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Learn60112-1-Ig
antibody from Proteintech Group
Targeting: IL1RL1
DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1
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ELISAAntibody data
- Antibody Data
- Antigen structure
- References [22]
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- Validations
- Western blot [1]
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- Product number
- 60112-1-Ig - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#60112-1-Ig, RRID:AB_2264785
- Product name
- ST2 antibody
- Antibody type
- Monoclonal
- Description
- ST2 antibody (Cat. #60112-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat, pig and has been validated for the following applications: FC, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat, Porcine
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 7A2A7
- Vial size
- 20ul, 150ul
Submitted references Modified Jiaoqi powder ameliorates ulcerative colitis through gut microbiota-tryptophan metabolism-AhR signaling modulating-ILC2/ILC3 balance.
The role of the IL-33/ST2/MAPK signalling pathway in macrophage polarisation and endometrial fibrosis.
Tetramethylpyrazine alleviates ventricular remodeling after myocardial infarction by regulating Sirt1/p300/Yy1/sST2 signaling axis.
Targeting of the IL-33/Wnt axis restricts breast cancer stemness and metastasis.
Fibroblast-derived IL-33 exacerbates orofacial neuropathic pain via the activation of TRPA1 in trigeminal ganglion neurons.
Exploring macrophage and nerve interaction in endometriosis-associated pain: the inductive role of IL-33.
Dietary Fiber-Derived Microbial Butyrate Suppresses ILC2-Dependent Airway Inflammation in COPD.
Partial reduction of interleukin-33 signaling improves senescence and renal injury in diabetic nephropathy.
IL-33/ST2 enhances MMP-12 expression by macrophages to mediate inflammatory and immune response in IgG4-Related Ophthalmic Disease.
Macrophages originated IL-33/ST2 inhibits ferroptosis in endometriosis via the ATF3/SLC7A11 axis.
IL-33 promotes pancreatic β-cell survival and insulin secretion under diabetogenic conditions through PPARγ.
Association of Soluble ST2 With Functional Outcome, Perihematomal Edema, and Immune Response After Intraparenchymal Hemorrhage.
Honokiol suppresses the aberrant interactions between renal resident macrophages and tubular epithelial cells in lupus nephritis through the NLRP3/IL-33/ST2 axis.
IL-33/ST2 mediating systemic inflammation and neuroinflammation through NF-kB participated in the neurocognitive impairment in obstructive sleep apnea.
sST2: A Bridge Between Sirt1/p53/p21 Signal-Induced Senescence and TGF-β1/Smad2/3 Regulation of Cardiac Fibrosis in Mouse Viral Myocarditis.
Targeting IL-17alpha to promote anti-PD-1 therapy effect by screening the tumor immune microenvironment in a mouse oral carcinogenesis model.
Intrarenal modulation of NF-κB activity attenuates cardiac injury in a swine model of CKD: a renal-cardio axis.
Molecular hydrogen alleviates asthma through inhibiting IL-33/ILC2 axis.
Interleukin-33 Promotes Serotonin Release from Enterochromaffin Cells for Intestinal Homeostasis.
Epithelial IL-33 appropriates exosome trafficking for secretion in chronic airway disease.
Fatty acid-binding protein 5 limits ILC2-mediated allergic lung inflammation in a murine asthma model.
Dysfunctional EAT thickness may promote maladaptive heart remodeling in CVD patients through the ST2-IL33 system, directly related to EPAC protein expression.
Jin T, Yi Q, Wang Y, Liu W, Zheng L, An J, Mi H, Zhou L, Liu F, Wang X
Frontiers in microbiology 2026;17:1764082
Frontiers in microbiology 2026;17:1764082
The role of the IL-33/ST2/MAPK signalling pathway in macrophage polarisation and endometrial fibrosis.
