y, Deng G, Bu Z, Li C, Jiang L, Chen H
PLoS pathogens 2018 Jan;14(1):e1006851
PLoS pathogens 2018 Jan;14(1):e1006851
Distinct temporal roles for the promyelocytic leukaemia (PML) protein in the sequential regulation of intracellular host immunity to HSV-1 infection.
Alandijany T, Roberts APE, Conn KL, Loney C, McFarlane S, Orr A, Boutell C
PLoS pathogens 2018 Jan;14(1):e1006769
PLoS pathogens 2018 Jan;14(1):e1006769
Type I IFN signature in childhood-onset systemic lupus erythematosus: a conspiracy of DNA- and RNA-sensing receptors?
Wahadat MJ, Bodewes ILA, Maria NI, van Helden-Meeuwsen CG, van Dijk-Hummelman A, Steenwijk EC, Kamphuis S, Versnel MA
Arthritis research & therapy 2018 Jan 10;20(1):4
Arthritis research & therapy 2018 Jan 10;20(1):4
Interferon-alpha enhances the antitumour activity of EGFR-targeted therapies by upregulating RIG-I in head and neck squamous cell carcinoma.
Ma H, Jin S, Yang W, Zhou G, Zhao M, Fang S, Zhang Z, Hu J
British journal of cancer 2018 Feb 20;118(4):509-521
British journal of cancer 2018 Feb 20;118(4):509-521
The large GTPase Mx1 binds Kif5B for cargo transport along microtubules.
Ringer K, Riehl J, Müller M, Dewes J, Hoff F, Jacob R
Traffic (Copenhagen, Denmark) 2018 Dec;19(12):947-964
Traffic (Copenhagen, Denmark) 2018 Dec;19(12):947-964
Inducible TAP1 Negatively Regulates the Antiviral Innate Immune Response by Targeting the TAK1 Complex.
Xia Z, Xu G, Yang X, Peng N, Zuo Q, Zhu S, Hao H, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2017 May 1;198(9):3690-3704
Journal of immunology (Baltimore, Md. : 1950) 2017 May 1;198(9):3690-3704
Inducible Rubicon facilitates viral replication by antagonizing interferon production.
Wan Y, Cao W, Han T, Ren S, Feng J, Chen T, Wang J, Broering R, Lu M, Zhu Y
Cellular & molecular immunology 2017 Jul;14(7):607-620
Cellular & molecular immunology 2017 Jul;14(7):607-620
Matrix Metalloproteinase 9 Facilitates Hepatitis B Virus Replication through Binding with Type I Interferon (IFN) Receptor 1 To Repress IFN/JAK/STAT Signaling.
Chen J, Xu W, Chen Y, Xie X, Zhang Y, Ma C, Yang Q, Han Y, Zhu C, Xiong Y, Wu K, Liu F, Liu Y, Wu J
Journal of virology 2017 Apr 15;91(8)
Journal of virology 2017 Apr 15;91(8)
Soluble IL-6 Receptor and IL-27 Subunit p28 Protein Complex Mediate the Antiviral Response through the Type III IFN Pathway.
Yang X, Hao H, Xia Z, Xu G, Cao Z, Chen X, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2016 Sep 15;197(6):2369-81
Journal of immunology (Baltimore, Md. : 1950) 2016 Sep 15;197(6):2369-81
Comparative Proteome Analysis of Porcine Jejunum Tissues in Response to a Virulent Strain of Porcine Epidemic Diarrhea Virus and Its Attenuated Strain.
Li Z, Chen F, Ye S, Guo X, Muhanmmad Memon A, Wu M, He Q
Viruses 2016 Nov 29;8(12)
Viruses 2016 Nov 29;8(12)
STAT1 and NF-κB Inhibitors Diminish Basal Interferon-Stimulated Gene Expression and Improve the Productive Infection of Oncolytic HSV in MPNST Cells.
Jackson JD, Markert JM, Li L, Carroll SL, Cassady KA
Molecular cancer research : MCR 2016 May;14(5):482-92
Molecular cancer research : MCR 2016 May;14(5):482-92
Association of Increased Treg Cell Levels With Elevated Indoleamine 2,3-Dioxygenase Activity and an Imbalanced Kynurenine Pathway in Interferon-Positive Primary Sjögren's Syndrome.
Maria NI, van Helden-Meeuwsen CG, Brkic Z, Paulissen SM, Steenwijk EC, Dalm VA, van Daele PL, Martin van Hagen P, Kroese FG, van Roon JA, Harkin A, Dik WA, Drexhage HA, Lubberts E, Versnel MA
Arthritis & rheumatology (Hoboken, N.J.) 2016 Jul;68(7):1688-99
Arthritis & rheumatology (Hoboken, N.J.) 2016 Jul;68(7):1688-99
MxA Mediates SUMO-Induced Resistance to Vesicular Stomatitis Virus.
