BS3304

antibody from Bioworld Technology, Inc

Targeting: GFRA4

Western blot (Data presented on provider website)

Antibody Data

Product number

BS3304

Provider

Bioworld Technology, Inc

Proper citation

Bioworld Technology Cat#BS3304, RRID:AB_1662306

Product name

GFRÏ« 4 (P178) polyclonal antibody

Antibody type

Polyclonal

Antigen

Synthetic peptide, corresponding to amino acids 148-195 of Human GFRÏ«-4.

Description

Glial cell line-derived neurotrophic factor (GDNF) and the related neurotrophic factor neurturin (NTN) are potent survival factors for central and peripheral neurons. Receptors for these factors include GFRÏ«-1 (previously designated GDNFR-Ï«), GFRÏ«-2 (also designated RETL2), GFRÏ«-3 and GFRÏ«-4 (also known as persephin receptor). The receptors do not contain transmembrane domains and are attached to the cell membrane by glycosylphosphoinositol linkage. Binding of GDNF or NTN to one of these receptors leads to the activation of the tyrosine kinase Ret. GFRÏ«-4 mediates the activation and GDNF-induced autophosphorylation of the RET receptor. It is mainly expressed in the adult thyroid gland, but lower levels may also be detected in fetal adrenal and thyroid glands.

Reactivity

Human

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.