Li G, Xu F, Luo S, Jin Y, Yuan L, Yang X, Xuan T, Liu D
International immunopharmacology 2026 Jul 1;180:116743
International immunopharmacology 2026 Jul 1;180:116743
Tetramethylpyrazine alleviates ventricular remodeling after myocardial infarction by regulating Sirt1/p300/Yy1/sST2 signaling axis.
Liu T, Zhang R, Wang T, Fang Z, Guo Y, Fan Y, Li X, Liu N, Liu P, Wang S, Chen L, Liu Q, Wang H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157662
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157662
Targeting of the IL-33/Wnt axis restricts breast cancer stemness and metastasis.
Fan G, Zuo S, Wang Z, Zhang S, Liu L, Luo H, Xie Y, Zhang Y, Li D
Scientific reports 2025 May 25;15(1):18172
Scientific reports 2025 May 25;15(1):18172
Fibroblast-derived IL-33 exacerbates orofacial neuropathic pain via the activation of TRPA1 in trigeminal ganglion neurons.
Ikehata Y, Oshima E, Hayashi Y, Tanaka Y, Sato H, Hitomi S, Shiratori-Hayashi M, Urata K, Kimura Y, Shibuta I, Ohba S, Iwata K, Mizuta K, Shirota T, Shinoda M
Brain, behavior, and immunity 2025 Jan;123:982-996
Brain, behavior, and immunity 2025 Jan;123:982-996
Exploring macrophage and nerve interaction in endometriosis-associated pain: the inductive role of IL-33.
Li J, Wu Z, Li N, Wang J, Huang M, Zhu L, Wan G, Zhang Z
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Feb 19;74(1):42
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Feb 19;74(1):42
Dietary Fiber-Derived Microbial Butyrate Suppresses ILC2-Dependent Airway Inflammation in COPD.
Jiang M, Wang J, Li Z, Xu D, Jing J, Li F, Ding J, Li Q
Mediators of inflammation 2024;2024:6263447
Mediators of inflammation 2024;2024:6263447
Partial reduction of interleukin-33 signaling improves senescence and renal injury in diabetic nephropathy.
Chen L, Gao C, Yin X, Mo L, Cheng X, Chen H, Jiang C, Wu B, Zhao Y, Li H, Li Y, Li J, Chen L, Deng Q, Yao P, Tang Y
MedComm 2024 Nov;5(11):e742
MedComm 2024 Nov;5(11):e742
IL-33/ST2 enhances MMP-12 expression by macrophages to mediate inflammatory and immune response in IgG4-Related Ophthalmic Disease.
Ding X, Yu Y, Su D, Lin M, Chen M, Xing Y, Li J
Cytokine 2024 Dec;184:156754
Cytokine 2024 Dec;184:156754
Macrophages originated IL-33/ST2 inhibits ferroptosis in endometriosis via the ATF3/SLC7A11 axis.
Wu Q, Liang Z, Jiang J, Feng X, Liu J, Zhang Z, Wang H, Wang N, Gou Y, Li Z, Cao Y
Cell death & disease 2023 Oct 11;14(10):668
Cell death & disease 2023 Oct 11;14(10):668
IL-33 promotes pancreatic β-cell survival and insulin secretion under diabetogenic conditions through PPARγ.
Lin J, Lan Y, Xiang D, Ma R, Chen Q, Ding K, Lu J
European journal of pharmacology 2023 Nov 15;959:176059
European journal of pharmacology 2023 Nov 15;959:176059
Association of Soluble ST2 With Functional Outcome, Perihematomal Edema, and Immune Response After Intraparenchymal Hemorrhage.
Bevers MB, Booraem C, Li K, Sreekrishnan A, Sastre C, Falcone GJ, Sheth KN, Sansing LH, Kimberly WT
Neurology 2023 Mar 28;100(13):e1329-e1338
Neurology 2023 Mar 28;100(13):e1329-e1338
Honokiol suppresses the aberrant interactions between renal resident macrophages and tubular epithelial cells in lupus nephritis through the NLRP3/IL-33/ST2 axis.