Maarifi G, Hannoun Z, Geoffroy MC, El Asmi F, Zarrouk K, Nisole S, Blondel D, Chelbi-Alix MK
Journal of virology 2016 Jul 15;90(14):6598-6610
Journal of virology 2016 Jul 15;90(14):6598-6610
Complex Interplay between HIV-1 Capsid and MX2-Independent Alpha Interferon-Induced Antiviral Factors.
Bulli L, Apolonia L, Kutzner J, Pollpeter D, Goujon C, Herold N, Schwarz SM, Giernat Y, Keppler OT, Malim MH, Schaller T
Journal of virology 2016 Aug 15;90(16):7469-7480
Journal of virology 2016 Aug 15;90(16):7469-7480
Human hepatitis B virus surface and e antigens inhibit major vault protein signaling in interferon induction pathways.
Liu S, Peng N, Xie J, Hao Q, Zhang M, Zhang Y, Xia Z, Xu G, Zhao F, Wang Q, Han T, Zhu Y
Journal of hepatology 2015 May;62(5):1015-23
Journal of hepatology 2015 May;62(5):1015-23
Interferon inducible antiviral MxA is inversely associated with prostate cancer and regulates cell cycle, invasion and Docetaxel induced apoptosis.
Brown SG, Knowell AE, Hunt A, Patel D, Bhosle S, Chaudhary J
The Prostate 2015 Feb 15;75(3):266-79
The Prostate 2015 Feb 15;75(3):266-79
Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice.
Knight JS, Subramanian V, O'Dell AA, Yalavarthi S, Zhao W, Smith CK, Hodgin JB, Thompson PR, Kaplan MJ
Annals of the rheumatic diseases 2015 Dec;74(12):2199-206
Annals of the rheumatic diseases 2015 Dec;74(12):2199-206
Hepatitis B virus hijacks CTHRC1 to evade host immunity and maintain replication.
Bai L, Zhang W, Tan L, Yang H, Ge M, Zhu C, Zhang R, Cao Y, Chen J, Luo Z, Ho W, Liu F, Wu K, Wu J
Journal of molecular cell biology 2015 Dec;7(6):543-56
Journal of molecular cell biology 2015 Dec;7(6):543-56
The large GTPase Mx1 is involved in apical transport in MDCK cells.
Hoff F, Greb C, Hollmann C, Hönig E, Jacob R
Traffic (Copenhagen, Denmark) 2014 Sep;15(9):983-96
Traffic (Copenhagen, Denmark) 2014 Sep;15(9):983-96
NRAV, a long noncoding RNA, modulates antiviral responses through suppression of interferon-stimulated gene transcription.
Ouyang J, Zhu X, Chen Y, Wei H, Chen Q, Chi X, Qi B, Zhang L, Zhao Y, Gao GF, Wang G, Chen JL
Cell host & microbe 2014 Nov 12;16(5):616-26
Cell host & microbe 2014 Nov 12;16(5):616-26
Interferon induction of IFITM proteins promotes infection by human coronavirus OC43.
Zhao X, Guo F, Liu F, Cuconati A, Chang J, Block TM, Guo JT
Proceedings of the National Academy of Sciences of the United States of America 2014 May 6;111(18):6756-61
Proceedings of the National Academy of Sciences of the United States of America 2014 May 6;111(18):6756-61
Epicutaneous application of toll-like receptor 7 agonists leads to systemic autoimmunity in wild-type mice: a new model of systemic Lupus erythematosus.
Yokogawa M, Takaishi M, Nakajima K, Kamijima R, Fujimoto C, Kataoka S, Terada Y, Sano S
Arthritis & rheumatology (Hoboken, N.J.) 2014 Mar;66(3):694-706
Arthritis & rheumatology (Hoboken, N.J.) 2014 Mar;66(3):694-706
MxA as a clinically applicable biomarker for identifying systemic interferon type I in primary Sjogren's syndrome.
Maria NI, Brkic Z, Waris M, van Helden-Meeuwsen CG, Heezen K, van de Merwe JP, van Daele PL, Dalm VA, Drexhage HA, Versnel MA
Annals of the rheumatic diseases 2014 Jun;73(6):1052-9
Annals of the rheumatic diseases 2014 Jun;73(6):1052-9
IL-27, a cytokine, and IFN-λ1, a type III IFN, are coordinated to regulate virus replication through type I IFN.