Ma Q, Xu M, Jing X, Qiu J, Huang S, Yan H, Yin L, Lou J, Zhao L, Fan Y, Qiu P
Cell death & disease 2023 Mar 1;14(3):174
Cell death & disease 2023 Mar 1;14(3):174
IL-33/ST2 mediating systemic inflammation and neuroinflammation through NF-kB participated in the neurocognitive impairment in obstructive sleep apnea.
Dandan-Zong, Shen C, Liu X, Liu T, Ou Y, Ouyang R
International immunopharmacology 2023 Feb;115:109604
International immunopharmacology 2023 Feb;115:109604
sST2: A Bridge Between Sirt1/p53/p21 Signal-Induced Senescence and TGF-β1/Smad2/3 Regulation of Cardiac Fibrosis in Mouse Viral Myocarditis.
Tan J, Wei J, Lu H
Inflammation 2023 Aug;46(4):1305-1317
Inflammation 2023 Aug;46(4):1305-1317
Targeting IL-17alpha to promote anti-PD-1 therapy effect by screening the tumor immune microenvironment in a mouse oral carcinogenesis model.
Wang S, Yu X, Li F, Fan H, Zhao E, Hu Z
Cancer biomarkers : section A of Disease markers 2021;31(4):339-350
Cancer biomarkers : section A of Disease markers 2021;31(4):339-350
Intrarenal modulation of NF-κB activity attenuates cardiac injury in a swine model of CKD: a renal-cardio axis.
Chade AR, Engel JE, Hall ME, Eirin A, Bidwell GL 3rd
American journal of physiology. Renal physiology 2021 Oct 1;321(4):F411-F423
American journal of physiology. Renal physiology 2021 Oct 1;321(4):F411-F423
Molecular hydrogen alleviates asthma through inhibiting IL-33/ILC2 axis.
Zhang J, Feng X, Fan Y, Zhu G, Bai C
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2021 May;70(5):569-579
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2021 May;70(5):569-579
Interleukin-33 Promotes Serotonin Release from Enterochromaffin Cells for Intestinal Homeostasis.
Chen Z, Luo J, Li J, Kim G, Stewart A, Urban JF Jr, Huang Y, Chen S, Wu LG, Chesler A, Trinchieri G, Li W, Wu C
Immunity 2021 Jan 12;54(1):151-163.e6
Immunity 2021 Jan 12;54(1):151-163.e6
Epithelial IL-33 appropriates exosome trafficking for secretion in chronic airway disease.
Katz-Kiriakos E, Steinberg DF, Kluender CE, Osorio OA, Newsom-Stewart C, Baronia A, Byers DE, Holtzman MJ, Katafiasz D, Bailey KL, Brody SL, Miller MJ, Alexander-Brett J
JCI insight 2021 Feb 22;6(4)
JCI insight 2021 Feb 22;6(4)
Fatty acid-binding protein 5 limits ILC2-mediated allergic lung inflammation in a murine asthma model.
Kobayashi S, Tayama S, Phung HT, Kagawa Y, Miyazaki H, Takahashi Y, Maruyama T, Ishii N, Owada Y
Scientific reports 2020 Oct 6;10(1):16617
Scientific reports 2020 Oct 6;10(1):16617
Dysfunctional EAT thickness may promote maladaptive heart remodeling in CVD patients through the ST2-IL33 system, directly related to EPAC protein expression.
Vianello E, Dozio E, Bandera F, Schmitz G, Nebuloni M, Longhi E, Tacchini L, Guazzi M, Corsi Romanelli MM
Scientific reports 2019 Jul 17;9(1):10331
Scientific reports 2019 Jul 17;9(1):10331
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ST2 antibody from Proteintech is a mouse monoclonal antibody to a recombinant protein of human ST2. This antibody recognizes human antigen. The ST2 antibody has been validated for the following applications: ELISA, WB analysis.