Cao Y, Zhang R, Zhang W, Zhu C, Yu Y, Song Y, Wang Q, Bai L, Liu Y, Wu K, Wu J
Journal of immunology (Baltimore, Md. : 1950) 2014 Jan 15;192(2):691-703
Journal of immunology (Baltimore, Md. : 1950) 2014 Jan 15;192(2):691-703
Vpx rescue of HIV-1 from the antiviral state in mature dendritic cells is independent of the intracellular deoxynucleotide concentration.
Reinhard C, Bottinelli D, Kim B, Luban J
Retrovirology 2014 Feb 1;11:12
Retrovirology 2014 Feb 1;11:12
Quantitative proteomic analysis reveals that transmissible gastroenteritis virus activates the JAK-STAT1 signaling pathway.
An K, Fang L, Luo R, Wang D, Xie L, Yang J, Chen H, Xiao S
Journal of proteome research 2014 Dec 5;13(12):5376-90
Journal of proteome research 2014 Dec 5;13(12):5376-90
Influenza A virus-induced degradation of eukaryotic translation initiation factor 4B contributes to viral replication by suppressing IFITM3 protein expression.
Wang S, Chi X, Wei H, Chen Y, Chen Z, Huang S, Chen JL
Journal of virology 2014 Aug;88(15):8375-85
Journal of virology 2014 Aug;88(15):8375-85
Serial cervicovaginal exposures with replication-deficient SIVsm induce higher dendritic cell (pDC) and CD4+ T-cell infiltrates not associated with prevention but a more severe SIVmac251 infection of rhesus macaques.
Abdulhaqq SA, Martinez MI, Kang G, Foulkes AS, Rodriguez IV, Nichols SM, Hunter M, Sariol CA, Ruiz LA, Ross BN, Yin X, Speicher DW, Haase AT, Marx PA, Li Q, Kraiselburd EN, Montaner LJ
Journal of acquired immune deficiency syndromes (1999) 2014 Apr 1;65(4):405-13
Journal of acquired immune deficiency syndromes (1999) 2014 Apr 1;65(4):405-13
MxA inhibits hepatitis B virus replication by interaction with hepatitis B core antigen.
Li N, Zhang L, Chen L, Feng W, Xu Y, Chen F, Liu X, Chen Z, Liu W
Hepatology (Baltimore, Md.) 2012 Sep;56(3):803-11
Hepatology (Baltimore, Md.) 2012 Sep;56(3):803-11
IFITM3 restricts the morbidity and mortality associated with influenza.
Everitt AR, Clare S, Pertel T, John SP, Wash RS, Smith SE, Chin CR, Feeley EM, Sims JS, Adams DJ, Wise HM, Kane L, Goulding D, Digard P, Anttila V, Baillie JK, Walsh TS, Hume DA, Palotie A, Xue Y, Colonna V, Tyler-Smith C, Dunning J, Gordon SB, GenISIS Investigators, MOSAIC Investigators, Smyth RL, Openshaw PJ, Dougan G, Brass AL, Kellam P
Nature 2012 Mar 25;484(7395):519-23
Nature 2012 Mar 25;484(7395):519-23
IFITM3 inhibits influenza A virus infection by preventing cytosolic entry.
Feeley EM, Sims JS, John SP, Chin CR, Pertel T, Chen LM, Gaiha GD, Ryan BJ, Donis RO, Elledge SJ, Brass AL
PLoS pathogens 2011 Oct;7(10):e1002337
PLoS pathogens 2011 Oct;7(10):e1002337
Vpx rescues HIV-1 transduction of dendritic cells from the antiviral state established by type 1 interferon.
Pertel T, Reinhard C, Luban J
Retrovirology 2011 Jun 22;8:49
Retrovirology 2011 Jun 22;8:49
Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections.
Jiang D, Weidner JM, Qing M, Pan XB, Guo H, Xu C, Zhang X, Birk A, Chang J, Shi PY, Block TM, Guo JT
Journal of virology 2010 Aug;84(16):8332-41
Journal of virology 2010 Aug;84(16):8332-41
Rac1 is required for oncolytic NDV replication in human cancer cells and establishes a link between tumorigenesis and sensitivity to oncolytic virus.
Puhlmann J, Puehler F, Mumberg D, Boukamp P, Beier R
Oncogene 2010 Apr 15;29(15):2205-16
Oncogene 2010 Apr 15;29(15):2205-16
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse spleen tissue were subjected to SDS PAGE followed by western blot with 13750-1-AP(MX1 antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The MX1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MX1. This antibody recognizes human, mouse antigen. The MX1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
